General information for g12193.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Scoloptoxin SSD14.
Parent gene
- The parent gene g12193 is located on chr_1: 21679814..21682921 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_1 | g12193 | g12193.t1 | TTS | g12193.t1 | 21679610 | 21679610 |
| chr_1 | g12193 | g12193.t1 | isoform | g12193.t1 | 21679814 | 21682921 |
| chr_1 | g12193 | g12193.t1 | exon | g12193.t1.exon1 | 21679814 | 21681300 |
| chr_1 | g12193 | g12193.t1 | cds | g12193.t1.CDS1 | 21679814 | 21681300 |
| chr_1 | g12193 | g12193.t1 | exon | g12193.t1.exon2 | 21681361 | 21681605 |
| chr_1 | g12193 | g12193.t1 | cds | g12193.t1.CDS2 | 21681361 | 21681605 |
| chr_1 | g12193 | g12193.t1 | exon | g12193.t1.exon3 | 21682914 | 21682921 |
| chr_1 | g12193 | g12193.t1 | cds | g12193.t1.CDS3 | 21682914 | 21682921 |
| chr_1 | g12193 | g12193.t1 | TSS | g12193.t1 | 21682989 | 21682989 |
Sequences
>g12193.t1 Gene=g12193 Length=1740
ATGGATTTAACAAATATTTCTCGAAAGCGAGTTTTTATTGCTTTATTCATATCAATCATA
ATAATTGTCGCTATAATCACCGCCTACCAGTTTGGTATTAAAAATGATGATGAGCCAAAA
ACAAGGCTTATGCATGGTGGTGCTGTTGCAGCTAATGGGAAAGAATGTGCTGAATTAGGT
GCAAATATTTTAAAACAAAAGGGATCAGTAGCTGATGCTGCTATAACAACTATGCTTTGC
GAAGGAATCACTTGTCCGCAGTCAACTGGGCTAGGTGGTGGTTTTCATTTGACAATTTAC
ATTAAGAGCAAAAATTTAGTCGAATGTCTCGATGCTCGTGAAACTGCACCTAAAAATTCC
CACCAACAAATGTTTGTTAATGATACGAAAAAATCGTCACTCGAAGGTGGTTTATCAATC
GCAGTCCCAGGAGAACTTAAAGGAATGTGGGAATTGCATCAACGCTATGGTAAACTTCCT
TGGAAAGACCTTTTCAAACCAGTGATTGATTTATGTCAGAATGGACATGAAGTAACTGAA
TATTTGGCACGAGTTTTGAGTAAAAAGAGTGAAGACATCAAAAACATTCCATCGCTTCGA
GAAGTATTTGTCAATCCACAAACGGGAGAATTATGGAAAGCAGGAGATAAAATTAAAAGA
TTAGCATTAGCAAAAACACTTGAGACAATTGCAAATGAAGGTGCTGATACAATGTATAGT
AAAAATGGAACTATTGGTCGCCAAATTTTAGAGGACATCAAGGAATTTGGTGGAATTTTA
ACAGAAGAAGATTTTACTAATTATAAAGTGAAATGGTTAAAACCAGCTGAAACAACTTTG
AAAAATGGCGAGCGTCTTTATTCTATGCCTTTATCAGGTTCAGGTGCACTTTTAATTTTC
ATTATGAATTTATTAAAACCTTATGATTTAAAAAATGATGTTTTGTCGAACCATCGTATA
ATTGAAGCTTATAAATTGGCATATGCTCGACGATCAGAACTTGCAGATCCTGCATTTGTC
GAAAGTGCTGAAATTTTGATTAGAAATTTAACCAACATTGACTATGCTAATGTAATGAGA
AAGAAAATTGATGATACAAGAACACACAATGATATTAATTATTATGAAGGACATTTTATA
TCACAAGAAGACCATGGAACTGCTCATATTAGCATTCTTGCACCCAATGGTGATGCAATT
TCAGTTACTGGAACAATAAACTATATTTTGGGTTCAATGAGAAGAAGTAAAACTGGAATT
ATTTTAAATGATGAAATGGATGATTTTAGTACACCTGGTCAAAAGAACATTTATGGCATT
TCACCTTCAGAAGCAAATTACATTCAACCAGGAAAGCGACCAATGTCTTCAATGGCTCCA
TCGATTGTTGTTAATAATGATGGAAATGTCGGATTAATAATTGGAAGTGCTGGAGGCTCT
CGAATAACAACTGCTATCGCTCACACAATCATTCAATATTATTTCCTAAAATCAAAAGAT
TCACTTTGGAATACTTTTTCAATGAAACGACTTCATCATCAATTATTGCCTAATAAAATT
TACTTTGAAGATGGGTTTGATGAGCAAATAATTAATCAATTGAACAAAACATTTAATCAT
GACGTTGAAAGAGTTATAGAGCCTATAGGCTTTGGGGCGCTTGTGGGCATTTATGCTGAC
AATGAATCAGTTCAAGGAGCTTACGATCCAAGAAGAGGTGGAAGTTCTGTGGTTTTTTAA
>g12193.t1 Gene=g12193 Length=579
MDLTNISRKRVFIALFISIIIIVAIITAYQFGIKNDDEPKTRLMHGGAVAANGKECAELG
ANILKQKGSVADAAITTMLCEGITCPQSTGLGGGFHLTIYIKSKNLVECLDARETAPKNS
HQQMFVNDTKKSSLEGGLSIAVPGELKGMWELHQRYGKLPWKDLFKPVIDLCQNGHEVTE
YLARVLSKKSEDIKNIPSLREVFVNPQTGELWKAGDKIKRLALAKTLETIANEGADTMYS
KNGTIGRQILEDIKEFGGILTEEDFTNYKVKWLKPAETTLKNGERLYSMPLSGSGALLIF
IMNLLKPYDLKNDVLSNHRIIEAYKLAYARRSELADPAFVESAEILIRNLTNIDYANVMR
KKIDDTRTHNDINYYEGHFISQEDHGTAHISILAPNGDAISVTGTINYILGSMRRSKTGI
ILNDEMDDFSTPGQKNIYGISPSEANYIQPGKRPMSSMAPSIVVNNDGNVGLIIGSAGGS
RITTAIAHTIIQYYFLKSKDSLWNTFSMKRLHHQLLPNKIYFEDGFDEQIINQLNKTFNH
DVERVIEPIGFGALVGIYADNESVQGAYDPRRGGSSVVF
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 15 | g12193.t1 | Gene3D | G3DSA:1.10.246.130 | - | 275 | 380 | 1.8E-26 |
| 14 | g12193.t1 | Gene3D | G3DSA:3.60.20.40 | - | 381 | 579 | 2.2E-60 |
| 2 | g12193.t1 | PANTHER | PTHR11686 | GAMMA GLUTAMYL TRANSPEPTIDASE | 9 | 576 | 5.4E-217 |
| 3 | g12193.t1 | PANTHER | PTHR11686:SF51 | GAMMA-GLUTAMYL TRANSPEPTIDASE, ISOFORM A | 9 | 576 | 5.4E-217 |
| 5 | g12193.t1 | PRINTS | PR01210 | Gamma-glutamyltranspeptidase signature | 69 | 94 | 3.0E-66 |
| 6 | g12193.t1 | PRINTS | PR01210 | Gamma-glutamyltranspeptidase signature | 139 | 157 | 3.0E-66 |
| 10 | g12193.t1 | PRINTS | PR01210 | Gamma-glutamyltranspeptidase signature | 157 | 176 | 3.0E-66 |
| 9 | g12193.t1 | PRINTS | PR01210 | Gamma-glutamyltranspeptidase signature | 259 | 275 | 3.0E-66 |
| 4 | g12193.t1 | PRINTS | PR01210 | Gamma-glutamyltranspeptidase signature | 289 | 308 | 3.0E-66 |
| 8 | g12193.t1 | PRINTS | PR01210 | Gamma-glutamyltranspeptidase signature | 387 | 405 | 3.0E-66 |
| 7 | g12193.t1 | PRINTS | PR01210 | Gamma-glutamyltranspeptidase signature | 410 | 428 | 3.0E-66 |
| 11 | g12193.t1 | PRINTS | PR01210 | Gamma-glutamyltranspeptidase signature | 450 | 465 | 3.0E-66 |
| 12 | g12193.t1 | PRINTS | PR01210 | Gamma-glutamyltranspeptidase signature | 475 | 492 | 3.0E-66 |
| 1 | g12193.t1 | Pfam | PF01019 | Gamma-glutamyltranspeptidase | 62 | 574 | 3.8E-160 |
| 16 | g12193.t1 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. | 1 | 11 | - |
| 19 | g12193.t1 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 12 | 32 | - |
| 18 | g12193.t1 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. | 33 | 285 | - |
| 20 | g12193.t1 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 286 | 305 | - |
| 17 | g12193.t1 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. | 306 | 579 | - |
| 13 | g12193.t1 | SUPERFAMILY | SSF56235 | N-terminal nucleophile aminohydrolases (Ntn hydrolases) | 43 | 578 | 5.02E-142 |
| 22 | g12193.t1 | TIGRFAM | TIGR00066 | g_glut_trans: gamma-glutamyltransferase | 49 | 571 | 3.2E-108 |
| 21 | g12193.t1 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. | 11 | 33 | - |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0006751 | glutathione catabolic process | BP |
| GO:0036374 | glutathione hydrolase activity | MF |
KEGG
Orthology
- This transcript has been annotated with K18592 (gamma-glutamyltranspeptidase / glutathione hydrolase / leukotriene-C4 hydrolase)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
