General information for g11730.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Alpha-aminoadipic semialdehyde synthase, mitochondrial.
Parent gene
- The parent gene g11730 is located on chr_1: 18106891..18109696 (+ strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_1 | g11730 | g11730.t1 | TSS | g11730.t1 | 18103398 | 18103398 |
| chr_1 | g11730 | g11730.t1 | isoform | g11730.t1 | 18103425 | 18106891 |
| chr_1 | g11730 | g11730.t1 | exon | g11730.t1.exon1 | 18103425 | 18103490 |
| chr_1 | g11730 | g11730.t1 | cds | g11730.t1.CDS1 | 18103425 | 18103490 |
| chr_1 | g11730 | g11730.t1 | exon | g11730.t1.exon2 | 18103556 | 18103599 |
| chr_1 | g11730 | g11730.t1 | cds | g11730.t1.CDS2 | 18103556 | 18103599 |
| chr_1 | g11730 | g11730.t1 | exon | g11730.t1.exon3 | 18103664 | 18103769 |
| chr_1 | g11730 | g11730.t1 | cds | g11730.t1.CDS3 | 18103664 | 18103769 |
| chr_1 | g11730 | g11730.t1 | exon | g11730.t1.exon4 | 18104068 | 18104308 |
| chr_1 | g11730 | g11730.t1 | cds | g11730.t1.CDS4 | 18104068 | 18104308 |
| chr_1 | g11730 | g11730.t1 | exon | g11730.t1.exon5 | 18104366 | 18104590 |
| chr_1 | g11730 | g11730.t1 | cds | g11730.t1.CDS5 | 18104366 | 18104590 |
| chr_1 | g11730 | g11730.t1 | exon | g11730.t1.exon6 | 18104652 | 18104822 |
| chr_1 | g11730 | g11730.t1 | cds | g11730.t1.CDS6 | 18104652 | 18104822 |
| chr_1 | g11730 | g11730.t1 | exon | g11730.t1.exon7 | 18104897 | 18106530 |
| chr_1 | g11730 | g11730.t1 | cds | g11730.t1.CDS7 | 18104897 | 18106530 |
| chr_1 | g11730 | g11730.t1 | exon | g11730.t1.exon8 | 18106583 | 18106891 |
| chr_1 | g11730 | g11730.t1 | cds | g11730.t1.CDS8 | 18106583 | 18106891 |
| chr_1 | g11730 | g11730.t1 | TTS | g11730.t1 | 18107225 | 18107225 |
Sequences
>g11730.t1 Gene=g11730 Length=2796
ATGTTGCGAATAAATAATCATCTAAAAATTGATAAAAAGATCAAAACTTTATTTCGTCAA
AAACATAATGGTACTGTTATAGCAATACGTCGAGAAGATCAGTCTGTATGGGAACGAAGA
GCTCCTTTTAATCCAGCAATGGTGAAAAGGCTAATAACAAAAGAAGGAGCAAAAGTTATA
GTACAGCCTTCTAATCGACGTGCCTATCCTATGCAGGCTTATTTAAATGCTGGAGCTGTG
ATTAATGAAGATATCAGCGAAGCATCTGTAATTTTTGGTGTAAAGCAAGTTCCTGTAGAT
TCTTTGATTCCCGATAAAACTTATTGTTTCTTTTCACATACAATAAAAGCACAAGAAACA
AATATGCCTCTCCTTGATGCAGTAATTGAGAAAAATATTCGTCTTATAGATTATGAGAAA
CTTATGGATCGTAATGGTTTGCGTTTAGTTGCATTTGGTAAATATGCTGGTGTTGCAGGA
ATGGTTAATATATTGCATGGGCTTGGACTACGACTTTTGGCTTTAGGACATCATACGCCA
TTTATGCAAATTTCACCTGCACATAATTATCGAAACTCAATGATGGCACGTCAAGCAGTT
CGTGATTGCGGTTACGAAATTTCGCTTGGAATGATGCCTAAATCCATCGGACCAATCACA
TTTATTTTTACAGGAACTGGAAGTGTATCTCAGGGAGCTCAACAAATATTTCAAGAGTTG
CCTGTTGAGTACGTTCCGCCAGATATGTTAAGGAAAGTTGCTGAGCATGGCAGTCAAAAT
AAATTGTATGGATGTGAAGTATCTAGAAGTGATCATTTAGAACGTCGAGAAGGAGGTGGA
TTTGATCCTATTGAATATGAACAGTTTCCTGAACGTTACATATCAACGTTTAGTAAGAAA
ATCGCTCCATATGCTTCAGTTATTGTAAATGGGATATATTGGGCTGTTGGATCTCCGAAA
TTAATAACTATTCCTGATGCAAAAAATCTTTTACGACCTGCCAATACACCTTGGCTTCCA
TCTTCTGTAGGGGCACCTTCATTGCCACATCGAATGCTTGCTATTTGTGATATATCAGCT
GATCCAGGCGGTTCAATAGAGTTTATGAATGAATGTACTACTATTGATACACCCTTTTGT
CTTTATGACGCAGACCGCAACAAAGATACAAAAAGTTTTAAAGGCCCTGGTGTACTTGTG
TGCTCTATTGATAATATGCCAACTCAATTACCAACAGAAGCTACCGATTATTTTGGTGAA
TTACTTTATCCATATGCTCTTGATATACTGAAATCTGATGCTTCCAAGCCACTTGAAGAA
CATAATTTTTTGCCAGAAGTTGAAGGTGCAATAATAGCTAGTAATGGAAAGTTAACACCT
AATTTTGAATACATTAATGAGCTACGAGAAGCAAATGTGAGAAAGAACAAAATCGATGGA
GCTACCTTCAGTAAAAGAGTTTTAGTTCTTGGGGCTGGCATGGTTTCAGCACCGCTTGTA
GAATATCTTAGCCGTGATAATGAATTAAGCATGAAAGTATGTTCACAAGTTAAAGAAGAA
GCAGACCGACTAGCTTTTCGTTATAATAATGTCGAATCTTTCTACATGGATGTTCGTAAT
AATCAAGAACATTTGGCAAAATTATGCGAAGAAGCCGATTGTGTTGTATCACTTTTACCT
TATGCTTTACACGGTCTTGTAGCAAAATATTGTGTTGAAGGAAAAACACATTTAGTAACT
GCAAGCTATGAATCTGATGAGGTTAAATCATATCATAAAGCTGCTAAAGCCGCAGGAATT
ACAATCTTGTCAGAATGTGGTTTGGATCCCGGCATTGATCACTTACTAGCAATGGAATGT
TTTCATGATGTACAAGAAAATGGTGGAGTAATCGAATCATTTGTGAGTTATTGTGGTGGT
TTTCCAGCGCCAGAATTTTCTGATAATCCTTTAAGATATAAATTTTCTTGGAGTCCACGC
GGTGCAATAATAAATACTCTTTCTGCAGCAAAATATTTAAGTAAGGGACAAATAGTTGAA
ATTTCAGGTGGTGGCGATTTAATGTCAACAACAAAAGAATTAAATTTTCTTCCTGGATTT
TCATTGGAAGGATTTCCTAATCGCGATTCACTTCAATATTTACAACTTTACGGATTAGGA
CCACAAGTTCATACATTTGTACGTGGAACTATTCGTTATAAGGGATTTACAGAGTGCATT
AAAACTATGCAATTGTTAGGACTCATTGATACAGAACCTCATCCCATGTTACATCCATCG
GGACCAGATGTAACTTGGCGTCAACTCTTAATTAATCTTCTTGGTTTAATTGATGAGGGA
ATATTTTATGAAAACTTGAAAATGAAATTAGCTGATCGAGTAGGTAACCCTGATTATTTA
GAAAACCTTGGTCTTTTGGAGGAGGATCTCATAGTAAAACAAGGAACTCCTCTTGATACA
TTGATTTATTATTTATCAAAGAAATTAGCATATGAAAAACATGAACGAGATCTTATAATT
TTGAGACATGACATAGGAGTACGATGGTCTGATGAACGTCGTGAAGAACGAGGAATAAAT
TTTGTTTGTTATGGTCAACCTGCATCTTCAAATGGACATTCAGCCATGGCATTAACGGTC
GGTTATCCAGCAGCTATCGCTGCTAAAATGATTCTTGATGGAGAAATTCAAGAGCGAGGA
GCTGTATTGCCTCTATCTCCTGATATCTACCGTCCTATGCTAACACGTTTGCGAGCTGAA
GGTCTTGAAGCAACGGAAATTATTAAACAACTTTAA
>g11730.t1 Gene=g11730 Length=931
MLRINNHLKIDKKIKTLFRQKHNGTVIAIRREDQSVWERRAPFNPAMVKRLITKEGAKVI
VQPSNRRAYPMQAYLNAGAVINEDISEASVIFGVKQVPVDSLIPDKTYCFFSHTIKAQET
NMPLLDAVIEKNIRLIDYEKLMDRNGLRLVAFGKYAGVAGMVNILHGLGLRLLALGHHTP
FMQISPAHNYRNSMMARQAVRDCGYEISLGMMPKSIGPITFIFTGTGSVSQGAQQIFQEL
PVEYVPPDMLRKVAEHGSQNKLYGCEVSRSDHLERREGGGFDPIEYEQFPERYISTFSKK
IAPYASVIVNGIYWAVGSPKLITIPDAKNLLRPANTPWLPSSVGAPSLPHRMLAICDISA
DPGGSIEFMNECTTIDTPFCLYDADRNKDTKSFKGPGVLVCSIDNMPTQLPTEATDYFGE
LLYPYALDILKSDASKPLEEHNFLPEVEGAIIASNGKLTPNFEYINELREANVRKNKIDG
ATFSKRVLVLGAGMVSAPLVEYLSRDNELSMKVCSQVKEEADRLAFRYNNVESFYMDVRN
NQEHLAKLCEEADCVVSLLPYALHGLVAKYCVEGKTHLVTASYESDEVKSYHKAAKAAGI
TILSECGLDPGIDHLLAMECFHDVQENGGVIESFVSYCGGFPAPEFSDNPLRYKFSWSPR
GAIINTLSAAKYLSKGQIVEISGGGDLMSTTKELNFLPGFSLEGFPNRDSLQYLQLYGLG
PQVHTFVRGTIRYKGFTECIKTMQLLGLIDTEPHPMLHPSGPDVTWRQLLINLLGLIDEG
IFYENLKMKLADRVGNPDYLENLGLLEEDLIVKQGTPLDTLIYYLSKKLAYEKHERDLII
LRHDIGVRWSDERREERGINFVCYGQPASSNGHSAMALTVGYPAAIAAKMILDGEIQERG
AVLPLSPDIYRPMLTRLRAEGLEATEIIKQL
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 15 | g11730.t1 | CDD | cd12189 | LKR_SDH_like | 26 | 469 | 0 |
| 12 | g11730.t1 | Gene3D | G3DSA:3.40.50.720 | - | 25 | 175 | 0 |
| 11 | g11730.t1 | Gene3D | G3DSA:3.40.50.720 | - | 485 | 918 | 0 |
| 13 | g11730.t1 | Gene3D | G3DSA:3.30.360.10 | Dihydrodipicolinate Reductase; domain 2 | 608 | 877 | 0 |
| 14 | g11730.t1 | Gene3D | G3DSA:1.10.1870.10 | Domain 3 | 735 | 830 | 0 |
| 4 | g11730.t1 | PANTHER | PTHR11133:SF21 | ALPHA-AMINOADIPIC SEMIALDEHYDE SYNTHASE, MITOCHONDRIAL | 24 | 926 | 0 |
| 5 | g11730.t1 | PANTHER | PTHR11133 | SACCHAROPINE DEHYDROGENASE | 24 | 926 | 0 |
| 3 | g11730.t1 | Pfam | PF05222 | Alanine dehydrogenase/PNT, N-terminal domain | 29 | 159 | 0 |
| 2 | g11730.t1 | Pfam | PF03435 | Saccharopine dehydrogenase NADP binding domain | 487 | 603 | 0 |
| 1 | g11730.t1 | Pfam | PF16653 | Saccharopine dehydrogenase C-terminal domain | 607 | 922 | 0 |
| 9 | g11730.t1 | SMART | SM01003 | AlaDh_PNT_N_2 | 28 | 159 | 0 |
| 10 | g11730.t1 | SMART | SM01002 | AlaDh_PNT_C_2 | 199 | 402 | 0 |
| 7 | g11730.t1 | SUPERFAMILY | SSF52283 | Formate/glycerate dehydrogenase catalytic domain-like | 26 | 233 | 0 |
| 6 | g11730.t1 | SUPERFAMILY | SSF51735 | NAD(P)-binding Rossmann-fold domains | 485 | 661 | 0 |
| 8 | g11730.t1 | SUPERFAMILY | SSF55347 | Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 608 | 870 | 0 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0055114 | NA | NA |
| GO:0016491 | oxidoreductase activity | MF |
KEGG
Orthology
- This transcript has been annotated with K14157 (alpha-aminoadipic semialdehyde synthase)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
