General information for g15007.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Venom carboxylesterase-6.
Parent gene
- The parent gene g15007 is located on chr_4: 3499603..3501820 (+ strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_4 | g15007 | g15007.t1 | isoform | g15007.t1 | 3498314 | 3500758 |
| chr_4 | g15007 | g15007.t1 | exon | g15007.t1.exon1 | 3498314 | 3498667 |
| chr_4 | g15007 | g15007.t1 | cds | g15007.t1.CDS1 | 3498314 | 3498667 |
| chr_4 | g15007 | g15007.t1 | exon | g15007.t1.exon2 | 3498719 | 3498772 |
| chr_4 | g15007 | g15007.t1 | cds | g15007.t1.CDS2 | 3498719 | 3498772 |
| chr_4 | g15007 | g15007.t1 | exon | g15007.t1.exon3 | 3498828 | 3499071 |
| chr_4 | g15007 | g15007.t1 | cds | g15007.t1.CDS3 | 3498828 | 3499071 |
| chr_4 | g15007 | g15007.t1 | exon | g15007.t1.exon4 | 3499134 | 3499384 |
| chr_4 | g15007 | g15007.t1 | cds | g15007.t1.CDS4 | 3499134 | 3499384 |
| chr_4 | g15007 | g15007.t1 | exon | g15007.t1.exon5 | 3499456 | 3499615 |
| chr_4 | g15007 | g15007.t1 | cds | g15007.t1.CDS5 | 3499456 | 3499615 |
| chr_4 | g15007 | g15007.t1 | exon | g15007.t1.exon6 | 3499707 | 3499885 |
| chr_4 | g15007 | g15007.t1 | cds | g15007.t1.CDS6 | 3499707 | 3499885 |
| chr_4 | g15007 | g15007.t1 | exon | g15007.t1.exon7 | 3499938 | 3500233 |
| chr_4 | g15007 | g15007.t1 | cds | g15007.t1.CDS7 | 3499938 | 3500233 |
| chr_4 | g15007 | g15007.t1 | exon | g15007.t1.exon8 | 3500530 | 3500758 |
| chr_4 | g15007 | g15007.t1 | cds | g15007.t1.CDS8 | 3500530 | 3500758 |
| chr_4 | g15007 | g15007.t1 | TSS | g15007.t1 | NA | NA |
| chr_4 | g15007 | g15007.t1 | TTS | g15007.t1 | NA | NA |
Sequences
>g15007.t1 Gene=g15007 Length=1767
ATGAAATTTTTACTAATTTTCATTTTTGCTTTCAATTTTATTTTTGACTTTTCTTCTGCA
CGAACTTCAGAAAGCTTAAAAGTAGAAATCGAAGATGGAAAAATTATTGGTGGATGGATG
ACATCACTTTCAGGCAAAATTATTCGTGCTTTTATGGGAATTCCTTATGCTGCACCACCA
ATTGGTGATTTAAGATTTAAAGCACCACAAAAAGTTAAACCATGGGGAAATGTCAGTTTA
TTAGCTCAAAAAGAGCCACCAATGTGTACACAAATTAACACTTTTAATGACATGTACAGT
GAAACTGTTTATGGACAAGAAGATTGCTTATATTTGAATGTTTATACACCTGAGATAACA
AAAAAAATTACTAAAAAATTGCCTGTGCTTGTTTGGATTCACAGTGGTGCATGGCTTGTT
GGTCATGCTGGATATACAGATTATAGTCCAGAATATTTACTTGAACATGACATTATTCTT
GTCACTGGAAATTATCGCTTGGGTGCACTTGGATTTCTTTCAACTGAAGATGAATATTCA
CCAGGAAATTACGGTTTCAAAGACCAATTGGAAATTCTCAGATGGGTTAAGAAAAATATT
GAGAAATTTGGTGGTGATGCAAATTCTGTTACTCTTGCAGGAGAAAGTGCAGGTGCAGCT
GCTGTGAATTATCACATGTTTTCACCAAAATCACGTGGACTTTTTCATAGAGCAATTTCA
CAATCAGGACATTTATTCAATCCTTGGGCAGATCCAGCTCATAAAGGAAAAGCAAAAGAA
AATGCAATAAGACTGGCAGAAAAATTACATTGTTCAAAATCAGGAATTTCTACCAAAAGT
TTGATTGAATGTTTGAGAAAAATTTCAGCTGAAGAAATCACTCGAGTTCTACGTGATCTT
CCTGTATGGGACAACGATCCATTAATTGCATTTCAACCAGTCATTGAGAATTTTGATTCA
AATGAAGAGCCATTTATTTCTGAATTAAAATATGAAAAATTATCTTTAGATATTCCATGG
ATTGTTGGTATAACAAGTGAAGAAGGATTAATGAAAAGTGCTTCATTTTTTAACAACGCA
GAAAAACTCAAAGAATTAGAAGAAAATTGGAAGAAAATTTTACCAGTTACATTCTACTAT
GATCATCTTCCTGAAAATGAAGTTGATGAAATAAATCAAAAAATTTACAATTTTTATTTC
AAAGAAAGTTCTTTTAGCAATAACAAGGAAAATTTGACGAATATGTGGTCTGAAGGATGG
TTTGGTGGATTCTTTGATAATCTTTCATATAGATTCAAAAGTAATGATCGTGAAAACACA
TTTGTTTATTTATTCACTCACAAAGGAGCTGCAAGTTTTTCTGAATATTTTTTGGGAGAA
AAAGAAGAATTTTATGGAACATGTCATGTTGATGAAATTTTTCATTTGTTTCCTATCCAG
AAATATTTTCCAGATTATATGAGTGCTATGCCAACACAGGAAGACAGAAAAATTACTGAA
ATAATTACAAAGCTTTGGGCCAATTTTGTTACTTTTGGAAATCCCACACCGAATTATTCG
GAAGAATCCAAATTCCCTATTTGGAAACCAGCGACGAAATTTCCACTTGATTTTATGAAA
ATTGGAAATGAAAATGGAGCAAGTGAAATTTTATTGGAAATGAAAAAAGATTTATATCCT
GAAAGAGCAAATTTTTGGATAGAACTTAGAAAAAAATATGGTCTTCATCTTTGGGCATTT
GATTTAAATGGAAGAGATGAATTATAA
>g15007.t1 Gene=g15007 Length=588
MKFLLIFIFAFNFIFDFSSARTSESLKVEIEDGKIIGGWMTSLSGKIIRAFMGIPYAAPP
IGDLRFKAPQKVKPWGNVSLLAQKEPPMCTQINTFNDMYSETVYGQEDCLYLNVYTPEIT
KKITKKLPVLVWIHSGAWLVGHAGYTDYSPEYLLEHDIILVTGNYRLGALGFLSTEDEYS
PGNYGFKDQLEILRWVKKNIEKFGGDANSVTLAGESAGAAAVNYHMFSPKSRGLFHRAIS
QSGHLFNPWADPAHKGKAKENAIRLAEKLHCSKSGISTKSLIECLRKISAEEITRVLRDL
PVWDNDPLIAFQPVIENFDSNEEPFISELKYEKLSLDIPWIVGITSEEGLMKSASFFNNA
EKLKELEENWKKILPVTFYYDHLPENEVDEINQKIYNFYFKESSFSNNKENLTNMWSEGW
FGGFFDNLSYRFKSNDRENTFVYLFTHKGAASFSEYFLGEKEEFYGTCHVDEIFHLFPIQ
KYFPDYMSAMPTQEDRKITEIITKLWANFVTFGNPTPNYSEESKFPIWKPATKFPLDFMK
IGNENGASEILLEMKKDLYPERANFWIELRKKYGLHLWAFDLNGRDEL
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 8 | g15007.t1 | Gene3D | G3DSA:3.40.50.1820 | - | 5 | 575 | 2.2E-149 |
| 2 | g15007.t1 | PANTHER | PTHR11559:SF395 | CARBOXYLIC ESTER HYDROLASE | 17 | 573 | 1.1E-175 |
| 3 | g15007.t1 | PANTHER | PTHR11559 | CARBOXYLESTERASE | 17 | 573 | 1.1E-175 |
| 1 | g15007.t1 | Pfam | PF00135 | Carboxylesterase family | 26 | 566 | 4.9E-130 |
| 10 | g15007.t1 | Phobius | SIGNAL_PEPTIDE | Signal peptide region | 1 | 20 | - |
| 11 | g15007.t1 | Phobius | SIGNAL_PEPTIDE_N_REGION | N-terminal region of a signal peptide. | 1 | 3 | - |
| 12 | g15007.t1 | Phobius | SIGNAL_PEPTIDE_H_REGION | Hydrophobic region of a signal peptide. | 4 | 15 | - |
| 13 | g15007.t1 | Phobius | SIGNAL_PEPTIDE_C_REGION | C-terminal region of a signal peptide. | 16 | 20 | - |
| 9 | g15007.t1 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. | 21 | 588 | - |
| 5 | g15007.t1 | ProSitePatterns | PS00941 | Carboxylesterases type-B signature 2. | 107 | 117 | - |
| 6 | g15007.t1 | ProSitePatterns | PS00122 | Carboxylesterases type-B serine active site. | 203 | 218 | - |
| 4 | g15007.t1 | SUPERFAMILY | SSF53474 | alpha/beta-Hydrolases | 24 | 566 | 7.28E-120 |
| 7 | g15007.t1 | SignalP_EUK | SignalP-noTM | SignalP-noTM | 1 | 20 | - |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
There are no GO annotations for this transcript.
KEGG
Orthology
This gene did not have any KEGG ortholog annotations (KAAS, GHOSTZ).
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
