General information for g11263.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Type II inositol 1,4,5-trisphosphate 5-phosphatase.
Parent gene
- The parent gene g11263 is located on chr_1: 15158026..15159937 (+ strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_1 | g11263 | g11263.t1 | TSS | g11263.t1 | 15155165 | 15155165 |
| chr_1 | g11263 | g11263.t1 | isoform | g11263.t1 | 15155253 | 15158026 |
| chr_1 | g11263 | g11263.t1 | exon | g11263.t1.exon1 | 15155253 | 15155327 |
| chr_1 | g11263 | g11263.t1 | cds | g11263.t1.CDS1 | 15155253 | 15155327 |
| chr_1 | g11263 | g11263.t1 | exon | g11263.t1.exon2 | 15155398 | 15155704 |
| chr_1 | g11263 | g11263.t1 | cds | g11263.t1.CDS2 | 15155398 | 15155704 |
| chr_1 | g11263 | g11263.t1 | exon | g11263.t1.exon3 | 15155765 | 15156457 |
| chr_1 | g11263 | g11263.t1 | cds | g11263.t1.CDS3 | 15155765 | 15156457 |
| chr_1 | g11263 | g11263.t1 | exon | g11263.t1.exon4 | 15156522 | 15157850 |
| chr_1 | g11263 | g11263.t1 | cds | g11263.t1.CDS4 | 15156522 | 15157850 |
| chr_1 | g11263 | g11263.t1 | exon | g11263.t1.exon5 | 15157905 | 15158026 |
| chr_1 | g11263 | g11263.t1 | cds | g11263.t1.CDS5 | 15157905 | 15158026 |
| chr_1 | g11263 | g11263.t1 | TTS | g11263.t1 | 15158349 | 15158349 |
Sequences
>g11263.t1 Gene=g11263 Length=2526
ATGGGCGATAACTTGAAATATTCCATCCTTCAAACGGTGGAACAGAAATTTCGTCTCGGT
GAAGTTGTGTTAGTTATTTTTGAAGCCTATCAGATTGTCGGTGCTGAACATCAGAATCGA
GTTCTTGTTGTGGTGAAATCGGGAAATTCATCGGCTCTTTTTTCGTTTGCTATTGCCAAT
TATCCACCAATAAATCTCTCTGATCTTCATATTAATGCTGTGCTTCCTATTAACGAGACT
TTCATTATTGATAACAGGCCTGGCAGTGGCATTTCATCGCATCAATTTCAAATTTTGAGT
GGGAATGAAACATTTACTTATTATTATTATCCCGATCATAATAAGGAACAATTTGATAAA
GTTTTGAGGAAACTAATTCAAGAGTATTCTGAAGAGAATCATGGAAATTTCATGTGGCTT
GATGCTTATAAAAGCTCAGATCTCTCTGAAATTGATCTTGATATTGCAACAAATAAACTT
CCGCCTAAAAATCGTGAATCAAAATTCAGAGAAGAGTTGGAGCGTAGAAAACCGGAATAT
ACAATTTATGAGCCATATAAAATATTTTGTGCAACGTGGAATGTTAACTTACAACAGCCA
AAAGAAGATTTAGTGTTACGTGAATGGCTCTCAACCACTGAAGATGCGCCAGATATTTAT
GCCATCGGCCTACAAGAAATTGATATGTCAGCTGAGACAATTATAAGGAGCGAAACACGT
CCTGATTACAATTGGATCGCTAAAATTCTTGAAGGTGTACATCCTGGTGATGCATATGAA
GAATTAATTTCTGTTAGATTTGTTGGAATGATGTTGACTATTGTTATTAAACAATCACTA
AGAAGTTCAGTATCAAAAATTACAACTTCGATGGTAGGAACTGGAACATTGAATTTCGGT
AATAAAGGCGGTGTTGGTGTTAGTCTTCAACTCAATGAAAATTTTTTGTGTTTCATTAAT
TCACATCTTGCTGCACATGTTCAAGAGTTTGAACGAAGAAATGAAGATCATGATGAAATT
TTAAGAAGAATGCAATTTAAAGATGGTTTTAGAACCCGAAATATTCTTGAACATGATCAA
ATATTTTGGATAGGCGATCTCAATTATCGTATTGCAACAGCAATTGATGATGGGCAAATA
AAAAATTTTTGCGAATATGAAAAACTTTTTTATCTTGATCAATTGTATATTGAACACGTA
AAGAAAAAGAGAGTATTTCGTGATTTTCAAGAAGGTAAAATTACATTTAAACCAACTTAT
AAATATGATCCTGGAACAGATGAATGGGATTCGAGTGAAAAAAATAGAGCACCAGCATGG
TGTGATAGAATCTTTTGGAAAGGTCAAAAAGTAGAACAATTATGTTATAAAAGTGTAATG
CAATTGAGAATAAGTGATCATAAACCGGTCTATAGTGTTTTTATCACATATATAATGACG
CGTGATGAGAAAAAGTTTAAGAGAGTGCATGAAGAAGTGCTAAAAACTGTTGATAAATAT
GAAAATGATAATCAACCACAAATGACTGTTGCAGAAACTGACCTCGATTTTGGCATATTA
AGATATCATGAAATGTATAGTCGAGAATTGTTAGTTGCAAATAATTGTCATTTACCTGTT
CATTTTAAATTTTTATCTAAGGACATTGTCAGTTCAAGTGTTTGTGAAGATTGGATAAGA
ATATCTCATAAAAGTGGTGAATTATTGACAGGAAACTCAATGAGCATTCGCATAGACATT
TTTATAGATGAGAGTTCAGCATCAAAAATAATGCGAAGATTAAAAGATGCACAAATTAAT
GTCAAAGTACCACTCGATATTCTTGTTCTTCATGTAGAAAATGGAAGAGATATTTTTATA
ACAGTTTTTGGTGAATATCAACCAAGTATTTTCGGTTTACGATTAGATACATTGATGAAA
TTAAATAAATCTGTTCTTGAATATTCTTTGAAAGAATTGATGGATATTGATGATGATGCC
AATAATTTAATTCCATTTTATAACAATGCAAAAGCACCCCGTGAAATTTATTTAATGATT
GACTATTTATATCGAAACGGTCTAAATATCCCACATCTATTTACAATACAAAGACGACAT
AAATTGAGTCCGCGTATTTGTGCAATAAGAGACTGGCTTGATTCATGGTCAGTTGAAAAT
TTTCCTGGAACACCACAAACTGCTGCCGAAATTCTTTTAAAAATATTTGAAGCCTCACCT
GAGCCACTTGTTACAATCACAGAACGTGAATTACAAATTTATGTTCAATATTTTGACAGA
TGCAAAGAGTTAGTTCAGAATAAGATGCCACTGCTCAACCGTAAAATATTTCTCTATGTT
ATCATGTTTCTTAAAGAAATTCAAAAGAATTATACCATTAATGGGATGGATGATAGAACT
ATTGCAAAAATCTTTGCACCTGCTTTATGTCGACATCAAAATGATCAATTTAGTCAGAAA
TTTCTACTTCTGTTTTTATCAAATGACATTAAAGATTTTGCACGAGTTGAACTCGAAAAA
AATTGA
>g11263.t1 Gene=g11263 Length=841
MGDNLKYSILQTVEQKFRLGEVVLVIFEAYQIVGAEHQNRVLVVVKSGNSSALFSFAIAN
YPPINLSDLHINAVLPINETFIIDNRPGSGISSHQFQILSGNETFTYYYYPDHNKEQFDK
VLRKLIQEYSEENHGNFMWLDAYKSSDLSEIDLDIATNKLPPKNRESKFREELERRKPEY
TIYEPYKIFCATWNVNLQQPKEDLVLREWLSTTEDAPDIYAIGLQEIDMSAETIIRSETR
PDYNWIAKILEGVHPGDAYEELISVRFVGMMLTIVIKQSLRSSVSKITTSMVGTGTLNFG
NKGGVGVSLQLNENFLCFINSHLAAHVQEFERRNEDHDEILRRMQFKDGFRTRNILEHDQ
IFWIGDLNYRIATAIDDGQIKNFCEYEKLFYLDQLYIEHVKKKRVFRDFQEGKITFKPTY
KYDPGTDEWDSSEKNRAPAWCDRIFWKGQKVEQLCYKSVMQLRISDHKPVYSVFITYIMT
RDEKKFKRVHEEVLKTVDKYENDNQPQMTVAETDLDFGILRYHEMYSRELLVANNCHLPV
HFKFLSKDIVSSSVCEDWIRISHKSGELLTGNSMSIRIDIFIDESSASKIMRRLKDAQIN
VKVPLDILVLHVENGRDIFITVFGEYQPSIFGLRLDTLMKLNKSVLEYSLKELMDIDDDA
NNLIPFYNNAKAPREIYLMIDYLYRNGLNIPHLFTIQRRHKLSPRICAIRDWLDSWSVEN
FPGTPQTAAEILLKIFEASPEPLVTITERELQIYVQYFDRCKELVQNKMPLLNRKIFLYV
IMFLKEIQKNYTINGMDDRTIAKIFAPALCRHQNDQFSQKFLLLFLSNDIKDFARVELEK
N
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 14 | g11263.t1 | Coils | Coil | Coil | 835 | 841 | - |
| 12 | g11263.t1 | Gene3D | G3DSA:2.30.29.110 | - | 6 | 151 | 7.9E-7 |
| 11 | g11263.t1 | Gene3D | G3DSA:3.60.10.10 | - | 162 | 507 | 2.8E-116 |
| 10 | g11263.t1 | Gene3D | G3DSA:2.60.40.10 | Immunoglobulins | 508 | 640 | 1.8E-35 |
| 13 | g11263.t1 | Gene3D | G3DSA:1.10.555.10 | - | 672 | 832 | 4.0E-26 |
| 4 | g11263.t1 | PANTHER | PTHR11200 | INOSITOL 5-PHOSPHATASE | 166 | 714 | 1.7E-140 |
| 5 | g11263.t1 | PANTHER | PTHR11200:SF163 | TYPE II INOSITOL 1,4,5-TRISPHOSPHATE 5-PHOSPHATASE | 166 | 714 | 1.7E-140 |
| 2 | g11263.t1 | Pfam | PF16776 | Type II inositol 1,4,5-trisphosphate 5-phosphatase PH domain | 12 | 144 | 4.2E-16 |
| 3 | g11263.t1 | Pfam | PF03372 | Endonuclease/Exonuclease/phosphatase family | 191 | 467 | 8.4E-12 |
| 1 | g11263.t1 | Pfam | PF00620 | RhoGAP domain | 673 | 815 | 5.0E-11 |
| 15 | g11263.t1 | ProSiteProfiles | PS50238 | Rho GTPase-activating proteins domain profile. | 654 | 841 | 15.116 |
| 8 | g11263.t1 | SMART | SM00128 | i5p_5 | 184 | 482 | 1.2E-76 |
| 9 | g11263.t1 | SMART | SM00324 | RhoGAP_3 | 670 | 838 | 2.7E-5 |
| 7 | g11263.t1 | SUPERFAMILY | SSF56219 | DNase I-like | 168 | 503 | 2.75E-62 |
| 6 | g11263.t1 | SUPERFAMILY | SSF48350 | GTPase activation domain, GAP | 627 | 818 | 1.84E-19 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0007165 | signal transduction | BP |
| GO:0046856 | phosphatidylinositol dephosphorylation | BP |
KEGG
Orthology
- This transcript has been annotated with K01099 (inositol polyphosphate 5-phosphatase INPP5B/F)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
