General information for g11722.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Phosphatidylinositol 3-kinase catalytic subunit type 3.
Parent gene
- The parent gene g11722 is located on chr_1: 18076751..18077285 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_1 | g11722 | g11722.t1 | isoform | g11722.t1 | 18074050 | 18077285 |
| chr_1 | g11722 | g11722.t1 | exon | g11722.t1.exon1 | 18074050 | 18075512 |
| chr_1 | g11722 | g11722.t1 | cds | g11722.t1.CDS1 | 18074050 | 18075512 |
| chr_1 | g11722 | g11722.t1 | exon | g11722.t1.exon2 | 18075572 | 18076124 |
| chr_1 | g11722 | g11722.t1 | cds | g11722.t1.CDS2 | 18075572 | 18076124 |
| chr_1 | g11722 | g11722.t1 | exon | g11722.t1.exon3 | 18076500 | 18077285 |
| chr_1 | g11722 | g11722.t1 | cds | g11722.t1.CDS3 | 18076500 | 18077285 |
| chr_1 | g11722 | g11722.t1 | TSS | g11722.t1 | 18077359 | 18077359 |
| chr_1 | g11722 | g11722.t1 | TTS | g11722.t1 | NA | NA |
Sequences
>g11722.t1 Gene=g11722 Length=2802
ATGGACGATAACGTATTTCGATACATTTACAGTTGTTCCTTAGAGCAAAGAGTGCAAATT
AAAATAGGCTCTTTAGATGGATCTGCACTGAATAAACCTGATTTTGAAAAATTGCTTTCA
AATCCAAATTTATGTCATTCTGGACTTTATTCAGACCCATGTGCGCCATTTCTCGTGAAA
ATTCAATGCTATAATAACAAAAAACCATTTGGACTTGCTGTGAACACTTCATATAAAGCC
TTTAGTAAAAGATGGAATTGGAATCAATGGATTGTTCTACCTTTTAATTATTGCGATTTA
CCTCGTAATGCAGTCCTTTGTTTTACAATTTACGATTGTACTGGAGCAGGTGAAATGTCA
GTGATCGGTGGAACATCAATTTCTATCTTTGGCAAACATGGAATCTTCCGAGAGGGAATG
TTCGATTTAAAAGTTTGGCCCAATCAAATAGCTGATCCAATTGCGACTCCAGGAAAATGT
AAAAGTGACTCTAATGATATGACTCAACATCAAATGCAACGTCTTGCAAAATTGGCTAAA
AAGCATAGAAATGGACAAATTGAAAAGGTTGATTGGCTTGATCGTCTAACGTTCCGAGAA
ATTGAAGTTATAAATGAAAAAGAAAAGAGAGAATCAAATTATCTTTATTTAATGATTGAA
TTCCCATCAGTGAGCTATCAAGACAAAAATTATACTATAATATATTATGAACCAACTGGT
GATAAAAAATTTTCTTTTATATCAAAACCAAAAATAGTCACAGTTCCTGATTCAGAAATA
TTGCAAGAAAACCTAGTTGAAAAAAAACATCATCGATTGGCACGTTCAGCTCGTTCAGGT
TTATCTGATCGCGATGCAAAGCCAACCGCTCAAATTAGAGATCAACTACACTCACTTGTG
CATAGATCACCAACATTTCAATTAAACAGTGAAGAACAGGATTTGATATGGAAATATAGA
TTTTATTTAAGCACTCAAAAGAAGGCGCTTACAAAATTTCTTAAATGTATTAATTGGCAA
ACATCTGCAGAAGTAAGACAAGCTCTTAATCTTCTGGACTTATGGGCACCAATGGATGTT
GAAGATGCTCTTGAATTATTGAGTCCGAATTTTCAACATCCAGCTGTTAGGCGATATGCG
ATAACACGTCTAAAGCAGTCACAGGATGATGATTTACTTCTCTATTTACTTCAGCTTGTA
CAAGCATTAAAATATGAAAATTTTGATGATATTTTTGAATGGCGTCGACGTGTTATGAAT
GAAAAAGACATTTTAAAATCGATTGATGATAACAATTCCACTACTAACGATCAAAGTTCA
ATTTCTGATTCCATAATGGCTCAATCTATGACATCTCAACAATTTTTAAATGAATCAGAA
GAAATAATTGTACCACCTTTAAATCAACAATCTATCATGTCAAGTTCAATATTTTATGAT
CAACAAAATGATAATATAAGTGATCAACCGAGAATTGATGATTCTAATAATGATGTAACA
TCAGATATTTCAAATACTTTGATGAATTCAAAAAGTTCATATATTTGTGATTTAGCAACA
TTTTTAATTCAAAGAGCATGTAAAAATCCAACACTCGCTAATTTTTTCTATTGGTATTTG
TTGATAGAATGTGAAGATCATGAAACTGTTAGAAAAAAAGACGAAAGAGTGCGAGAGATG
TATGAAAATGTGCAAAAAATTTTCCTTAAAACTCTGGAAATGGGTAATACAGATTTGAAA
ATCATTCATTCTAATTTGATGAAACAAAAATGCTTTATTGAAAATTTGGTCAAACTAGTG
AAATTAGTTGCAAAAGACTCTGGCAATAGAAAGAAGAAGACAGAAAAATTTCAACAATTG
TTGTGTGATTCAGATGAATTTAAAATTAATTTCACAAGCTTTGAACCATTACCGCTTCCA
CTTAATCCAGAAATATTTATAAAAGGCATCGTAACATCAAAAGTCTCACTTTTCAAATCA
GCCTTAATGCCAGCAAAATTAACATTCCTTACGACTAATGATACAGAATATGTTGCAATT
TTTAAAAATGGCGATGATTTACGTCAGGATCAACTCATTTTACAAATGATTACTCTCATG
GATAAGTTACTAAGAAAAGAAAATTTAGATTTAAAGCTTACTCCATATCGGGTATTAGCA
TTATCATCTAAACATGGCTTTATGCAATATATTGAATCTATAACAGTTGCGGAGGCACTC
AAAACAGAAGGAACAATATTGAATTTTTTTAAAAAGCATAATCCTTGTGATACATCCTTG
TATGGCATTCAATCTGAAGTTATGGATACATATATAAAAAGTTGTGCCGGTTATTGTGTC
ATTACATACTTGCTAGGTGTCGGTGATAGACATTTGGATAATTTACTTTTAACTAAAAAT
GGAAATCTATTTCATATAGATTTTGGATATATTTTAGGACGAGATCCGAAACCTCTTCCT
CCACCTATGAAATTAAGCAAGGAGATGGTCGATGCTATGGGAGGAATAAATTCTGATCAT
TATCATGAGTTTAGGAAACAATGTTATACAGCTTTTCTTCATCTTCGACGACATGCAAAT
GTCATGTTAAATTTATTTTCACTTATGACAGATGCTTCAGTTCCCGATATTGCATTAGAA
CCTGATAAAGCAGTAAAGAAAGTAGAAGATAATCTTAAATTGAATTTAACAGATGAAGAG
GCAGTTCAACATTTACAAAATCTTTTAGATGTTTCTCTTTCTGCTGTTATGCCTGCATTA
GTTGAACAAATACATAAATTAGCTCAATATTGGAGAACATAA
>g11722.t1 Gene=g11722 Length=933
MDDNVFRYIYSCSLEQRVQIKIGSLDGSALNKPDFEKLLSNPNLCHSGLYSDPCAPFLVK
IQCYNNKKPFGLAVNTSYKAFSKRWNWNQWIVLPFNYCDLPRNAVLCFTIYDCTGAGEMS
VIGGTSISIFGKHGIFREGMFDLKVWPNQIADPIATPGKCKSDSNDMTQHQMQRLAKLAK
KHRNGQIEKVDWLDRLTFREIEVINEKEKRESNYLYLMIEFPSVSYQDKNYTIIYYEPTG
DKKFSFISKPKIVTVPDSEILQENLVEKKHHRLARSARSGLSDRDAKPTAQIRDQLHSLV
HRSPTFQLNSEEQDLIWKYRFYLSTQKKALTKFLKCINWQTSAEVRQALNLLDLWAPMDV
EDALELLSPNFQHPAVRRYAITRLKQSQDDDLLLYLLQLVQALKYENFDDIFEWRRRVMN
EKDILKSIDDNNSTTNDQSSISDSIMAQSMTSQQFLNESEEIIVPPLNQQSIMSSSIFYD
QQNDNISDQPRIDDSNNDVTSDISNTLMNSKSSYICDLATFLIQRACKNPTLANFFYWYL
LIECEDHETVRKKDERVREMYENVQKIFLKTLEMGNTDLKIIHSNLMKQKCFIENLVKLV
KLVAKDSGNRKKKTEKFQQLLCDSDEFKINFTSFEPLPLPLNPEIFIKGIVTSKVSLFKS
ALMPAKLTFLTTNDTEYVAIFKNGDDLRQDQLILQMITLMDKLLRKENLDLKLTPYRVLA
LSSKHGFMQYIESITVAEALKTEGTILNFFKKHNPCDTSLYGIQSEVMDTYIKSCAGYCV
ITYLLGVGDRHLDNLLLTKNGNLFHIDFGYILGRDPKPLPPPMKLSKEMVDAMGGINSDH
YHEFRKQCYTAFLHLRRHANVMLNLFSLMTDASVPDIALEPDKAVKKVEDNLKLNLTDEE
AVQHLQNLLDVSLSAVMPALVEQIHKLAQYWRT
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 14 | g11722.t1 | CDD | cd08397 | C2_PI3K_class_III | 25 | 186 | 8.47028E-54 |
| 13 | g11722.t1 | CDD | cd00896 | PI3Kc_III | 586 | 929 | 0.0 |
| 11 | g11722.t1 | Gene3D | G3DSA:2.60.40.150 | - | 45 | 173 | 2.5E-13 |
| 9 | g11722.t1 | Gene3D | G3DSA:3.30.1010.10 | - | 577 | 732 | 8.5E-55 |
| 10 | g11722.t1 | Gene3D | G3DSA:1.10.1070.11 | - | 733 | 933 | 7.2E-83 |
| 4 | g11722.t1 | PANTHER | PTHR10048 | PHOSPHATIDYLINOSITOL KINASE | 34 | 926 | 4.9E-204 |
| 5 | g11722.t1 | PANTHER | PTHR10048:SF7 | PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3 | 34 | 926 | 4.9E-204 |
| 12 | g11722.t1 | PIRSF | PIRSF000587 | PI3K_Vps34 | 1 | 933 | 0.0 |
| 3 | g11722.t1 | Pfam | PF00792 | Phosphoinositide 3-kinase C2 | 56 | 198 | 4.1E-37 |
| 2 | g11722.t1 | Pfam | PF00613 | Phosphoinositide 3-kinase family, accessory domain (PIK domain) | 285 | 562 | 2.9E-57 |
| 1 | g11722.t1 | Pfam | PF00454 | Phosphatidylinositol 3- and 4-kinase | 739 | 877 | 2.1E-35 |
| 16 | g11722.t1 | ProSitePatterns | PS00915 | Phosphatidylinositol 3- and 4-kinases signature 1. | 681 | 695 | - |
| 15 | g11722.t1 | ProSitePatterns | PS00916 | Phosphatidylinositol 3- and 4-kinases signature 2. | 774 | 794 | - |
| 20 | g11722.t1 | ProSiteProfiles | PS51547 | Phosphatidylinositol 3-kinase C2 (PI3K C2) domain profile. | 35 | 182 | 34.072 |
| 22 | g11722.t1 | ProSiteProfiles | PS51545 | PIK helical domain profile. | 282 | 564 | 31.216 |
| 21 | g11722.t1 | ProSiteProfiles | PS50290 | Phosphatidylinositol 3- and 4-kinases family profile. | 677 | 931 | 80.721 |
| 18 | g11722.t1 | SMART | SM00142 | pi3k_hr3_6 | 20 | 130 | 4.5E-26 |
| 17 | g11722.t1 | SMART | SM00145 | pi3k_hr2_4 | 283 | 581 | 5.3E-84 |
| 19 | g11722.t1 | SMART | SM00146 | pi3k_hr1_6 | 678 | 930 | 2.3E-103 |
| 8 | g11722.t1 | SUPERFAMILY | SSF49562 | C2 domain (Calcium/lipid-binding domain, CaLB) | 38 | 156 | 7.77E-30 |
| 6 | g11722.t1 | SUPERFAMILY | SSF48371 | ARM repeat | 267 | 563 | 9.78E-62 |
| 7 | g11722.t1 | SUPERFAMILY | SSF56112 | Protein kinase-like (PK-like) | 585 | 929 | 1.86E-84 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0016303 | 1-phosphatidylinositol-3-kinase activity | MF |
| GO:0016301 | kinase activity | MF |
| GO:0048015 | phosphatidylinositol-mediated signaling | BP |
| GO:0046854 | phosphatidylinositol phosphate biosynthetic process | BP |
KEGG
Orthology
- This transcript has been annotated with K00914 (phosphatidylinositol 3-kinase)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
