General information for g11186.t3
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Adenosylhomocysteinase-like 1.
Parent gene
- The parent gene g11186 is located on chr_1: 14476826..14479399 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_1 | g11186 | g11186.t3 | isoform | g11186.t3 | 14472513 | 14474626 |
| chr_1 | g11186 | g11186.t3 | exon | g11186.t3.exon1 | 14472513 | 14473396 |
| chr_1 | g11186 | g11186.t3 | TTS | g11186.t3 | 14472515 | 14472515 |
| chr_1 | g11186 | g11186.t3 | cds | g11186.t3.CDS1 | 14473269 | 14473396 |
| chr_1 | g11186 | g11186.t3 | exon | g11186.t3.exon2 | 14473478 | 14473750 |
| chr_1 | g11186 | g11186.t3 | cds | g11186.t3.CDS2 | 14473478 | 14473750 |
| chr_1 | g11186 | g11186.t3 | exon | g11186.t3.exon3 | 14473852 | 14474127 |
| chr_1 | g11186 | g11186.t3 | cds | g11186.t3.CDS3 | 14473852 | 14474127 |
| chr_1 | g11186 | g11186.t3 | exon | g11186.t3.exon4 | 14474224 | 14474626 |
| chr_1 | g11186 | g11186.t3 | cds | g11186.t3.CDS4 | 14474224 | 14474431 |
| chr_1 | g11186 | g11186.t3 | TSS | g11186.t3 | 14475396 | 14475396 |
Sequences
>g11186.t3 Gene=g11186 Length=1836
GTTCGTTGGGCAGCCTGCAACATTTATTCAACACAAAATGAAGTGGCCGCAGCTCTAGCC
GAAAGTGGATTTAGTGTATTTGCGTGGCGCGGCGAGACGGAAGAAGATTTCTGGTGGTGT
ATTGATAAATGTGTTAATGCAGAAAATTGGCAACCAAACCTGATACTCGATGATGGTGGT
GATGCAACGCATTTAATGTTGAAAAAATATCCAGCCATGTTTAAAATGGTGAAGGGTATC
GTTGAAGAGAGTGTCACAGGCGTACATCGACTTTATCAATTGTCTAAAAGTGGCAAACTG
ACAGTTCCTGCGATGAATGTCCATGATTCTGTTATCAAGACTAAATTTGATAATTTCTAT
AGTTGCAAAGAGAGCATAATTGATAGTTTAAAACGTTCGACTGACATTATGTTTTCGGGA
AAACAAGTCGCACTATGTGGATATGGTGAAGTCGGTAAAGGTTGTTCGCAAGCTTTAAAA
GCACTCGGATGCATCGTCTACGTCACCGAAATCGATCCTATTTGTGCGCTACAAGCAAGC
GTTGATGGCTTTCGTGTTGTTAAGCTAAATGAGATAATTCGAAATGTTGATATCGTAATC
ACGACTACTGGCAATAAAAGCGTAGTTACTCGAGAGCACATGGAGAAAATGAAGAATGGC
TGCATTGTATGCAATATGGGCCATTCAAACACAGAAATCGATGTTAAAGATCTCCGCACG
CCAGATTTGACATGGGAAAAAGTTCGTTCACAGGTCGATCATATCATTTTTCCTGATGGA
AAGCGAATAGTTTTATTAGCTGAAGGACGTTTGGTTAATCTTTCTTGCTCAAGTGTTCCA
TCATTTTGTGCTAGTATCACATCTGCAACGCAAGCATTAGCTTTAATTGAACTTTATAAT
GCACAGGCAGGTCGCTATAAATGCGACGTTTATTTATTATCAAGAAAAATGGACGAGTAT
GTCGCGATTTTACATTTACCAACATTTGATGCACATTTAACAGAGCTTACAGATGAGCAA
GCTAAATACATGGGTCTCAGCAAAGCTGGTCCTTTTAAGCCCAACTATTATCGTTATTAA
AGAAAAAAAAAAATCACAAATTATGGCGCTCCAAGAAAAAAGAAGAATACCTGTAATGAA
TGAAAAGAATATTTTTATCAACTAATAACGATGATGACGATTCTTAACAAAATTTGACGA
ATTTTTATTTTTATGATGTTCTTAATAAAAGTTAAACTTACTTATGTACTTCCCATCGTT
GACGACAGATAGGCGATAAAATTAAGTGAAAAAAATGTAATCTTAATTTCGCGAGCATTG
CATAGAAAATATTTAGAAAGAAATGCTGAAAAAATGTTAAATCAATTTTTTTCAATCAAC
ATCACACTTTAATTGTGTATTAATACCCATACATATATTTTTTGGTATATTTTTAATATA
TCCTTTTTCAAACGCTCTTTCTCCCTTCCTCAATCCTACACAACATTTTAAGTCTATTGA
TATAAATAAATAAACTAAACTAAAAAATCAATTTTATTTTTGCAAAAAAATTCAATAATA
AAAAAATAAGCCCATTACATCACACGCTTACAAGTGTGAGGGTGAAAAAATATAAAATTC
AAGTGAAGCACGAATAGATAGTGAAATTCTTTTTTCACTAATTAGAATTAAATCAGTTAC
TTAAATGATATAACAAATAATTAATAAATTAGTGAAAGAAATTGATAAATATTGGATTTG
TGGAGGGATAAAAAATATTTATTAATGTCAATTCAAAAAAATGAATAAATATGGGAAAAA
CTGCTATAGATGACGAATAAAATGAGAACAAATGAA
>g11186.t3 Gene=g11186 Length=294
MLKKYPAMFKMVKGIVEESVTGVHRLYQLSKSGKLTVPAMNVHDSVIKTKFDNFYSCKES
IIDSLKRSTDIMFSGKQVALCGYGEVGKGCSQALKALGCIVYVTEIDPICALQASVDGFR
VVKLNEIIRNVDIVITTTGNKSVVTREHMEKMKNGCIVCNMGHSNTEIDVKDLRTPDLTW
EKVRSQVDHIIFPDGKRIVLLAEGRLVNLSCSSVPSFCASITSATQALALIELYNAQAGR
YKCDVYLLSRKMDEYVAILHLPTFDAHLTELTDEQAKYMGLSKAGPFKPNYYRY
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 12 | g11186.t3 | Gene3D | G3DSA:3.40.50.1480 | - | 1 | 59 | 1.4E-17 |
| 10 | g11186.t3 | Gene3D | G3DSA:3.40.50.720 | - | 60 | 212 | 4.9E-71 |
| 11 | g11186.t3 | Gene3D | G3DSA:3.40.50.1480 | - | 213 | 294 | 1.3E-28 |
| 3 | g11186.t3 | PANTHER | PTHR23420 | ADENOSYLHOMOCYSTEINASE | 2 | 294 | 1.4E-185 |
| 4 | g11186.t3 | PANTHER | PTHR23420:SF2 | ADENOSYLHOMOCYSTEINASE 3 | 2 | 294 | 1.4E-185 |
| 1 | g11186.t3 | Pfam | PF05221 | S-adenosyl-L-homocysteine hydrolase | 3 | 293 | 2.6E-48 |
| 2 | g11186.t3 | Pfam | PF00670 | S-adenosyl-L-homocysteine hydrolase, NAD binding domain | 53 | 213 | 1.0E-77 |
| 9 | g11186.t3 | ProSitePatterns | PS00739 | S-adenosyl-L-homocysteine hydrolase signature 2. | 75 | 91 | - |
| 8 | g11186.t3 | SMART | SM00996 | AdoHcyase_2 | 1 | 293 | 5.2E-105 |
| 7 | g11186.t3 | SMART | SM00997 | AdoHcyase_NAD_2 | 53 | 214 | 2.3E-97 |
| 6 | g11186.t3 | SUPERFAMILY | SSF52283 | Formate/glycerate dehydrogenase catalytic domain-like | 2 | 294 | 1.81E-41 |
| 5 | g11186.t3 | SUPERFAMILY | SSF51735 | NAD(P)-binding Rossmann-fold domains | 53 | 212 | 4.65E-63 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0004013 | adenosylhomocysteinase activity | MF |
KEGG
Orthology
This gene did not have any KEGG ortholog annotations (KAAS, GHOSTZ).
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
