General information for g11524.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Atypical protein kinase C.
Parent gene
- The parent gene g11524 is located on chr_1: 16809191..16813400 (+ strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_1 | g11524 | g11524.t1 | TSS | g11524.t1 | 16808602 | 16808602 |
| chr_1 | g11524 | g11524.t1 | isoform | g11524.t1 | 16809191 | 16813400 |
| chr_1 | g11524 | g11524.t1 | exon | g11524.t1.exon1 | 16809191 | 16809536 |
| chr_1 | g11524 | g11524.t1 | cds | g11524.t1.CDS1 | 16809191 | 16809536 |
| chr_1 | g11524 | g11524.t1 | exon | g11524.t1.exon2 | 16809874 | 16810109 |
| chr_1 | g11524 | g11524.t1 | cds | g11524.t1.CDS2 | 16809874 | 16810109 |
| chr_1 | g11524 | g11524.t1 | exon | g11524.t1.exon3 | 16810365 | 16810876 |
| chr_1 | g11524 | g11524.t1 | cds | g11524.t1.CDS3 | 16810365 | 16810876 |
| chr_1 | g11524 | g11524.t1 | exon | g11524.t1.exon4 | 16810978 | 16811047 |
| chr_1 | g11524 | g11524.t1 | cds | g11524.t1.CDS4 | 16810978 | 16811047 |
| chr_1 | g11524 | g11524.t1 | exon | g11524.t1.exon5 | 16811511 | 16811669 |
| chr_1 | g11524 | g11524.t1 | cds | g11524.t1.CDS5 | 16811511 | 16811669 |
| chr_1 | g11524 | g11524.t1 | exon | g11524.t1.exon6 | 16811829 | 16812214 |
| chr_1 | g11524 | g11524.t1 | cds | g11524.t1.CDS6 | 16811829 | 16812214 |
| chr_1 | g11524 | g11524.t1 | exon | g11524.t1.exon7 | 16812284 | 16812392 |
| chr_1 | g11524 | g11524.t1 | cds | g11524.t1.CDS7 | 16812284 | 16812392 |
| chr_1 | g11524 | g11524.t1 | exon | g11524.t1.exon8 | 16812518 | 16812662 |
| chr_1 | g11524 | g11524.t1 | cds | g11524.t1.CDS8 | 16812518 | 16812662 |
| chr_1 | g11524 | g11524.t1 | exon | g11524.t1.exon9 | 16812736 | 16813118 |
| chr_1 | g11524 | g11524.t1 | cds | g11524.t1.CDS9 | 16812736 | 16813118 |
| chr_1 | g11524 | g11524.t1 | exon | g11524.t1.exon10 | 16813197 | 16813400 |
| chr_1 | g11524 | g11524.t1 | cds | g11524.t1.CDS10 | 16813197 | 16813400 |
| chr_1 | g11524 | g11524.t1 | TTS | g11524.t1 | NA | NA |
Sequences
>g11524.t1 Gene=g11524 Length=2550
ATGGCTTGGGGATTTTGGTCAGCGAGCACAGTTTCTGATCGAGGGCGTTCGCCAAGAAGG
GCAACAACAAGTTCTAGTGCAATTTACTATCAAACTCAACCTCAGCAATCTCAGCAACAG
CATCAAACTCAACAGCAGTATGTAATCAATCAATGTTCTCAGCAGGATGAGACAGCCAGT
TGTCATATGGTGCCAATGACCTCACAGCAGCAACAATCGTCAAGACCACCATCAAGACCA
CCCTCACGACCAGGCACAGCTGCTGCTTCGGTTTGTGCAAGCCCATGTCAAAGTGTCTGT
CATAGTCCTACTTGCCAAAGTCCATCATGTCAGAGTGGAACCACAGAATCTCCTGAACCT
CAACAATGTCACGATTGTCAAGAGCCACAATGTCAATATAATCAGCAGCAACAGCAACAA
CAGCAGCAAATACAGCACTCACACCAACAGCAGCATCAGCATCATCTTCAACAGCAGCAG
CCACCGCCTCATATTTCACAGGAACCGATTCTTCTTCCACATATGCATCAAATTCAATAT
ACATATTCACGTCGTACATCTTTGGATAGCAATGCAATCGATAATCAGTTATCGGATATA
ATATGTCGAGCAATACAGCCTTCAATACAATCCGCAAGTAATACATTAACACGAAATGCG
TCATTGCAAGGTGGTGACATTGGTGACTATGCTGTGCCGCAAGCTCATTTGCATCATCAT
ATTATTGCACCAGCGAAATCAAACTCGTCATTGATGCGATGCGGTTCTTGTCCTGGTTCG
ACAGGTGTATCAAGAAGAGGTTCAAGTTCCGAATCAAGTCCTGCTGGTAACGTAAGTGTT
ATTGCGGGCAGTGATGGCATCAGTATGTGTAGAGCGGGTTCTGGTTACTATACCGATACA
ACCTCGCATTACGATCGAATGCCTTTACCTATTCCGATTGTTCCAGTATCTCATACAGCT
CATATGAGCAATCTTCATTCAGAAGACGAGATAGAGCCTGCATATGCTACTGTCTTTCCA
AATACGACCGCAAATATACCGCAACCTCAACAGCAAATAAGCTATCAAACTGATGATCGA
AGCATTTATCGTAGGGGTGCTCGACGGTGGAGAAAATTGTACCGAATTAATGGACACATT
TTTCAAGCTAAGCGATTTAATAGAAAAGCATTTTGCACATTTTGTCATGACCGAATTTGG
GGCTTAGGCAAACAAGGATTTAAATGCATACAATGTAAATTACTGGTACACAAAAAATGT
CATAAACTGGTGCAAAGGCCATGTGGGAAAGATTATAGTGATATCACTACAGACAGTGGT
GAGGAGTTGAATGGAAACAATGAAATGCCCTCGTATAGCTATCATTGTGATTTGTCAGAT
TGTAGTCAAAATTATATGTCTGATCAAGAGCAAGAAGTTGATTGTCAGACACCAATTCAA
AAACAGTACTCACTTGATGATTTTGAATTAATTCGAGTTATTGGTCGAGGAAGTTATGCA
AAAGTTCTCATGGTTGAATTGAAAAAGACTCGTCGTATTTATGCTATGAAAGTGATTAAA
AAGGCATTAGTAACGGACGATGAGGATATTGATTGGGTACAAACAGAGAAACATGTCTTT
GAAACAGCATCGAATCATCCCTTTCTTGTTGGCTTACATTCATGTTTTCAGACGCCATCA
CGACTCTTCTTTGTCATCGAGTTTGTACGTGGTGGTGATTTAATGTTTCACATGCAACGT
CAACGAAAGCTACCCGAAGAGCATGCACGCTTTTATGCTGCAGAAATCAGCTTAGCGTTA
AACTTCTTGCATGAAAAGGGCATAATTTATCGTGATCTAAAACTTGACAATGTGTTACTT
GATCATGAGGGACATATTAAATTAACGGATTACGGTATGTGTAAAGAAGGAATTGGTCCA
GGCGATAAGACAAGCACTTTTTGTGGAACGCCCAATTATATTGCACCGGAGATTTTAAGA
GGCGAAGATTATGGCTTTAGTGTCGACTGGTGGGCGCTTGGTGTTCTACTCTATGAAATG
CTCTGTGGCCGCAGTCCATTCGACATCTCCGGTATTGAAAATACGGAACCCACTACGAAT
TTATGTCAATCACGAAAGCGTCGAAGCATACATTCGACATCATTCCTTCAAACAACAGAA
GACTTTTTATTTCAAGTTATACTCGAAAAAGCAATTCGTATTCCTCGTTCACTAAGCGTG
AAAGCAGCATCCGTATTGAAAGGTTTCCTTAATAAAAATCAGGACGAACGACTCGGCTGT
CAACGAGAAAATGGCTTTCTCGATATTGTCAATCACCAGTTTTTCAAAACAATAGATTGG
GAAATGCTTGAGCAAAAGCAAGTCACTCCACCATTCCAACCAAGACTAGAAAATGAGCGC
GACTTGACAAACTTCCCACCAGAATTTACCGATGAACCCGTTCAATTAACACCCGATGAG
GATAGAATTATTGACAAGATAGATCAATCAGAATTTGAGGGATTTGAGTATGTCAATCCA
TTGTTAATGACTTTTGATGATTGTGTCTGA
>g11524.t1 Gene=g11524 Length=849
MAWGFWSASTVSDRGRSPRRATTSSSAIYYQTQPQQSQQQHQTQQQYVINQCSQQDETAS
CHMVPMTSQQQQSSRPPSRPPSRPGTAAASVCASPCQSVCHSPTCQSPSCQSGTTESPEP
QQCHDCQEPQCQYNQQQQQQQQQIQHSHQQQHQHHLQQQQPPPHISQEPILLPHMHQIQY
TYSRRTSLDSNAIDNQLSDIICRAIQPSIQSASNTLTRNASLQGGDIGDYAVPQAHLHHH
IIAPAKSNSSLMRCGSCPGSTGVSRRGSSSESSPAGNVSVIAGSDGISMCRAGSGYYTDT
TSHYDRMPLPIPIVPVSHTAHMSNLHSEDEIEPAYATVFPNTTANIPQPQQQISYQTDDR
SIYRRGARRWRKLYRINGHIFQAKRFNRKAFCTFCHDRIWGLGKQGFKCIQCKLLVHKKC
HKLVQRPCGKDYSDITTDSGEELNGNNEMPSYSYHCDLSDCSQNYMSDQEQEVDCQTPIQ
KQYSLDDFELIRVIGRGSYAKVLMVELKKTRRIYAMKVIKKALVTDDEDIDWVQTEKHVF
ETASNHPFLVGLHSCFQTPSRLFFVIEFVRGGDLMFHMQRQRKLPEEHARFYAAEISLAL
NFLHEKGIIYRDLKLDNVLLDHEGHIKLTDYGMCKEGIGPGDKTSTFCGTPNYIAPEILR
GEDYGFSVDWWALGVLLYEMLCGRSPFDISGIENTEPTTNLCQSRKRRSIHSTSFLQTTE
DFLFQVILEKAIRIPRSLSVKAASVLKGFLNKNQDERLGCQRENGFLDIVNHQFFKTIDW
EMLEQKQVTPPFQPRLENERDLTNFPPEFTDEPVQLTPDEDRIIDKIDQSEFEGFEYVNP
LLMTFDDCV
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 15 | g11524.t1 | CDD | cd00029 | C1 | 379 | 428 | 2.5163E-14 |
| 16 | g11524.t1 | CDD | cd05588 | STKc_aPKC | 492 | 838 | 0.0 |
| 13 | g11524.t1 | Gene3D | G3DSA:3.30.60.20 | - | 365 | 440 | 9.8E-21 |
| 12 | g11524.t1 | Gene3D | G3DSA:3.30.200.20 | Phosphorylase Kinase; domain 1 | 485 | 833 | 2.2E-132 |
| 14 | g11524.t1 | Gene3D | G3DSA:1.10.510.10 | Transferase(Phosphotransferase) domain 1 | 572 | 806 | 2.2E-132 |
| 27 | g11524.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 1 | 43 | - |
| 26 | g11524.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 10 | 43 | - |
| 24 | g11524.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 59 | 76 | - |
| 25 | g11524.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 59 | 86 | - |
| 23 | g11524.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 137 | 163 | - |
| 4 | g11524.t1 | PANTHER | PTHR24351:SF216 | PROTEIN KINASE C | 338 | 841 | 1.3E-238 |
| 5 | g11524.t1 | PANTHER | PTHR24351 | RIBOSOMAL PROTEIN S6 KINASE | 338 | 841 | 1.3E-238 |
| 8 | g11524.t1 | PRINTS | PR00008 | Diacylglycerol/phorbol-ester binding signature | 376 | 390 | 7.3E-7 |
| 9 | g11524.t1 | PRINTS | PR00008 | Diacylglycerol/phorbol-ester binding signature | 392 | 401 | 7.3E-7 |
| 7 | g11524.t1 | PRINTS | PR00008 | Diacylglycerol/phorbol-ester binding signature | 405 | 416 | 7.3E-7 |
| 6 | g11524.t1 | PRINTS | PR00008 | Diacylglycerol/phorbol-ester binding signature | 417 | 429 | 7.3E-7 |
| 3 | g11524.t1 | Pfam | PF00130 | Phorbol esters/diacylglycerol binding domain (C1 domain) | 379 | 430 | 4.4E-13 |
| 2 | g11524.t1 | Pfam | PF00069 | Protein kinase domain | 488 | 775 | 1.1E-63 |
| 1 | g11524.t1 | Pfam | PF00433 | Protein kinase C terminal domain | 796 | 837 | 8.1E-7 |
| 21 | g11524.t1 | ProSitePatterns | PS00479 | Zinc finger phorbol-ester/DAG-type signature. | 379 | 428 | - |
| 22 | g11524.t1 | ProSitePatterns | PS00107 | Protein kinases ATP-binding region signature. | 494 | 521 | - |
| 20 | g11524.t1 | ProSitePatterns | PS00108 | Serine/Threonine protein kinases active-site signature. | 608 | 620 | - |
| 29 | g11524.t1 | ProSiteProfiles | PS50081 | Zinc finger phorbol-ester/DAG-type profile. | 378 | 428 | 14.654 |
| 30 | g11524.t1 | ProSiteProfiles | PS50011 | Protein kinase domain profile. | 488 | 775 | 44.993 |
| 28 | g11524.t1 | ProSiteProfiles | PS51285 | AGC-kinase C-terminal domain profile. | 776 | 847 | 17.574 |
| 19 | g11524.t1 | SMART | SM00109 | c1_12 | 379 | 428 | 6.2E-12 |
| 18 | g11524.t1 | SMART | SM00220 | serkin_6 | 488 | 775 | 5.1E-91 |
| 17 | g11524.t1 | SMART | SM00133 | pkinase_C_6 | 776 | 839 | 4.5E-21 |
| 10 | g11524.t1 | SUPERFAMILY | SSF57889 | Cysteine-rich domain | 364 | 430 | 3.59E-19 |
| 11 | g11524.t1 | SUPERFAMILY | SSF56112 | Protein kinase-like (PK-like) | 485 | 826 | 2.05E-85 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0005524 | ATP binding | MF |
| GO:0004674 | protein serine/threonine kinase activity | MF |
| GO:0007163 | establishment or maintenance of cell polarity | BP |
| GO:0004672 | protein kinase activity | MF |
| GO:0006468 | protein phosphorylation | BP |
| GO:0035556 | intracellular signal transduction | BP |
KEGG
Orthology
This gene did not have any KEGG ortholog annotations (KAAS, GHOSTZ).
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
