General information for g14091.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Tyrosine aminotransferase.
Parent gene
- The parent gene g14091 is located on chr_1: 34580479..34581493 (+ strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_1 | g14091 | g14091.t1 | TSS | g14091.t1 | 34579018 | 34579018 |
| chr_1 | g14091 | g14091.t1 | isoform | g14091.t1 | 34579079 | 34580479 |
| chr_1 | g14091 | g14091.t1 | exon | g14091.t1.exon1 | 34579079 | 34579226 |
| chr_1 | g14091 | g14091.t1 | cds | g14091.t1.CDS1 | 34579079 | 34579226 |
| chr_1 | g14091 | g14091.t1 | exon | g14091.t1.exon2 | 34579299 | 34580072 |
| chr_1 | g14091 | g14091.t1 | cds | g14091.t1.CDS2 | 34579299 | 34580072 |
| chr_1 | g14091 | g14091.t1 | exon | g14091.t1.exon3 | 34580124 | 34580199 |
| chr_1 | g14091 | g14091.t1 | cds | g14091.t1.CDS3 | 34580124 | 34580199 |
| chr_1 | g14091 | g14091.t1 | exon | g14091.t1.exon4 | 34580257 | 34580479 |
| chr_1 | g14091 | g14091.t1 | cds | g14091.t1.CDS4 | 34580257 | 34580479 |
| chr_1 | g14091 | g14091.t1 | TTS | g14091.t1 | 34580550 | 34580550 |
Sequences
>g14091.t1 Gene=g14091 Length=1221
ATGTCGCGAAATTGGGTAAAAATTAAGATTTCTGATTATGCTAGACTGAGTGTCAATCCT
TTGCGTAAAATTACACAAGAACAAAAGGTTGAGCCAAATCCTTTAAAAAGGTCAATAACT
TTACAACTTGGTGATCCCACAATTTTCGGAAATTTTCCCCCTCCAATTTCACTGATTAAC
GCACTCAATAATGCTGTACATAGGGATAAATTTCCTTACAACTTGAGTTATGGAAAATAT
GAGAGTCGTAAAGCAGTTGCAGAATATTCAAAGCATCAAGGTTTAGTGACAGCTGATGAC
GTCATTTTAGCAAGTGGTTGTAGTCATGCTATGGAAATGTGTGTTTTAACATTGACTGCA
TCTGGAGAGAATGTTTTAATACCAAAGCCATGTTATAATTATAAAACATGGCTCGATGGT
GTGAAAATTGAAACTAGAGCATATAATTTAAATCCTGAACAAAGTTGGAACATTGATTTA
AAAGATATGGAATCCTTAATTGATGAAAAAACTCGTTGTATAATTGTTAATAATCCAGGA
AATCCATGTGGAAATGTTTTTAGTAAAGACCATATTATAGATCTTTTAGCTTTGGCTGAG
AAACATAAACTTCCTATTGTTGCTGATGAAATTTATGAGCATTTCGTTTTTCCTGGTATT
GAATATCATTCAATTAGCTCTCTATCAAAAACTGTCCCAATTTTAACATGCTCTGGATTA
TCGAAAAGATTTCTTGTTCCTGGCATTAGAATGGGCTGGATAATCATTCATGATCGTAAT
GATTCACTGAGTGAAGTGAAACAAGGATTGCGAAATGTTTCTGCAAGAATATTGGGACCT
AATTCAACAGTTCAATATGCATTACCTGAAATTTTACAAAATACTCAACAACAATTCTTT
GTTAATAAAATGATGAAAATTGCTTGCAATGCTGAACTTGCTTATGGCTTACTAAATCAA
ATACCTGGTTTGAAACCAATCAAACCACGTGGATCAATGTATATGATGATAAAAATTGAA
CTGGAGAAATTTCCTGAATTTAAGAGTTGTATGGAATTCACTCAACAATTAATAAGAGAG
CAAAGTGTGCTTGTTTTTCCTTCTTATCCTTGCTTCAATTATCCTGGTTTCATGAGAATT
GTTTTAACTGTAACTAACGACATGATTGAAGAAGCTTGTGCAAGAATTAAAGAATTTTGT
GAGACACATGTTGTCAATTAG
>g14091.t1 Gene=g14091 Length=406
MSRNWVKIKISDYARLSVNPLRKITQEQKVEPNPLKRSITLQLGDPTIFGNFPPPISLIN
ALNNAVHRDKFPYNLSYGKYESRKAVAEYSKHQGLVTADDVILASGCSHAMEMCVLTLTA
SGENVLIPKPCYNYKTWLDGVKIETRAYNLNPEQSWNIDLKDMESLIDEKTRCIIVNNPG
NPCGNVFSKDHIIDLLALAEKHKLPIVADEIYEHFVFPGIEYHSISSLSKTVPILTCSGL
SKRFLVPGIRMGWIIIHDRNDSLSEVKQGLRNVSARILGPNSTVQYALPEILQNTQQQFF
VNKMMKIACNAELAYGLLNQIPGLKPIKPRGSMYMMIKIELEKFPEFKSCMEFTQQLIRE
QSVLVFPSYPCFNYPGFMRIVLTVTNDMIEEACARIKEFCETHVVN
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 8 | g14091.t1 | CDD | cd00609 | AAT_like | 44 | 398 | 9.10971E-78 |
| 5 | g14091.t1 | Gene3D | G3DSA:3.90.1150.10 | Aspartate Aminotransferase | 40 | 400 | 3.3E-116 |
| 6 | g14091.t1 | Gene3D | G3DSA:3.40.640.10 | - | 56 | 295 | 3.3E-116 |
| 2 | g14091.t1 | PANTHER | PTHR45744 | TYROSINE AMINOTRANSFERASE | 8 | 404 | 5.3E-140 |
| 3 | g14091.t1 | PANTHER | PTHR45744:SF2 | TYROSINE AMINOTRANSFERASE | 8 | 404 | 5.3E-140 |
| 7 | g14091.t1 | PIRSF | PIRSF000517 | Tyr_transaminase | 2 | 406 | 1.6E-142 |
| 1 | g14091.t1 | Pfam | PF00155 | Aminotransferase class I and II | 39 | 396 | 1.6E-58 |
| 9 | g14091.t1 | ProSitePatterns | PS00105 | Aminotransferases class-I pyridoxal-phosphate attachment site. | 239 | 252 | - |
| 4 | g14091.t1 | SUPERFAMILY | SSF53383 | PLP-dependent transferases | 14 | 402 | 4.49E-77 |
| 10 | g14091.t1 | TIGRFAM | TIGR01264 | tyr_amTase_E: tyrosine aminotransferase | 7 | 403 | 8.7E-157 |
| 11 | g14091.t1 | TIGRFAM | TIGR01265 | tyr_nico_aTase: tyrosine/nicotianamine family aminotransferase | 7 | 403 | 1.5E-142 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0009072 | aromatic amino acid family metabolic process | BP |
| GO:0009058 | biosynthetic process | BP |
| GO:0006520 | cellular amino acid metabolic process | BP |
| GO:0008483 | transaminase activity | MF |
| GO:0004838 | L-tyrosine:2-oxoglutarate aminotransferase activity | MF |
| GO:0003824 | catalytic activity | MF |
| GO:0030170 | pyridoxal phosphate binding | MF |
KEGG
Orthology
- This transcript has been annotated with K14260 (alanine-synthesizing transaminase)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
