General information for g14860.t4
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Cyclin-dependent-like kinase 5.
Parent gene
- The parent gene g14860 is located on chr_4: 2688255..2689235 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_4 | g14860 | g14860.t4 | TTS | g14860.t4 | 2686480 | 2686480 |
| chr_4 | g14860 | g14860.t4 | isoform | g14860.t4 | 2687016 | 2689060 |
| chr_4 | g14860 | g14860.t4 | exon | g14860.t4.exon1 | 2687016 | 2687443 |
| chr_4 | g14860 | g14860.t4 | exon | g14860.t4.exon2 | 2688263 | 2689060 |
| chr_4 | g14860 | g14860.t4 | cds | g14860.t4.CDS1 | 2688393 | 2688854 |
| chr_4 | g14860 | g14860.t4 | TSS | g14860.t4 | NA | NA |
Sequences
>g14860.t4 Gene=g14860 Length=1226
ATGAGGATGATAAAGGAGTGCCATCATCAGCATTACGTGAAATTTGCCTATTAAAAGAAC
TCAAGCATAAAAATATCGTTCGACTTTATGATGTATTGCATTCAGATAAAAAATTGACAT
TAGTTTTTGAGCATTGCGATCAAGATTTGAAGAAATATTTTGATTCACTCAATGGTGACA
TTTCATTGGATATTGTAAAATCTTTCATGTATCAATTACTTCGTGGACTTGCATTTTGTC
ATAGTCATAATGTCCTGCATCGAGATTTAAAGCCACAAAATCTTTTAATTAACAAAAATA
ATGAATTAAAATTGGCTGATTTTGGTCTTGCTCGTGCTTTTGGAATTCCAGTTAAATGTT
ATTCAGCTGAAGTTGTAACATTATGGTATCGACCTCCAGATGTTCTTTTTGGTGCCAAAT
TGTACACAACAAGTATTGATTGTTGGTCAGCTGGTTGCATTTTTGCAGAAATGGCGAATG
CAGGCAGACCACTGTTTCCAGGATCAGACGTTGATGATCAACTGAAAAGAATTTTTAAAC
TGTTAGGAACACCTACAGAAGATACTTGGCCTGGGTTGACTCAATTGTCTGATTATAAAC
CTTTTCCATGTAAATTTTTCTCCTTTTGCAATTTTCAAATTTTTATAACAAATTTATATT
TTTTTTAGTGTATCCTGCAACAAACAATTGGAACCAAGTTGTACCGAGACTGAATAGCAA
AGGCCGTGATTTGCTTCAAAAACTTCTCGTGTGTCGTCCAACATTAAGACTCAGTGCCGA
ACAAGCTATGGCTCATCCTACATTCCAAAATAAAATTTGATTTTATTTTTTATTTTAGCA
GTTGTGAGTTTCAGAAACTATCAGATATTTATTTGTTAATATGATAGAATTTGAATTTCT
TGAGCAAACTTTAATTTTTCAGAATTAGCTTTCTTATTCGAAAACATTTTTTTTGCAAGC
ATGTTTTCTAAAAGTTTTCTTTTTTACTATTCAGATTTATTCACCGGCTCAAATGATCAT
ACTTAAAAATTAAATTTCACCATACTCAGAAATAAAAAATATTCATGTGTTTTGGTAATA
GAAACTTTAGTTTATATATATTAGTTCACATATTAAATGAGTTTTAAGAATTTGAATTTT
GACAAATAGCAATAGAAAAAGAACCAAGAAAATTGAGGAACTTTTGTATGTATGTGTGAA
TCATACACATTAATACGTTCTTTATT
>g14860.t4 Gene=g14860 Length=153
MYQLLRGLAFCHSHNVLHRDLKPQNLLINKNNELKLADFGLARAFGIPVKCYSAEVVTLW
YRPPDVLFGAKLYTTSIDCWSAGCIFAEMANAGRPLFPGSDVDDQLKRIFKLLGTPTEDT
WPGLTQLSDYKPFPCKFFSFCNFQIFITNLYFF
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 7 | g14860.t4 | Gene3D | G3DSA:1.10.510.10 | Transferase(Phosphotransferase) domain 1 | 1 | 130 | 5.2E-54 |
| 2 | g14860.t4 | PANTHER | PTHR24056:SF46 | CYCLIN-DEPENDENT-LIKE KINASE 5 | 1 | 136 | 1.7E-71 |
| 3 | g14860.t4 | PANTHER | PTHR24056 | CELL DIVISION PROTEIN KINASE | 1 | 136 | 1.7E-71 |
| 1 | g14860.t4 | Pfam | PF00069 | Protein kinase domain | 1 | 128 | 8.0E-37 |
| 6 | g14860.t4 | ProSitePatterns | PS00108 | Serine/Threonine protein kinases active-site signature. | 16 | 28 | - |
| 8 | g14860.t4 | ProSiteProfiles | PS50011 | Protein kinase domain profile. | 1 | 153 | 26.704 |
| 5 | g14860.t4 | SMART | SM00220 | serkin_6 | 1 | 146 | 6.7E-9 |
| 4 | g14860.t4 | SUPERFAMILY | SSF56112 | Protein kinase-like (PK-like) | 1 | 141 | 3.37E-52 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0005524 | ATP binding | MF |
| GO:0004672 | protein kinase activity | MF |
| GO:0006468 | protein phosphorylation | BP |
KEGG
Orthology
This gene did not have any KEGG ortholog annotations (KAAS, GHOSTZ).
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
