Gene loci information

Transcript annotation

  • This transcript has been annotated as Disks large 1 tumor suppressor protein.

Parent gene

Gene structure

  • The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.

Chromosome Gene Transcript Category ID Start End
chr_1 g13718 g13718.t1 TSS g13718.t1 32012596 32012596
chr_1 g13718 g13718.t1 isoform g13718.t1 32013125 32025389
chr_1 g13718 g13718.t1 exon g13718.t1.exon1 32013125 32013211
chr_1 g13718 g13718.t1 cds g13718.t1.CDS1 32013125 32013211
chr_1 g13718 g13718.t1 exon g13718.t1.exon2 32016441 32016464
chr_1 g13718 g13718.t1 cds g13718.t1.CDS2 32016441 32016464
chr_1 g13718 g13718.t1 exon g13718.t1.exon3 32016531 32016592
chr_1 g13718 g13718.t1 cds g13718.t1.CDS3 32016531 32016592
chr_1 g13718 g13718.t1 exon g13718.t1.exon4 32016657 32016870
chr_1 g13718 g13718.t1 cds g13718.t1.CDS4 32016657 32016870
chr_1 g13718 g13718.t1 exon g13718.t1.exon5 32016937 32017011
chr_1 g13718 g13718.t1 cds g13718.t1.CDS5 32016937 32017011
chr_1 g13718 g13718.t1 exon g13718.t1.exon6 32017078 32017526
chr_1 g13718 g13718.t1 cds g13718.t1.CDS6 32017078 32017526
chr_1 g13718 g13718.t1 exon g13718.t1.exon7 32017759 32017813
chr_1 g13718 g13718.t1 cds g13718.t1.CDS7 32017759 32017813
chr_1 g13718 g13718.t1 exon g13718.t1.exon8 32017874 32017906
chr_1 g13718 g13718.t1 cds g13718.t1.CDS8 32017874 32017906
chr_1 g13718 g13718.t1 exon g13718.t1.exon9 32018198 32018752
chr_1 g13718 g13718.t1 cds g13718.t1.CDS9 32018198 32018752
chr_1 g13718 g13718.t1 exon g13718.t1.exon10 32019009 32019114
chr_1 g13718 g13718.t1 cds g13718.t1.CDS10 32019009 32019114
chr_1 g13718 g13718.t1 exon g13718.t1.exon11 32019424 32019480
chr_1 g13718 g13718.t1 cds g13718.t1.CDS11 32019424 32019480
chr_1 g13718 g13718.t1 exon g13718.t1.exon12 32019764 32019808
chr_1 g13718 g13718.t1 cds g13718.t1.CDS12 32019764 32019808
chr_1 g13718 g13718.t1 exon g13718.t1.exon13 32024517 32024666
chr_1 g13718 g13718.t1 cds g13718.t1.CDS13 32024517 32024666
chr_1 g13718 g13718.t1 exon g13718.t1.exon14 32024727 32024899
chr_1 g13718 g13718.t1 cds g13718.t1.CDS14 32024727 32024899
chr_1 g13718 g13718.t1 exon g13718.t1.exon15 32024959 32025071
chr_1 g13718 g13718.t1 cds g13718.t1.CDS15 32024959 32025071
chr_1 g13718 g13718.t1 exon g13718.t1.exon16 32025132 32025223
chr_1 g13718 g13718.t1 cds g13718.t1.CDS16 32025132 32025223
chr_1 g13718 g13718.t1 exon g13718.t1.exon17 32025283 32025389
chr_1 g13718 g13718.t1 cds g13718.t1.CDS17 32025283 32025389
chr_1 g13718 g13718.t1 TTS g13718.t1 32025764 32025764

Sequences

>g13718.t1 Gene=g13718 Length=2397
ATGACGACACGAAAGAAGAATAAAAATCAACAGAAGGAGACTGGTGGATTTATAAAAAAG
GTTTCATCATTATTTAATTTAGATACGGCATCAGCAGGAACGGATGCAAAAGTCAATGGA
GATGATCAATGGGTGCATGAGGAAATCGCTTTATCACGAGGCTCAAGTGGACTCGGATTC
AGTATAGCAGGAGGCACTGATAATCCACACATCGGGACTGATACATCAATTTATATCACA
AAAATAATTCCCGGTGGAGCCGCATATTCAGACGGTCGTATTCAAGTAAATGACATTATT
GTATCAGTCAATGATGTATCAGTTGTTGATGTTACGCATGCACTTGCTGTTGAAGCGCTT
AAAAGTGCTGGTGATAGAGTCAAATTGAATGTTAAAAGAAAACGTCCACCAGCCGTTCCA
CAAACTGCTGAAATCGATCTCGTAAAGGGTGACAAAACATTGGGTTTTAGTATAGCAGGA
GGCATAGGAAATCAACATATTCCAGGTGATAATGGAATTTATGTTACAAAAATAATGGAT
GGTGGAGCAGCAGCAGTTGATGGTCGACTAAGTATTGGCGACAAATTGCTCAATGTTAAA
ACAAAGACGATGAACAAAAATTTAGAGAATGTTTCACACGAAGATGCTGTTGCAACGCTT
AAAGCAATTACTGATCGTGTGGTTTTAACAGTACAGAAAGCTCAACATGTTGTTCATAGC
ACATCATACCTTAATCAAAACAATTCACAATCAATGAATGCAATGAATAATATTAGTACC
ACAGGTTTAGACCTTAATGATAGCGGAAGAACTCATTCACCTCTGCCCGTCTTGGAAAAT
TCATCATCGCGACATGCATCTACAAATGTTTTGGCAACGCCGCGTGCCGTCAGTCATGAA
GATATCACAAGAGAACCGCGAACTATAGTGATTCATAAAGGCAAGACGGCATCAAAAGCT
TTAGGCTTGAATATTGTCGGCGGCGAAGATGGCCAGGTAGGAATTTATGTATCATTTATA
CTGGCTGGTGGTCCTGCTGATCTTAGTGGTGACTTGAAACGTGGCGATCAATTGCTATCG
GTTAATGGTATTAATTTGCGAAATGCAACGCATGAAGAAGCAGCGGCTGCACTTAAAAAT
TCTGGTGATACAGTTACACTCGTGGCTCAATATCGACCCGAAGACTATAATCGATTTGAG
GCACGAATTCATGAATTAAAGCAGCAAGCGGCAGCAGCTGTACAATCTGGCACAGGAACA
CTCTTGCGTACATCACAAAAACGTTCACTCTATGTGAGAGCTTTGTTCGACTATGATCCA
AATCGAGATGACGGATTACCAACACGTGGTCTGCCATTTAAGCATGGCGATATTTTACAT
GTAACGAATGCATCCGATGATGAGTGGTGGCAAGCGAGACGCGTCATTGGAGATGGTGAA
GAAGATAATATGGGTATTGTGCCATCAAAAAGACGCTGGGAGAGAAAACAAAGAGCGAGG
GATCGTAGTGTTAAATTTCAAGGATACCAAGCACCCGCAAATGTTGCAGAAAAGACGTCA
ACATTGGACCGAAAAAAGAAAAATTTCTCATTTAGTCGAAGATTCCCGTTCATGAAGAGT
CGTGAAGATGGCAAGAACGAGGATGGATCAGATCAAGAACTTAATGGAAATGGCATTGAC
CATAATTTAAATTCAAATGGTCACGATAGCGAACAGCCTTTTATGCTATGCTACACACAA
GATGATGCCAATAATGCTGAAGTATCGGAGGAAAATGTTCTCTCATATGAATCAGTTCAA
AGATTGCAAATCAATTACACACGCCCTGTCATCATTTTGGGTCCATTAAAAGACCGCATC
AATGACGATTTGATATCAGAATATCCCGACAAATTTGGCAGCTGTGTGCCACATACCACA
AGACCGAAACGTGATTATGAAGTTGACGGTCGAGATTATCATTTCGTTGCATCACGAGAG
CAAATGGAACGTGACATTCAAAATCATCTATTTATCGAAGCAGGACAGTATAATGAAAAT
CTTTATGGTACTTCTGTTGCATCTGTACGAGAAGTCGCTGAAAAGCAAGGAAAACATTGC
ATTTTAGATGTATCGGGCAATGCCATTAAGCGACTCCAAGTAGCTCAATTATATCCAATT
GCTATTTTTATTAAGCCAAAATCTGTTGAATCCATTATGGAAATGAATCGTCGAATGACA
GAAGAGCAAGCAAAGAAGACATTTGAACGTGCTCTGAAAATGGAACAAGAATTTGGAGAA
TATTTCACTGGTGTCGTACAAGGCGATACGATTGAGGAAATTTATAACAAAACAAAGCAA
ATGATTTGGGCGCAATCAGGCAAGGAAATATGGGTGCCGTCGAAAGAATCTCTATGA

>g13718.t1 Gene=g13718 Length=798
MTTRKKNKNQQKETGGFIKKVSSLFNLDTASAGTDAKVNGDDQWVHEEIALSRGSSGLGF
SIAGGTDNPHIGTDTSIYITKIIPGGAAYSDGRIQVNDIIVSVNDVSVVDVTHALAVEAL
KSAGDRVKLNVKRKRPPAVPQTAEIDLVKGDKTLGFSIAGGIGNQHIPGDNGIYVTKIMD
GGAAAVDGRLSIGDKLLNVKTKTMNKNLENVSHEDAVATLKAITDRVVLTVQKAQHVVHS
TSYLNQNNSQSMNAMNNISTTGLDLNDSGRTHSPLPVLENSSSRHASTNVLATPRAVSHE
DITREPRTIVIHKGKTASKALGLNIVGGEDGQVGIYVSFILAGGPADLSGDLKRGDQLLS
VNGINLRNATHEEAAAALKNSGDTVTLVAQYRPEDYNRFEARIHELKQQAAAAVQSGTGT
LLRTSQKRSLYVRALFDYDPNRDDGLPTRGLPFKHGDILHVTNASDDEWWQARRVIGDGE
EDNMGIVPSKRRWERKQRARDRSVKFQGYQAPANVAEKTSTLDRKKKNFSFSRRFPFMKS
REDGKNEDGSDQELNGNGIDHNLNSNGHDSEQPFMLCYTQDDANNAEVSEENVLSYESVQ
RLQINYTRPVIILGPLKDRINDDLISEYPDKFGSCVPHTTRPKRDYEVDGRDYHFVASRE
QMERDIQNHLFIEAGQYNENLYGTSVASVREVAEKQGKHCILDVSGNAIKRLQVAQLYPI
AIFIKPKSVESIMEMNRRMTEEQAKKTFERALKMEQEFGEYFTGVVQGDTIEEIYNKTKQ
MIWAQSGKEIWVPSKESL

Protein features from InterProScan

Transcript Database ID Name Start End E.value
24 g13718.t1 CDD cd00992 PDZ_signaling 48 132 8.48472E-12
26 g13718.t1 CDD cd00992 PDZ_signaling 144 232 9.85589E-16
25 g13718.t1 CDD cd00992 PDZ_signaling 306 388 3.82299E-25
23 g13718.t1 CDD cd11861 SH3_DLG-like 431 491 7.77507E-39
27 g13718.t1 CDD cd00071 GMPK 609 726 2.90738E-28
20 g13718.t1 Coils Coil Coil 396 416 -
18 g13718.t1 Gene3D G3DSA:2.30.42.10 - 31 138 1.1E-31
19 g13718.t1 Gene3D G3DSA:2.30.42.10 - 139 234 4.8E-27
17 g13718.t1 Gene3D G3DSA:2.30.42.10 - 303 421 3.2E-35
15 g13718.t1 Gene3D G3DSA:2.30.30.40 SH3 Domains 422 524 5.8E-34
16 g13718.t1 Gene3D G3DSA:2.30.30.40 SH3 Domains 587 793 1.8E-88
13 g13718.t1 Gene3D G3DSA:3.40.50.300 - 605 787 1.8E-88
14 g13718.t1 Gene3D G3DSA:3.30.63.10 Guanylate Kinase phosphate binding domain 636 697 1.8E-88
6 g13718.t1 PANTHER PTHR23119 DISCS LARGE 28 794 0.0
7 g13718.t1 PANTHER PTHR23119:SF5 DISKS LARGE HOMOLOG 1 28 794 0.0
22 g13718.t1 PIRSF PIRSF001741 MAGUK_DLGH 2 559 2.4E-198
21 g13718.t1 PIRSF PIRSF001741 MAGUK_DLGH 553 798 9.0E-127
5 g13718.t1 Pfam PF00595 PDZ domain 49 131 3.2E-21
3 g13718.t1 Pfam PF00595 PDZ domain 145 232 6.2E-16
4 g13718.t1 Pfam PF00595 PDZ domain 317 389 5.2E-19
1 g13718.t1 Pfam PF00018 SH3 domain 433 489 3.1E-8
2 g13718.t1 Pfam PF00625 Guanylate kinase 607 784 3.1E-66
33 g13718.t1 ProSitePatterns PS00856 Guanylate kinase-like signature. 639 656 -
38 g13718.t1 ProSiteProfiles PS50106 PDZ domain profile. 48 135 22.898
36 g13718.t1 ProSiteProfiles PS50106 PDZ domain profile. 144 235 21.129
37 g13718.t1 ProSiteProfiles PS50106 PDZ domain profile. 308 393 23.059
35 g13718.t1 ProSiteProfiles PS50002 Src homology 3 (SH3) domain profile. 427 497 18.476
34 g13718.t1 ProSiteProfiles PS50052 Guanylate kinase-like domain profile. 607 783 43.158
29 g13718.t1 SMART SM00228 pdz_new 56 135 1.8E-23
30 g13718.t1 SMART SM00228 pdz_new 152 235 2.3E-15
28 g13718.t1 SMART SM00228 pdz_new 319 393 1.5E-22
31 g13718.t1 SMART SM00326 SH3_2 430 496 5.4E-6
32 g13718.t1 SMART SM00072 gk_7 606 786 5.2E-75
10 g13718.t1 SUPERFAMILY SSF50156 PDZ domain-like 41 136 4.21E-27
8 g13718.t1 SUPERFAMILY SSF50156 PDZ domain-like 138 236 1.31E-20
9 g13718.t1 SUPERFAMILY SSF50156 PDZ domain-like 295 399 1.06E-30
12 g13718.t1 SUPERFAMILY SSF50044 SH3-domain 424 633 1.71E-28
11 g13718.t1 SUPERFAMILY SSF52540 P-loop containing nucleoside triphosphate hydrolases 605 795 1.24E-55

Transmembrane regions from TMHMM

Disordered region

IUPRED3 score over 0.5 is predictive of a disordered region.

GO terms from InterProScan

GOID TERM ONTOLOGY
GO:0005515 protein binding MF

KEGG

Orthology

Pathway

  • This transcript belongs to the following pathways

Expression

Transcript expression in Pv11 cells

TPM values are indicated as average +/- STDEV.

Differential expression

Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.

Raw TPM values