General information for g12730.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Aldo-keto reductase family 1 member A1-A.
Parent gene
- The parent gene g12730 is located on chr_1: 25510928..25512446 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_1 | g12730 | g12730.t1 | isoform | g12730.t1 | 25510928 | 25512446 |
| chr_1 | g12730 | g12730.t1 | exon | g12730.t1.exon1 | 25510928 | 25511232 |
| chr_1 | g12730 | g12730.t1 | cds | g12730.t1.CDS1 | 25510928 | 25511232 |
| chr_1 | g12730 | g12730.t1 | exon | g12730.t1.exon2 | 25511286 | 25511862 |
| chr_1 | g12730 | g12730.t1 | cds | g12730.t1.CDS2 | 25511286 | 25511862 |
| chr_1 | g12730 | g12730.t1 | exon | g12730.t1.exon3 | 25512328 | 25512338 |
| chr_1 | g12730 | g12730.t1 | cds | g12730.t1.CDS3 | 25512328 | 25512338 |
| chr_1 | g12730 | g12730.t1 | exon | g12730.t1.exon4 | 25512395 | 25512446 |
| chr_1 | g12730 | g12730.t1 | cds | g12730.t1.CDS4 | 25512395 | 25512446 |
| chr_1 | g12730 | g12730.t1 | TSS | g12730.t1 | NA | NA |
| chr_1 | g12730 | g12730.t1 | TTS | g12730.t1 | NA | NA |
Sequences
>g12730.t1 Gene=g12730 Length=945
ATGACAACTATTACATTAAATAATGGAAAAGAATTTCCAGTTGTTGGTTTTGGAACTTCA
CGAATATCATCGGATGTTATCATTCAAGCAGTAAAAGATGCAATTGATGCTGGATATCGT
CACATTGATTGTGCTCACATTTATGGTAATGAACATGAAATTGGTGAAGCAATTAATGCA
AAAATCGCTGAAGGTATCGTCAAGCGTGAAGATCTTTTTGTAGTTTCAAAACTTTGGAAT
TGTTTTCATGAACCAATAGAAGTTAAGCAAGCACTTGAACATTCATTGAAGCAACTAAAT
GTAGATTATCTTGACTTGTACCTCATGCATTGGCCATTCGCTTATCAAAAATCTAATGAA
CTTTGCCCAAAAAATGAAGCTGGTGAAATTCTCTATGGAAATACTGATATTCTTGACACT
TATCGTGCAATGGAGGAACTTGTTGATGCTGGATTGACTAAAAGTATTGGAATTTCAAAT
TTTAATATCAAACAAATTGATTACATTACTAAAAATGCTCGCATTCAACCAGTAACCAAT
CAAGTTGAATGTCATCCATATTTGTTGAACAAAAAATTATCTGATTTCTGCAAGAGCAAG
AATATTGTAATCACTGCTTATGCACCACTTGGATCACCAGCTCGTCCACGGGCAACGCCA
GATTATCATGTGCTTTTAGAAGAACCGAAATTATTAGAAATCGCCGAAAAGCACAAAAAG
ACACCAGCACAAGTTTTAATTCGATTCCAAGTTCAGCTTGGTCATGTTGCCATTCCTAAG
TCAGTTACGAAGGATCGCATAATCAGCAATTTTGATGTCTTCAACTTTACTTTGAGTGAC
AGTGACATGAATGATTTGCAAAGCTTTGGACATGTTGAACGTGTAATCACAATGTCTCGT
GATAAGGATCATCCAAATTATCCCTTTAATGATGAAGAAGCTTGA
>g12730.t1 Gene=g12730 Length=314
MTTITLNNGKEFPVVGFGTSRISSDVIIQAVKDAIDAGYRHIDCAHIYGNEHEIGEAINA
KIAEGIVKREDLFVVSKLWNCFHEPIEVKQALEHSLKQLNVDYLDLYLMHWPFAYQKSNE
LCPKNEAGEILYGNTDILDTYRAMEELVDAGLTKSIGISNFNIKQIDYITKNARIQPVTN
QVECHPYLLNKKLSDFCKSKNIVITAYAPLGSPARPRATPDYHVLLEEPKLLEIAEKHKK
TPAQVLIRFQVQLGHVAIPKSVTKDRIISNFDVFNFTLSDSDMNDLQSFGHVERVITMSR
DKDHPNYPFNDEEA
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 13 | g12730.t1 | Gene3D | G3DSA:3.20.20.100 | - | 1 | 313 | 1.4E-128 |
| 2 | g12730.t1 | PANTHER | PTHR11732:SF482 | ZGC:56622 | 3 | 310 | 1.1E-118 |
| 3 | g12730.t1 | PANTHER | PTHR11732 | ALDO/KETO REDUCTASE | 3 | 310 | 1.1E-118 |
| 14 | g12730.t1 | PIRSF | PIRSF000097 | AKR | 1 | 313 | 1.4E-124 |
| 5 | g12730.t1 | PRINTS | PR00069 | Aldo-keto reductase signature | 34 | 58 | 1.5E-59 |
| 7 | g12730.t1 | PRINTS | PR00069 | Aldo-keto reductase signature | 94 | 112 | 1.5E-59 |
| 8 | g12730.t1 | PRINTS | PR00069 | Aldo-keto reductase signature | 144 | 161 | 1.5E-59 |
| 4 | g12730.t1 | PRINTS | PR00069 | Aldo-keto reductase signature | 178 | 207 | 1.5E-59 |
| 6 | g12730.t1 | PRINTS | PR00069 | Aldo-keto reductase signature | 225 | 249 | 1.5E-59 |
| 1 | g12730.t1 | Pfam | PF00248 | Aldo/keto reductase family | 16 | 288 | 8.9E-54 |
| 11 | g12730.t1 | ProSitePatterns | PS00798 | Aldo/keto reductase family signature 1. | 38 | 55 | - |
| 10 | g12730.t1 | ProSitePatterns | PS00062 | Aldo/keto reductase family signature 2. | 144 | 161 | - |
| 12 | g12730.t1 | ProSitePatterns | PS00063 | Aldo/keto reductase family putative active site signature. | 258 | 273 | - |
| 9 | g12730.t1 | SUPERFAMILY | SSF51430 | NAD(P)-linked oxidoreductase | 2 | 299 | 2.88E-96 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0047834 | D-threo-aldose 1-dehydrogenase activity | MF |
| GO:0055114 | NA | NA |
| GO:0016491 | oxidoreductase activity | MF |
KEGG
Orthology
This gene did not have any KEGG ortholog annotations (KAAS, GHOSTZ).
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
