General information for g14174.t7
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Uroporphyrinogen decarboxylase.
Parent gene
- The parent gene g14174 is located on chr_1: 35236950..35240093 (+ strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_1 | g14174 | g14174.t7 | TSS | g14174.t7 | 35236699 | 35236699 |
| chr_1 | g14174 | g14174.t7 | isoform | g14174.t7 | 35236794 | 35238042 |
| chr_1 | g14174 | g14174.t7 | exon | g14174.t7.exon1 | 35236794 | 35236811 |
| chr_1 | g14174 | g14174.t7 | cds | g14174.t7.CDS1 | 35236794 | 35236811 |
| chr_1 | g14174 | g14174.t7 | exon | g14174.t7.exon2 | 35236981 | 35237097 |
| chr_1 | g14174 | g14174.t7 | cds | g14174.t7.CDS2 | 35236981 | 35237097 |
| chr_1 | g14174 | g14174.t7 | exon | g14174.t7.exon3 | 35237173 | 35238042 |
| chr_1 | g14174 | g14174.t7 | cds | g14174.t7.CDS3 | 35237173 | 35238042 |
| chr_1 | g14174 | g14174.t7 | TTS | g14174.t7 | 35238155 | 35238155 |
Sequences
>g14174.t7 Gene=g14174 Length=1005
ATGCAATATCAACCGAAGAACTTTCCTGTGCTCAAAAATGACAATCTATTGCGTGCGGCT
CGTGGTGATAAAGTTGATCGAGTGCCGGTTTGGGTGATGAGACAAGCTGGAAGATATCTA
CCTGAATTTCGTGAACGACGATTCGATCTTGATGCATCGATTATCTTTTCTGATATTCTC
GTCATTCCACAAGCTCTTGGTATGGAAGTTGAAATGAGACCAGGTCACGGACCGGTTTTT
CCTGAGCCATTGCAAGATATTAAAGATGTGTCACGATTGAATGCTGATGGCGCTATCGAT
AGATTAAAATACGTTGGTGATGCAATTACACTCATGAGACATACACTCGAAGGAAAAGTT
CCACTCTTTGGATTTACTGGTGCTCCATGGACACTTATGGGTTACATGATTGAAGGAGGT
GGCAGCAAAACAATGTCAAAGGCTCGTAGTTGGCTTAAAGATCATTCCGAAGAATCTCGC
AATCTTCTTTCTCTTCTCACTGATGTTATTGTTGATTATTTAGTGATGCAAGTGAAAGCT
GGTGCACAAATTTTACAAGTGTTCGAATCAAGTGCTGAATATATCAGCAAAGAAGAATTT
ATTGAATTTGCACTGCCATACCTAAAAGAAATTCGAATTAAAACACAAGAGAAACTCAAT
AAACAAGACATTGAGCTCGTTCCAATGGTTGTATTTGCAAAAGGTGCCATGCATTCACTA
GCTGAAATGTCTGATTTGGGATACGATGTCATCGGACTTGACTGGACAGTTGATCCTGAA
GAAGCAAGAAAAATTGTTGGACCAAATGTCACACTTCAAGGAAATTTGAATCCACAAGAT
CTTTATAAATCGCAAGAGGAAATTCGTGAATTGACAAGAACTATGGTGAGAAAGTTTGGA
AAAGATCGTTACATTGCTAATCTTGGACATGGAATTACGCCTCAAACACCAATTGAGAGC
ATGACAACTTTTGTTGATACCGTTCATTCCGCTTTTGACGATTAA
>g14174.t7 Gene=g14174 Length=334
MQYQPKNFPVLKNDNLLRAARGDKVDRVPVWVMRQAGRYLPEFRERRFDLDASIIFSDIL
VIPQALGMEVEMRPGHGPVFPEPLQDIKDVSRLNADGAIDRLKYVGDAITLMRHTLEGKV
PLFGFTGAPWTLMGYMIEGGGSKTMSKARSWLKDHSEESRNLLSLLTDVIVDYLVMQVKA
GAQILQVFESSAEYISKEEFIEFALPYLKEIRIKTQEKLNKQDIELVPMVVFAKGAMHSL
AEMSDLGYDVIGLDWTVDPEEARKIVGPNVTLQGNLNPQDLYKSQEEIRELTRTMVRKFG
KDRYIANLGHGITPQTPIESMTTFVDTVHSAFDD
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 11 | g14174.t7 | CDD | cd00717 | URO-D | 17 | 330 | 3.1752E-162 |
| 9 | g14174.t7 | Gene3D | G3DSA:3.20.20.210 | - | 1 | 333 | 4.4E-137 |
| 2 | g14174.t7 | PANTHER | PTHR21091:SF169 | UROPORPHYRINOGEN DECARBOXYLASE | 6 | 47 | 1.0E-152 |
| 4 | g14174.t7 | PANTHER | PTHR21091 | METHYLTETRAHYDROFOLATE:HOMOCYSTEINE METHYLTRANSFERASE RELATED | 6 | 47 | 1.0E-152 |
| 3 | g14174.t7 | PANTHER | PTHR21091:SF169 | UROPORPHYRINOGEN DECARBOXYLASE | 46 | 330 | 1.0E-152 |
| 5 | g14174.t7 | PANTHER | PTHR21091 | METHYLTETRAHYDROFOLATE:HOMOCYSTEINE METHYLTRANSFERASE RELATED | 46 | 330 | 1.0E-152 |
| 1 | g14174.t7 | Pfam | PF01208 | Uroporphyrinogen decarboxylase (URO-D) | 46 | 330 | 2.5E-98 |
| 8 | g14174.t7 | ProSitePatterns | PS00906 | Uroporphyrinogen decarboxylase signature 1. | 29 | 38 | - |
| 7 | g14174.t7 | ProSitePatterns | PS00907 | Uroporphyrinogen decarboxylase signature 2. | 123 | 139 | - |
| 6 | g14174.t7 | SUPERFAMILY | SSF51726 | UROD/MetE-like | 8 | 330 | 3.66E-99 |
| 10 | g14174.t7 | TIGRFAM | TIGR01464 | hemE: uroporphyrinogen decarboxylase | 46 | 330 | 4.2E-102 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0004853 | uroporphyrinogen decarboxylase activity | MF |
| GO:0006779 | porphyrin-containing compound biosynthetic process | BP |
KEGG
Orthology
This gene did not have any KEGG ortholog annotations (KAAS, GHOSTZ).
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below. There were no conditions that were differentially expressed