General information for g10986.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Putative Suppressor of tumorigenicity 14 protein-like protein.
Parent gene
- The parent gene g10986 is located on chr_1: 13172765..13174626 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_1 | g10986 | g10986.t1 | TTS | g10986.t1 | 13172684 | 13172684 |
| chr_1 | g10986 | g10986.t1 | isoform | g10986.t1 | 13172765 | 13174626 |
| chr_1 | g10986 | g10986.t1 | exon | g10986.t1.exon1 | 13172765 | 13173021 |
| chr_1 | g10986 | g10986.t1 | cds | g10986.t1.CDS1 | 13172765 | 13173021 |
| chr_1 | g10986 | g10986.t1 | exon | g10986.t1.exon2 | 13173085 | 13173102 |
| chr_1 | g10986 | g10986.t1 | cds | g10986.t1.CDS2 | 13173085 | 13173102 |
| chr_1 | g10986 | g10986.t1 | exon | g10986.t1.exon3 | 13173171 | 13174249 |
| chr_1 | g10986 | g10986.t1 | cds | g10986.t1.CDS3 | 13173171 | 13174249 |
| chr_1 | g10986 | g10986.t1 | exon | g10986.t1.exon4 | 13174322 | 13174626 |
| chr_1 | g10986 | g10986.t1 | cds | g10986.t1.CDS4 | 13174322 | 13174626 |
| chr_1 | g10986 | g10986.t1 | TSS | g10986.t1 | 13174644 | 13174644 |
Sequences
>g10986.t1 Gene=g10986 Length=1659
ATGTTGTTGACAATAACAAAAACAATAATATTCCTTGTATTATTTCATCATTCGACTTTT
GCTGCAAATTTTACATGCCTGAATGGCGATATTGTGGGTGCATTGAATATATGCAATGGA
ATTTCGAATTGTGCAGACGGGTCCGATGAAAGAAGCGAATTGTGTTCTACTATAATATGT
CAACCACAACAATTCAAATGCCATTATGGCGGATGTGTAGATCGAGGAAAGTTTTGCAAT
AAAATTCATGATTGCCTTGATGGTTCAGACGAATTTAATTGCGGTAGATCTAATAAAAGT
TGCGAATCAACTGAATTTTACTGCACAAGTGATGAAACATGCATAGATGTCACACTGATT
TGTAACAATTACAGGGATTGCCCAAACGGCGAAGATGAAAACGTATGTCAATCACAATTA
TGTCCTAAAAATAGTTTTCGCTGCAGTCATGGTCGATGTATTGATGAAAAGTTACTCTGT
GACAATTTCAATGACTGTATCACAGGTGATGATGAATCGGATTTATTATGCAATGCACAA
GTAAACGACTGTTATGAATGTAATAATATCAATTGTCCTCCTATAAATTCAAATCGCTTA
GACATCATATCGTGTATATACGAAAACGAAACTGTTTCATGCGAAGATAATGAAATAAAG
CCAGGAACAATAGTAAATTATGCTTGCAAAATACACTATGAACCAATTAATAATATTCAT
AAGTTCAATTATCAAACAACATGCCAAAGAAATGGCCAGTGGTCATCGGAAATTTTGAAA
TGTACACCAAAATGCGGCTACTTAAAAAATTCCATTTCCCTCATAGTGAACGGCTTTCCA
ACAGAAGAGCTATTTCCATGGCATGCAACAATTTTCATAAAGCGTAAAAGCGGATTTGAA
TTTGCTTGCGGTGCATCATTACTTTCCGAATCGACTCTCGTGTCAGCATCTCATTGTTTT
AACGGATTAAATGAATCAGATGTAAAAATCGCAGTCGGTAAACGATACAGTAATTTAGAA
ATTCAGGAAAATGAGATAAATGCAAAGATTTTCAATGTTTCACGTATCTACCGGCATCCA
TTATATTTGGACAAAATTGGAAATTATGGACAAGATATTGCACTTGTTGAGCTAGACGAA
ATTATTGAATTGAGCGATGACGTTCATCCAATCTGTATAGATTGGCAAAAAAACGACGAC
TATTTGGCTGAAAATCAATTAGGAATTGTTGTCGGTATGGGAATCACAGAGAACGAGACA
TTCAGTGATGTAATTCGAATGGCATCACTTAAAGTCATACCGACACAAGATTGCATAAAT
AAGCAGCCAAAGGATTTTCGAAAATATATTACATTCACAACTTTTTGTGCTGGCACTGAC
AATGGCACTTCAGTTTGCAATGGTGATTCCGGAGGAGGATTTGTAACTTTATCGAGAGAT
AAGAAGAAATGGTTAATTCGAGGGATTGTTAGTCTAAGTCCTCGAAAGCGTTCAACTTTC
TTTTGTGATCCACACAAATACACAATATTCACAAAAATTGATGTTTACGTCAGATGGATC
AAGTTTATACTCGATAGCATTGAAGTGAGGATGATGATGACTAAGAAGGCAACGGCGACA
ATACTTGAGAATGAAAATTTCAATTTGCCAGTTCTTTAA
>g10986.t1 Gene=g10986 Length=552
MLLTITKTIIFLVLFHHSTFAANFTCLNGDIVGALNICNGISNCADGSDERSELCSTIIC
QPQQFKCHYGGCVDRGKFCNKIHDCLDGSDEFNCGRSNKSCESTEFYCTSDETCIDVTLI
CNNYRDCPNGEDENVCQSQLCPKNSFRCSHGRCIDEKLLCDNFNDCITGDDESDLLCNAQ
VNDCYECNNINCPPINSNRLDIISCIYENETVSCEDNEIKPGTIVNYACKIHYEPINNIH
KFNYQTTCQRNGQWSSEILKCTPKCGYLKNSISLIVNGFPTEELFPWHATIFIKRKSGFE
FACGASLLSESTLVSASHCFNGLNESDVKIAVGKRYSNLEIQENEINAKIFNVSRIYRHP
LYLDKIGNYGQDIALVELDEIIELSDDVHPICIDWQKNDDYLAENQLGIVVGMGITENET
FSDVIRMASLKVIPTQDCINKQPKDFRKYITFTTFCAGTDNGTSVCNGDSGGGFVTLSRD
KKKWLIRGIVSLSPRKRSTFFCDPHKYTIFTKIDVYVRWIKFILDSIEVRMMMTKKATAT
ILENENFNLPVL
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 33 | g10986.t1 | CDD | cd00112 | LDLa | 60 | 94 | 6.77087E-9 |
| 32 | g10986.t1 | CDD | cd00112 | LDLa | 101 | 136 | 7.56317E-6 |
| 31 | g10986.t1 | CDD | cd00112 | LDLa | 141 | 174 | 8.15345E-7 |
| 34 | g10986.t1 | CDD | cd00033 | CCP | 208 | 261 | 4.72621E-5 |
| 35 | g10986.t1 | CDD | cd00190 | Tryp_SPc | 275 | 523 | 1.38731E-47 |
| 20 | g10986.t1 | Gene3D | G3DSA:4.10.400.10 | - | 24 | 57 | 5.7E-7 |
| 23 | g10986.t1 | Gene3D | G3DSA:4.10.400.10 | - | 58 | 91 | 8.2E-11 |
| 22 | g10986.t1 | Gene3D | G3DSA:4.10.400.10 | - | 98 | 144 | 2.9E-10 |
| 21 | g10986.t1 | Gene3D | G3DSA:4.10.400.10 | - | 145 | 174 | 7.4E-9 |
| 19 | g10986.t1 | Gene3D | G3DSA:2.10.70.10 | Complement Module | 202 | 263 | 1.2E-7 |
| 25 | g10986.t1 | Gene3D | G3DSA:2.40.10.10 | - | 275 | 513 | 6.2E-51 |
| 24 | g10986.t1 | Gene3D | G3DSA:2.40.10.10 | - | 286 | 520 | 6.2E-51 |
| 5 | g10986.t1 | PANTHER | PTHR24260 | - | 260 | 530 | 1.7E-60 |
| 6 | g10986.t1 | PANTHER | PTHR24260:SF110 | GH19262P | 260 | 530 | 1.7E-60 |
| 10 | g10986.t1 | PRINTS | PR00261 | Low density lipoprotein (LDL) receptor signature | 29 | 50 | 1.6E-17 |
| 7 | g10986.t1 | PRINTS | PR00261 | Low density lipoprotein (LDL) receptor signature | 70 | 91 | 1.6E-17 |
| 9 | g10986.t1 | PRINTS | PR00261 | Low density lipoprotein (LDL) receptor signature | 112 | 133 | 1.6E-17 |
| 8 | g10986.t1 | PRINTS | PR00261 | Low density lipoprotein (LDL) receptor signature | 151 | 172 | 1.6E-17 |
| 4 | g10986.t1 | Pfam | PF00057 | Low-density lipoprotein receptor domain class A | 60 | 94 | 4.1E-9 |
| 3 | g10986.t1 | Pfam | PF00057 | Low-density lipoprotein receptor domain class A | 100 | 136 | 5.9E-7 |
| 2 | g10986.t1 | Pfam | PF00057 | Low-density lipoprotein receptor domain class A | 141 | 173 | 3.1E-7 |
| 1 | g10986.t1 | Pfam | PF00089 | Trypsin | 276 | 520 | 5.7E-39 |
| 27 | g10986.t1 | Phobius | SIGNAL_PEPTIDE | Signal peptide region | 1 | 21 | - |
| 28 | g10986.t1 | Phobius | SIGNAL_PEPTIDE_N_REGION | N-terminal region of a signal peptide. | 1 | 7 | - |
| 29 | g10986.t1 | Phobius | SIGNAL_PEPTIDE_H_REGION | Hydrophobic region of a signal peptide. | 8 | 16 | - |
| 30 | g10986.t1 | Phobius | SIGNAL_PEPTIDE_C_REGION | C-terminal region of a signal peptide. | 17 | 21 | - |
| 26 | g10986.t1 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. | 22 | 552 | - |
| 42 | g10986.t1 | ProSitePatterns | PS01209 | LDL-receptor class A (LDLRA) domain signature. | 153 | 177 | - |
| 43 | g10986.t1 | ProSitePatterns | PS00134 | Serine proteases, trypsin family, histidine active site. | 314 | 319 | - |
| 46 | g10986.t1 | ProSiteProfiles | PS50068 | LDL-receptor class A (LDLRA) domain profile. | 59 | 95 | 11.863 |
| 47 | g10986.t1 | ProSiteProfiles | PS50068 | LDL-receptor class A (LDLRA) domain profile. | 100 | 137 | 11.663 |
| 48 | g10986.t1 | ProSiteProfiles | PS50068 | LDL-receptor class A (LDLRA) domain profile. | 140 | 178 | 11.5 |
| 44 | g10986.t1 | ProSiteProfiles | PS50923 | Sushi/CCP/SCR domain profile. | 190 | 263 | 8.251 |
| 45 | g10986.t1 | ProSiteProfiles | PS50240 | Serine proteases, trypsin domain profile. | 275 | 525 | 23.867 |
| 40 | g10986.t1 | SMART | SM00192 | LDLa_2 | 19 | 57 | 0.0076 |
| 41 | g10986.t1 | SMART | SM00192 | LDLa_2 | 59 | 96 | 3.0E-9 |
| 39 | g10986.t1 | SMART | SM00192 | LDLa_2 | 100 | 138 | 1.3E-6 |
| 38 | g10986.t1 | SMART | SM00192 | LDLa_2 | 140 | 179 | 5.5E-8 |
| 37 | g10986.t1 | SMART | SM00020 | trypsin_2 | 274 | 520 | 2.7E-44 |
| 13 | g10986.t1 | SUPERFAMILY | SSF57424 | LDL receptor-like module | 21 | 56 | 1.07E-6 |
| 14 | g10986.t1 | SUPERFAMILY | SSF57424 | LDL receptor-like module | 54 | 94 | 6.81E-10 |
| 11 | g10986.t1 | SUPERFAMILY | SSF57424 | LDL receptor-like module | 100 | 136 | 1.44E-7 |
| 12 | g10986.t1 | SUPERFAMILY | SSF57424 | LDL receptor-like module | 136 | 177 | 1.44E-8 |
| 15 | g10986.t1 | SUPERFAMILY | SSF57535 | Complement control module/SCR domain | 206 | 262 | 1.33E-6 |
| 16 | g10986.t1 | SUPERFAMILY | SSF50494 | Trypsin-like serine proteases | 245 | 523 | 1.31E-52 |
| 18 | g10986.t1 | SignalP_EUK | SignalP-noTM | SignalP-noTM | 1 | 21 | - |
| 36 | g10986.t1 | SignalP_GRAM_NEGATIVE | SignalP-noTM | SignalP-noTM | 1 | 21 | - |
| 17 | g10986.t1 | SignalP_GRAM_POSITIVE | SignalP-TM | SignalP-TM | 1 | 21 | - |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0004252 | serine-type endopeptidase activity | MF |
| GO:0006508 | proteolysis | BP |
| GO:0005515 | protein binding | MF |
KEGG
Orthology
This gene did not have any KEGG ortholog annotations (KAAS, GHOSTZ).
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
