General information for g11439.t10
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as MAP kinase-activated protein kinase 2.
Parent gene
- The parent gene g11439 is located on chr_1: 16251185..16252138 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_1 | g11439 | g11439.t10 | TTS | g11439.t10 | 16249170 | 16249170 |
| chr_1 | g11439 | g11439.t10 | isoform | g11439.t10 | 16249383 | 16252138 |
| chr_1 | g11439 | g11439.t10 | exon | g11439.t10.exon1 | 16249383 | 16249551 |
| chr_1 | g11439 | g11439.t10 | cds | g11439.t10.CDS1 | 16249383 | 16249551 |
| chr_1 | g11439 | g11439.t10 | exon | g11439.t10.exon2 | 16249611 | 16249836 |
| chr_1 | g11439 | g11439.t10 | cds | g11439.t10.CDS2 | 16249611 | 16249836 |
| chr_1 | g11439 | g11439.t10 | exon | g11439.t10.exon3 | 16249900 | 16249988 |
| chr_1 | g11439 | g11439.t10 | cds | g11439.t10.CDS3 | 16249900 | 16249988 |
| chr_1 | g11439 | g11439.t10 | exon | g11439.t10.exon4 | 16250046 | 16250165 |
| chr_1 | g11439 | g11439.t10 | cds | g11439.t10.CDS4 | 16250046 | 16250165 |
| chr_1 | g11439 | g11439.t10 | exon | g11439.t10.exon5 | 16250677 | 16250808 |
| chr_1 | g11439 | g11439.t10 | cds | g11439.t10.CDS5 | 16250677 | 16250808 |
| chr_1 | g11439 | g11439.t10 | exon | g11439.t10.exon6 | 16251190 | 16251250 |
| chr_1 | g11439 | g11439.t10 | cds | g11439.t10.CDS6 | 16251190 | 16251250 |
| chr_1 | g11439 | g11439.t10 | exon | g11439.t10.exon7 | 16251311 | 16251379 |
| chr_1 | g11439 | g11439.t10 | cds | g11439.t10.CDS7 | 16251311 | 16251329 |
| chr_1 | g11439 | g11439.t10 | exon | g11439.t10.exon8 | 16251437 | 16251518 |
| chr_1 | g11439 | g11439.t10 | exon | g11439.t10.exon9 | 16251585 | 16251646 |
| chr_1 | g11439 | g11439.t10 | exon | g11439.t10.exon10 | 16251712 | 16252138 |
| chr_1 | g11439 | g11439.t10 | TSS | g11439.t10 | 16252138 | 16252138 |
Sequences
>g11439.t10 Gene=g11439 Length=1437
ATACTTGAATAATAGGCTCTTGTAAAAGAGTGTAATATTTTTCTCTTTGAAATTATTTTT
AAAGTTTCTTCCTACTTTTTAAATCGCACTTGTTGAAACGATAGAACATTGTGTTTTTAT
GTAGAATAAAGAGTATTATAAATTAAATATTAGTGTAATTATAATATTTACTTAAAATAA
GTAAACAAATCGATATCTTTAAAAGAGAAGGTCGCTCTGGAAAAAAATATTTTTCTGACA
TGTTTAAAATTAATACAAATACGACTAATCCACCTCAAATGAGTACATCACAGAATTTCA
CTTTGGTTCCGAAAACAACAAGAATCACTGACGAATATGAGATATCGAACAATGTTTTGG
GATTAGGTATAATATTGTGAAAATAATTAACAGAGAGGTCTGGTTTATATACCCTCCTAA
AATTTTGGCATAAATGGAAAAGTTGTGCAATGCACAAGAAAAAGTGATAATACTAAATAC
GCATTGAAGGTACTACATGATAATAGCAAAGCACGGAGAGAAGTGGAATTGCATTGGCGT
GTTAGTGGTTGTCGACATATTGTGAATATTGTTGATGTTTTTGAGAACACTTATGGTGGC
ACAAAATGTTTGTTAGTTGTAATGGAACTCATGACTGGTGGTGAGCTCTTCAATCGTATC
CAAGAACGTCAAGATGGACCTTTTACTGAACGTGAAGCTGCACAAATCATGCATGAGATA
TGCATTGCATTGAAATATCTTCATGATCGAAATATTGCTCATAGAGATTTAAAGCCAGAA
AATCTACTTTACTCAAGTCAAGATTGTGATGCGATTATTAAATTAACTGGTGAGCGTTCG
AGTTTTGGATTTGCCAAAGAGACACACATAAAAGACACGCTCCAGACACCTTGTTATACT
CCTTATTATGCTGCTCCAGAAATTCTAGGACCAGAAAAATACGATCGTTCTTGTGACTTA
TGGTCGTTGGGAGTGATAATGTATATTCTGCTTTGCGGTTTCCCTCCATTTTATAGCAAC
CACGGTCTTGCCATTTCACCAGGTATGAAAAATCGCATTCGAACTGGTCAATATGATTTT
CCATTGCCCGAGTGGCAAAACGTCAGTAATGATGCTAAAGATTTGATTCGAGGAATGTTG
AATGTAAACCCCAATGAACGACTTACTATTGACGAAGTAATGAAAAATAATTGGATCGCA
CAATATACTAACGTTCCCCAAACACCTTTACACACAAATCGTGTCTTGAAAGAAGAAGAA
CAACAATGGCCTGAAGTACAAGAAGAAATGAATCGTTCACTTGCTAGCATGAGAGTTGAT
TATGGCTTAGTACTCAAAAACATTGATAACTCGAGTAATTCACTTTTAAATAAACGCAAA
AAAGCAAAAGGCACACAGGGTGAAGCTTCAACAACGAAATTTTCAACACAGTTTTAA
>g11439.t10 Gene=g11439 Length=271
MELMTGGELFNRIQERQDGPFTEREAAQIMHEICIALKYLHDRNIAHRDLKPENLLYSSQ
DCDAIIKLTGERSSFGFAKETHIKDTLQTPCYTPYYAAPEILGPEKYDRSCDLWSLGVIM
YILLCGFPPFYSNHGLAISPGMKNRIRTGQYDFPLPEWQNVSNDAKDLIRGMLNVNPNER
LTIDEVMKNNWIAQYTNVPQTPLHTNRVLKEEEQQWPEVQEEMNRSLASMRVDYGLVLKN
IDNSSNSLLNKRKKAKGTQGEASTTKFSTQF
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 6 | g11439.t10 | Gene3D | G3DSA:1.10.510.10 | Transferase(Phosphotransferase) domain 1 | 4 | 192 | 5.4E-62 |
| 5 | g11439.t10 | Gene3D | G3DSA:4.10.1170.10 | MAP kinase activated protein kinase 2 | 200 | 265 | 2.1E-25 |
| 12 | g11439.t10 | MobiDBLite | mobidb-lite | consensus disorder prediction | 249 | 271 | - |
| 2 | g11439.t10 | PANTHER | PTHR24349 | SERINE/THREONINE-PROTEIN KINASE | 1 | 263 | 2.2E-117 |
| 3 | g11439.t10 | PANTHER | PTHR24349:SF63 | MAP KINASE-ACTIVATED PROTEIN KINASE 2 | 1 | 263 | 2.2E-117 |
| 1 | g11439.t10 | Pfam | PF00069 | Protein kinase domain | 1 | 192 | 7.7E-50 |
| 7 | g11439.t10 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. | 1 | 112 | - |
| 9 | g11439.t10 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 113 | 131 | - |
| 8 | g11439.t10 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. | 132 | 271 | - |
| 10 | g11439.t10 | ProSitePatterns | PS00108 | Serine/Threonine protein kinases active-site signature. | 45 | 57 | - |
| 13 | g11439.t10 | ProSiteProfiles | PS50011 | Protein kinase domain profile. | 1 | 192 | 33.319 |
| 11 | g11439.t10 | SMART | SM00220 | serkin_6 | 1 | 192 | 4.0E-36 |
| 4 | g11439.t10 | SUPERFAMILY | SSF56112 | Protein kinase-like (PK-like) | 1 | 233 | 2.73E-60 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0005524 | ATP binding | MF |
| GO:0004672 | protein kinase activity | MF |
| GO:0006468 | protein phosphorylation | BP |
KEGG
Orthology
This gene did not have any KEGG ortholog annotations (KAAS, GHOSTZ).
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
