General information for g11175.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Serine/threonine-protein kinase hippo.
Parent gene
- The parent gene g11175 is located on chr_1: 14424338..14425152 (+ strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_1 | g11175 | g11175.t1 | TSS | g11175.t1 | 14422051 | 14422051 |
| chr_1 | g11175 | g11175.t1 | isoform | g11175.t1 | 14422240 | 14424572 |
| chr_1 | g11175 | g11175.t1 | exon | g11175.t1.exon1 | 14422240 | 14422262 |
| chr_1 | g11175 | g11175.t1 | cds | g11175.t1.CDS1 | 14422240 | 14422262 |
| chr_1 | g11175 | g11175.t1 | exon | g11175.t1.exon2 | 14422445 | 14422571 |
| chr_1 | g11175 | g11175.t1 | cds | g11175.t1.CDS2 | 14422445 | 14422571 |
| chr_1 | g11175 | g11175.t1 | exon | g11175.t1.exon3 | 14422640 | 14422774 |
| chr_1 | g11175 | g11175.t1 | cds | g11175.t1.CDS3 | 14422640 | 14422774 |
| chr_1 | g11175 | g11175.t1 | exon | g11175.t1.exon4 | 14422891 | 14423162 |
| chr_1 | g11175 | g11175.t1 | cds | g11175.t1.CDS4 | 14422891 | 14423162 |
| chr_1 | g11175 | g11175.t1 | exon | g11175.t1.exon5 | 14423224 | 14423327 |
| chr_1 | g11175 | g11175.t1 | cds | g11175.t1.CDS5 | 14423224 | 14423327 |
| chr_1 | g11175 | g11175.t1 | exon | g11175.t1.exon6 | 14423383 | 14424341 |
| chr_1 | g11175 | g11175.t1 | cds | g11175.t1.CDS6 | 14423383 | 14424341 |
| chr_1 | g11175 | g11175.t1 | exon | g11175.t1.exon7 | 14424402 | 14424572 |
| chr_1 | g11175 | g11175.t1 | cds | g11175.t1.CDS7 | 14424402 | 14424572 |
| chr_1 | g11175 | g11175.t1 | TTS | g11175.t1 | 14425102 | 14425102 |
Sequences
>g11175.t1 Gene=g11175 Length=1791
ATGTCGAACAATAATACCAAGAGATCATTGAAAAAATTATCAGAGGAATCACTCACACGG
CAGCCGGAGGAAGTTTTTGATATTATCTGCAAATTGGGTGAAGGCAGTTATGGAAGTGTA
TATAAGGCCTTACACAAAGAAAGTGATCAAATTTTAGCCATTAAGCAAGTTCCCGTTGAT
ACAGATCTTCAGGAAATTATTAAAGAAATCTCAATAATGCAGCAATGCGATTCGCCATAT
GTAGTTAAATATTATGGAAGTTATTTTAAAAACACTGATTTGTGGATTGTTATGGAATAT
TGCGGAGCCGGTAGTGTTTCTGATATAATGAGATTACGCAAAAAGACGTTGACTGAAGAT
GAAATTTCTACAATACTTAGTGATACGCTAAAGGGTCTTGAGTATCTGCACTTGCGAAGG
AAAATTCATAGGGATATTAAAGCTGGAAATATTCTCTTAAATTCAGAAGGTCATGCCAAA
TTAGCTGATTTTGGTGTTGCTGGTCAATTAACAGATACTATGGCAAAGAGGAATACAGTT
ATTGGCACACCTTTTTGGATGGCACCAGAAGTTATTGAAGAAATTGGTTATGATTGTGTA
GCAGATATTTGGTCTTTAGGAATAACTGCATTAGAAATGGCAGAAGGGAAGCCACCTTAT
GGTTCAATTCATCCAATGCGAGCCATTTTTATGATTCCAACAAAACCTCCACCTTCATTT
CGTGAACCCGATCGTTGGTCAGCTGAATTCATTGATTTTGTTAGTTTGTGTTTAGTGAAA
AATCCAGAAGAACGTGCAACTGCCACTGATCTTCTTCAACATGAATTTATAAGAAATGCT
AAACCTAACAGTATTCTGAGTAATATGATTGCGGAAGCCAAAGAGATTCGTGAAAATCAA
AGTTATACACGTGCAGCGGCCATTCAACAAGCCAATAAACAATTGCAAAGTCAAAATGAT
GATAGTGATGATGAAAATTCGGGAACAATGAAGAAAAATGATTTGGATTGTGGAACTTTG
GTGCCATCGAAGGACGATGAGGGTGAATTGACAATGATTGCGCATACTGATTGTGGAACA
CTTGTTCCCGACAATGGCACTATGATTGAGTTACAATCAAATCTAGGAACAATGGTTATA
AATTCAGATTCTGAAGAATCAACTATGAAACGTCATGACACGAATCCAGATAAACCCAAA
TATCGTCCACTTTTTCTTGACCATTTTGATAAAAAGGAAGCAGAAGGAAATGTTTTAGCA
AATAGTATAATCTTGCATGAAGATGGTCTTCAAGAAGTACCAAAAATGCAAGTACCTGCA
AAAAATACTCCACAACAAATTCAACAGCAATTAATGAATGCACCTCCGCCTGCTGCTCAA
ACATCTTCAACACAAATGCCAGAACAAGATCATCAAATGGCCAAATTACAGCAACAACTT
CAACAGCAGCACTTATTAAATCAGGCACATGCTCAACAAATGCCTATAGCCTCAGCACCC
ACTGATGTCAGTGAAAATTTACAGCATCAATTCCAACAACAACAGCAGCAACAACAACAA
CAATATCAACCACCTGAAAATATTTTAAAATATCGTACTTTAGATTGCGATTATGAATTT
TTGAAATTTTTGAGTTATGAAGAGTTGGAACAAAGATTAGCAAGTCTTGATAAAGAAATG
GATAAAGAATTTGAAGAGACTAAAAAGCGTTATAAAGCAAAACGGAAGCCAATAATTGAA
GCCATTGAAGCAAAACAGCAGAAACGAAAACAGAAAACAGAAGAATTTTAA
>g11175.t1 Gene=g11175 Length=596
MSNNNTKRSLKKLSEESLTRQPEEVFDIICKLGEGSYGSVYKALHKESDQILAIKQVPVD
TDLQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIMRLRKKTLTED
EISTILSDTLKGLEYLHLRRKIHRDIKAGNILLNSEGHAKLADFGVAGQLTDTMAKRNTV
IGTPFWMAPEVIEEIGYDCVADIWSLGITALEMAEGKPPYGSIHPMRAIFMIPTKPPPSF
REPDRWSAEFIDFVSLCLVKNPEERATATDLLQHEFIRNAKPNSILSNMIAEAKEIRENQ
SYTRAAAIQQANKQLQSQNDDSDDENSGTMKKNDLDCGTLVPSKDDEGELTMIAHTDCGT
LVPDNGTMIELQSNLGTMVINSDSEESTMKRHDTNPDKPKYRPLFLDHFDKKEAEGNVLA
NSIILHEDGLQEVPKMQVPAKNTPQQIQQQLMNAPPPAAQTSSTQMPEQDHQMAKLQQQL
QQQHLLNQAHAQQMPIASAPTDVSENLQHQFQQQQQQQQQQYQPPENILKYRTLDCDYEF
LKFLSYEELEQRLASLDKEMDKEFEETKKRYKAKRKPIIEAIEAKQQKRKQKTEEF
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 12 | g11175.t1 | CDD | cd06612 | STKc_MST1_2 | 22 | 277 | 0.0 |
| 10 | g11175.t1 | Coils | Coil | Coil | 305 | 325 | - |
| 11 | g11175.t1 | Coils | Coil | Coil | 546 | 566 | - |
| 8 | g11175.t1 | Gene3D | G3DSA:3.30.200.20 | Phosphorylase Kinase; domain 1 | 14 | 100 | 5.5E-35 |
| 9 | g11175.t1 | Gene3D | G3DSA:1.10.510.10 | Transferase(Phosphotransferase) domain 1 | 101 | 312 | 2.4E-79 |
| 16 | g11175.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 312 | 339 | - |
| 15 | g11175.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 439 | 524 | - |
| 4 | g11175.t1 | PANTHER | PTHR48015:SF34 | - | 4 | 422 | 1.5E-200 |
| 6 | g11175.t1 | PANTHER | PTHR48015 | SERINE/THREONINE-PROTEIN KINASE TAO | 4 | 422 | 1.5E-200 |
| 3 | g11175.t1 | PANTHER | PTHR48015:SF34 | - | 531 | 588 | 1.5E-200 |
| 5 | g11175.t1 | PANTHER | PTHR48015 | SERINE/THREONINE-PROTEIN KINASE TAO | 531 | 588 | 1.5E-200 |
| 2 | g11175.t1 | Pfam | PF00069 | Protein kinase domain | 29 | 277 | 2.3E-68 |
| 1 | g11175.t1 | Pfam | PF11629 | C terminal SARAH domain of Mst1 | 538 | 585 | 4.7E-22 |
| 14 | g11175.t1 | ProSitePatterns | PS00107 | Protein kinases ATP-binding region signature. | 32 | 55 | - |
| 18 | g11175.t1 | ProSiteProfiles | PS50011 | Protein kinase domain profile. | 26 | 277 | 49.686 |
| 17 | g11175.t1 | ProSiteProfiles | PS50951 | SARAH domain profile. | 538 | 585 | 13.572 |
| 13 | g11175.t1 | SMART | SM00220 | serkin_6 | 26 | 277 | 2.6E-100 |
| 7 | g11175.t1 | SUPERFAMILY | SSF56112 | Protein kinase-like (PK-like) | 26 | 491 | 7.01E-89 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0007165 | signal transduction | BP |
| GO:0005524 | ATP binding | MF |
| GO:0004674 | protein serine/threonine kinase activity | MF |
| GO:0004672 | protein kinase activity | MF |
| GO:0006468 | protein phosphorylation | BP |
KEGG
Orthology
- This transcript has been annotated with K04412 (serine/threonine kinase 3)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
