General information for g14174.t5
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Uroporphyrinogen decarboxylase.
Parent gene
- The parent gene g14174 is located on chr_1: 35236950..35240093 (+ strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_1 | g14174 | g14174.t5 | TSS | g14174.t5 | 35236699 | 35236699 |
| chr_1 | g14174 | g14174.t5 | isoform | g14174.t5 | 35236794 | 35238042 |
| chr_1 | g14174 | g14174.t5 | exon | g14174.t5.exon1 | 35236794 | 35236811 |
| chr_1 | g14174 | g14174.t5 | cds | g14174.t5.CDS1 | 35236794 | 35236811 |
| chr_1 | g14174 | g14174.t5 | exon | g14174.t5.exon2 | 35236981 | 35237387 |
| chr_1 | g14174 | g14174.t5 | cds | g14174.t5.CDS2 | 35236981 | 35237387 |
| chr_1 | g14174 | g14174.t5 | exon | g14174.t5.exon3 | 35237463 | 35238042 |
| chr_1 | g14174 | g14174.t5 | cds | g14174.t5.CDS3 | 35237463 | 35238042 |
| chr_1 | g14174 | g14174.t5 | TTS | g14174.t5 | 35238155 | 35238155 |
Sequences
>g14174.t5 Gene=g14174 Length=1005
ATGCAATATCAACCGAAGAACTTTCCTGTGCTCAAAAATGACAATCTATTGCGTGCGGCT
CGTGGTGATAAAGTTGATCGAGTGCCGGTTTGGGTGATGAGACAAGCTGGAAGATATCTA
CCTGAATTTCGTGAAGTTCGCGCTGAAAGTGATTTCTTCAAAGTCTGTCGTACACCTGAA
CTTGCTGTTGAAGTCACTATGCAACCTATTCGACGATTCGATCTTGATGCATCGATTATC
TTTTCTGATATTCTCGTCATTCCACAAGCTCTTGGTATGGAAGTTGAAATGAGACCAGGT
CACGGACCGGTTTTTCCTGAGCCATTGCAAGATATTAAAGATGTGTCACGATTGAATGCT
GATGGCGCTATCGATAGATTAAAATACGTTGGTGATGCAATTACACTCATGAGACATACA
CTCGACAAAACAATGTCAAAGGCTCGTAGTTGGCTTAAAGATCATTCCGAAGAATCTCGC
AATCTTCTTTCTCTTCTCACTGATGTTATTGTTGATTATTTAGTGATGCAAGTGAAAGCT
GGTGCACAAATTTTACAAGTGTTCGAATCAAGTGCTGAATATATCAGCAAAGAAGAATTT
ATTGAATTTGCACTGCCATACCTAAAAGAAATTCGAATTAAAACACAAGAGAAACTCAAT
AAACAAGACATTGAGCTCGTTCCAATGGTTGTATTTGCAAAAGGTGCCATGCATTCACTA
GCTGAAATGTCTGATTTGGGATACGATGTCATCGGACTTGACTGGACAGTTGATCCTGAA
GAAGCAAGAAAAATTGTTGGACCAAATGTCACACTTCAAGGAAATTTGAATCCACAAGAT
CTTTATAAATCGCAAGAGGAAATTCGTGAATTGACAAGAACTATGGTGAGAAAGTTTGGA
AAAGATCGTTACATTGCTAATCTTGGACATGGAATTACGCCTCAAACACCAATTGAGAGC
ATGACAACTTTTGTTGATACCGTTCATTCCGCTTTTGACGATTAA
>g14174.t5 Gene=g14174 Length=334
MQYQPKNFPVLKNDNLLRAARGDKVDRVPVWVMRQAGRYLPEFREVRAESDFFKVCRTPE
LAVEVTMQPIRRFDLDASIIFSDILVIPQALGMEVEMRPGHGPVFPEPLQDIKDVSRLNA
DGAIDRLKYVGDAITLMRHTLDKTMSKARSWLKDHSEESRNLLSLLTDVIVDYLVMQVKA
GAQILQVFESSAEYISKEEFIEFALPYLKEIRIKTQEKLNKQDIELVPMVVFAKGAMHSL
AEMSDLGYDVIGLDWTVDPEEARKIVGPNVTLQGNLNPQDLYKSQEEIRELTRTMVRKFG
KDRYIANLGHGITPQTPIESMTTFVDTVHSAFDD
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 9 | g14174.t5 | CDD | cd00717 | URO-D | 17 | 330 | 4.12058E-157 |
| 8 | g14174.t5 | Gene3D | G3DSA:3.20.20.210 | - | 1 | 333 | 8.4E-133 |
| 2 | g14174.t5 | PANTHER | PTHR21091:SF169 | UROPORPHYRINOGEN DECARBOXYLASE | 6 | 142 | 4.7E-146 |
| 4 | g14174.t5 | PANTHER | PTHR21091 | METHYLTETRAHYDROFOLATE:HOMOCYSTEINE METHYLTRANSFERASE RELATED | 6 | 142 | 4.7E-146 |
| 3 | g14174.t5 | PANTHER | PTHR21091:SF169 | UROPORPHYRINOGEN DECARBOXYLASE | 142 | 330 | 4.7E-146 |
| 5 | g14174.t5 | PANTHER | PTHR21091 | METHYLTETRAHYDROFOLATE:HOMOCYSTEINE METHYLTRANSFERASE RELATED | 142 | 330 | 4.7E-146 |
| 1 | g14174.t5 | Pfam | PF01208 | Uroporphyrinogen decarboxylase (URO-D) | 143 | 330 | 8.3E-57 |
| 7 | g14174.t5 | ProSitePatterns | PS00906 | Uroporphyrinogen decarboxylase signature 1. | 29 | 38 | - |
| 6 | g14174.t5 | SUPERFAMILY | SSF51726 | UROD/MetE-like | 8 | 330 | 2.27E-95 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0004853 | uroporphyrinogen decarboxylase activity | MF |
| GO:0006779 | porphyrin-containing compound biosynthetic process | BP |
KEGG
Orthology
This gene did not have any KEGG ortholog annotations (KAAS, GHOSTZ).
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
