General information for g14411.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Cystathionine gamma-lyase.
Parent gene
- The parent gene g14411 is located on chr_4: 362015..362631 (+ strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_4 | g14411 | g14411.t1 | TSS | g14411.t1 | 358967 | 358967 |
| chr_4 | g14411 | g14411.t1 | isoform | g14411.t1 | 359199 | 362631 |
| chr_4 | g14411 | g14411.t1 | exon | g14411.t1.exon1 | 359199 | 359227 |
| chr_4 | g14411 | g14411.t1 | cds | g14411.t1.CDS1 | 359199 | 359227 |
| chr_4 | g14411 | g14411.t1 | exon | g14411.t1.exon2 | 361049 | 361147 |
| chr_4 | g14411 | g14411.t1 | cds | g14411.t1.CDS2 | 361049 | 361147 |
| chr_4 | g14411 | g14411.t1 | exon | g14411.t1.exon3 | 361370 | 361434 |
| chr_4 | g14411 | g14411.t1 | cds | g14411.t1.CDS3 | 361370 | 361434 |
| chr_4 | g14411 | g14411.t1 | exon | g14411.t1.exon4 | 361494 | 361867 |
| chr_4 | g14411 | g14411.t1 | cds | g14411.t1.CDS4 | 361494 | 361867 |
| chr_4 | g14411 | g14411.t1 | exon | g14411.t1.exon5 | 361923 | 362025 |
| chr_4 | g14411 | g14411.t1 | cds | g14411.t1.CDS5 | 361923 | 362025 |
| chr_4 | g14411 | g14411.t1 | exon | g14411.t1.exon6 | 362081 | 362631 |
| chr_4 | g14411 | g14411.t1 | cds | g14411.t1.CDS6 | 362081 | 362631 |
| chr_4 | g14411 | g14411.t1 | TTS | g14411.t1 | 362827 | 362827 |
Sequences
>g14411.t1 Gene=g14411 Length=1221
ATGGATCAATTAAATGAGAAATTCTCAGGATTGACGTTTGGAGAACGCTTGGGGTTTAAA
AAAACTGATGACGGATTTGCAACAAAAGCTATACACGCCGGTCAAGAACCAGAACAATGG
AAATGCAGAGCTGTGGTTCCGTTAATTTCTCTTTCAACAACATTCAAACAATTTGCACCA
GCACAACATGCAGGTTATGAATACAGTCGTTCAGGAAATCCAACAAGAAATGTTCTTGAG
ACATGCCTTGCTGCTCTTGATAATGCAAAATTTGCACTTACATTTGCTTCAGGTCTTGGT
GCACAAACTGCCATTATAAGCACTCTTAAAACAGGCGATGCAATTATTACTGGCGATGAT
GTTTATGGAGGAACTAATCGCTTATTTCGTAATCTCGCAGTCAATATGGGAATGGAAGTC
ATTTTTGTTGATATGACTGATCTTAAAAATTTAGAACGTGCTATGAAAGAAAATGTGAAA
CTCGTTTGGTTAGAAACTCCTACAAATCCCAGCATGAAAGTCATTGATATTGAGAATGTT
TGTAAATTTGTTCATGAAAATTCAAAGGCCATTGTTTTAGTTGATAATACATTCCTTTCA
CCATACTTTCAACGTCCAATTGACCTTGGTGCTGATGCTGTAACTTATTCATTAACAAAA
TATATGAATGGCCATGCAGACGTTGTGATGGGGAGTATAGCTACAAGTAATTCAAAACTA
TATGAAAGTCTCAAATTTTATCAAAATGCCACTGGAATTGTACCTTCCCCTTTTGACTGT
TATTTGGTTAATCGAAGTCTTAAAACTCTTGCACTTCGTATGGAACACCATTTTAAAACA
TCAGTAGCTATTGCAAAATATCTTGAAACTCATGATAGAGTTGAAAGAGTTATGCATCCA
GCACTGCCATCACATCCTCAATATGATATTACTTTGAAGCAAACTTATGGTCATTCAGGC
ATTTTTTCTTTTTATTTACGCAATGGAAATCTCGAAAGTTCAACGAAATTCTTGCAAGCT
TTGAAAATTTTTATGATAGCAGAATCACTTGGTGGATTCGAGAGTTTGGTTGAATTGCCC
TCAGTTATGACACATGCAAGCGTTCCCGAAGAACAAAGAGCTGAACTTGGAATTAATGAT
GGATTAATTAGAGTAAGTGTCGGATTGGAAAATGCAAAAGATTTGATTGAAGATTTTGAA
AATGCTTTTAAAGTAATTTAA
>g14411.t1 Gene=g14411 Length=406
MDQLNEKFSGLTFGERLGFKKTDDGFATKAIHAGQEPEQWKCRAVVPLISLSTTFKQFAP
AQHAGYEYSRSGNPTRNVLETCLAALDNAKFALTFASGLGAQTAIISTLKTGDAIITGDD
VYGGTNRLFRNLAVNMGMEVIFVDMTDLKNLERAMKENVKLVWLETPTNPSMKVIDIENV
CKFVHENSKAIVLVDNTFLSPYFQRPIDLGADAVTYSLTKYMNGHADVVMGSIATSNSKL
YESLKFYQNATGIVPSPFDCYLVNRSLKTLALRMEHHFKTSVAIAKYLETHDRVERVMHP
ALPSHPQYDITLKQTYGHSGIFSFYLRNGNLESSTKFLQALKIFMIAESLGGFESLVELP
SVMTHASVPEEQRAELGINDGLIRVSVGLENAKDLIEDFENAFKVI
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 8 | g14411.t1 | CDD | cd00614 | CGS_like | 44 | 404 | 0 |
| 6 | g14411.t1 | Gene3D | G3DSA:3.40.640.10 | - | 25 | 270 | 0 |
| 5 | g14411.t1 | Gene3D | G3DSA:3.90.1150.10 | Aspartate Aminotransferase | 271 | 406 | 0 |
| 2 | g14411.t1 | PANTHER | PTHR11808:SF15 | CYSTATHIONINE GAMMA-LYASE | 21 | 405 | 0 |
| 3 | g14411.t1 | PANTHER | PTHR11808 | TRANS-SULFURATION ENZYME FAMILY MEMBER | 21 | 405 | 0 |
| 7 | g14411.t1 | PIRSF | PIRSF001434 | CGS | 15 | 406 | 0 |
| 1 | g14411.t1 | Pfam | PF01053 | Cys/Met metabolism PLP-dependent enzyme | 27 | 404 | 0 |
| 4 | g14411.t1 | SUPERFAMILY | SSF53383 | PLP-dependent transferases | 47 | 404 | 0 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0019346 | transsulfuration | BP |
| GO:0003824 | catalytic activity | MF |
| GO:0030170 | pyridoxal phosphate binding | MF |
KEGG
Orthology
- This transcript has been annotated with K01758 (cystathionine gamma-lyase)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
