General information for g12609.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Aminoacylase-1.
Parent gene
- The parent gene g12609 is located on chr_1: 24780967..24781548 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_1 | g12609 | g12609.t1 | TTS | g12609.t1 | 24780154 | 24780154 |
| chr_1 | g12609 | g12609.t1 | isoform | g12609.t1 | 24780290 | 24781548 |
| chr_1 | g12609 | g12609.t1 | exon | g12609.t1.exon1 | 24780290 | 24780912 |
| chr_1 | g12609 | g12609.t1 | cds | g12609.t1.CDS1 | 24780290 | 24780912 |
| chr_1 | g12609 | g12609.t1 | exon | g12609.t1.exon2 | 24780967 | 24781458 |
| chr_1 | g12609 | g12609.t1 | cds | g12609.t1.CDS2 | 24780967 | 24781458 |
| chr_1 | g12609 | g12609.t1 | exon | g12609.t1.exon3 | 24781527 | 24781548 |
| chr_1 | g12609 | g12609.t1 | cds | g12609.t1.CDS3 | 24781527 | 24781548 |
| chr_1 | g12609 | g12609.t1 | TSS | g12609.t1 | 24781608 | 24781608 |
Sequences
>g12609.t1 Gene=g12609 Length=1137
ATGACTGAGAAATCAAAGACTGATGCTTGTGTTGAATTTCTGAAGAAACTTGCAGAAGAG
TTGAAAGTTGAATTTAAAGTTTCTTGCCCGGCAAAAGATGATAGGCCGACAGTCATTTTA
TCAGTCATTGGAACTCAGCCAGAATTGCCAGCAATAATGTTAAATTCTCATATGGATGTT
GTTCCTGTTTTTGAAGAGTTTTGGACACATAAACCATTTGATGCTGATATTGATGAAGAA
GGGAAAATTTTTGCTCGTGGTGCACAAGATATGAAGTGTGTTGGAATGCAATATTTAGCT
GCCATCAGAAGATTAAAAAGACATAATGTCACACTAAAAAGAACAATTCATGTGACATTT
GTACCTGATGAGGAAATTTTTGGACCAGATGGAATGAAGGCTTTTGTAAATCACAACGAT
TTTCGTCAGTTGAATGTCGGTTTCTTACTTGATGAAGGAATTGCAAGTCCAACTAATGTT
TTTAGTGTTTTTTATGGCGAGAGAACTTGCTGGCAAATTCTCTTTAGAATTCATGGACAA
CCAGGTCATGGATCTCTTTTACTTGAAGACACAGCTGCTGAAAGTATGCATTTTTTATTG
AACAAAATTTATGATTTTCGTAGAAGTCAAGAGAAAATGCTCGAAGATAATCCAATTCTT
GAACTGGGTGATGTTACAACAATCAATGTCACACGAATCAATGGCGGAAAACAGAGAAAT
GTTTTGCCAGCTTTTATTGAATTAACTGTTGATATTCGTATGGCGTTGACTGTAAATTTG
GATGATTTTGAAGCAATGATTAATCGATGGGCTAAAGAATGTGGAAAGAAAATTGAAATT
GAATTTGTTACCAAAGAACCATTTTGTCCACCTACAAAAATTGATGACAGCAATGCTTAT
TGGACTGCATTCAAGAGTGCAGTAGATGAATTAAATTTGGAGATTAAACCGTTAGTTTTT
CCTGCTGGAACTGACGCTGCTTATGTCAGAGCAGTTGGAATTCCTGCAATCGGTTTCAGT
CCAATGAATAATACTCCTGTTTTACTTCATGACCACGATGAATTTCTTCATGCTGATGTG
TATCTCAAAGGAATTGAAATTTATGAAAAAATTCTCGAAAAAGTTTGCAATTTTTAA
>g12609.t1 Gene=g12609 Length=378
MTEKSKTDACVEFLKKLAEELKVEFKVSCPAKDDRPTVILSVIGTQPELPAIMLNSHMDV
VPVFEEFWTHKPFDADIDEEGKIFARGAQDMKCVGMQYLAAIRRLKRHNVTLKRTIHVTF
VPDEEIFGPDGMKAFVNHNDFRQLNVGFLLDEGIASPTNVFSVFYGERTCWQILFRIHGQ
PGHGSLLLEDTAAESMHFLLNKIYDFRRSQEKMLEDNPILELGDVTTINVTRINGGKQRN
VLPAFIELTVDIRMALTVNLDDFEAMINRWAKECGKKIEIEFVTKEPFCPPTKIDDSNAY
WTAFKSAVDELNLEIKPLVFPAGTDAAYVRAVGIPAIGFSPMNNTPVLLHDHDEFLHADV
YLKGIEIYEKILEKVCNF
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 9 | g12609.t1 | Gene3D | G3DSA:3.40.630.10 | Zn peptidases | 1 | 172 | 8.7E-51 |
| 8 | g12609.t1 | Gene3D | G3DSA:3.30.70.360 | - | 173 | 285 | 3.6E-21 |
| 10 | g12609.t1 | Gene3D | G3DSA:3.30.70.1640 | - | 298 | 378 | 3.4E-35 |
| 3 | g12609.t1 | PANTHER | PTHR45892 | AMINOACYLASE-1 | 5 | 377 | 1.8E-151 |
| 4 | g12609.t1 | PANTHER | PTHR45892:SF1 | AMINOACYLASE-1 | 5 | 377 | 1.8E-151 |
| 12 | g12609.t1 | PIRSF | PIRSF036696 | ACY-1 | 2 | 378 | 3.3E-164 |
| 2 | g12609.t1 | Pfam | PF01546 | Peptidase family M20/M25/M40 | 53 | 373 | 9.8E-40 |
| 1 | g12609.t1 | Pfam | PF07687 | Peptidase dimerisation domain | 166 | 273 | 3.1E-11 |
| 7 | g12609.t1 | ProSitePatterns | PS00758 | ArgE / dapE / ACY1 / CPG2 / yscS family signature 1. | 52 | 61 | - |
| 5 | g12609.t1 | SUPERFAMILY | SSF53187 | Zn-dependent exopeptidases | 7 | 377 | 3.02E-53 |
| 6 | g12609.t1 | SUPERFAMILY | SSF55031 | Bacterial exopeptidase dimerisation domain | 171 | 281 | 6.28E-13 |
| 11 | g12609.t1 | TIGRFAM | TIGR01880 | Ac-peptdase-euk: N-acyl-L-amino-acid amidohydrolase | 8 | 377 | 1.1E-153 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0016787 | hydrolase activity | MF |
| GO:0006520 | cellular amino acid metabolic process | BP |
| GO:0004046 | aminoacylase activity | MF |
| GO:0005737 | cytoplasm | CC |
KEGG
Orthology
- This transcript has been annotated with K01439 (succinyl-diaminopimelate desuccinylase)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
