General information for g11580.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as MAGUK p55 subfamily member 5.
Parent gene
- The parent gene g11580 is located on chr_1: 17310257..17311292 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_1 | g11580 | g11580.t1 | isoform | g11580.t1 | 17303057 | 17310257 |
| chr_1 | g11580 | g11580.t1 | exon | g11580.t1.exon1 | 17303057 | 17303236 |
| chr_1 | g11580 | g11580.t1 | cds | g11580.t1.CDS1 | 17303057 | 17303236 |
| chr_1 | g11580 | g11580.t1 | exon | g11580.t1.exon2 | 17303290 | 17303471 |
| chr_1 | g11580 | g11580.t1 | cds | g11580.t1.CDS2 | 17303290 | 17303471 |
| chr_1 | g11580 | g11580.t1 | exon | g11580.t1.exon3 | 17303548 | 17303679 |
| chr_1 | g11580 | g11580.t1 | cds | g11580.t1.CDS3 | 17303548 | 17303679 |
| chr_1 | g11580 | g11580.t1 | exon | g11580.t1.exon4 | 17303748 | 17304618 |
| chr_1 | g11580 | g11580.t1 | cds | g11580.t1.CDS4 | 17303748 | 17304618 |
| chr_1 | g11580 | g11580.t1 | exon | g11580.t1.exon5 | 17304682 | 17304927 |
| chr_1 | g11580 | g11580.t1 | cds | g11580.t1.CDS5 | 17304682 | 17304927 |
| chr_1 | g11580 | g11580.t1 | exon | g11580.t1.exon6 | 17304986 | 17305200 |
| chr_1 | g11580 | g11580.t1 | cds | g11580.t1.CDS6 | 17304986 | 17305200 |
| chr_1 | g11580 | g11580.t1 | exon | g11580.t1.exon7 | 17305269 | 17305846 |
| chr_1 | g11580 | g11580.t1 | cds | g11580.t1.CDS7 | 17305269 | 17305846 |
| chr_1 | g11580 | g11580.t1 | exon | g11580.t1.exon8 | 17305976 | 17306088 |
| chr_1 | g11580 | g11580.t1 | cds | g11580.t1.CDS8 | 17305976 | 17306088 |
| chr_1 | g11580 | g11580.t1 | exon | g11580.t1.exon9 | 17306581 | 17307207 |
| chr_1 | g11580 | g11580.t1 | cds | g11580.t1.CDS9 | 17306581 | 17307207 |
| chr_1 | g11580 | g11580.t1 | exon | g11580.t1.exon10 | 17307459 | 17307589 |
| chr_1 | g11580 | g11580.t1 | cds | g11580.t1.CDS10 | 17307459 | 17307589 |
| chr_1 | g11580 | g11580.t1 | exon | g11580.t1.exon11 | 17309505 | 17309562 |
| chr_1 | g11580 | g11580.t1 | cds | g11580.t1.CDS11 | 17309505 | 17309562 |
| chr_1 | g11580 | g11580.t1 | exon | g11580.t1.exon12 | 17309623 | 17309802 |
| chr_1 | g11580 | g11580.t1 | cds | g11580.t1.CDS12 | 17309623 | 17309802 |
| chr_1 | g11580 | g11580.t1 | exon | g11580.t1.exon13 | 17310216 | 17310257 |
| chr_1 | g11580 | g11580.t1 | cds | g11580.t1.CDS13 | 17310216 | 17310257 |
| chr_1 | g11580 | g11580.t1 | TSS | g11580.t1 | NA | NA |
| chr_1 | g11580 | g11580.t1 | TTS | g11580.t1 | NA | NA |
Sequences
>g11580.t1 Gene=g11580 Length=3555
ATGAATAGTAAACCTGCATTGACGCCACAAAACTCATCAAAACAAGTTGTTGAGTTGGAA
GGATATGTAATAATTCTAGTTGAGGGAAGAGATGGCAAAATTAAATTATACGGTAGTCCA
GCAGATCGTGATGGTCTTGAAGTAGCTGACGAAATTCTCGATGTCAACGAAAAGAAACTT
GATGATGTTCCTCGTGCTCTTGTTATAAAACATATACATGAGTGTATACAGTCATGCATG
ATAAAATTGCGAGTAAAACGTCGAAGTGATTCTAGACTAGCTGGTGAATTGTGTAATACT
GTACAAGATGCATTTCTCATTGCTGTCGAACAACAAGCTCGTGAACGTCTTCAACGTTTG
TCAGCTCTCAAGAGAATCACACCAGTTGATATAAGTCAGCTATCAATAAAGTTGAATCAA
CAAAATCCAAAAGGGGTAACGACAACCCAAGATTATAGTTTTTTAAAGGATTCATCGCCA
ATCTATGTGACATCCCTATCAAATAATAATAACAGTACTGTAACAAGTGCAGCAACATCG
ACAGCTAAAATTTCAACTGTTCATCCACCATCTATCAAAAGTCCTACAGTGAAAAGTATT
AGTAATCCACTTTGTGAAACAACTGGTAATCATCCTGAATTACACCATACTAATAGCACG
AGCAATCAATTACAATTACTAACAACTTCGATAATTCGCAAACCAATCACCTCCTCTAGT
ACGTTTGACAATATTAATAATAAAACGGTTCAGAATAACATAAACTATCTTGCTTCTACA
TCGTCTATTCCCTCCTCAACGACATCACAACAACAAATAATCAAACAAACGTCAAACGCG
TCAGTAACACATGGAACAACAACAGCAGCAATACCATTAACTGATCCTAGTAGTGATTTA
AATAAACATAGCGCTAACCTAACCAATAACATTAATGTAATCAACAACAATGTCAGTAAT
CAGTTGCCAAATAATGTAGATTTTGATCCAAATGAGGGTTGCACTAGTTATTATCATCCT
AATAATAATCGCACTGAGTTTTCTTTAGAATCTGATATCGCTCAAGAGGATCATTTTGAA
GGTACTAGCATATCAAAAGGCGGAACTGAGGTTTTACTTGGTATTGATCCGCTTTTGAAA
AACGAAAACAGAACGCGAAGACCATCACGTTCCAGTATATTAGTGCTGGGTGATGATTCA
TTGAAGCAAGTAGTGTCGAGTGGAAACTTCACAACAGCCGACATGTATTCAATCGAGAAC
GGACAGCATCGTGAGATGGCTGTTGATGTTCCAGAGTCATTTATTGCTCACAATAAGACG
CAACCAAGATATCCACCGCCTCGTAATCTCAACAATTCAACACTTTCAATGCCAACACCG
GCTTCGAAAGTAATCGGAAATGACATGAGACCAATCCCACCACCACGTGATCACATAAGA
AGCGATAATGCTCAACAATTTCAAACAAAAGTGGGCAATATTGGTCAAATTCTTGAGCCA
ACATCTGATCAAATGGATAGTATTAAAAAGTATCAAGATCAACTTCGACAACGTCGTGAA
AAGGAAGAGCGTATTGCAGCCACAAATGAGTTTTTACGCAATAGTGTACGCGGATCGGAA
AAATTGAGAGCTCTTAAAGCTGAACATATTGCTCCACCACCAGTTGGTTTCGATAATGAA
GCCTATATAGTAGAGGACGATGACGATGTTAACAAAATGAATTTAATTGATTATGATGAA
ATGGTTGCAACAATGCAAAGACTTCAAATTAATTTCAAAAAGCATGGCATGCATGCATTA
GCCAGTCGTTTAAATATTGCTCAAAACTTGTTATTGAAATCTGTAGTTGCAAAAGCATTA
GATACACGAGTGCATCTTCTACATAGACGTTTTCCGCGTGTTCAAAATCCAATTTCTTAT
AATGCTCAAAAGTTGACAAAAGATTGTGTTGAAGCATTATCTGAGTCAAATTCACATTTA
GCAAATGAGCTTTGCGATTTGTTGACATCTTATGAAATGGAAGGATTACTACAGGCACAT
GATAGCATTGCATCTCTAACTGATCGTGCATATTGTTCTCCTTCAAATTTAAATACATTG
CCTGCAAAGGTGCCATTACATCATACAGCATCAAATAGTCTAAAACATGAGACAAAAAGT
TATAGCAGTTCAAATGAAGACATTAAAAAGCCCGAATCGATTCCAATACCTTTCGGTGTA
TTGCGCGATGGAAGTCAAGATCATATTAGAATAATTCAAATTGAAAAGTCTTCAGAACCA
CTTGGCGCTACAATTCGTAATGAAGGTGAAGCAGTGGTGATAGGAAGAGTAGTTAGAGGT
GGTGCTGCTGAAAAATCGGGTCTTTTACATGAAGGTGATGAAATATTGGAAGTGAATGGA
ATCGAAATGCGCGGAAAATCTGTAAATGATGTATGCTCTATTCTTGCTGGAATGTCGGGA
ACATTGACTTTTTTAGTTGTGCCAGCAAATCGTGCTCCAGTCATAGTTGGTCGTGATCCA
CCGGTGCTTCATGTTCGTGCTCATTTTGATTATGATCCTGAGGATGATTTGTATATTCCA
TGTCGTGAATTGGGCATTAGTTTTCAAAAAGGTGATGTTCTACATGTAATTTCACGTGAA
GATCCTAATTGGTGGCAAGCATACCGTGAAGGTGAAGAAGATCAAACTTTAGCAGGACTT
ATTCCAAGTCAATCATTCCAGCATCAGCGTGAGTCAATGAAATTGGCTATTGCCGGAGAA
CTCGGTAATAGAGCGAAGAATAATCGCGAAAGTAAAAGTGCCACATCAACACTACTTTGT
GCTCGTAAAGGCCGAAGAAAAAGAAAGAAGGCAAATAATGAACATGGTTATCCACTTTAT
GCAACCACTACACATGATGAACCTGAACCAGAGATTTTGACATATGAAGAAGTAACATTA
TATTATCCACGCGCGTCACATAAGCGACCGATCGTCCTTATTGGTCCGCCAAATATTGGA
CGGCATGAGTTGAGACAACGATTGATGGCAGATTCTGATCGTTTTGCAGCTGCTGTTCCA
CATACATCGAGACCACGAAGGGAAGGAGAAGTACCTGGAGTCGATTACCATTTTATATCG
AGACAGCAGTTTGAAGCAGATATATTAGGTCGTAAATTTGTAGAGCATGGAGAATATGAG
AAAGCATATTATGGTACATCATTAGAAGCAATAAGAGCAGTAGTGGAGAGTGGAAAAATT
TGTGTTCTAAATTTACATCCTCAAAGTTTAAAAATTTTACGGCAATCAGATTTGAAGCCC
TACACTGTTTTAGTTGCTCCACCAAGTTTAGAAAAATTGCGTCAAAAGAAAATTAGAGCG
GGAGAGCCTTATAAGGAGGAAGAACTGAAAGAAATAATAGCGACAGCGCGAGATATGGAA
GCAAGATGGGGACATTTATTCGATATGATAATTATTAATAATGATACTGAACGAGCGTAT
CATCAATTATTGGCCGAAATAAATTCACTTGAACGAGAACCACAATGGGTAGAAAAATTG
AATAATAAGAGTTAA
>g11580.t1 Gene=g11580 Length=1184
MNSKPALTPQNSSKQVVELEGYVIILVEGRDGKIKLYGSPADRDGLEVADEILDVNEKKL
DDVPRALVIKHIHECIQSCMIKLRVKRRSDSRLAGELCNTVQDAFLIAVEQQARERLQRL
SALKRITPVDISQLSIKLNQQNPKGVTTTQDYSFLKDSSPIYVTSLSNNNNSTVTSAATS
TAKISTVHPPSIKSPTVKSISNPLCETTGNHPELHHTNSTSNQLQLLTTSIIRKPITSSS
TFDNINNKTVQNNINYLASTSSIPSSTTSQQQIIKQTSNASVTHGTTTAAIPLTDPSSDL
NKHSANLTNNINVINNNVSNQLPNNVDFDPNEGCTSYYHPNNNRTEFSLESDIAQEDHFE
GTSISKGGTEVLLGIDPLLKNENRTRRPSRSSILVLGDDSLKQVVSSGNFTTADMYSIEN
GQHREMAVDVPESFIAHNKTQPRYPPPRNLNNSTLSMPTPASKVIGNDMRPIPPPRDHIR
SDNAQQFQTKVGNIGQILEPTSDQMDSIKKYQDQLRQRREKEERIAATNEFLRNSVRGSE
KLRALKAEHIAPPPVGFDNEAYIVEDDDDVNKMNLIDYDEMVATMQRLQINFKKHGMHAL
ASRLNIAQNLLLKSVVAKALDTRVHLLHRRFPRVQNPISYNAQKLTKDCVEALSESNSHL
ANELCDLLTSYEMEGLLQAHDSIASLTDRAYCSPSNLNTLPAKVPLHHTASNSLKHETKS
YSSSNEDIKKPESIPIPFGVLRDGSQDHIRIIQIEKSSEPLGATIRNEGEAVVIGRVVRG
GAAEKSGLLHEGDEILEVNGIEMRGKSVNDVCSILAGMSGTLTFLVVPANRAPVIVGRDP
PVLHVRAHFDYDPEDDLYIPCRELGISFQKGDVLHVISREDPNWWQAYREGEEDQTLAGL
IPSQSFQHQRESMKLAIAGELGNRAKNNRESKSATSTLLCARKGRRKRKKANNEHGYPLY
ATTTHDEPEPEILTYEEVTLYYPRASHKRPIVLIGPPNIGRHELRQRLMADSDRFAAAVP
HTSRPRREGEVPGVDYHFISRQQFEADILGRKFVEHGEYEKAYYGTSLEAIRAVVESGKI
CVLNLHPQSLKILRQSDLKPYTVLVAPPSLEKLRQKKIRAGEPYKEEELKEIIATARDME
ARWGHLFDMIIINNDTERAYHQLLAEINSLEREPQWVEKLNNKS
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 17 | g11580.t1 | CDD | cd00992 | PDZ_signaling | 24 | 86 | 4.23529E-5 |
| 18 | g11580.t1 | CDD | cd00992 | PDZ_signaling | 749 | 827 | 7.31624E-18 |
| 16 | g11580.t1 | CDD | cd12036 | SH3_MPP5 | 844 | 905 | 1.17832E-42 |
| 19 | g11580.t1 | CDD | cd00071 | GMPK | 990 | 1164 | 4.37552E-33 |
| 15 | g11580.t1 | Coils | Coil | Coil | 1153 | 1173 | - |
| 14 | g11580.t1 | Gene3D | G3DSA:2.30.42.10 | - | 14 | 95 | 1.6E-6 |
| 12 | g11580.t1 | Gene3D | G3DSA:1.20.1270.460 | - | 632 | 694 | 2.1E-6 |
| 13 | g11580.t1 | Gene3D | G3DSA:2.30.42.10 | - | 745 | 833 | 3.9E-27 |
| 11 | g11580.t1 | Gene3D | G3DSA:2.30.30.40 | SH3 Domains | 834 | 968 | 3.9E-30 |
| 10 | g11580.t1 | Gene3D | G3DSA:3.40.50.300 | - | 976 | 1180 | 3.3E-76 |
| 4 | g11580.t1 | PANTHER | PTHR23122:SF14 | MAGUK P55 SUBFAMILY MEMBER 5 | 469 | 1177 | 4.1E-293 |
| 5 | g11580.t1 | PANTHER | PTHR23122 | MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK | 469 | 1177 | 4.1E-293 |
| 3 | g11580.t1 | Pfam | PF00595 | PDZ domain | 752 | 826 | 1.6E-11 |
| 1 | g11580.t1 | Pfam | PF07653 | Variant SH3 domain | 844 | 907 | 4.1E-11 |
| 2 | g11580.t1 | Pfam | PF00625 | Guanylate kinase | 988 | 1165 | 1.2E-44 |
| 20 | g11580.t1 | ProSitePatterns | PS00856 | Guanylate kinase-like signature. | 1022 | 1039 | - |
| 25 | g11580.t1 | ProSiteProfiles | PS51022 | L27 domain profile. | 635 | 691 | 13.801 |
| 28 | g11580.t1 | ProSiteProfiles | PS50106 | PDZ domain profile. | 751 | 830 | 16.747 |
| 27 | g11580.t1 | ProSiteProfiles | PS50002 | Src homology 3 (SH3) domain profile. | 840 | 911 | 20.851 |
| 26 | g11580.t1 | ProSiteProfiles | PS50052 | Guanylate kinase-like domain profile. | 988 | 1168 | 41.345 |
| 22 | g11580.t1 | SMART | SM00228 | pdz_new | 20 | 89 | 0.055 |
| 21 | g11580.t1 | SMART | SM00228 | pdz_new | 759 | 830 | 7.0E-16 |
| 23 | g11580.t1 | SMART | SM00326 | SH3_2 | 843 | 910 | 1.0E-9 |
| 24 | g11580.t1 | SMART | SM00072 | gk_7 | 987 | 1171 | 5.5E-58 |
| 6 | g11580.t1 | SUPERFAMILY | SSF50156 | PDZ domain-like | 38 | 90 | 1.84E-7 |
| 7 | g11580.t1 | SUPERFAMILY | SSF50156 | PDZ domain-like | 735 | 830 | 2.89E-21 |
| 9 | g11580.t1 | SUPERFAMILY | SSF50044 | SH3-domain | 814 | 923 | 3.02E-27 |
| 8 | g11580.t1 | SUPERFAMILY | SSF52540 | P-loop containing nucleoside triphosphate hydrolases | 988 | 1176 | 7.15E-54 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0070830 | bicellular tight junction assembly | BP |
| GO:0005515 | protein binding | MF |
| GO:0090162 | establishment of epithelial cell polarity | BP |
KEGG
Orthology
- This transcript has been annotated with K06091 (MAGUK p55 subfamily member 5)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
