General information for g10177.t2
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Putative Putative glutathione-specific gamma-glutamylcyclotransferase 2.
Parent gene
- The parent gene g10177 is located on chr_1: 8079769..8080957 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_1 | g10177 | g10177.t2 | isoform | g10177.t2 | 8076907 | 8080423 |
| chr_1 | g10177 | g10177.t2 | exon | g10177.t2.exon1 | 8076907 | 8076915 |
| chr_1 | g10177 | g10177.t2 | exon | g10177.t2.exon2 | 8079524 | 8080299 |
| chr_1 | g10177 | g10177.t2 | cds | g10177.t2.CDS1 | 8079769 | 8080299 |
| chr_1 | g10177 | g10177.t2 | exon | g10177.t2.exon3 | 8080358 | 8080423 |
| chr_1 | g10177 | g10177.t2 | cds | g10177.t2.CDS2 | 8080358 | 8080423 |
| chr_1 | g10177 | g10177.t2 | TSS | g10177.t2 | 8080519 | 8080519 |
| chr_1 | g10177 | g10177.t2 | TTS | g10177.t2 | NA | NA |
Sequences
>g10177.t2 Gene=g10177 Length=851
ATGGATAGTGTGAATAACATTTGCCAAAATTGTAATGAACTTTGGGTCTTTGGTTATGGA
TCATTGGTATGGAAGAATGCAGATTTTGAATTCGAAAGCAGTGTTGCAGGATTTTTAAAA
GGATTCAAAAGACGCTTTTATCAAAATAGCATTGATCATAGAGGAACAGAAAAATTTCCA
GGTCGTGTTGTTACGTTAATCAAGAGTGACGATCAAAATGAGAGAGTATATGGAATGGGT
TATAAAATTTCAAATGACAAAATCATGAAAGTACTTAATCATTTAGACTATCGCGAAAAA
AATGGATATGAACGCTGTGAAACATTTTTCTATCCTATCAATAATGAACAGCTCAAAAAG
AAGACTATAGTTTATGTGGCAAATGAGACTAATCCATCATGGAATAGTGATCATGATTTA
CATTCTATTGCTCGTCAAGTATTTAAAGCCATTGGACCATCAGGTGATAATATTTCATAT
GTTTATAATCTCTGCAATGCAATGAGAGAGCATTTTCCAAATCATTATCATGAAGATAGG
CATCTTTTTGAACTTGAAAAATTACTCAAAGAAATGAAAGAGAAGGCTAGTGAATAAAAA
GTACAGTGTTCATTCTTTAAATTTTTCAAGAGTTTTTTTTTATTTTGTATGTTATCCTAA
TTCACTTTTATTTTCTTTTGTGTTTCACAATTTTATTACAATTTTCTCCATCAAAAAAAT
TATCTCGTTAGTTCGATATAGTAAAGAAAAAGAGGAATCCTGATGACTTTTTTCTTTCTC
TCAATATAATTTGTGAATATGTATTTAAGTTTAATAAACACTATTTCATGTTTCAACATT
TAAAAAAAAAA
>g10177.t2 Gene=g10177 Length=198
MDSVNNICQNCNELWVFGYGSLVWKNADFEFESSVAGFLKGFKRRFYQNSIDHRGTEKFP
GRVVTLIKSDDQNERVYGMGYKISNDKIMKVLNHLDYREKNGYERCETFFYPINNEQLKK
KTIVYVANETNPSWNSDHDLHSIARQVFKAIGPSGDNISYVYNLCNAMREHFPNHYHEDR
HLFELEKLLKEMKEKASE
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 7 | g10177.t2 | CDD | cd06661 | GGCT_like | 16 | 127 | 5.79753E-10 |
| 6 | g10177.t2 | Coils | Coil | Coil | 182 | 198 | - |
| 5 | g10177.t2 | Gene3D | G3DSA:3.10.490.10 | Hypothetical upf0131 protein ytfp | 5 | 197 | 6.6E-10 |
| 2 | g10177.t2 | PANTHER | PTHR12192:SF20 | GLUTATHIONE-SPECIFIC GAMMA-GLUTAMYLCYCLOTRANSFERASE 2 | 6 | 196 | 1.1E-66 |
| 3 | g10177.t2 | PANTHER | PTHR12192 | CATION TRANSPORT PROTEIN CHAC-RELATED | 6 | 196 | 1.1E-66 |
| 1 | g10177.t2 | Pfam | PF04752 | ChaC-like protein | 14 | 191 | 1.8E-56 |
| 4 | g10177.t2 | SUPERFAMILY | SSF110857 | Gamma-glutamyl cyclotransferase-like | 14 | 135 | 2.35E-9 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0003839 | gamma-glutamylcyclotransferase activity | MF |
| GO:0006751 | glutathione catabolic process | BP |
KEGG
Orthology
- This transcript has been annotated with K07232 (glutathione-specific gamma-glutamylcyclotransferase)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
