General information for g11440.t7
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Alpha-actinin, sarcomeric.
Parent gene
- The parent gene g11440 is located on chr_1: 16259725..16260443 (+ strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_1 | g11440 | g11440.t7 | TSS | g11440.t7 | 16252413 | 16252413 |
| chr_1 | g11440 | g11440.t7 | isoform | g11440.t7 | 16252536 | 16257426 |
| chr_1 | g11440 | g11440.t7 | exon | g11440.t7.exon1 | 16252536 | 16252538 |
| chr_1 | g11440 | g11440.t7 | exon | g11440.t7.exon2 | 16254218 | 16254348 |
| chr_1 | g11440 | g11440.t7 | exon | g11440.t7.exon3 | 16256201 | 16256362 |
| chr_1 | g11440 | g11440.t7 | cds | g11440.t7.CDS1 | 16256291 | 16256362 |
| chr_1 | g11440 | g11440.t7 | exon | g11440.t7.exon4 | 16256424 | 16256678 |
| chr_1 | g11440 | g11440.t7 | cds | g11440.t7.CDS2 | 16256424 | 16256678 |
| chr_1 | g11440 | g11440.t7 | exon | g11440.t7.exon5 | 16256739 | 16256781 |
| chr_1 | g11440 | g11440.t7 | cds | g11440.t7.CDS3 | 16256739 | 16256781 |
| chr_1 | g11440 | g11440.t7 | exon | g11440.t7.exon6 | 16256840 | 16256950 |
| chr_1 | g11440 | g11440.t7 | cds | g11440.t7.CDS4 | 16256840 | 16256950 |
| chr_1 | g11440 | g11440.t7 | exon | g11440.t7.exon7 | 16257347 | 16257426 |
| chr_1 | g11440 | g11440.t7 | cds | g11440.t7.CDS5 | 16257347 | 16257426 |
| chr_1 | g11440 | g11440.t7 | TTS | g11440.t7 | NA | NA |
Sequences
>g11440.t7 Gene=g11440 Length=785
CAGGAAAAAAATGATGGATCAAAATGGATTGTATGCTGAAGAATATGGTGAAAATGGATA
TATGGAGCAGGAAGAAGAGTGGGAGCGGGAAGGTCTGCTAGATCCAGCATGGGAGAAGCA
ACAGAAAAAGGCAAACCTTTACCGCATGGTGCAACAGTCATTTGAGAAAAGCCGGAACTT
CAATCGAAAACATTGAAGATGATTTCCGCAATGGTCTTAAATTGATGCTTCTTTTGGAAG
TCATTTCTGGTGAAACATTACCAAAACCTGATCGTGGCAAGATGCGTTTCCACAAAATTG
CAAATGTGAACAAAGCTCTTGATTTTATCGCATCAAAAGGTGTTAAACTTGTCTCAATTG
GTGCTGAAGAAATTGTCGATGGAAACTTGAAAATGACTTTAGGTATGATTTGGACCATCA
TTTTAAGATTTGCCATCCAAGACATTTCTGTTGAGGAAATGACAGCTAAAGAGGGCTTAT
TGCTTTGGTGTCAACGCAAAACTGCTCCATACAAGAATGTTAATGTGCAAAATTTCCATC
TCAGTTTCAAGGACGGTTTAGCTTTTTGCGCATTGATTCATCGTCATCGTCCAGACTTGA
TCGATTATTCAAAATTGTCAAAGGACAATCCATTGGAGAATTTGAATACTGCATTCGACG
TTGCAGAAAAATACTTGGATATTCCAAGAATGTTGGATCCAGATGATTTACAAAACACTG
CAATGCCTGATGAACGTGCTGTTATGACTTATGTCTCATCTTATTATCATTGCTTTAGTG
GCGCA
>g11440.t7 Gene=g11440 Length=187
MLLLEVISGETLPKPDRGKMRFHKIANVNKALDFIASKGVKLVSIGAEEIVDGNLKMTLG
MIWTIILRFAIQDISVEEMTAKEGLLLWCQRKTAPYKNVNVQNFHLSFKDGLAFCALIHR
HRPDLIDYSKLSKDNPLENLNTAFDVAEKYLDIPRMLDPDDLQNTAMPDERAVMTYVSSY
YHCFSGA
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 9 | g11440.t7 | CDD | cd00014 | CH | 3 | 70 | 7.64643E-15 |
| 8 | g11440.t7 | CDD | cd00014 | CH | 81 | 182 | 4.58887E-28 |
| 7 | g11440.t7 | Gene3D | G3DSA:1.10.418.10 | - | 1 | 76 | 6.8E-28 |
| 6 | g11440.t7 | Gene3D | G3DSA:1.10.418.10 | - | 77 | 187 | 1.5E-49 |
| 3 | g11440.t7 | PANTHER | PTHR11915 | SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN | 1 | 187 | 1.2E-114 |
| 4 | g11440.t7 | PANTHER | PTHR11915:SF432 | ALPHA-ACTININ-3 | 1 | 187 | 1.2E-114 |
| 1 | g11440.t7 | Pfam | PF00307 | Calponin homology (CH) domain | 3 | 70 | 1.7E-11 |
| 2 | g11440.t7 | Pfam | PF00307 | Calponin homology (CH) domain | 80 | 185 | 1.8E-27 |
| 10 | g11440.t7 | ProSitePatterns | PS00020 | Actinin-type actin-binding domain signature 2. | 42 | 66 | - |
| 14 | g11440.t7 | ProSiteProfiles | PS50021 | Calponin homology (CH) domain profile. | 1 | 70 | 17.159 |
| 13 | g11440.t7 | ProSiteProfiles | PS50021 | Calponin homology (CH) domain profile. | 79 | 185 | 25.733 |
| 11 | g11440.t7 | SMART | SM00033 | ch_5 | 3 | 68 | 0.077 |
| 12 | g11440.t7 | SMART | SM00033 | ch_5 | 81 | 180 | 1.4E-25 |
| 5 | g11440.t7 | SUPERFAMILY | SSF47576 | Calponin-homology domain, CH-domain | 3 | 184 | 1.53E-69 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0005515 | protein binding | MF |
KEGG
Orthology
This gene did not have any KEGG ortholog annotations (KAAS, GHOSTZ).
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below. There were no conditions that were differentially expressed