Gene loci information

Transcript annotation

  • This transcript has been annotated as Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial.

Parent gene

Gene structure

  • The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.

Chromosome Gene Transcript Category ID Start End
chr_1 g11622 g11622.t8 TSS g11622.t8 17482591 17482591
chr_1 g11622 g11622.t8 isoform g11622.t8 17482779 17485437
chr_1 g11622 g11622.t8 exon g11622.t8.exon1 17482779 17483678
chr_1 g11622 g11622.t8 cds g11622.t8.CDS1 17483150 17483678
chr_1 g11622 g11622.t8 exon g11622.t8.exon2 17483732 17483828
chr_1 g11622 g11622.t8 cds g11622.t8.CDS2 17483732 17483828
chr_1 g11622 g11622.t8 exon g11622.t8.exon3 17483887 17484563
chr_1 g11622 g11622.t8 cds g11622.t8.CDS3 17483887 17484563
chr_1 g11622 g11622.t8 exon g11622.t8.exon4 17484620 17485437
chr_1 g11622 g11622.t8 cds g11622.t8.CDS4 17484620 17484768
chr_1 g11622 g11622.t8 TTS g11622.t8 NA NA

Sequences

>g11622.t8 Gene=g11622 Length=2492
ATGCTAATGTTGAGAAAAACCTTTGTTTCAAATTTAAGGTAAGTAATTTGCTACAACTCT
CTATCTAAAATAAATGATGAAGAAGAAAGATTTTAATGGTTGTTTATCAAATATTATAAT
CTTAATGTCATGATAAGTAAATTCACACCTTCTTTTCTTCTTTTAGACCTCGATATATTT
CGTCGGTTGTTCCAGAACATAATTTAAAAGATTTCGATGTGAAAAATGAGCCAATTTTAG
GGTATAAAAAAGGTTCAACAGAACGGAATGAATTAGTTAAAGCTCTTGAAGAAGCTAAAT
CAAATGTTGCTGATTGTCCTATTATCATTGGTGGAGAAGAATTTCGTACAAACGATGTTC
GTTATCAAGTTATGCCACATGATCATAAGCATCAAATTGCAAGATTTTATTATGCCGATG
CGAATTTGATCCAAAAAGCAATCAACAAGTCTATCGAAATGCAACCGAAATGGGATCGTA
CACCATTGAAAGAGCGTGTAGAAATTTGGGATCGTGCTGCATCACTTATGGCTAACAAGT
ATAGGCAAAAGCTTAATGCAGCTACAATGCTTGGTCAGTCAAAGACAGCCATTCAAGCCG
AAATCGATTCTGCAGCAGAACTTATCGATTTTATTCGCTTCAATGTTTTCTTTTTAAAAG
AAAATGCCAAATATCAACCAATTAGCGAGGATATCAAAGTGACTAAGAATTCAGTGCGAT
TCCGTGGAATTGATGGTTTTGTTGCAGCTATTTCACCGTTTAATTTTACTGCTATCGGAG
GAAATCTTTCATATACACCGGCATTAGTTGGTAATTCAGTCTTATGGAAACCATCTGACA
CTGCTGTATTATCAAATTGGACAATTTACGAAATAATGAGAGAAGCTGGTGTACCAGAAG
GTGTTGTTAATTTTATTCCTGCTGATGGTCCAATATTTGGTGATACAATTACCAAGTCGA
AATATCTTGGAGGTATTAATTTTACTGGTTCAGTTCCAACTTTCAATCGTCTTTGGAGAC
AAGTGGGTGAAAATATTGAAAATTATATAAATTATCCTAAATTAATTGGCGAGTGCGGTG
GAAAAAATTATCACTTTGTGCATCCTAGTGCAGATATTGAAACTGTTGTTACTGCTACTA
TTCGTTCTGCATTTGAATATTGTGGTCAAAAATGCTCTGCTTGTTCGCGTGCATATATTC
CAGAATCACTTTGGCCAAAGATAAAAGAAGGATTGCTACACGAACGTGCAAAATTAAAAG
TCGGAGATGTTACTGATTTCTCAACTTTTATGGGTGCAGTCATTGACGAAAAAGCATTTA
ATAGAATCAAATCTTATATTGACTACGCAAAAAGCTCTAACAATTTAGAGATTATCGGAG
GTGGTGGTTATGACAATAGTAAAGGTTATTTCATTGAACCAACCATCGTTCAAACTAAAG
ATCCTAAAGATAAGATCATGATTGAGGAGATTTTTGGACCAGTACTTACAATCTATGTAT
ATGCTGATAAAGATCTCGATTCAACAATGAAACTTGTTGGAAACTCAACACAATTTGCAT
TAACTGGTGCTGTATTTTCTACAAACGAGTCATTTTTAAAACGTGCACTTGAAGAGTTTA
AAATGACTGCTGGAAACTTTTATATTAACGATAAATCAACTGGCAGTGTTGTTGGACAAC
AACCATTTGGAGGATCACGTATGAGTGGCACAAACGATAAAGCAGGTGGTCCTCATTATG
CTATTCGATGGACAACAATACAATCAATAAAAGAGACATTTGTTCCATTACGGGATATAG
ATTATCCATATATGCGAGAATAAATTTTAACGTACTTAGCACACACATCTCATAACAATG
TTCGAACAAGTAGATTCTACGAATAATTGTCCCCCAATTCTATTCAAACTTGATTATCTC
GTGTAATGAAATGTATGTACTTAATCAAATTTGCCATAAATTTATAAGTTTTTTGATCAA
AATTTTTACATATTACCTTATTTCTTATACGAAGAATGTGTCAAGACATAAAAATTATCG
AAAGACTATTTCAATTTATTATTTTGATGACTAAGTATTAATTTACGTACTTATTGACTT
TTTTAATTGTTATTTTGTTACTTTTATTTTTCCTGATTGGCTGTGTGTAAAATGCGCAAA
TTGATTGATTCATTTTTTGCCTACACTACTTATTTCATAGAATATTATCATTTGTCAAAT
GTTACCAAAAAATATAATGTACTTGTGGAAAAGAGTAAACTTCTTTGCAATTAGATTCAA
CTAATTATAACGACTTGCATCACGGATGATAGATAATAATAATAAAATATGAAGAATGAA
AATCGTGAATATAATGGATTTATAATTTAGTATTAGATAGAATTTATTCAACTTTAAGTT
AAAAAATTTCACAATAATATTCTTATTGTTAGTACATTTAGAAATTTATTCATAATTTTG
TTCTTTGTATTGTTTTATACACGAATCGTGTT

>g11622.t8 Gene=g11622 Length=483
MPHDHKHQIARFYYADANLIQKAINKSIEMQPKWDRTPLKERVEIWDRAASLMANKYRQK
LNAATMLGQSKTAIQAEIDSAAELIDFIRFNVFFLKENAKYQPISEDIKVTKNSVRFRGI
DGFVAAISPFNFTAIGGNLSYTPALVGNSVLWKPSDTAVLSNWTIYEIMREAGVPEGVVN
FIPADGPIFGDTITKSKYLGGINFTGSVPTFNRLWRQVGENIENYINYPKLIGECGGKNY
HFVHPSADIETVVTATIRSAFEYCGQKCSACSRAYIPESLWPKIKEGLLHERAKLKVGDV
TDFSTFMGAVIDEKAFNRIKSYIDYAKSSNNLEIIGGGGYDNSKGYFIEPTIVQTKDPKD
KIMIEEIFGPVLTIYVYADKDLDSTMKLVGNSTQFALTGAVFSTNESFLKRALEEFKMTA
GNFYINDKSTGSVVGQQPFGGSRMSGTNDKAGGPHYAIRWTTIQSIKETFVPLRDIDYPY
MRE

Protein features from InterProScan

Transcript Database ID Name Start End E.value
9 g11622.t8 CDD cd07123 ALDH_F4-17_P5CDH 1 472 0.0
6 g11622.t8 Gene3D G3DSA:3.40.605.10 Aldehyde Dehydrogenase; Chain A 1 467 8.6E-201
7 g11622.t8 Gene3D G3DSA:3.40.309.10 Aldehyde Dehydrogenase; Chain A 238 435 8.6E-201
2 g11622.t8 PANTHER PTHR14516 1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE FAMILY MEMBER 2 482 1.6E-263
3 g11622.t8 PANTHER PTHR14516:SF6 DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE, MITOCHONDRIAL-LIKE PROTEIN 2 482 1.6E-263
1 g11622.t8 Pfam PF00171 Aldehyde dehydrogenase family 5 465 6.3E-102
5 g11622.t8 ProSitePatterns PS00070 Aldehyde dehydrogenases cysteine active site. 261 272 -
4 g11622.t8 SUPERFAMILY SSF53720 ALDH-like 6 467 2.88E-113
8 g11622.t8 TIGRFAM TIGR01236 D1pyr5carbox1: 1-pyrroline-5-carboxylate dehydrogenase 1 481 1.2E-216

Transmembrane regions from TMHMM

Disordered region

IUPRED3 score over 0.5 is predictive of a disordered region.

GO terms from InterProScan

GOID TERM ONTOLOGY
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor MF
GO:0010133 proline catabolic process to glutamate BP
GO:0055114 NA NA
GO:0016491 oxidoreductase activity MF
GO:0003842 1-pyrroline-5-carboxylate dehydrogenase activity MF

KEGG

Orthology

Pathway

  • This transcript belongs to the following pathways

Expression

Transcript expression in Pv11 cells

TPM values are indicated as average +/- STDEV.

Differential expression

Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.

Raw TPM values