Gene loci information

Transcript annotation

  • This transcript has been annotated as Disks large 1 tumor suppressor protein.

Parent gene

Gene structure

  • The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.

Chromosome Gene Transcript Category ID Start End
chr_1 g13718 g13718.t14 isoform g13718.t14 32018198 32024897
chr_1 g13718 g13718.t14 exon g13718.t14.exon1 32018198 32018752
chr_1 g13718 g13718.t14 cds g13718.t14.CDS1 32018648 32018752
chr_1 g13718 g13718.t14 exon g13718.t14.exon2 32019009 32019114
chr_1 g13718 g13718.t14 cds g13718.t14.CDS2 32019009 32019114
chr_1 g13718 g13718.t14 exon g13718.t14.exon3 32019424 32019480
chr_1 g13718 g13718.t14 cds g13718.t14.CDS3 32019424 32019480
chr_1 g13718 g13718.t14 exon g13718.t14.exon4 32024517 32024666
chr_1 g13718 g13718.t14 cds g13718.t14.CDS4 32024517 32024666
chr_1 g13718 g13718.t14 exon g13718.t14.exon5 32024727 32024897
chr_1 g13718 g13718.t14 cds g13718.t14.CDS5 32024727 32024896
chr_1 g13718 g13718.t14 TTS g13718.t14 32025764 32025764
chr_1 g13718 g13718.t14 TSS g13718.t14 NA NA

Sequences

>g13718.t14 Gene=g13718 Length=1039
GGAATTTATGTATCATTTATACTGGCTGGTGGTCCTGCTGATCTTAGTGGTGACTTGAAA
CGTGGCGATCAATTGCTATCGGTTAATGGTATTAATTTGCGAAATGCAACGCATGAAGAA
GCAGCGGCTGCACTTAAAAATTCTGGTGATACAGTTACACTCGTGGCTCAATATCGACCC
GAAGACTATAATCGATTTGAGGCACGAATTCATGAATTAAAGCAGCAAGCGGCAGCAGCT
GTACAATCTGGCACAGGAACACTCTTGCGTACATCACAAAAACGTTCACTCTATGTGAGA
GCTTTGTTCGACTATGATCCAAATCGAGATGACGGATTACCAACACGTGGTCTGCCATTT
AAGCATGGCGATATTTTACATGTAACGAATGCATCCGATGATGAGTGGTGGCAAGCGAGA
CGCGTCATTGGAGATGGTGAAGAAGATAATATGGGTATTGTGCCATCAAAAAGACGCTGG
GAGAGAAAACAAAGAGCGAGGGATCGTAGTGTTAAATTTCAAGGATACCAAGCACCCGCA
AATGTTGCAGAAAAGACGTCAACATTGGACCGAAAAAAGAAAAATTTCTCATTTAGTCGA
AGATTCCCGTTCATGAAGAGTCGTGAAGATGGCAAGAACGAGGATGGATCAGATCAAGAA
CTTAATGGAAATGGCATTGACCATAATTTAAATTCAAATGGTCACGATAGCGAACAGCTA
TCGGAGGAAAATGTTCTCTCATATGAATCAGTTCAAAGATTGCAAATCAATTACACACGC
CCTGTCATCATTTTGGGTCCATTAAAAGACCGCATCAATGACGATTTGATATCAGAATAT
CCCGACAAATTTGGCAGCTGTGTGCCACATACCACAAGACCGAAACGTGATTATGAAGTT
GACGGTCGAGATTATCATTTCGTTGCATCACGAGAGCAAATGGAACGTGACATTCAAAAT
CATCTATTTATCGAAGCAGGACAGTATAATGAAAATCTTTATGGTACTTCTGTTGCATCT
GTACGAGAAGTCGCTGAAA

>g13718.t14 Gene=g13718 Length=196
MGIVPSKRRWERKQRARDRSVKFQGYQAPANVAEKTSTLDRKKKNFSFSRRFPFMKSRED
GKNEDGSDQELNGNGIDHNLNSNGHDSEQLSEENVLSYESVQRLQINYTRPVIILGPLKD
RINDDLISEYPDKFGSCVPHTTRPKRDYEVDGRDYHFVASREQMERDIQNHLFIEAGQYN
ENLYGTSVASVREVAE

Protein features from InterProScan

Transcript Database ID Name Start End E.value
5 g13718.t14 Gene3D G3DSA:3.40.50.300 - 103 196 2.0E-39
8 g13718.t14 MobiDBLite mobidb-lite consensus disorder prediction 1 20 -
11 g13718.t14 MobiDBLite mobidb-lite consensus disorder prediction 1 40 -
9 g13718.t14 MobiDBLite mobidb-lite consensus disorder prediction 50 69 -
10 g13718.t14 MobiDBLite mobidb-lite consensus disorder prediction 50 67 -
2 g13718.t14 PANTHER PTHR23122:SF72 DISKS LARGE 1 TUMOR SUPPRESSOR PROTEIN-LIKE PROTEIN 1 196 2.2E-80
3 g13718.t14 PANTHER PTHR23122 MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK 1 196 2.2E-80
1 g13718.t14 Pfam PF00625 Guanylate kinase 109 196 5.4E-36
6 g13718.t14 ProSitePatterns PS00856 Guanylate kinase-like signature. 141 158 -
12 g13718.t14 ProSiteProfiles PS50052 Guanylate kinase-like domain profile. 109 196 27.524
7 g13718.t14 SMART SM00072 gk_7 108 196 3.3E-4
4 g13718.t14 SUPERFAMILY SSF52540 P-loop containing nucleoside triphosphate hydrolases 107 195 1.65E-28

Transmembrane regions from TMHMM

Disordered region

IUPRED3 score over 0.5 is predictive of a disordered region.

GO terms from InterProScan

There are no GO annotations for this transcript.

KEGG

Orthology

This gene did not have any KEGG ortholog annotations (KAAS, GHOSTZ).

Expression

Transcript expression in Pv11 cells

TPM values are indicated as average +/- STDEV.

Differential expression

Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.

Raw TPM values