General information for g13718.t9
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Disks large 1 tumor suppressor protein.
Parent gene
- The parent gene g13718 is located on chr_1: 32025389..32026087 (+ strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_1 | g13718 | g13718.t9 | TSS | g13718.t9 | 32012596 | 32012596 |
| chr_1 | g13718 | g13718.t9 | isoform | g13718.t9 | 32012938 | 32024666 |
| chr_1 | g13718 | g13718.t9 | exon | g13718.t9.exon1 | 32012938 | 32013211 |
| chr_1 | g13718 | g13718.t9 | cds | g13718.t9.CDS1 | 32013125 | 32013211 |
| chr_1 | g13718 | g13718.t9 | exon | g13718.t9.exon2 | 32016441 | 32016464 |
| chr_1 | g13718 | g13718.t9 | cds | g13718.t9.CDS2 | 32016441 | 32016464 |
| chr_1 | g13718 | g13718.t9 | exon | g13718.t9.exon3 | 32016531 | 32016592 |
| chr_1 | g13718 | g13718.t9 | cds | g13718.t9.CDS3 | 32016531 | 32016592 |
| chr_1 | g13718 | g13718.t9 | exon | g13718.t9.exon4 | 32016657 | 32016870 |
| chr_1 | g13718 | g13718.t9 | cds | g13718.t9.CDS4 | 32016657 | 32016870 |
| chr_1 | g13718 | g13718.t9 | exon | g13718.t9.exon5 | 32016937 | 32017011 |
| chr_1 | g13718 | g13718.t9 | cds | g13718.t9.CDS5 | 32016937 | 32017011 |
| chr_1 | g13718 | g13718.t9 | exon | g13718.t9.exon6 | 32017078 | 32017526 |
| chr_1 | g13718 | g13718.t9 | cds | g13718.t9.CDS6 | 32017078 | 32017526 |
| chr_1 | g13718 | g13718.t9 | exon | g13718.t9.exon7 | 32017759 | 32017813 |
| chr_1 | g13718 | g13718.t9 | cds | g13718.t9.CDS7 | 32017759 | 32017813 |
| chr_1 | g13718 | g13718.t9 | exon | g13718.t9.exon8 | 32017874 | 32017906 |
| chr_1 | g13718 | g13718.t9 | cds | g13718.t9.CDS8 | 32017874 | 32017906 |
| chr_1 | g13718 | g13718.t9 | exon | g13718.t9.exon9 | 32018198 | 32018752 |
| chr_1 | g13718 | g13718.t9 | cds | g13718.t9.CDS9 | 32018198 | 32018752 |
| chr_1 | g13718 | g13718.t9 | exon | g13718.t9.exon10 | 32019009 | 32019114 |
| chr_1 | g13718 | g13718.t9 | cds | g13718.t9.CDS10 | 32019009 | 32019114 |
| chr_1 | g13718 | g13718.t9 | exon | g13718.t9.exon11 | 32019424 | 32019480 |
| chr_1 | g13718 | g13718.t9 | cds | g13718.t9.CDS11 | 32019424 | 32019480 |
| chr_1 | g13718 | g13718.t9 | exon | g13718.t9.exon12 | 32019764 | 32019808 |
| chr_1 | g13718 | g13718.t9 | cds | g13718.t9.CDS12 | 32019764 | 32019808 |
| chr_1 | g13718 | g13718.t9 | exon | g13718.t9.exon13 | 32024517 | 32024666 |
| chr_1 | g13718 | g13718.t9 | cds | g13718.t9.CDS13 | 32024517 | 32024665 |
| chr_1 | g13718 | g13718.t9 | TTS | g13718.t9 | 32025489 | 32025489 |
Sequences
>g13718.t9 Gene=g13718 Length=2099
AAAAGGCACAATACCATAAAATGTTATATAAATAAAAAGAAAAGTGTGAAAATTTTTGTT
GAAAAAAATTGAACTTGACATTTACATTAAAGAACGAATCAAAAAATAATTAATCAAATT
GATTGGATTTTATCTCTATTAACAACTATAACTTTGATACTAAGCTAATAATATATAATA
AAAAAGTATGACGACACGAAAGAAGAATAAAAATCAACAGAAGGAGACTGGTGGATTTAT
AAAAAAGGTTTCATCATTATTTAATTTAGATACGGCATCAGCAGGAACGGATGCAAAAGT
CAATGGAGATGATCAATGGGTGCATGAGGAAATCGCTTTATCACGAGGCTCAAGTGGACT
CGGATTCAGTATAGCAGGAGGCACTGATAATCCACACATCGGGACTGATACATCAATTTA
TATCACAAAAATAATTCCCGGTGGAGCCGCATATTCAGACGGTCGTATTCAAGTAAATGA
CATTATTGTATCAGTCAATGATGTATCAGTTGTTGATGTTACGCATGCACTTGCTGTTGA
AGCGCTTAAAAGTGCTGGTGATAGAGTCAAATTGAATGTTAAAAGAAAACGTCCACCAGC
CGTTCCACAAACTGCTGAAATCGATCTCGTAAAGGGTGACAAAACATTGGGTTTTAGTAT
AGCAGGAGGCATAGGAAATCAACATATTCCAGGTGATAATGGAATTTATGTTACAAAAAT
AATGGATGGTGGAGCAGCAGCAGTTGATGGTCGACTAAGTATTGGCGACAAATTGCTCAA
TGTTAAAACAAAGACGATGAACAAAAATTTAGAGAATGTTTCACACGAAGATGCTGTTGC
AACGCTTAAAGCAATTACTGATCGTGTGGTTTTAACAGTACAGAAAGCTCAACATGTTGT
TCATAGCACATCATACCTTAATCAAAACAATTCACAATCAATGAATGCAATGAATAATAT
TAGTACCACAGGTTTAGACCTTAATGATAGCGGAAGAACTCATTCACCTCTGCCCGTCTT
GGAAAATTCATCATCGCGACATGCATCTACAAATGTTTTGGCAACGCCGCGTGCCGTCAG
TCATGAAGATATCACAAGAGAACCGCGAACTATAGTGATTCATAAAGGCAAGACGGCATC
AAAAGCTTTAGGCTTGAATATTGTCGGCGGCGAAGATGGCCAGGTAGGAATTTATGTATC
ATTTATACTGGCTGGTGGTCCTGCTGATCTTAGTGGTGACTTGAAACGTGGCGATCAATT
GCTATCGGTTAATGGTATTAATTTGCGAAATGCAACGCATGAAGAAGCAGCGGCTGCACT
TAAAAATTCTGGTGATACAGTTACACTCGTGGCTCAATATCGACCCGAAGACTATAATCG
ATTTGAGGCACGAATTCATGAATTAAAGCAGCAAGCGGCAGCAGCTGTACAATCTGGCAC
AGGAACACTCTTGCGTACATCACAAAAACGTTCACTCTATGTGAGAGCTTTGTTCGACTA
TGATCCAAATCGAGATGACGGATTACCAACACGTGGTCTGCCATTTAAGCATGGCGATAT
TTTACATGTAACGAATGCATCCGATGATGAGTGGTGGCAAGCGAGACGCGTCATTGGAGA
TGGTGAAGAAGATAATATGGGTATTGTGCCATCAAAAAGACGCTGGGAGAGAAAACAAAG
AGCGAGGGATCGTAGTGTTAAATTTCAAGGATACCAAGCACCCGCAAATGTTGCAGAAAA
GACGTCAACATTGGACCGAAAAAAGAAAAATTTCTCATTTAGTCGAAGATTCCCGTTCAT
GAAGAGTCGTGAAGATGGCAAGAACGAGGATGGATCAGATCAAGAACTTAATGGAAATGG
CATTGACCATAATTTAAATTCAAATGGTCACGATAGCGAACAGCCTTTTATGCTATGCTA
CACACAAGATGATGCCAATAATGCTGAAGTATCGGAGGAAAATGTTCTCTCATATGAATC
AGTTCAAAGATTGCAAATCAATTACACACGCCCTGTCATCATTTTGGGTCCATTAAAAGA
CCGCATCAATGACGATTTGATATCAGAATATCCCGACAAATTTGGCAGCTGTGTGCCAC
>g13718.t9 Gene=g13718 Length=637
MTTRKKNKNQQKETGGFIKKVSSLFNLDTASAGTDAKVNGDDQWVHEEIALSRGSSGLGF
SIAGGTDNPHIGTDTSIYITKIIPGGAAYSDGRIQVNDIIVSVNDVSVVDVTHALAVEAL
KSAGDRVKLNVKRKRPPAVPQTAEIDLVKGDKTLGFSIAGGIGNQHIPGDNGIYVTKIMD
GGAAAVDGRLSIGDKLLNVKTKTMNKNLENVSHEDAVATLKAITDRVVLTVQKAQHVVHS
TSYLNQNNSQSMNAMNNISTTGLDLNDSGRTHSPLPVLENSSSRHASTNVLATPRAVSHE
DITREPRTIVIHKGKTASKALGLNIVGGEDGQVGIYVSFILAGGPADLSGDLKRGDQLLS
VNGINLRNATHEEAAAALKNSGDTVTLVAQYRPEDYNRFEARIHELKQQAAAAVQSGTGT
LLRTSQKRSLYVRALFDYDPNRDDGLPTRGLPFKHGDILHVTNASDDEWWQARRVIGDGE
EDNMGIVPSKRRWERKQRARDRSVKFQGYQAPANVAEKTSTLDRKKKNFSFSRRFPFMKS
REDGKNEDGSDQELNGNGIDHNLNSNGHDSEQPFMLCYTQDDANNAEVSEENVLSYESVQ
RLQINYTRPVIILGPLKDRINDDLISEYPDKFGSCVP
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 18 | g13718.t9 | CDD | cd00992 | PDZ_signaling | 48 | 132 | 8.72408E-12 |
| 20 | g13718.t9 | CDD | cd00992 | PDZ_signaling | 144 | 232 | 1.08496E-15 |
| 19 | g13718.t9 | CDD | cd00992 | PDZ_signaling | 306 | 388 | 4.41247E-25 |
| 17 | g13718.t9 | CDD | cd11861 | SH3_DLG-like | 431 | 491 | 5.86971E-39 |
| 16 | g13718.t9 | Coils | Coil | Coil | 396 | 416 | - |
| 14 | g13718.t9 | Gene3D | G3DSA:2.30.42.10 | - | 31 | 141 | 8.2E-32 |
| 13 | g13718.t9 | Gene3D | G3DSA:2.30.42.10 | - | 142 | 242 | 3.8E-27 |
| 15 | g13718.t9 | Gene3D | G3DSA:2.30.42.10 | - | 303 | 422 | 2.3E-35 |
| 12 | g13718.t9 | Gene3D | G3DSA:2.30.30.40 | SH3 Domains | 423 | 525 | 4.2E-34 |
| 11 | g13718.t9 | Gene3D | G3DSA:3.40.50.300 | - | 592 | 637 | 8.7E-11 |
| 5 | g13718.t9 | PANTHER | PTHR23119 | DISCS LARGE | 28 | 637 | 1.3E-210 |
| 6 | g13718.t9 | PANTHER | PTHR23119:SF5 | DISKS LARGE HOMOLOG 1 | 28 | 637 | 1.3E-210 |
| 4 | g13718.t9 | Pfam | PF00595 | PDZ domain | 49 | 131 | 2.3E-21 |
| 2 | g13718.t9 | Pfam | PF00595 | PDZ domain | 145 | 232 | 4.5E-16 |
| 3 | g13718.t9 | Pfam | PF00595 | PDZ domain | 317 | 389 | 3.8E-19 |
| 1 | g13718.t9 | Pfam | PF00018 | SH3 domain | 433 | 489 | 2.4E-8 |
| 28 | g13718.t9 | ProSiteProfiles | PS50106 | PDZ domain profile. | 48 | 135 | 22.898 |
| 26 | g13718.t9 | ProSiteProfiles | PS50106 | PDZ domain profile. | 144 | 235 | 21.129 |
| 27 | g13718.t9 | ProSiteProfiles | PS50106 | PDZ domain profile. | 308 | 393 | 23.059 |
| 25 | g13718.t9 | ProSiteProfiles | PS50002 | Src homology 3 (SH3) domain profile. | 427 | 497 | 18.476 |
| 22 | g13718.t9 | SMART | SM00228 | pdz_new | 56 | 135 | 1.8E-23 |
| 23 | g13718.t9 | SMART | SM00228 | pdz_new | 152 | 235 | 2.3E-15 |
| 21 | g13718.t9 | SMART | SM00228 | pdz_new | 319 | 393 | 1.5E-22 |
| 24 | g13718.t9 | SMART | SM00326 | SH3_2 | 430 | 496 | 5.4E-6 |
| 9 | g13718.t9 | SUPERFAMILY | SSF50156 | PDZ domain-like | 41 | 136 | 3.02E-27 |
| 7 | g13718.t9 | SUPERFAMILY | SSF50156 | PDZ domain-like | 138 | 236 | 9.73E-21 |
| 8 | g13718.t9 | SUPERFAMILY | SSF50156 | PDZ domain-like | 295 | 399 | 7.49E-31 |
| 10 | g13718.t9 | SUPERFAMILY | SSF50044 | SH3-domain | 424 | 633 | 1.06E-28 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0005515 | protein binding | MF |
KEGG
Orthology
This gene did not have any KEGG ortholog annotations (KAAS, GHOSTZ).
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
