General information for g12610.t2
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Aminoacylase-1B.
Parent gene
- The parent gene g12610 is located on chr_1: 24782653..24783615 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_1 | g12610 | g12610.t2 | TTS | g12610.t2 | 24782001 | 24782001 |
| chr_1 | g12610 | g12610.t2 | isoform | g12610.t2 | 24782072 | 24782889 |
| chr_1 | g12610 | g12610.t2 | exon | g12610.t2.exon1 | 24782072 | 24782279 |
| chr_1 | g12610 | g12610.t2 | cds | g12610.t2.CDS1 | 24782072 | 24782279 |
| chr_1 | g12610 | g12610.t2 | exon | g12610.t2.exon2 | 24782336 | 24782889 |
| chr_1 | g12610 | g12610.t2 | cds | g12610.t2.CDS2 | 24782336 | 24782874 |
| chr_1 | g12610 | g12610.t2 | TSS | g12610.t2 | 24783710 | 24783710 |
Sequences
>g12610.t2 Gene=g12610 Length=762
GGTGGTGTTGAAGGAATGCGTGATTTTATTCATACTGATTCGTTTAAAAAATTAAATGCT
GGCTTTTCACTTGATGAAGGTATTGCAAGTCCAACTGATACTTTTAATGTCTTTTATGCT
GAACGATCAATTTGGCATATTCAATTTGAAATTCCTGGAAACCCAGGACATGGAAGTTTG
CTATTGAAAAATACAGCTGGTGAAAAACTTGAGAAACTTTTGAATCGCTTTATTGAATTT
CGTGATAGTCAAGTGAAACGTTTGGCAGAAAATCCTGATCTTCTTATTGGCGATGTTACA
ACTGTAAATGTTACACAAATTCATGGTGGTGTTCAATCGAATGTTATCCCTCCAGAATTT
AAAATGGTAATCGATGCTCGGCTTGCACTTGATGTCAATCATGCTGAATTTGAAAATATG
ATCAAAAAATGGTGTGAAGAAGCTGGCGAAGGAATTAAATTTGATTATGAACAAAAACAA
CCAAAAGTTGAAGCTACAAAAACTGACAAAAGCAACCCTTATTTTACTGCATTTAAATCT
GCTATTGATGAACTTGGACTTGATATTAAACTTCAAGTCTTCCCTGGTGGAACTGATTCA
CGATATTTGAGAGGTGTTGGCATTCCTGCAATTGGTTTCAGTCCAATGAATAACACACCA
GTTTTGCTTCATGATAATGACGAATTTCTTCGTGCTGATGTTTATTTGAAAGGAATTGAA
ATCTACAAGAAAATTATCAGCAATATTGCAAATTTGGATTAA
>g12610.t2 Gene=g12610 Length=248
MRDFIHTDSFKKLNAGFSLDEGIASPTDTFNVFYAERSIWHIQFEIPGNPGHGSLLLKNT
AGEKLEKLLNRFIEFRDSQVKRLAENPDLLIGDVTTVNVTQIHGGVQSNVIPPEFKMVID
ARLALDVNHAEFENMIKKWCEEAGEGIKFDYEQKQPKVEATKTDKSNPYFTAFKSAIDEL
GLDIKLQVFPGGTDSRYLRGVGIPAIGFSPMNNTPVLLHDNDEFLRADVYLKGIEIYKKI
ISNIANLD
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 7 | g12610.t2 | Gene3D | G3DSA:3.30.70.360 | - | 38 | 153 | 0 |
| 8 | g12610.t2 | Gene3D | G3DSA:3.30.70.1640 | - | 167 | 247 | 0 |
| 3 | g12610.t2 | PANTHER | PTHR45892 | AMINOACYLASE-1 | 1 | 247 | 0 |
| 4 | g12610.t2 | PANTHER | PTHR45892:SF1 | AMINOACYLASE-1 | 1 | 247 | 0 |
| 10 | g12610.t2 | PIRSF | PIRSF036696 | ACY-1 | 1 | 248 | 0 |
| 1 | g12610.t2 | Pfam | PF07687 | Peptidase dimerisation domain | 34 | 145 | 0 |
| 2 | g12610.t2 | Pfam | PF01546 | Peptidase family M20/M25/M40 | 146 | 242 | 0 |
| 5 | g12610.t2 | SUPERFAMILY | SSF53187 | Zn-dependent exopeptidases | 4 | 247 | 0 |
| 6 | g12610.t2 | SUPERFAMILY | SSF55031 | Bacterial exopeptidase dimerisation domain | 40 | 153 | 0 |
| 9 | g12610.t2 | TIGRFAM | TIGR01880 | Ac-peptdase-euk: N-acyl-L-amino-acid amidohydrolase | 1 | 246 | 0 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0016787 | hydrolase activity | MF |
| GO:0006520 | cellular amino acid metabolic process | BP |
| GO:0004046 | aminoacylase activity | MF |
| GO:0005737 | cytoplasm | CC |
KEGG
Orthology
This gene did not have any KEGG ortholog annotations (KAAS, GHOSTZ).
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
