General information for g11186.t10
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Adenosylhomocysteinase-like 1.
Parent gene
- The parent gene g11186 is located on chr_1: 14476826..14479399 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_1 | g11186 | g11186.t10 | TTS | g11186.t10 | 14473247 | 14473247 |
| chr_1 | g11186 | g11186.t10 | isoform | g11186.t10 | 14473872 | 14479399 |
| chr_1 | g11186 | g11186.t10 | exon | g11186.t10.exon1 | 14473872 | 14474127 |
| chr_1 | g11186 | g11186.t10 | cds | g11186.t10.CDS1 | 14473874 | 14474127 |
| chr_1 | g11186 | g11186.t10 | exon | g11186.t10.exon2 | 14474224 | 14474626 |
| chr_1 | g11186 | g11186.t10 | cds | g11186.t10.CDS2 | 14474224 | 14474626 |
| chr_1 | g11186 | g11186.t10 | exon | g11186.t10.exon3 | 14474893 | 14475029 |
| chr_1 | g11186 | g11186.t10 | cds | g11186.t10.CDS3 | 14474893 | 14475029 |
| chr_1 | g11186 | g11186.t10 | exon | g11186.t10.exon4 | 14475098 | 14475244 |
| chr_1 | g11186 | g11186.t10 | cds | g11186.t10.CDS4 | 14475098 | 14475244 |
| chr_1 | g11186 | g11186.t10 | exon | g11186.t10.exon5 | 14476077 | 14476179 |
| chr_1 | g11186 | g11186.t10 | cds | g11186.t10.CDS5 | 14476077 | 14476179 |
| chr_1 | g11186 | g11186.t10 | exon | g11186.t10.exon6 | 14477827 | 14477967 |
| chr_1 | g11186 | g11186.t10 | cds | g11186.t10.CDS6 | 14477827 | 14477967 |
| chr_1 | g11186 | g11186.t10 | exon | g11186.t10.exon7 | 14479391 | 14479399 |
| chr_1 | g11186 | g11186.t10 | TSS | g11186.t10 | 14479517 | 14479517 |
Sequences
>g11186.t10 Gene=g11186 Length=1196
GCTAAAAAGATGCACCAAATAAATTCCACCTCGACAATTGGAGAGTCAAATCTCTCGCAT
AATCCAAGCAATGCTTCGATGGCACCAAAATCAGCAACCGTTCAATTTGTGAGTGACTCT
CCCATAACCGATCCAGGACAGACTACCAAGGAAAAGGATAAAGATGTGAAAAACATTTCT
AGTGCCCTTAAAAAGTCAAGTCGCTATCGTAGTCGCAGTCTTTCAGCAAGTTCAACTGAC
TCATATAGCTCTGCATCATATACAGGAAGTTCAAGCGAGGACGATGATGCATCACCTCGT
GAAAAAATTCAAAGCAATTCGAAAGGATTTGCGGACTTTTGTGTAAGAAATATTCAACAA
CATGCGTTTGGCCGGCGTGAAATTGAAATTGCCGAGCAAGAGATGCCAGGAATTATGGCA
TTAAGGAAACGTGCTTCCGAAGATAAGCCCCTTAAGAATGCTAAAATTGTTGGATGCACA
CATGTTAATGCGCAAACGGCTGTTCTTATTGAAACTTTAGCAGCACTCGGAGCTTCTGTT
CGTTGGGCAGCCTGCAACATTTATTCAACACAAAATGAAGTGGCCGCAGCTCTAGCCGAA
AGTGGATTTAGTGTATTTGCGTGGCGCGGCGAGACGGAAGAAGATTTCTGGTGGTGTATT
GATAAATGTGTTAATGCAGAAAATTGGCAACCAAACCTGATACTCGATGATGGTGGTGAT
GCAACGCATTTAATGTTGAAAAAATATCCAGCCATGTTTAAAATGGTGAAGGGTATCGTT
GAAGAGAGTGTCACAGGCGTACATCGACTTTATCAATTGTCTAAAAGTGGCAAACTGACA
GTTCCTGCGATGAATGTCCATGATTCTGTTATCAAGACTAAATTTGATAATTTCTATAGT
TGCAAAGAGAGCATAATTGATAGTTTAAAACGTTCGACTGACATTATGTTTTCGGGAAAA
CAAGTCGCACTATGTGGATATGGTGAAGTCGGTAAAGGTTGTTCGCAAGCTTTAAAAGCA
CTCGGATGCATCGTCTACGTCACCGAAATCGATCCTATTTGTGCGCTACAAGCAAGCGTT
GATGGCTTTCGTGTTGTTAAGCTAAATGAGATAATTCGAAATGTTGATATCGTAATCACG
ACTACTGGCAATAAAAGCGTAGTTACTCGAGAGCACATGGAGAAAATGAAGAATGG
>g11186.t10 Gene=g11186 Length=395
MHQINSTSTIGESNLSHNPSNASMAPKSATVQFVSDSPITDPGQTTKEKDKDVKNISSAL
KKSSRYRSRSLSASSTDSYSSASYTGSSSEDDDASPREKIQSNSKGFADFCVRNIQQHAF
GRREIEIAEQEMPGIMALRKRASEDKPLKNAKIVGCTHVNAQTAVLIETLAALGASVRWA
ACNIYSTQNEVAAALAESGFSVFAWRGETEEDFWWCIDKCVNAENWQPNLILDDGGDATH
LMLKKYPAMFKMVKGIVEESVTGVHRLYQLSKSGKLTVPAMNVHDSVIKTKFDNFYSCKE
SIIDSLKRSTDIMFSGKQVALCGYGEVGKGCSQALKALGCIVYVTEIDPICALQASVDGF
RVVKLNEIIRNVDIVITTTGNKSVVTREHMEKMKN
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 16 | g11186.t10 | Gene3D | G3DSA:3.40.50.1480 | - | 92 | 244 | 2.0E-67 |
| 17 | g11186.t10 | Gene3D | G3DSA:3.40.50.1480 | - | 245 | 295 | 4.5E-65 |
| 15 | g11186.t10 | Gene3D | G3DSA:3.40.50.720 | - | 296 | 395 | 4.5E-65 |
| 13 | g11186.t10 | MobiDBLite | mobidb-lite | consensus disorder prediction | 1 | 42 | - |
| 14 | g11186.t10 | MobiDBLite | mobidb-lite | consensus disorder prediction | 1 | 102 | - |
| 11 | g11186.t10 | MobiDBLite | mobidb-lite | consensus disorder prediction | 43 | 58 | - |
| 12 | g11186.t10 | MobiDBLite | mobidb-lite | consensus disorder prediction | 59 | 90 | - |
| 3 | g11186.t10 | PANTHER | PTHR23420 | ADENOSYLHOMOCYSTEINASE | 57 | 395 | 5.6E-180 |
| 4 | g11186.t10 | PANTHER | PTHR23420:SF2 | ADENOSYLHOMOCYSTEINASE 3 | 57 | 395 | 5.6E-180 |
| 1 | g11186.t10 | Pfam | PF05221 | S-adenosyl-L-homocysteine hydrolase | 109 | 244 | 3.5E-65 |
| 2 | g11186.t10 | Pfam | PF00670 | S-adenosyl-L-homocysteine hydrolase, NAD binding domain | 294 | 395 | 3.2E-48 |
| 10 | g11186.t10 | ProSitePatterns | PS00738 | S-adenosyl-L-homocysteine hydrolase signature 1. | 181 | 195 | - |
| 9 | g11186.t10 | ProSitePatterns | PS00739 | S-adenosyl-L-homocysteine hydrolase signature 2. | 316 | 332 | - |
| 8 | g11186.t10 | SMART | SM00996 | AdoHcyase_2 | 109 | 395 | 3.1E-113 |
| 7 | g11186.t10 | SMART | SM00997 | AdoHcyase_NAD_2 | 294 | 395 | 2.5E-36 |
| 6 | g11186.t10 | SUPERFAMILY | SSF52283 | Formate/glycerate dehydrogenase catalytic domain-like | 109 | 297 | 9.35E-79 |
| 5 | g11186.t10 | SUPERFAMILY | SSF51735 | NAD(P)-binding Rossmann-fold domains | 294 | 395 | 1.69E-39 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0004013 | adenosylhomocysteinase activity | MF |
KEGG
Orthology
This gene did not have any KEGG ortholog annotations (KAAS, GHOSTZ).
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
