Gene loci information

Transcript annotation

  • This transcript has been annotated as Mitogen-activated protein kinase kinase kinase kinase 3.

Parent gene

Gene structure

  • The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.

Chromosome Gene Transcript Category ID Start End
chr_1 g12126 g12126.t7 isoform g12126.t7 21184066 21185582
chr_1 g12126 g12126.t7 exon g12126.t7.exon1 21184066 21184435
chr_1 g12126 g12126.t7 cds g12126.t7.CDS1 21184401 21184435
chr_1 g12126 g12126.t7 exon g12126.t7.exon2 21184491 21184526
chr_1 g12126 g12126.t7 cds g12126.t7.CDS2 21184491 21184526
chr_1 g12126 g12126.t7 exon g12126.t7.exon3 21184595 21184688
chr_1 g12126 g12126.t7 cds g12126.t7.CDS3 21184595 21184688
chr_1 g12126 g12126.t7 exon g12126.t7.exon4 21184795 21185089
chr_1 g12126 g12126.t7 cds g12126.t7.CDS4 21184795 21185089
chr_1 g12126 g12126.t7 exon g12126.t7.exon5 21185272 21185399
chr_1 g12126 g12126.t7 cds g12126.t7.CDS5 21185272 21185399
chr_1 g12126 g12126.t7 exon g12126.t7.exon6 21185496 21185582
chr_1 g12126 g12126.t7 cds g12126.t7.CDS6 21185496 21185582
chr_1 g12126 g12126.t7 TSS g12126.t7 21185641 21185641
chr_1 g12126 g12126.t7 TTS g12126.t7 NA NA

Sequences

>g12126.t7 Gene=g12126 Length=1010
ATGCAGCCGATATACAAAAGTAATCCGCATGAAGATTACGAGTTGTTGCAGAAAATAGGC
TCAGGCACTTATGGGAGTGTGTATAAAGGAAGGAATGTAAAAACGGGCGAATATGCAGCT
ATTAAAGTCATAAAAATAGAAACGGGCGATGACTTTCAACAGATCGAACAAGAAATCACC
ATGCTCAAGGGCTGCAATCATAAAAACATCATAAGTTACTATGGCTCATATCTTCGTCGA
GATAAATTGTGGATATGCATGGAATTGTGTGCGTACAGCTTGCAAGATATTTATCAAGTC
ATTGGACCACTGACAGAACAGCAAATAGCATACGTGTGTCGAGAAACGTTACTTGGTTTA
CAATATTTGCATAATCGAGGAAAGATGCATAGAGATATCAAGGGAGCCAATATTTTGTTG
ACTGACAATGGTGATGTAAAATTAGCTGATTTTGGAGTGTCTGCACAAATCACTGCAACA
ATTAATAAGCGGAAAAGTTTTATTGGAACTCCATATTGGATGAGTCCAGAAGTTGCTGCA
GTTGAAAGAAAAGGAGGATATAATCATTTGTGTGATATTTGGGCGGTTGGGATTACTGCT
ATTGAACTTGCTGAGCTTCAACCCCCGATGTTTGAGGTTTATGCATCCAATGAGAGTTTT
ATTTCTTATGTCTAAAAGCAACTTTAAACCTCCTACGTTAAAGGAGAAAGAGCTGTGGTC
ACCTATATTTCATTCCTTTGTTAAAATCGCACTTACGAAAAATCCGAAAAAGCGTCCAGA
TTCTGAGCGATTACTTCAGCATCCGTTTGTTAATGGTGGTGGTGCTGGAACGGGCGAAAT
GTCGGTTCGTTTGATGCGAGAACTTTTGCACAAATATCAAAATCCTCACAATTACAATGA
TCATGAGATTGACGATGAAGGTGCTGTAGGCATTTCTTCTGTTCCAAAACGCATTCCAAG
TAAAATCGGGACTGTAGAAAGAGTTCATCATATGCATGGAGAAAGCTCAA

>g12126.t7 Gene=g12126 Length=224
MQPIYKSNPHEDYELLQKIGSGTYGSVYKGRNVKTGEYAAIKVIKIETGDDFQQIEQEIT
MLKGCNHKNIISYYGSYLRRDKLWICMELCAYSLQDIYQVIGPLTEQQIAYVCRETLLGL
QYLHNRGKMHRDIKGANILLTDNGDVKLADFGVSAQITATINKRKSFIGTPYWMSPEVAA
VERKGGYNHLCDIWAVGITAIELAELQPPMFEVYASNESFISYV

Protein features from InterProScan

Transcript Database ID Name Start End E.value
5 g12126.t7 Gene3D G3DSA:1.10.510.10 Transferase(Phosphotransferase) domain 1 9 223 1.2E-87
2 g12126.t7 PANTHER PTHR48012:SF18 HAPPYHOUR, ISOFORM A 4 212 6.9E-129
3 g12126.t7 PANTHER PTHR48012 STERILE20-LIKE KINASE, ISOFORM B-RELATED 4 212 6.9E-129
6 g12126.t7 PIRSF PIRSF000654 ILK 2 220 4.5E-19
1 g12126.t7 Pfam PF00069 Protein kinase domain 13 211 1.1E-55
7 g12126.t7 ProSitePatterns PS00107 Protein kinases ATP-binding region signature. 19 42 -
9 g12126.t7 ProSiteProfiles PS50011 Protein kinase domain profile. 13 224 42.308
8 g12126.t7 SMART SM00220 serkin_6 13 221 2.1E-62
4 g12126.t7 SUPERFAMILY SSF56112 Protein kinase-like (PK-like) 6 212 1.35E-71

Transmembrane regions from TMHMM

Disordered region

IUPRED3 score over 0.5 is predictive of a disordered region.

GO terms from InterProScan

GOID TERM ONTOLOGY
GO:0005524 ATP binding MF
GO:0004672 protein kinase activity MF
GO:0006468 protein phosphorylation BP

KEGG

Orthology

This gene did not have any KEGG ortholog annotations (KAAS, GHOSTZ).

Expression

Transcript expression in Pv11 cells

TPM values are indicated as average +/- STDEV.

Differential expression

Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below. There were no conditions that were differentially expressed