General information for g12734.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Aldo-keto reductase family 1 member B10.
Parent gene
- The parent gene g12734 is located on chr_1: 25518444..25519323 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_1 | g12734 | g12734.t1 | isoform | g12734.t1 | 25518086 | 25519323 |
| chr_1 | g12734 | g12734.t1 | exon | g12734.t1.exon1 | 25518086 | 25518387 |
| chr_1 | g12734 | g12734.t1 | cds | g12734.t1.CDS1 | 25518086 | 25518387 |
| chr_1 | g12734 | g12734.t1 | exon | g12734.t1.exon2 | 25518441 | 25519017 |
| chr_1 | g12734 | g12734.t1 | cds | g12734.t1.CDS2 | 25518441 | 25519017 |
| chr_1 | g12734 | g12734.t1 | exon | g12734.t1.exon3 | 25519187 | 25519197 |
| chr_1 | g12734 | g12734.t1 | cds | g12734.t1.CDS3 | 25519187 | 25519197 |
| chr_1 | g12734 | g12734.t1 | exon | g12734.t1.exon4 | 25519263 | 25519323 |
| chr_1 | g12734 | g12734.t1 | cds | g12734.t1.CDS4 | 25519263 | 25519323 |
| chr_1 | g12734 | g12734.t1 | TSS | g12734.t1 | 25519375 | 25519375 |
| chr_1 | g12734 | g12734.t1 | TTS | g12734.t1 | NA | NA |
Sequences
>g12734.t1 Gene=g12734 Length=951
ATGTCACCAGTTCATACTTTAGTTTTGAATAATGGAAAGAAAATTCCCATTGTTGGTTTA
GGTACATGGAATTCACCACCTGGTGTTGTTGCTCAAGCTGTAAAAGATGCAATTGATGCT
GGCTATCGTCATATTGATTGTGCTCATTGCTATCAAAATGAACATGAAGTTGGTGAAGGA
ATCAATGCCAAAATCGCTGAAGGTGTTATCAAACGTGAAGACATTTTTGTAACATCAAAA
TTATGGAACACTCATCATGAACCGATGGATGTTAAGCCAGCACTTCAGCATACATTGAAG
CAACTAAATTTATCCTATGTTGACTTATATTTAATTCATTGGCCATTCGCCTATCAAAAG
TCGGATGAAATTTTTCCAAGAGATTCAAATGGAAAAATTTTGCATTCAAGAGTTGATTTT
GTTGACACTTATCGTGCAATGGAATATCTTGTTGATGATGGTTTAGCAAAAAGTATTGGA
GTGTCAAATTTTAATATTCAACAACTTGAGTATATTCTCAAGAATGCTCGTATTCAACCA
GTCACTAATCAAATTGAATGCCATCCATATTTGTTAAATAAGAAATTAAGTGAATATTGC
AAGAGCAAAAATATTCTTATAACTGCTTATTCACCACTTGGTTCACCTGCTCGTCCATGG
GTTAAATCTGACGATCGAGTTCTTTTACAGGAACCAAAACTTCTTGAAATTGCTAAAAAG
CACAAAAAGACACCAGCACAAATTTTAATCCGTTTCCAAATGCAACTCGGCAATATTGTC
ATTCCAAAGTCAGTTACTAAAGAGAGAATCATCAGTAATTTTGATGTCTTTGATTTTACA
CTAAACGAAAGTGACATGAATGATTTGCAAAATTTTGGATATGTTGAACGTATATGCCCT
ATGTTTGAAGACACAAAACATCCTGATTATCCTTTCAATGACGAGGCTTAA
>g12734.t1 Gene=g12734 Length=316
MSPVHTLVLNNGKKIPIVGLGTWNSPPGVVAQAVKDAIDAGYRHIDCAHCYQNEHEVGEG
INAKIAEGVIKREDIFVTSKLWNTHHEPMDVKPALQHTLKQLNLSYVDLYLIHWPFAYQK
SDEIFPRDSNGKILHSRVDFVDTYRAMEYLVDDGLAKSIGVSNFNIQQLEYILKNARIQP
VTNQIECHPYLLNKKLSEYCKSKNILITAYSPLGSPARPWVKSDDRVLLQEPKLLEIAKK
HKKTPAQILIRFQMQLGNIVIPKSVTKERIISNFDVFDFTLNESDMNDLQNFGYVERICP
MFEDTKHPDYPFNDEA
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 13 | g12734.t1 | Gene3D | G3DSA:3.20.20.100 | - | 4 | 316 | 5.4E-134 |
| 2 | g12734.t1 | PANTHER | PTHR11732:SF294 | ALDO-KETO REDUCTASE FAMILY 1 MEMBER B1 | 6 | 314 | 3.5E-126 |
| 3 | g12734.t1 | PANTHER | PTHR11732 | ALDO/KETO REDUCTASE | 6 | 314 | 3.5E-126 |
| 14 | g12734.t1 | PIRSF | PIRSF000097 | AKR | 1 | 316 | 4.6E-131 |
| 8 | g12734.t1 | PRINTS | PR00069 | Aldo-keto reductase signature | 37 | 61 | 5.0E-57 |
| 7 | g12734.t1 | PRINTS | PR00069 | Aldo-keto reductase signature | 97 | 115 | 5.0E-57 |
| 4 | g12734.t1 | PRINTS | PR00069 | Aldo-keto reductase signature | 147 | 164 | 5.0E-57 |
| 6 | g12734.t1 | PRINTS | PR00069 | Aldo-keto reductase signature | 181 | 210 | 5.0E-57 |
| 5 | g12734.t1 | PRINTS | PR00069 | Aldo-keto reductase signature | 228 | 252 | 5.0E-57 |
| 1 | g12734.t1 | Pfam | PF00248 | Aldo/keto reductase family | 18 | 291 | 2.8E-52 |
| 11 | g12734.t1 | ProSitePatterns | PS00798 | Aldo/keto reductase family signature 1. | 41 | 58 | - |
| 10 | g12734.t1 | ProSitePatterns | PS00062 | Aldo/keto reductase family signature 2. | 147 | 164 | - |
| 12 | g12734.t1 | ProSitePatterns | PS00063 | Aldo/keto reductase family putative active site signature. | 261 | 276 | - |
| 9 | g12734.t1 | SUPERFAMILY | SSF51430 | NAD(P)-linked oxidoreductase | 6 | 307 | 8.25E-98 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0047834 | D-threo-aldose 1-dehydrogenase activity | MF |
| GO:0055114 | NA | NA |
| GO:0016491 | oxidoreductase activity | MF |
KEGG
Orthology
- This transcript has been annotated with K00011 (aldehyde reductase)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
