Gene loci information

Transcript annotation

  • This transcript has been annotated as Probable multidrug resistance-associated protein lethal(2)03659.

Parent gene

Gene structure

  • The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.

Chromosome Gene Transcript Category ID Start End
chr_3 g155 g155.t1 isoform g155.t1 1413944 1423382
chr_3 g155 g155.t1 exon g155.t1.exon1 1413944 1414217
chr_3 g155 g155.t1 cds g155.t1.CDS1 1413944 1414217
chr_3 g155 g155.t1 exon g155.t1.exon2 1414396 1415038
chr_3 g155 g155.t1 cds g155.t1.CDS2 1414396 1415038
chr_3 g155 g155.t1 exon g155.t1.exon3 1415237 1415470
chr_3 g155 g155.t1 cds g155.t1.CDS3 1415237 1415470
chr_3 g155 g155.t1 exon g155.t1.exon4 1416369 1416519
chr_3 g155 g155.t1 cds g155.t1.CDS4 1416369 1416519
chr_3 g155 g155.t1 exon g155.t1.exon5 1416587 1416956
chr_3 g155 g155.t1 cds g155.t1.CDS5 1416587 1416956
chr_3 g155 g155.t1 exon g155.t1.exon6 1417852 1418045
chr_3 g155 g155.t1 cds g155.t1.CDS6 1417852 1418045
chr_3 g155 g155.t1 exon g155.t1.exon7 1418114 1418281
chr_3 g155 g155.t1 cds g155.t1.CDS7 1418114 1418281
chr_3 g155 g155.t1 exon g155.t1.exon8 1418368 1419395
chr_3 g155 g155.t1 cds g155.t1.CDS8 1418368 1419395
chr_3 g155 g155.t1 exon g155.t1.exon9 1419460 1419676
chr_3 g155 g155.t1 cds g155.t1.CDS9 1419460 1419676
chr_3 g155 g155.t1 exon g155.t1.exon10 1420629 1420836
chr_3 g155 g155.t1 cds g155.t1.CDS10 1420629 1420836
chr_3 g155 g155.t1 exon g155.t1.exon11 1423072 1423382
chr_3 g155 g155.t1 cds g155.t1.CDS11 1423072 1423382
chr_3 g155 g155.t1 TSS g155.t1 1423789 1423789
chr_3 g155 g155.t1 TTS g155.t1 NA NA

Sequences

>g155.t1 Gene=g155 Length=3798
ATGAATGATATCAACGATGATTACATCCGAAAGCACGCGGAGGAGCGCGCAAACTTTATT
TCAAAAATCACGTTTTTCTGGCTCATTGACCTCTTTAAACTTGGTCAAAAATATCAAATC
ACAGCCAATGATGATATTTTTGGTATTCGTCGTGATGACGCGAGTGCAAAATTGTCAAAA
ATATTTTCCGCATTATGGAAGAGTGAATTAAGTAATGGTGGGAATAGCTTATGGCGAGTT
ATTCGAAAAGTTTATGGTCTTCGAGTAGCTTTTTGTGGTTTGACATTTTCGATTGTGGAT
ACAATTTTTAGGTTACTTCAACCACAATTTTTGGGCGCATTTATAAGCTTTTTTGTGCCA
AATCAAACAAGCGTAAGCACGAGTCAAGCCATTTACTTCGCAGCTGGTACTATTTCATGT
TCCCTCATACCTGTTTTAGTGTTTCATCCATTCTTTTTGTATACTTTAAACATTGGACAA
CGCATTCGAATAGCATGTTGCTCTTTGCTATACAAGAAGGTGTTGAAATTGTCAAAAAAT
TCCACTCAATTTCACATAATTGTGACGAATCTTATATCACGCGATATGAACAAACTCGAC
TATGCTATTGCAACATGTCATGAAATTTATAGGATACCACTTGAAGCACTATTCATTGCA
TATTTCATTTACAAAGAGACTGGCATAGTTGGACTTTTTGGCATCATCTCAATGATAGCG
TTTGTCCCATTATTATTCTACATCATAAAGCGATCGACAATTTATCGCTTGCGGGCAGCT
CAGCATACAGAAAGTCGTGTTCATTTGATGGGCGAAATTATCAAACGAATTGCAACCATA
AAAACATTTTGTATGGAACAAATTTACGCAAAGATGATTAAGGAACGCAGACTGAATGAA
ATTGAAATGGTTCGTGGTGTATTGTATCTTCGGGCAACTTCTGTCTCGTTAAATTTTCTT
CTTAAATTTTCAATTTTTGTATGTATTGCAAGTGCATTAAGTTGGGATAATCATTTGAAT
GCTAGCAGTGTTTATATTGTTATATCATATTATACCATGTTGTTCACATCTATGTTACAA
TTTTGGCCTTTATTAGTGACAAATGCTATGGATGCTTACCATACAATCGAAAGAGTACAA
GAAGTTCTTTTAACATTCAACATTTCCAATAAAAAAGAAGAAAAAGATAGTTCAGAAATT
TCTCAAGATGTAGCTTTAACAGAAAAACTCATGCCAGATCAAAAGTCAAAATCAGCACAA
AGAAGAATCAATGAAGAAAGTGACATTAAGGGAATTCAAATTAAAAATTTAATTACACAA
TTGAATGTAAAATGCAATCATCTTGAGATTAATGAAAATAAATCTTATGCACTTGTGAAT
TCAGCATCGACACTTATTGAAGTTCTCATTGGTGAAGTTGAGATTGAATCTGGTGATATT
GAAATAAATGGCAGCATCAGTTATGCATCAAAGAGTCCTTGGATATTTGCTGGAAGCATC
AGAGAGAACATAACTTTTACAGAGCAATTCGATGTCGAGAGATACTCGATGATATTGAAG
CTTTTTGAAATTGAAAAAGAAATTCAAGCTCTGCCAAATGGCGATGATACTTTAGTTGAC
GAGTTTTGCTTGAGTGACAGCTTTAAGATGCGAATACATCTCGCCAGATGTTTGTATAGA
AATGCCGATATTTACGTTATTGACAATTGCTTTTCAGATATAGCAACAAATCAAGTTGCA
GAGGCTTTTGAAAAGATATTTAAGAACAAAATATCATTAATTGCCACAAATCAACAACAT
GTCATAAATCAGACAAGTGAAATAATTTCTGTCCAAGACAACTCAATAAATATTATCGGA
TTATCGAAAGACTTTACTCTGTCCGAAACAAAAAACACCAATGAGGATTGTATTTCTACA
GAAATCACTAGGAAACAAAGTTCAAACTCATTTGTCGTACATCAAGAAAATTCAGAGAAT
CAAATTAGCGAAAGCATTGAATGGAGCAGCTATAGAAAGTACCTAAAGTCTATAAGTGGT
AGCAAATGCGGTATTTTATGGCTCATAATTCTATTTATATTCGCTCAACTGAACACGAGC
GGATTAGAGCTATTCATATCGAAGTGGCTCAATCATGTGGAAATGGTGCCGTATCGACAT
GTGCTGAGTGTGAATTTCACGGCAAAAAATAATAACAGTACTTTCCGAGAAAATGAGGCA
TTTGTGAGCAATTATGATAATTGGGTCAATTTTGTCTATTTCTATTCAATTATCCTTTGC
ACGTTGCTTTATTTCACGGTGCATCGATCATTTTTGTTCTTCAAATTGTGCCTTCGTGCC
AGTGTTCTCATTCACGATCGACTTTTTTGCGGCATTACAAGAGCTACCATGAGATTTTTT
CAATGCAATTCATTACGACAAATTCTGAATCATTTTACAGCAGACATCGAAAAATTAGAC
AATCAAGTACCGATAACAATTTACGATTCAATTGCTTTCTTGTTCGAAACAGTTGGCATT
TTTATACTCATCACACTTGTTAATTATTGGCTTTTGTTGCCGACACTCATTCTACTGTTT
GCAGTGTTTACATTTCGTTCATGCTACACCGATACAGCACGAAGTCTCCGTCGTGTCGAG
TCATTAACTCACAACTCTATTCATTCTCGGCTCATTTCGACATTTCATGGATTATCAACA
ATTCGCTCAACACATTCTGAGAAAATTTTGATGGATGAGTTTCATCGTAATATGGATCTT
AATACGTCGGCAATGTATCTAAATTTGGCCGCAACGCGAGCATTTGCCTTATGGCTCGAT
ATCATGTGTTGTGTCTACATATGTGTTGTAATATTAAGTTTTCTATTATTCAAAAGTGAA
GGCATTCGACAGACAGTTGAAGTTGGTCACAATATGATATCGGTTGAAAAAATTTTTCGT
TATCAATACATTACAACAGAACCACAATTTCGAACACCTAATAAACATCGACCTTCAAAA
AATTGGCCACAAAGTGCAAAAATTATTTTCAATAATTTCCATCTGCGTTACACATCAAGT
GGCAATGATGTTCTTAAAGATTTAAGTTTCAAAATTCATTCGGGCGAAAAGATTGGTATT
GTGGGTGAAACAAAGACAGGTAAAAGTTCTATTGTACAGGCTCTATTACGTTTTGCTTTC
AATGAAGGAACCATTGAAATTGATGACATAAATATTGAAACTCTGGGTATTCATGATCTT
CGTAGATGCTTTGGGATAATTCCACAAAATCCTATTCTTTTTGAAGGATCAATACGTTGT
AATTTAGATCCGTTAGAGCAGAATACAGATGAAAATATTTGGAATGCACTGGAGCGTGTT
GGAATTAAGGAAAATATTTTGAATGTTGTTGGTGGTTTAAGTTCTTCAGCGAATGAGCAA
ATACTTAATGTTAAAAAAATGCAACTTTTTTACATCGCACGTGCTTTTCTTGCTAAAAAT
AAAATTTTAATTCTGGATGAAACAACAGATGTGCTAAAGATTGATGATGCTAATGAAATT
CAAGATGTTATTCGTCGAAACTTTTCCAACTGTACGATAATGGTCATTTCGCAACGTCTT
GAAAGTATAATGGATTGTGATAATATCATTGTGCTTGATGATGGAAGAATTGTCGAGTTT
GGTCATCCTTATGAATTAATACAAATCTCAAGGGGTCAATTTAGGTCTATGATTGATAGA
ACTGGATATGCGAATGCTATGAATTTAATTAAGATGGCAGAGAGAAGTTATTTTACCAAA
AAAACATTAACAACTTAA

>g155.t1 Gene=g155 Length=1265
MNDINDDYIRKHAEERANFISKITFFWLIDLFKLGQKYQITANDDIFGIRRDDASAKLSK
IFSALWKSELSNGGNSLWRVIRKVYGLRVAFCGLTFSIVDTIFRLLQPQFLGAFISFFVP
NQTSVSTSQAIYFAAGTISCSLIPVLVFHPFFLYTLNIGQRIRIACCSLLYKKVLKLSKN
STQFHIIVTNLISRDMNKLDYAIATCHEIYRIPLEALFIAYFIYKETGIVGLFGIISMIA
FVPLLFYIIKRSTIYRLRAAQHTESRVHLMGEIIKRIATIKTFCMEQIYAKMIKERRLNE
IEMVRGVLYLRATSVSLNFLLKFSIFVCIASALSWDNHLNASSVYIVISYYTMLFTSMLQ
FWPLLVTNAMDAYHTIERVQEVLLTFNISNKKEEKDSSEISQDVALTEKLMPDQKSKSAQ
RRINEESDIKGIQIKNLITQLNVKCNHLEINENKSYALVNSASTLIEVLIGEVEIESGDI
EINGSISYASKSPWIFAGSIRENITFTEQFDVERYSMILKLFEIEKEIQALPNGDDTLVD
EFCLSDSFKMRIHLARCLYRNADIYVIDNCFSDIATNQVAEAFEKIFKNKISLIATNQQH
VINQTSEIISVQDNSINIIGLSKDFTLSETKNTNEDCISTEITRKQSSNSFVVHQENSEN
QISESIEWSSYRKYLKSISGSKCGILWLIILFIFAQLNTSGLELFISKWLNHVEMVPYRH
VLSVNFTAKNNNSTFRENEAFVSNYDNWVNFVYFYSIILCTLLYFTVHRSFLFFKLCLRA
SVLIHDRLFCGITRATMRFFQCNSLRQILNHFTADIEKLDNQVPITIYDSIAFLFETVGI
FILITLVNYWLLLPTLILLFAVFTFRSCYTDTARSLRRVESLTHNSIHSRLISTFHGLST
IRSTHSEKILMDEFHRNMDLNTSAMYLNLAATRAFALWLDIMCCVYICVVILSFLLFKSE
GIRQTVEVGHNMISVEKIFRYQYITTEPQFRTPNKHRPSKNWPQSAKIIFNNFHLRYTSS
GNDVLKDLSFKIHSGEKIGIVGETKTGKSSIVQALLRFAFNEGTIEIDDINIETLGIHDL
RRCFGIIPQNPILFEGSIRCNLDPLEQNTDENIWNALERVGIKENILNVVGGLSSSANEQ
ILNVKKMQLFYIARAFLAKNKILILDETTDVLKIDDANEIQDVIRRNFSNCTIMVISQRL
ESIMDCDNIIVLDDGRIVEFGHPYELIQISRGQFRSMIDRTGYANAMNLIKMAERSYFTK
KTLTT

Protein features from InterProScan

Transcript Database ID Name Start End E.value
40 g155.t1 CDD cd18579 ABC_6TM_ABCC_D1 92 379 1.93144E-58
39 g155.t1 CDD cd18580 ABC_6TM_ABCC_D2 685 981 3.73484E-51
41 g155.t1 CDD cd03244 ABCC_MRP_domain2 1007 1223 2.30935E-84
15 g155.t1 Coils Coil Coil 802 822 -
13 g155.t1 Gene3D G3DSA:1.20.1560.10 - 76 385 1.5E-10
12 g155.t1 Gene3D G3DSA:3.40.50.300 - 400 655 1.3E-30
14 g155.t1 Gene3D G3DSA:1.20.1560.10 - 656 981 4.9E-19
11 g155.t1 Gene3D G3DSA:3.40.50.300 - 991 1239 1.6E-66
5 g155.t1 PANTHER PTHR24223 ATP-BINDING CASSETTE SUB-FAMILY C 12 1241 6.5E-260
6 g155.t1 PANTHER PTHR24223:SF324 LD17001P 12 1241 6.5E-260
2 g155.t1 Pfam PF00664 ABC transporter transmembrane region 92 358 4.6E-11
3 g155.t1 Pfam PF00005 ABC transporter 463 571 1.6E-5
1 g155.t1 Pfam PF00664 ABC transporter transmembrane region 705 959 1.1E-18
4 g155.t1 Pfam PF00005 ABC transporter 1025 1169 8.6E-18
17 g155.t1 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. 1 84 -
36 g155.t1 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane. 85 106 -
26 g155.t1 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. 107 129 -
29 g155.t1 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane. 130 154 -
20 g155.t1 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. 155 200 -
32 g155.t1 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane. 201 223 -
25 g155.t1 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. 224 228 -
35 g155.t1 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane. 229 249 -
18 g155.t1 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. 250 307 -
34 g155.t1 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane. 308 332 -
27 g155.t1 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. 333 343 -
33 g155.t1 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane. 344 365 -
16 g155.t1 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. 366 684 -
28 g155.t1 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane. 685 706 -
22 g155.t1 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. 707 747 -
38 g155.t1 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane. 748 767 -
21 g155.t1 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. 768 824 -
31 g155.t1 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane. 825 844 -
24 g155.t1 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. 845 849 -
37 g155.t1 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane. 850 869 -
19 g155.t1 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. 870 934 -
30 g155.t1 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane. 935 957 -
23 g155.t1 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. 958 1265 -
54 g155.t1 ProSiteProfiles PS50929 ABC transporter integral membrane type-1 fused domain profile. 93 361 21.936
57 g155.t1 ProSiteProfiles PS50893 ATP-binding cassette, ABC transporter-type domain profile. 423 638 8.67
55 g155.t1 ProSiteProfiles PS50929 ABC transporter integral membrane type-1 fused domain profile. 704 952 20.043
56 g155.t1 ProSiteProfiles PS50893 ATP-binding cassette, ABC transporter-type domain profile. 1008 1239 13.025
53 g155.t1 SMART SM00382 AAA_5 1034 1215 1.4E-8
8 g155.t1 SUPERFAMILY SSF90123 ABC transporter transmembrane region 77 365 9.55E-23
10 g155.t1 SUPERFAMILY SSF52540 P-loop containing nucleoside triphosphate hydrolases 446 623 6.53E-23
7 g155.t1 SUPERFAMILY SSF90123 ABC transporter transmembrane region 674 981 1.7E-29
9 g155.t1 SUPERFAMILY SSF52540 P-loop containing nucleoside triphosphate hydrolases 1000 1237 1.52E-52
52 g155.t1 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane. 84 106 -
49 g155.t1 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane. 131 153 -
47 g155.t1 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane. 201 223 -
45 g155.t1 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane. 227 249 -
51 g155.t1 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane. 307 329 -
48 g155.t1 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane. 344 366 -
42 g155.t1 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane. 684 706 -
44 g155.t1 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane. 751 773 -
43 g155.t1 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane. 823 845 -
50 g155.t1 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane. 850 869 -
46 g155.t1 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane. 935 957 -

Transmembrane regions from TMHMM

Disordered region

IUPRED3 score over 0.5 is predictive of a disordered region.

GO terms from InterProScan

GOID TERM ONTOLOGY
GO:0055085 transmembrane transport BP
GO:0005524 ATP binding MF
GO:0042626 ATPase-coupled transmembrane transporter activity MF
GO:0016021 integral component of membrane CC

KEGG

Orthology

This gene did not have any KEGG ortholog annotations (KAAS, GHOSTZ).

Expression

Transcript expression in Pv11 cells

TPM values are indicated as average +/- STDEV.

Differential expression

Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.

Raw TPM values