General information for g12091.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Putative 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha.
Parent gene
- The parent gene g12091 is located on chr_1: 20887255..20888346 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_1 | g12091 | g12091.t1 | TTS | g12091.t1 | 20886792 | 20886792 |
| chr_1 | g12091 | g12091.t1 | isoform | g12091.t1 | 20886891 | 20887906 |
| chr_1 | g12091 | g12091.t1 | exon | g12091.t1.exon1 | 20886891 | 20887198 |
| chr_1 | g12091 | g12091.t1 | cds | g12091.t1.CDS1 | 20886891 | 20887198 |
| chr_1 | g12091 | g12091.t1 | exon | g12091.t1.exon2 | 20887270 | 20887464 |
| chr_1 | g12091 | g12091.t1 | cds | g12091.t1.CDS2 | 20887270 | 20887464 |
| chr_1 | g12091 | g12091.t1 | exon | g12091.t1.exon3 | 20887585 | 20887593 |
| chr_1 | g12091 | g12091.t1 | cds | g12091.t1.CDS3 | 20887585 | 20887593 |
| chr_1 | g12091 | g12091.t1 | exon | g12091.t1.exon4 | 20887652 | 20887785 |
| chr_1 | g12091 | g12091.t1 | cds | g12091.t1.CDS4 | 20887652 | 20887785 |
| chr_1 | g12091 | g12091.t1 | exon | g12091.t1.exon5 | 20887848 | 20887906 |
| chr_1 | g12091 | g12091.t1 | cds | g12091.t1.CDS5 | 20887848 | 20887906 |
| chr_1 | g12091 | g12091.t1 | TSS | g12091.t1 | 20888086 | 20888086 |
Sequences
>g12091.t1 Gene=g12091 Length=705
ATGGCAGCACTTTATATTCCTTATTTTGCAATCCGAGGGAAAACTGTTGAAAATATTTTA
ATTTACGCTGAAACAATCAAACATTTAACTAGGGTATTAGGCATTACATGGACATTGAGA
GGTGCAGAAAGCTTAATGGAAAATAAATCATTTATTATTATAGCTAACCATCAAACTTCA
GTGGACATTATGGGCATGTTTAATATATGGCACGTCATTCAAAGCATGACTGTGATTGCG
AAAAAAGAGTTGCTATATGCGGGGCCTTTCGGCATTGCCGCTTATCTATCGGGTTTAATT
TTTATTGATCGTCATAGCTCGAAAGGAAAAGAAACAATGAATCAAGCAATGGAAGTGCTT
AAGAAAAACAACACAAAACTGTGGATATTCCCAGAAGGAACAAGAAGAAACACTGGTGAA
ATTCACAATTTCAAAAAGGGAGCATTTCACACTGCAATTCAATATGAAATTCCAATTATT
CCCATAGTTTTCAGCTCATATCGTCATTTTCTAGATGATAAAAATAAGAAGTTTGATGAG
GGAGAAATTATTCTAACTGTCTTACCCACAATCAAAACTAAAGGACTAAAATTGAGTGAT
ATTGATGAATTAATGGAGAAGACTAAGAAAGAAATGACTTTGGTGTACAAAAAAATTTCT
GATGAAGCAGCTGAGAATTTAAAACAATCAAAAAACAAACTGTGA
>g12091.t1 Gene=g12091 Length=234
MAALYIPYFAIRGKTVENILIYAETIKHLTRVLGITWTLRGAESLMENKSFIIIANHQTS
VDIMGMFNIWHVIQSMTVIAKKELLYAGPFGIAAYLSGLIFIDRHSSKGKETMNQAMEVL
KKNNTKLWIFPEGTRRNTGEIHNFKKGAFHTAIQYEIPIIPIVFSSYRHFLDDKNKKFDE
GEIILTVLPTIKTKGLKLSDIDELMEKTKKEMTLVYKKISDEAAENLKQSKNKL
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 10 | g12091.t1 | CDD | cd07989 | LPLAT_AGPAT-like | 26 | 209 | 2.58727E-45 |
| 2 | g12091.t1 | PANTHER | PTHR10434:SF50 | 1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE | 3 | 232 | 2.8E-92 |
| 3 | g12091.t1 | PANTHER | PTHR10434 | 1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE | 3 | 232 | 2.8E-92 |
| 1 | g12091.t1 | Pfam | PF01553 | Acyltransferase | 39 | 165 | 2.0E-29 |
| 8 | g12091.t1 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. | 1 | 83 | - |
| 9 | g12091.t1 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 84 | 102 | - |
| 7 | g12091.t1 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. | 103 | 234 | - |
| 5 | g12091.t1 | SMART | SM00563 | plsc_2 | 51 | 167 | 1.9E-34 |
| 4 | g12091.t1 | SUPERFAMILY | SSF69593 | Glycerol-3-phosphate (1)-acyltransferase | 30 | 223 | 1.22E-36 |
| 6 | g12091.t1 | TIGRFAM | TIGR00530 | AGP_acyltrn: 1-acylglycerol-3-phosphate O-acyltransferases | 39 | 164 | 5.8E-36 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0016020 | membrane | CC |
| GO:0008654 | phospholipid biosynthetic process | BP |
| GO:0016746 | acyltransferase activity | MF |
| GO:0003841 | 1-acylglycerol-3-phosphate O-acyltransferase activity | MF |
KEGG
Orthology
- This transcript has been annotated with K13509 (lysophosphatidate acyltransferase)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
