Gene loci information

Transcript annotation

  • This transcript has been annotated as MAP kinase-activated protein kinase 2.

Parent gene

Gene structure

  • The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.

Chromosome Gene Transcript Category ID Start End
chr_1 g11439 g11439.t2 TTS g11439.t2 16249170 16249170
chr_1 g11439 g11439.t2 isoform g11439.t2 16249383 16251899
chr_1 g11439 g11439.t2 exon g11439.t2.exon1 16249383 16249551
chr_1 g11439 g11439.t2 exon g11439.t2.exon2 16249611 16249836
chr_1 g11439 g11439.t2 exon g11439.t2.exon3 16249900 16249988
chr_1 g11439 g11439.t2 exon g11439.t2.exon4 16250046 16250156
chr_1 g11439 g11439.t2 cds g11439.t2.CDS1 16250128 16250156
chr_1 g11439 g11439.t2 exon g11439.t2.exon5 16250681 16250808
chr_1 g11439 g11439.t2 cds g11439.t2.CDS2 16250681 16250808
chr_1 g11439 g11439.t2 exon g11439.t2.exon6 16251190 16251250
chr_1 g11439 g11439.t2 cds g11439.t2.CDS3 16251190 16251250
chr_1 g11439 g11439.t2 exon g11439.t2.exon7 16251311 16251379
chr_1 g11439 g11439.t2 cds g11439.t2.CDS4 16251311 16251379
chr_1 g11439 g11439.t2 exon g11439.t2.exon8 16251437 16251518
chr_1 g11439 g11439.t2 cds g11439.t2.CDS5 16251437 16251518
chr_1 g11439 g11439.t2 exon g11439.t2.exon9 16251585 16251646
chr_1 g11439 g11439.t2 cds g11439.t2.CDS6 16251585 16251646
chr_1 g11439 g11439.t2 exon g11439.t2.exon10 16251773 16251899
chr_1 g11439 g11439.t2 cds g11439.t2.CDS7 16251773 16251899
chr_1 g11439 g11439.t2 TSS g11439.t2 16252138 16252138

Sequences

>g11439.t2 Gene=g11439 Length=1124
ATGTTTAAAATTAATACAAATACGACTAATCCACCTCAAATGAGTACATCACAGAATTTC
ACTTTGGTTCCGAAAACAACAAGAATCACTGACGAATATGAGATATCGAACAATGTTTTG
GGATTAGGCATAAATGGAAAAGTTGTGCAATGCACAAGAAAAAGTGATAATACTAAATAC
GCATTGAAGGTACTACATGATAATAGCAAAGCACGGAGAGAAGTGGAATTGCATTGGCGT
GTTAGTGGTTGTCGACATATTGTGAATATTGTTGATGTTTTTGAGAACACTTATGGTGGC
ACAAAATGTTTGTTAGTTGTAATGGAACTCATGACTGGTGGTGAGCTCTTCAATCGTATC
CAAGAACGTCAAGATGGACCTTTTACTGAACGTGAAGCTGCACAAATCATGCATGAGATA
TGCATTGCATTGAAATATCTTCATGATCGAAATATTGCTCATAGAGATTTAAAGCCAGAA
AATCTACTTTACTCAAGTCAAGATTGTGATGCGATTATTAAATTAACTGTTTTGGATTTG
CCAAAGAGACACACATAAAAGACACGCTCCAGACACCTTGTTATACTCCTTATTATGCTG
CTCCAGAAATTCTAGGACCAGAAAAATACGATCGTTCTTGTGACTTATGGTCGTTGGGAG
TGATAATGTATATTCTGCTTTGCGGTTTCCCTCCATTTTATAGCAACCACGGTCTTGCCA
TTTCACCAGGTATGAAAAATCGCATTCGAACTGGTCAATATGATTTTCCATTGCCCGAGT
GGCAAAACGTCAGTAATGATGCTAAAGATTTGATTCGAGGAATGTTGAATGTAAACCCCA
ATGAACGACTTACTATTGACGAAGTAATGAAAAATAATTGGATCGCACAATATACTAACG
TTCCCCAAACACCTTTACACACAAATCGTGTCTTGAAAGAAGAAGAACAACAATGGCCTG
AAGTACAAGAAGAAATGAATCGTTCACTTGCTAGCATGAGAGTTGATTATGGCTTAGTAC
TCAAAAACATTGATAACTCGAGTAATTCACTTTTAAATAAACGCAAAAAAGCAAAAGGCA
CACAGGGTGAAGCTTCAACAACGAAATTTTCAACACAGTTTTAA

>g11439.t2 Gene=g11439 Length=185
MFKINTNTTNPPQMSTSQNFTLVPKTTRITDEYEISNNVLGLGINGKVVQCTRKSDNTKY
ALKVLHDNSKARREVELHWRVSGCRHIVNIVDVFENTYGGTKCLLVVMELMTGGELFNRI
QERQDGPFTEREAAQIMHEICIALKYLHDRNIAHRDLKPENLLYSSQDCDAIIKLTVLDL
PKRHT

Protein features from InterProScan

Transcript Database ID Name Start End E.value
8 g11439.t2 Gene3D G3DSA:3.30.200.20 Phosphorylase Kinase; domain 1 16 111 1.5E-40
9 g11439.t2 Gene3D G3DSA:1.10.510.10 Transferase(Phosphotransferase) domain 1 112 185 3.3E-20
2 g11439.t2 PANTHER PTHR24349 SERINE/THREONINE-PROTEIN KINASE 16 181 2.2E-65
3 g11439.t2 PANTHER PTHR24349:SF64 MAP KINASE-ACTIVATED PROTEIN KINASE 3 16 181 2.2E-65
1 g11439.t2 Pfam PF00069 Protein kinase domain 38 176 4.3E-31
7 g11439.t2 ProSitePatterns PS00107 Protein kinases ATP-binding region signature. 40 63 -
6 g11439.t2 ProSitePatterns PS00108 Serine/Threonine protein kinases active-site signature. 152 164 -
10 g11439.t2 ProSiteProfiles PS50011 Protein kinase domain profile. 34 185 22.803
5 g11439.t2 SMART SM00220 serkin_6 34 185 1.4E-10
4 g11439.t2 SUPERFAMILY SSF56112 Protein kinase-like (PK-like) 22 176 1.15E-42

Transmembrane regions from TMHMM

Disordered region

IUPRED3 score over 0.5 is predictive of a disordered region.

GO terms from InterProScan

GOID TERM ONTOLOGY
GO:0005524 ATP binding MF
GO:0004672 protein kinase activity MF
GO:0006468 protein phosphorylation BP

KEGG

Orthology

This gene did not have any KEGG ortholog annotations (KAAS, GHOSTZ).

Expression

Transcript expression in Pv11 cells

TPM values are indicated as average +/- STDEV.

Differential expression

Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.

Raw TPM values