Gene loci information

Transcript annotation

  • This transcript has been annotated as Aldo-keto reductase family 1 member B1.

Parent gene

Gene structure

  • The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.

Chromosome Gene Transcript Category ID Start End
chr_4 g15759 g15759.t11 TTS g15759.t11 6681153 6681153
chr_4 g15759 g15759.t11 isoform g15759.t11 6681429 6682283
chr_4 g15759 g15759.t11 exon g15759.t11.exon1 6681429 6681502
chr_4 g15759 g15759.t11 exon g15759.t11.exon2 6681603 6681688
chr_4 g15759 g15759.t11 cds g15759.t11.CDS1 6681640 6681688
chr_4 g15759 g15759.t11 exon g15759.t11.exon3 6681744 6681990
chr_4 g15759 g15759.t11 cds g15759.t11.CDS2 6681744 6681990
chr_4 g15759 g15759.t11 exon g15759.t11.exon4 6682046 6682283
chr_4 g15759 g15759.t11 cds g15759.t11.CDS3 6682046 6682268
chr_4 g15759 g15759.t11 TSS g15759.t11 NA NA

Sequences

>g15759.t11 Gene=g15759 Length=645
GACACATGGAAAGCAATGGAGGAATTAGTTGAAGCTGGATTAGTAAAATCAATTGGTCTG
AGCAATTTCAATTCAAAACAAATCGAACGTGTACTGGCTGTAGCTAAAATCAAACCAGTA
ATGAACCAAGTTGAATGCCATCCTTATTTGACACAGAAGAAATTAATTGAATTCTGTCGT
AGTAAAGGCATTGCTGTTACTGCATATTCACCACTGGGGTCTAACGACCGTCCTTGGGCA
AAACCAGATGATCCACAGCTCATGGATGATCCAAGAATTGTTGCTTTAGCAGAAAAGTAT
CAAAAAACTCCAGCTCAAATTCTTATTCGGTATCAAATTCAACGTAGAGTTGTTGTCATT
CCTAAATCAGTCACAAAATCAAGAATCATTAGCAACTTTGATGTTTTTGGCTTTGAATTA
TCTTCTGAAGATATTGCAAGTATCGATAGCATTGACTGCAATGGAAGATTGTGTCATTTG
AATTGGGTTTCTCATCATCCACATTATCCATTTGGAACAGACGTTGAATTTTAAATATAA
AAGTTTCAAAAAATATTAATTTTTTTATCAAATTTAATTGATTTAAATCACTGTTACAAA
ATTTGCCATTTAAAATTTAATTTGATGGAAAATTACAAGTAAATG

>g15759.t11 Gene=g15759 Length=172
MEELVEAGLVKSIGLSNFNSKQIERVLAVAKIKPVMNQVECHPYLTQKKLIEFCRSKGIA
VTAYSPLGSNDRPWAKPDDPQLMDDPRIVALAEKYQKTPAQILIRYQIQRRVVVIPKSVT
KSRIISNFDVFGFELSSEDIASIDSIDCNGRLCHLNWVSHHPHYPFGTDVEF

Protein features from InterProScan

Transcript Database ID Name Start End E.value
10 g15759.t11 Gene3D G3DSA:3.20.20.100 - 1 170 1.0E-73
2 g15759.t11 PANTHER PTHR11732:SF294 ALDO-KETO REDUCTASE FAMILY 1 MEMBER B1 1 168 3.3E-68
3 g15759.t11 PANTHER PTHR11732 ALDO/KETO REDUCTASE 1 168 3.3E-68
6 g15759.t11 PRINTS PR00069 Aldo-keto reductase signature 1 18 6.5E-34
5 g15759.t11 PRINTS PR00069 Aldo-keto reductase signature 35 64 6.5E-34
4 g15759.t11 PRINTS PR00069 Aldo-keto reductase signature 82 106 6.5E-34
1 g15759.t11 Pfam PF00248 Aldo/keto reductase family 1 146 1.0E-28
8 g15759.t11 ProSitePatterns PS00062 Aldo/keto reductase family signature 2. 1 18 -
9 g15759.t11 ProSitePatterns PS00063 Aldo/keto reductase family putative active site signature. 115 130 -
7 g15759.t11 SUPERFAMILY SSF51430 NAD(P)-linked oxidoreductase 1 166 1.19E-53

Transmembrane regions from TMHMM

Disordered region

IUPRED3 score over 0.5 is predictive of a disordered region.

GO terms from InterProScan

GOID TERM ONTOLOGY
GO:0047834 D-threo-aldose 1-dehydrogenase activity MF
GO:0055114 NA NA
GO:0016491 oxidoreductase activity MF

KEGG

Orthology

This gene did not have any KEGG ortholog annotations (KAAS, GHOSTZ).

Expression

Transcript expression in Pv11 cells

TPM values are indicated as average +/- STDEV.

Differential expression

Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.

Raw TPM values