General information for g14860.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Cyclin-dependent kinase 5-like protein.
Parent gene
- The parent gene g14860 is located on chr_4: 2688255..2689235 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_4 | g14860 | g14860.t1 | TTS | g14860.t1 | 2687436 | 2687436 |
| chr_4 | g14860 | g14860.t1 | isoform | g14860.t1 | 2688244 | 2689235 |
| chr_4 | g14860 | g14860.t1 | exon | g14860.t1.exon1 | 2688244 | 2688392 |
| chr_4 | g14860 | g14860.t1 | cds | g14860.t1.CDS1 | 2688244 | 2688392 |
| chr_4 | g14860 | g14860.t1 | exon | g14860.t1.exon2 | 2688452 | 2689060 |
| chr_4 | g14860 | g14860.t1 | cds | g14860.t1.CDS2 | 2688452 | 2689060 |
| chr_4 | g14860 | g14860.t1 | exon | g14860.t1.exon3 | 2689124 | 2689235 |
| chr_4 | g14860 | g14860.t1 | cds | g14860.t1.CDS3 | 2689124 | 2689235 |
| chr_4 | g14860 | g14860.t1 | TSS | g14860.t1 | NA | NA |
Sequences
>g14860.t1 Gene=g14860 Length=870
ATGCAAAAATACGAGAAATTAGAGAAAATTGGTGAAGGAACTTATGGAACAGTTTTTAAA
GGAAGAAATCGTGAAACTATGGAAATTGTGGCATTAAAAAGAGTTCGATTGGATGAGGAT
GATAAAGGAGTGCCATCATCAGCATTACGTGAAATTTGCCTATTAAAAGAACTCAAGCAT
AAAAATATCGTTCGACTTTATGATGTATTGCATTCAGATAAAAAATTGACATTAGTTTTT
GAGCATTGCGATCAAGATTTGAAGAAATATTTTGATTCACTCAATGGTGACATTTCATTG
GATATTGTAAAATCTTTCATGTATCAATTACTTCGTGGACTTGCATTTTGTCATAGTCAT
AATGTCCTGCATCGAGATTTAAAGCCACAAAATCTTTTAATTAACAAAAATAATGAATTA
AAATTGGCTGATTTTGGTCTTGCTCGTGCTTTTGGAATTCCAGTTAAATGTTATTCAGCT
GAAGTTGTAACATTATGGTATCGACCTCCAGATGTTCTTTTTGGTGCCAAATTGTACACA
ACAAGTATTGATTGTTGGTCAGCTGGTTGCATTTTTGCAGAAATGGCGAATGCAGGCAGA
CCACTGTTTCCAGGATCAGACGTTGATGATCAACTGAAAAGAATTTTTAAACTGTTAGGA
ACACCTACAGAAGATACTTGGCCTGGGTTGACTCAATTGTCTGATTATAAACCTTTTCCA
TTGTATCCTGCAACAAACAATTGGAACCAAGTTGTACCGAGACTGAATAGCAAAGGCCGT
GATTTGCTTCAAAAACTTCTCGTGTGTCGTCCAACATTAAGACTCAGTGCCGAACAAGCT
ATGGCTCATCCGTACTTTACTGAAAATTAA
>g14860.t1 Gene=g14860 Length=289
MQKYEKLEKIGEGTYGTVFKGRNRETMEIVALKRVRLDEDDKGVPSSALREICLLKELKH
KNIVRLYDVLHSDKKLTLVFEHCDQDLKKYFDSLNGDISLDIVKSFMYQLLRGLAFCHSH
NVLHRDLKPQNLLINKNNELKLADFGLARAFGIPVKCYSAEVVTLWYRPPDVLFGAKLYT
TSIDCWSAGCIFAEMANAGRPLFPGSDVDDQLKRIFKLLGTPTEDTWPGLTQLSDYKPFP
LYPATNNWNQVVPRLNSKGRDLLQKLLVCRPTLRLSAEQAMAHPYFTEN
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 7 | g14860.t1 | CDD | cd07839 | STKc_CDK5 | 3 | 286 | 0.0 |
| 5 | g14860.t1 | Gene3D | G3DSA:3.30.200.20 | Phosphorylase Kinase; domain 1 | 1 | 84 | 4.3E-37 |
| 6 | g14860.t1 | Gene3D | G3DSA:1.10.510.10 | Transferase(Phosphotransferase) domain 1 | 85 | 285 | 1.1E-67 |
| 2 | g14860.t1 | PANTHER | PTHR24056:SF46 | CYCLIN-DEPENDENT-LIKE KINASE 5 | 1 | 288 | 2.9E-136 |
| 3 | g14860.t1 | PANTHER | PTHR24056 | CELL DIVISION PROTEIN KINASE | 1 | 288 | 2.9E-136 |
| 1 | g14860.t1 | Pfam | PF00069 | Protein kinase domain | 4 | 286 | 7.0E-75 |
| 9 | g14860.t1 | ProSitePatterns | PS00107 | Protein kinases ATP-binding region signature. | 10 | 33 | - |
| 8 | g14860.t1 | ProSitePatterns | PS00108 | Serine/Threonine protein kinases active-site signature. | 122 | 134 | - |
| 11 | g14860.t1 | ProSiteProfiles | PS50011 | Protein kinase domain profile. | 4 | 286 | 46.76 |
| 10 | g14860.t1 | SMART | SM00220 | serkin_6 | 4 | 286 | 1.3E-99 |
| 4 | g14860.t1 | SUPERFAMILY | SSF56112 | Protein kinase-like (PK-like) | 1 | 288 | 3.24E-97 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0005524 | ATP binding | MF |
| GO:0004672 | protein kinase activity | MF |
| GO:0006468 | protein phosphorylation | BP |
KEGG
Orthology
- This transcript has been annotated with K02090 (cyclin-dependent kinase 5)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
