General information for g14830.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Glutathione hydrolase 1 proenzyme.
Parent gene
- The parent gene g14830 is located on chr_4: 2572882..2574942 (+ strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_4 | g14830 | g14830.t1 | isoform | g14830.t1 | 2572882 | 2574942 |
| chr_4 | g14830 | g14830.t1 | exon | g14830.t1.exon1 | 2572882 | 2573107 |
| chr_4 | g14830 | g14830.t1 | cds | g14830.t1.CDS1 | 2572882 | 2573107 |
| chr_4 | g14830 | g14830.t1 | exon | g14830.t1.exon2 | 2573168 | 2573723 |
| chr_4 | g14830 | g14830.t1 | cds | g14830.t1.CDS2 | 2573168 | 2573723 |
| chr_4 | g14830 | g14830.t1 | exon | g14830.t1.exon3 | 2574012 | 2574942 |
| chr_4 | g14830 | g14830.t1 | cds | g14830.t1.CDS3 | 2574012 | 2574942 |
| chr_4 | g14830 | g14830.t1 | TSS | g14830.t1 | NA | NA |
| chr_4 | g14830 | g14830.t1 | TTS | g14830.t1 | NA | NA |
Sequences
>g14830.t1 Gene=g14830 Length=1713
ATGGTTTTTAAATCTCGTTTAGCTGTGAAAATTTCAATTTTGCTCCTTGCAGTTTTAATT
TTTATAGGAATTATCACAGGTTGCATTTTATATGCAAATTTCACTGCTAAATATTCAACT
GGTGCTGTAGCAAGCAACGGTATTGAATGTGCAGGATTAGGAAGAAAAATTTTTGAAAAA
GGTGGAACAGTCGCTGATGTTGCTGTAACTACAATTTTATGTGAAGGAATTGCAAGTCCT
CAAAGTTGTGGAGTTGGAGGTGGATTTATTTTAGTGATGTATCTTAAAAATCAAAACCTT
GTTAAAGTCCTAAACGCACGTGAAAGAGCACCAAGAAATTCAACAGCTGACATGTATGTA
GCAAATCCTCGTGAATCATCTAATGGTGGGAAAGCTGTTGCAGTACCTGGTGATATTAAA
GGTCTATGGGAATTGCATCAAAATCATGGAAAATTGCCATGGAAAGATTTATTACAGCCA
ATAATCGATCTATGTCGAAATGGAATTGAAGTTTCTATAACATTAGCACAAATGATAAAA
AGTTATGAAGATGAAGTTCGTGCCGAAGCAGGTTTAAGAGAAATTTTTATAAATCAAGCG
ACAAATGAAACTTTTAAAGCTGGTGAAAAATATAAAAATGTTAAACTTGCTGAGACACTT
GAAATTATCGCTAGAGATGGTGCTGATGCAATGTACGGTGGCGGTGAAATCGGAAAGAAG
TTTGTTGAAGATGTGCAAAAACATGGTGGAATTATGATTGAGAAAGATCTTAGAGATTAT
CGCGCTGAATGGATAACACCAGTAAGTACAACAATAATTGATAACTCAACACTTTACACA
GCATCACTTCCAAGTAGTGGTTCAATGCTTGCTCTTATGTTAAATCTTCTTCGTAATGAT
GACATCAAACCAAATGCTCAAGGTTATCATCGAATAATTGAAGCAATGAAAATTGCATTT
GCTCATCGAACTCGTATTGGAGCTGAATTAAATGAAGAAGTAAAGTCAATAATGAAACAA
ATGTCTGAAAAAAGCTATGCTGATTCACTTTATAATCTCATCAGTGATCAAGGAACAAAA
AATGACGCATCTTATTATGGAGCAAAAACAGCTGATGTTGATGATAAAGGCACAGCACAT
TTGTCAATTCTCGCACTAAATGGAGACGCGATATCCGTTACAAACACAATTAATGATATT
TTTGGTGCAATGTTTCGCTCAGAGCAAACTGGAATAATTCCAAATGATGAAATGGATGAT
TTTTCAGTTCCTGGTGGACCAAATTCTGATGGAGTTGTTCCATCGCCTAATAATTTTGCA
ATTCCAGGAAATAATCCAATTTCTTCTATGGTGCCAACAATTGTAGTTGATGCAAATGGT
GAATTTAGAATGGCAGTAGGTGCTGCAGGTGGTCGAAGAATCATTTCCTCAACTTTTACA
GTTCTTTATCGTCATTTATATTTTAAAGAATCACTTGAAAAAGCAATGAATGCTTCAAGA
TTTCATCATCAATTGACACCAATGGAATTAGTTTATGAACCAAATTTTGATCCAGAAATA
TTGACTTATTTAAATCAAACAATGGGCCATCGAATTAGAGATTATCGATCAAATATTGCT
AATGTTGTTGCAATTTCAAAAATAAATGGTGAAGTTTTTGCTAATTATGATATAAGAAGA
AGTGGAAGTGTTGAAATTTTTGAAGGAATTTAA
>g14830.t1 Gene=g14830 Length=570
MVFKSRLAVKISILLLAVLIFIGIITGCILYANFTAKYSTGAVASNGIECAGLGRKIFEK
GGTVADVAVTTILCEGIASPQSCGVGGGFILVMYLKNQNLVKVLNARERAPRNSTADMYV
ANPRESSNGGKAVAVPGDIKGLWELHQNHGKLPWKDLLQPIIDLCRNGIEVSITLAQMIK
SYEDEVRAEAGLREIFINQATNETFKAGEKYKNVKLAETLEIIARDGADAMYGGGEIGKK
FVEDVQKHGGIMIEKDLRDYRAEWITPVSTTIIDNSTLYTASLPSSGSMLALMLNLLRND
DIKPNAQGYHRIIEAMKIAFAHRTRIGAELNEEVKSIMKQMSEKSYADSLYNLISDQGTK
NDASYYGAKTADVDDKGTAHLSILALNGDAISVTNTINDIFGAMFRSEQTGIIPNDEMDD
FSVPGGPNSDGVVPSPNNFAIPGNNPISSMVPTIVVDANGEFRMAVGAAGGRRIISSTFT
VLYRHLYFKESLEKAMNASRFHHQLTPMELVYEPNFDPEILTYLNQTMGHRIRDYRSNIA
NVVAISKINGEVFANYDIRRSGSVEIFEGI
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 15 | g14830.t1 | Gene3D | G3DSA:1.10.246.130 | - | 267 | 370 | 1.2E-21 |
| 14 | g14830.t1 | Gene3D | G3DSA:3.60.20.40 | - | 373 | 567 | 5.5E-61 |
| 2 | g14830.t1 | PANTHER | PTHR11686 | GAMMA GLUTAMYL TRANSPEPTIDASE | 10 | 565 | 3.6E-193 |
| 3 | g14830.t1 | PANTHER | PTHR11686:SF51 | GAMMA-GLUTAMYL TRANSPEPTIDASE, ISOFORM A | 10 | 565 | 3.6E-193 |
| 7 | g14830.t1 | PRINTS | PR01210 | Gamma-glutamyltranspeptidase signature | 63 | 88 | 5.2E-60 |
| 8 | g14830.t1 | PRINTS | PR01210 | Gamma-glutamyltranspeptidase signature | 132 | 150 | 5.2E-60 |
| 10 | g14830.t1 | PRINTS | PR01210 | Gamma-glutamyltranspeptidase signature | 150 | 169 | 5.2E-60 |
| 11 | g14830.t1 | PRINTS | PR01210 | Gamma-glutamyltranspeptidase signature | 251 | 267 | 5.2E-60 |
| 6 | g14830.t1 | PRINTS | PR01210 | Gamma-glutamyltranspeptidase signature | 281 | 300 | 5.2E-60 |
| 4 | g14830.t1 | PRINTS | PR01210 | Gamma-glutamyltranspeptidase signature | 378 | 396 | 5.2E-60 |
| 5 | g14830.t1 | PRINTS | PR01210 | Gamma-glutamyltranspeptidase signature | 402 | 420 | 5.2E-60 |
| 12 | g14830.t1 | PRINTS | PR01210 | Gamma-glutamyltranspeptidase signature | 442 | 457 | 5.2E-60 |
| 9 | g14830.t1 | PRINTS | PR01210 | Gamma-glutamyltranspeptidase signature | 467 | 484 | 5.2E-60 |
| 1 | g14830.t1 | Pfam | PF01019 | Gamma-glutamyltranspeptidase | 56 | 562 | 4.8E-151 |
| 16 | g14830.t1 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. | 1 | 11 | - |
| 18 | g14830.t1 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 12 | 32 | - |
| 17 | g14830.t1 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. | 33 | 570 | - |
| 20 | g14830.t1 | ProSiteProfiles | PS51257 | Prokaryotic membrane lipoprotein lipid attachment site profile. | 1 | 28 | 6.0 |
| 13 | g14830.t1 | SUPERFAMILY | SSF56235 | N-terminal nucleophile aminohydrolases (Ntn hydrolases) | 36 | 564 | 4.82E-136 |
| 19 | g14830.t1 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. | 13 | 35 | - |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0006751 | glutathione catabolic process | BP |
| GO:0036374 | glutathione hydrolase activity | MF |
KEGG
Orthology
- This transcript has been annotated with K18592 (gamma-glutamyltranspeptidase / glutathione hydrolase / leukotriene-C4 hydrolase)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
