General information for g15288.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Cytochrome P450 6a2.
Parent gene
- The parent gene g15288 is located on chr_4: 4838149..4839677 (+ strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_4 | g15288 | g15288.t1 | isoform | g15288.t1 | 4837691 | 4839677 |
| chr_4 | g15288 | g15288.t1 | exon | g15288.t1.exon1 | 4837691 | 4837733 |
| chr_4 | g15288 | g15288.t1 | cds | g15288.t1.CDS1 | 4837691 | 4837733 |
| chr_4 | g15288 | g15288.t1 | exon | g15288.t1.exon2 | 4838149 | 4838908 |
| chr_4 | g15288 | g15288.t1 | cds | g15288.t1.CDS2 | 4838149 | 4838908 |
| chr_4 | g15288 | g15288.t1 | exon | g15288.t1.exon3 | 4839027 | 4839461 |
| chr_4 | g15288 | g15288.t1 | cds | g15288.t1.CDS3 | 4839027 | 4839461 |
| chr_4 | g15288 | g15288.t1 | exon | g15288.t1.exon4 | 4839521 | 4839677 |
| chr_4 | g15288 | g15288.t1 | cds | g15288.t1.CDS4 | 4839521 | 4839677 |
| chr_4 | g15288 | g15288.t1 | TTS | g15288.t1 | 4839920 | 4839920 |
| chr_4 | g15288 | g15288.t1 | TSS | g15288.t1 | NA | NA |
Sequences
>g15288.t1 Gene=g15288 Length=1395
ATGAAATTGAAAACACAAACCTTTGAAATTCGCAGCAGTCCAGGAAGTGTTGGAACAGTA
GGATTTAAAGAGCATTCTTGTGAATTCTTTAAGCGACAATATGACAAATTTAAAGATAAA
GCTCCTGCTTTTGGTGTATTTTTTTTTATGCAGACATCACTTGCAATTACTGACCCTGAA
TTGATTAAAGAAGTTTTTGTAAGAAATTTTGAAAGTTTTCATGAGCGTGGATTTTTTATT
AATGAACAAGCTGATCCATTATCAGCTCATTTGTTTGCTCTTGGTGGTCAACAATGGAAA
GAGTTGAGGGCAAAATTGAGTCCCACATTTACATCAGGACGAATGAAAATGATGTTTCCA
TTGGTAGTTAAAGCAGCTGATCGAATGGTTGAATATTTAATGCCATATGCAGACAACATT
GAAGAATTAGAAGTTAAAGAAGTTTATGCAGAATTCACTACTGAAGTTATTTCTAGTGTT
GCTTTTGGATTAGACATTCCTTGTCTAGGAAATCCAGATAGTGAATTTAGAAAAGTTTCA
AAAACACTCTTTGAACCGACAAAATTAGAAAATATAAAAATAATGTTCATTTTTGCTTTT
CCTGAACTTGCAAAAGGGTTAAATATGAGGTTTATTCCAAAGAAATCAGCAGATTTTTTC
ATGGGAGTTATTCGAGATACGCTAGAATATCGTGAAAAAAATAATGTTGAGAGAAATGAC
TTTTTGCAACTGTTGATAAACATAAGAGATACAGAAGGAATGACTTTCAATGAAATTGCT
GCAAACTCTTTTATTTTCTTTAATGCTGGTTTCGAGACAAGCTCAAGTGTGATGACATTT
AGTACTTATGAACTTGCATTAAATCAAGACATTCAAGAGAGACTTCGTACTGAAATTAAT
GAAGTTATTGCAAAAAACAATGGAGAAATCACTTATGAATCTATCATGGAAATGAAATAT
CTTGACATGGTTTTCAATGAAACACTTCGAAAATATCCAATTGTTGATATTCAAATTAGA
AAGTCAGTGAAAGATTTTGCAATTCCAAATACAAATTTAGTGATTCCTGCAAATACTGGG
ATCATGATTCCAGTTTATGCAATTCATCATGATGAGAAATACTATGAAAACCCAGATAAA
TTTGATCCTGAAAGATTCACTGAAGAAATTGTAAGAAAACAATTGCCGTACACATTTATT
CCATTTAGTGAAGGACCAAGGCAATGCATAGGATTAAGATTTGGAACAATGCAAGCAAAA
ATAGGAATTGTAAAACTTGTAAAAAACTTCAAAATATTACCATGCAGTAAAACTTTGATT
CCGATGAAATACAATCCACCTTCTGGCTTCATGAGTCCTCTTGGCGGAATGTGGCTTAAA
TTTGAAAAATTGTGA
>g15288.t1 Gene=g15288 Length=464
MKLKTQTFEIRSSPGSVGTVGFKEHSCEFFKRQYDKFKDKAPAFGVFFFMQTSLAITDPE
LIKEVFVRNFESFHERGFFINEQADPLSAHLFALGGQQWKELRAKLSPTFTSGRMKMMFP
LVVKAADRMVEYLMPYADNIEELEVKEVYAEFTTEVISSVAFGLDIPCLGNPDSEFRKVS
KTLFEPTKLENIKIMFIFAFPELAKGLNMRFIPKKSADFFMGVIRDTLEYREKNNVERND
FLQLLINIRDTEGMTFNEIAANSFIFFNAGFETSSSVMTFSTYELALNQDIQERLRTEIN
EVIAKNNGEITYESIMEMKYLDMVFNETLRKYPIVDIQIRKSVKDFAIPNTNLVIPANTG
IMIPVYAIHHDEKYYENPDKFDPERFTEEIVRKQLPYTFIPFSEGPRQCIGLRFGTMQAK
IGIVKLVKNFKILPCSKTLIPMKYNPPSGFMSPLGGMWLKFEKL
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 17 | g15288.t1 | Gene3D | G3DSA:1.10.630.10 | Cytochrome p450 | 6 | 464 | 4.9E-127 |
| 2 | g15288.t1 | PANTHER | PTHR24292 | CYTOCHROME P450 | 20 | 464 | 1.8E-172 |
| 3 | g15288.t1 | PANTHER | PTHR24292:SF95 | CYP6A16, ISOFORM B-RELATED | 20 | 464 | 1.8E-172 |
| 7 | g15288.t1 | PRINTS | PR00463 | E-class P450 group I signature | 61 | 82 | 2.5E-23 |
| 6 | g15288.t1 | PRINTS | PR00463 | E-class P450 group I signature | 258 | 275 | 2.5E-23 |
| 13 | g15288.t1 | PRINTS | PR00385 | P450 superfamily signature | 269 | 286 | 3.2E-10 |
| 8 | g15288.t1 | PRINTS | PR00463 | E-class P450 group I signature | 278 | 304 | 2.5E-23 |
| 5 | g15288.t1 | PRINTS | PR00463 | E-class P450 group I signature | 322 | 340 | 2.5E-23 |
| 11 | g15288.t1 | PRINTS | PR00385 | P450 superfamily signature | 323 | 334 | 3.2E-10 |
| 10 | g15288.t1 | PRINTS | PR00463 | E-class P450 group I signature | 364 | 388 | 2.5E-23 |
| 9 | g15288.t1 | PRINTS | PR00463 | E-class P450 group I signature | 399 | 409 | 2.5E-23 |
| 12 | g15288.t1 | PRINTS | PR00385 | P450 superfamily signature | 400 | 409 | 3.2E-10 |
| 4 | g15288.t1 | PRINTS | PR00463 | E-class P450 group I signature | 409 | 432 | 2.5E-23 |
| 14 | g15288.t1 | PRINTS | PR00385 | P450 superfamily signature | 409 | 420 | 3.2E-10 |
| 1 | g15288.t1 | Pfam | PF00067 | Cytochrome P450 | 30 | 453 | 4.9E-95 |
| 16 | g15288.t1 | ProSitePatterns | PS00086 | Cytochrome P450 cysteine heme-iron ligand signature. | 402 | 411 | - |
| 15 | g15288.t1 | SUPERFAMILY | SSF48264 | Cytochrome P450 | 23 | 462 | 5.63E-113 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0020037 | heme binding | MF |
| GO:0016705 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | MF |
| GO:0005506 | iron ion binding | MF |
| GO:0055114 | NA | NA |
KEGG
Orthology
- This transcript has been annotated with K17691 (cytochrome P450 family 3 subfamily A7)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
