General information for g16739.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Cytochrome P450 6A1.
Parent gene
- The parent gene g16739 is located on chr_4: 10766069..10768163 (+ strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_4 | g16739 | g16739.t1 | isoform | g16739.t1 | 10766069 | 10768163 |
| chr_4 | g16739 | g16739.t1 | exon | g16739.t1.exon1 | 10766069 | 10766645 |
| chr_4 | g16739 | g16739.t1 | cds | g16739.t1.CDS1 | 10766069 | 10766645 |
| chr_4 | g16739 | g16739.t1 | exon | g16739.t1.exon2 | 10766704 | 10767053 |
| chr_4 | g16739 | g16739.t1 | cds | g16739.t1.CDS2 | 10766704 | 10767053 |
| chr_4 | g16739 | g16739.t1 | exon | g16739.t1.exon3 | 10767190 | 10767358 |
| chr_4 | g16739 | g16739.t1 | cds | g16739.t1.CDS3 | 10767190 | 10767358 |
| chr_4 | g16739 | g16739.t1 | exon | g16739.t1.exon4 | 10767498 | 10767731 |
| chr_4 | g16739 | g16739.t1 | cds | g16739.t1.CDS4 | 10767498 | 10767731 |
| chr_4 | g16739 | g16739.t1 | exon | g16739.t1.exon5 | 10767792 | 10767816 |
| chr_4 | g16739 | g16739.t1 | cds | g16739.t1.CDS5 | 10767792 | 10767816 |
| chr_4 | g16739 | g16739.t1 | exon | g16739.t1.exon6 | 10768007 | 10768163 |
| chr_4 | g16739 | g16739.t1 | cds | g16739.t1.CDS6 | 10768007 | 10768163 |
| chr_4 | g16739 | g16739.t1 | TSS | g16739.t1 | NA | NA |
| chr_4 | g16739 | g16739.t1 | TTS | g16739.t1 | NA | NA |
Sequences
>g16739.t1 Gene=g16739 Length=1512
ATGATTGTCAATATTTTGCTTTACATTGTGTTTTCAATTGCTGCTGCAATTTATTTTTAT
TTCAAAAGAAAATACAATTATTTTAAAGATCGTGGAATTCCACACATTAAGCCAAAATTT
CCAATGGGAAATTTACAAGGAATTGGTTCAACTGACCACATTTTTGATGTTGTTTGCGAT
GTTTATAACAAATTCAAAGGAAAAGGTCCAATCATAGGATTGTACAGCGTCACAACACCA
ATTTATCTTATCACTGATCTTGAACTTATTAAAAAAATCACCATTGGTGATTTTAATTAT
TTTATTAATCGTGGTGGTTTTGTAAATGAAAAAGAAGAACCTTTAACTGCTCATCTTTTT
ACACTTCGTGATGATAAATGGCGATTTATTCGAAACAAGTTAAGTGCAGCATTCAGTTCA
GGAAAAATGAAGGCAATGTATTTTACAATTAGTGACAAAGGTCGTGATTATGTTGAATTA
GTAAGCAAAGCTGTGACAAAGACAAAATCAATTGATATCAAAGAATTGACTAACCGTTTT
ACTATTGACATTGTCAGTTCAGTTGCTTTCGGAATGGAATCAAACACAATGAAATACCAA
CATCCTGAATTGGTCAACATTTTTCATGAAATTTTTGATCCTGATGCAACACTCTTTCAA
AAATTTTTCATCATGGCATCTTTCCCAAGAATTGCAAAAGCACTCAAATTGAGATTCTTT
TCAAAGCAAATTTCTGACTTTTTCATGAATGTTGTTGGATCAAATATTGAAAGTAGAGAA
AAATTGGGTGACAATCGACAAGACTTTTTAAATATGTTAATTCAACTAAAGAACAAAGGA
TCAATTGATGGAGAATTTTCAACAGAGACGAGAAAAATTTCGATGAACGATGTCATGGCG
CAAAGTTTTGTGTTTTTCTTTGCTGGGGCTGACACATCAAGTTCAACAATTTCATTGACA
TTAGCAGAACTAGCTCATCACACGGAAGTTCAAGAAAAACTGAGAACTGAAATTTTAGAA
AAAACAAAGGAAGAAAAAGATGAAATTAGTTATGAAACATTGCAAGAAATGACTTATTTA
AATCAAGTTGTAAATGAAATTCTTCGAATGTACTCAAGTGGTTCAATTTTAATACGACAA
GCTGCTAAAGACTATAAAGTTGAAAATACAAAACATATCATTCCAAAAGGTGCTGACGTT
TGGATTTCTATGATTGGAATTCATTATGATGAAAAATATTGGAAAAATCCTTACAAATTT
GATCCAGAAAGATTTACACAAGAAGAAATTGCTAAAAGACCAAATTATTGTTATGCTCCA
TTTGGTGATGGTCCAAGAGCTTGCATTGGAATGCAATATGCTCTTTTAACGGTCAAATTC
GGTGTAGCAACAATCATTAAAAACTTTAAAGTCACGCCAAATTCCAAAATGAAATATCCA
ATTAAATTGAATCCAAAAGCTACCAATTTGGAACCTATTGGTGGCTATCAGTTGGATTTT
GAAAAAGTCTGA
>g16739.t1 Gene=g16739 Length=503
MIVNILLYIVFSIAAAIYFYFKRKYNYFKDRGIPHIKPKFPMGNLQGIGSTDHIFDVVCD
VYNKFKGKGPIIGLYSVTTPIYLITDLELIKKITIGDFNYFINRGGFVNEKEEPLTAHLF
TLRDDKWRFIRNKLSAAFSSGKMKAMYFTISDKGRDYVELVSKAVTKTKSIDIKELTNRF
TIDIVSSVAFGMESNTMKYQHPELVNIFHEIFDPDATLFQKFFIMASFPRIAKALKLRFF
SKQISDFFMNVVGSNIESREKLGDNRQDFLNMLIQLKNKGSIDGEFSTETRKISMNDVMA
QSFVFFFAGADTSSSTISLTLAELAHHTEVQEKLRTEILEKTKEEKDEISYETLQEMTYL
NQVVNEILRMYSSGSILIRQAAKDYKVENTKHIIPKGADVWISMIGIHYDEKYWKNPYKF
DPERFTQEEIAKRPNYCYAPFGDGPRACIGMQYALLTVKFGVATIIKNFKVTPNSKMKYP
IKLNPKATNLEPIGGYQLDFEKV
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 16 | g16739.t1 | Gene3D | G3DSA:1.10.630.10 | Cytochrome p450 | 16 | 503 | 2.3E-125 |
| 2 | g16739.t1 | PANTHER | PTHR24292 | CYTOCHROME P450 | 6 | 503 | 7.7E-160 |
| 3 | g16739.t1 | PANTHER | PTHR24292:SF95 | CYP6A16, ISOFORM B-RELATED | 6 | 503 | 7.7E-160 |
| 7 | g16739.t1 | PRINTS | PR00463 | E-class P450 group I signature | 65 | 84 | 2.5E-20 |
| 4 | g16739.t1 | PRINTS | PR00463 | E-class P450 group I signature | 297 | 314 | 2.5E-20 |
| 13 | g16739.t1 | PRINTS | PR00385 | P450 superfamily signature | 308 | 325 | 4.8E-10 |
| 9 | g16739.t1 | PRINTS | PR00463 | E-class P450 group I signature | 317 | 343 | 2.5E-20 |
| 8 | g16739.t1 | PRINTS | PR00463 | E-class P450 group I signature | 361 | 379 | 2.5E-20 |
| 12 | g16739.t1 | PRINTS | PR00385 | P450 superfamily signature | 362 | 373 | 4.8E-10 |
| 5 | g16739.t1 | PRINTS | PR00463 | E-class P450 group I signature | 403 | 427 | 2.5E-20 |
| 6 | g16739.t1 | PRINTS | PR00463 | E-class P450 group I signature | 438 | 448 | 2.5E-20 |
| 11 | g16739.t1 | PRINTS | PR00385 | P450 superfamily signature | 439 | 448 | 4.8E-10 |
| 10 | g16739.t1 | PRINTS | PR00463 | E-class P450 group I signature | 448 | 471 | 2.5E-20 |
| 14 | g16739.t1 | PRINTS | PR00385 | P450 superfamily signature | 448 | 459 | 4.8E-10 |
| 1 | g16739.t1 | Pfam | PF00067 | Cytochrome P450 | 38 | 492 | 1.0E-93 |
| 18 | g16739.t1 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. | 1 | 5 | - |
| 19 | g16739.t1 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 6 | 21 | - |
| 17 | g16739.t1 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. | 22 | 503 | - |
| 21 | g16739.t1 | ProSitePatterns | PS00086 | Cytochrome P450 cysteine heme-iron ligand signature. | 441 | 450 | - |
| 15 | g16739.t1 | SUPERFAMILY | SSF48264 | Cytochrome P450 | 33 | 500 | 7.2E-105 |
| 20 | g16739.t1 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. | 2 | 21 | - |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0020037 | heme binding | MF |
| GO:0016705 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | MF |
| GO:0005506 | iron ion binding | MF |
| GO:0055114 | NA | NA |
KEGG
Orthology
This gene did not have any KEGG ortholog annotations (KAAS, GHOSTZ).
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below. There were no conditions that were differentially expressed