General information for g11008.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Alkaline phosphatase, tissue-nonspecific isozyme.
Parent gene
- The parent gene g11008 is located on chr_1: 13386651..13388557 (+ strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_1 | g11008 | g11008.t1 | isoform | g11008.t1 | 13386651 | 13388557 |
| chr_1 | g11008 | g11008.t1 | exon | g11008.t1.exon1 | 13386651 | 13388073 |
| chr_1 | g11008 | g11008.t1 | cds | g11008.t1.CDS1 | 13386651 | 13388073 |
| chr_1 | g11008 | g11008.t1 | exon | g11008.t1.exon2 | 13388346 | 13388557 |
| chr_1 | g11008 | g11008.t1 | cds | g11008.t1.CDS2 | 13388346 | 13388557 |
| chr_1 | g11008 | g11008.t1 | TTS | g11008.t1 | 13388754 | 13388754 |
| chr_1 | g11008 | g11008.t1 | TSS | g11008.t1 | NA | NA |
Sequences
>g11008.t1 Gene=g11008 Length=1635
ATGAAGCAAATAGCTGTGATATTTTTAGTATTATTTTTATTGATATCATGTCACGGTGAA
AAAACTTTTTTTATGAAATTAACTCGAATGTTGTCTGATACTGAAAATCAAGATCAATCT
TCAATACCAAAAGAAAATAATTTTGAGAATTATAAAAAAAGTACACAGAACATAGATGAA
CGTGAATTTGAATCAAATTTTTGGAAAAAAGAAGCTCAAAGGAAATTGAAATCTCAAATT
GAGAAAAAATTTAATACAAATATTGCAAAGAATGTGATTCTATTTATGGGTGATGGTATG
AGTTTATCAACAATTACAGCGAGTCGTATCTACGAAGGTCAATTAAAGCACAAAACTGGC
GAGGAAAATTCATTATCGTTTGAAAATTTTGATCACATTGGTCTATCAAAAAGTTATTGT
GTGGATAAACAGACAGCTGATTCAGCTTGCTCTGCCACTGCCTATTTCACAGGAGTTAAA
AACAATTATACAACTGTCGGTGTAAATGCAAAAGTTCAATATAAAGATTGTAAAGCTTCA
CTTAAAAAAGAAAATCAATTGTCATCATTCATTGAGTGGGCACAAAAAGCAGGAAAAGCA
ACAGGTATTGTCACAAATACTCGAGTTACACATGCGTCTCCTTCTGCTGCCTACGCAAAA
ACTTCAAATCGAGACTGGGAAAGTGACTTAAATATTGCACAATCAAATAATACAGATGGT
TGTGATGATATCGCATTGCAGTTGATCACTAGTGAACCAGGCAAAAATATAAATGTGATT
TATGGTGGTGGAAGGAAAAAGTTTATCGGAAATAATATAATCGAAACGACATCAGCCAGT
AGAGGTGAACGTCTCGATGGTCGTGATTTGATAGATGAATGGCTAGAAGACAAACGTATG
AGAAATATGAAAAATGCTCACTATATACATAATCGAGATGGACTGAATTCTTTAAATACT
AATGATGCAGAATATGTTTTAGGATTGTTTGCAAATTCACATCTTGATTATCATTTAAAT
AGAAATCCTCAAGAACCGACATTAAAAGAAATGACAATATCTGCAATTGAAGTTTTGAAA
AAGTCTAAAAATGGATTTGTTCTATTTGTTGAAGGAGGTCGTATCGATCAAGCACATCAC
AACAATATGGCAAAATTGGCATTGGATGAAACAGTTCAATTATCCGAAGCAGTTCAAAGT
GCTGTTGATATGACAAATGAAAAAGATACGTTAATAATTGTAACATCTGATCATTCTCAT
ACTATGACTTTAGCTGGTTATTCATCACGTGGAGCAGATATCTTGGGTTACAATACACAA
ATTTCTGATATTGATAAAATGCCTTACATGACATTATCATATACAAGTGGTCCATCTGCT
GCCAAAGGAGGTCGTGATCATATGCCAAATAAAGATGAAATGAAGCAAAACAGCTATGAT
TATCCAAGTTTGGTGCCACTGTCTTATGAGACACACTCCGGAGAAGATGTTGTGATTTAT
GGAAGAGGTCCATACGCACATTTGTTTGATGGTGTTCTTGAACAAAATATGATACCACAT
ATAATTGCATATGCCGCTTGTATTGCCGATAATAAAAGTGATCTTACAGCATGTGACAAT
AAAAACAGTAAATAA
>g11008.t1 Gene=g11008 Length=544
MKQIAVIFLVLFLLISCHGEKTFFMKLTRMLSDTENQDQSSIPKENNFENYKKSTQNIDE
REFESNFWKKEAQRKLKSQIEKKFNTNIAKNVILFMGDGMSLSTITASRIYEGQLKHKTG
EENSLSFENFDHIGLSKSYCVDKQTADSACSATAYFTGVKNNYTTVGVNAKVQYKDCKAS
LKKENQLSSFIEWAQKAGKATGIVTNTRVTHASPSAAYAKTSNRDWESDLNIAQSNNTDG
CDDIALQLITSEPGKNINVIYGGGRKKFIGNNIIETTSASRGERLDGRDLIDEWLEDKRM
RNMKNAHYIHNRDGLNSLNTNDAEYVLGLFANSHLDYHLNRNPQEPTLKEMTISAIEVLK
KSKNGFVLFVEGGRIDQAHHNNMAKLALDETVQLSEAVQSAVDMTNEKDTLIIVTSDHSH
TMTLAGYSSRGADILGYNTQISDIDKMPYMTLSYTSGPSAAKGGRDHMPNKDEMKQNSYD
YPSLVPLSYETHSGEDVVIYGRGPYAHLFDGVLEQNMIPHIIAYAACIADNKSDLTACDN
KNSK
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 17 | g11008.t1 | CDD | cd16012 | ALP | 90 | 527 | 3.42775E-118 |
| 11 | g11008.t1 | Gene3D | G3DSA:3.40.720.10 | Alkaline Phosphatase | 62 | 539 | 4.2E-183 |
| 2 | g11008.t1 | PANTHER | PTHR11596 | ALKALINE PHOSPHATASE | 6 | 532 | 1.9E-203 |
| 3 | g11008.t1 | PANTHER | PTHR11596:SF75 | ALKALINE PHOSPHATASE-RELATED | 6 | 532 | 1.9E-203 |
| 5 | g11008.t1 | PRINTS | PR00113 | Alkaline phosphatase signature | 89 | 109 | 1.1E-46 |
| 8 | g11008.t1 | PRINTS | PR00113 | Alkaline phosphatase signature | 145 | 160 | 1.1E-46 |
| 6 | g11008.t1 | PRINTS | PR00113 | Alkaline phosphatase signature | 194 | 214 | 1.1E-46 |
| 7 | g11008.t1 | PRINTS | PR00113 | Alkaline phosphatase signature | 256 | 266 | 1.1E-46 |
| 4 | g11008.t1 | PRINTS | PR00113 | Alkaline phosphatase signature | 347 | 376 | 1.1E-46 |
| 1 | g11008.t1 | Pfam | PF00245 | Alkaline phosphatase | 89 | 528 | 3.9E-138 |
| 13 | g11008.t1 | Phobius | SIGNAL_PEPTIDE | Signal peptide region | 1 | 19 | - |
| 14 | g11008.t1 | Phobius | SIGNAL_PEPTIDE_N_REGION | N-terminal region of a signal peptide. | 1 | 3 | - |
| 15 | g11008.t1 | Phobius | SIGNAL_PEPTIDE_H_REGION | Hydrophobic region of a signal peptide. | 4 | 15 | - |
| 16 | g11008.t1 | Phobius | SIGNAL_PEPTIDE_C_REGION | C-terminal region of a signal peptide. | 16 | 19 | - |
| 12 | g11008.t1 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. | 20 | 544 | - |
| 19 | g11008.t1 | ProSiteProfiles | PS51257 | Prokaryotic membrane lipoprotein lipid attachment site profile. | 1 | 17 | 5.0 |
| 18 | g11008.t1 | SMART | SM00098 | alk_phosph_2 | 90 | 529 | 2.8E-180 |
| 9 | g11008.t1 | SUPERFAMILY | SSF53649 | Alkaline phosphatase-like | 63 | 529 | 1.14E-144 |
| 10 | g11008.t1 | SignalP_EUK | SignalP-noTM | SignalP-noTM | 1 | 19 | - |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0003824 | catalytic activity | MF |
| GO:0016791 | phosphatase activity | MF |
KEGG
Orthology
- This transcript has been annotated with K01077 (alkaline phosphatase)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
