General information for g17037.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Insulin-like receptor.
Parent gene
- The parent gene g17037 is located on chr_4: 12272402..12278370 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_4 | g17037 | g17037.t1 | isoform | g17037.t1 | 12272402 | 12278370 |
| chr_4 | g17037 | g17037.t1 | exon | g17037.t1.exon1 | 12272402 | 12272740 |
| chr_4 | g17037 | g17037.t1 | cds | g17037.t1.CDS1 | 12272402 | 12272740 |
| chr_4 | g17037 | g17037.t1 | exon | g17037.t1.exon2 | 12272794 | 12272935 |
| chr_4 | g17037 | g17037.t1 | cds | g17037.t1.CDS2 | 12272794 | 12272935 |
| chr_4 | g17037 | g17037.t1 | exon | g17037.t1.exon3 | 12273148 | 12273625 |
| chr_4 | g17037 | g17037.t1 | cds | g17037.t1.CDS3 | 12273148 | 12273625 |
| chr_4 | g17037 | g17037.t1 | exon | g17037.t1.exon4 | 12274054 | 12275148 |
| chr_4 | g17037 | g17037.t1 | cds | g17037.t1.CDS4 | 12274054 | 12275148 |
| chr_4 | g17037 | g17037.t1 | exon | g17037.t1.exon5 | 12275421 | 12275538 |
| chr_4 | g17037 | g17037.t1 | cds | g17037.t1.CDS5 | 12275421 | 12275538 |
| chr_4 | g17037 | g17037.t1 | exon | g17037.t1.exon6 | 12275684 | 12276769 |
| chr_4 | g17037 | g17037.t1 | cds | g17037.t1.CDS6 | 12275684 | 12276769 |
| chr_4 | g17037 | g17037.t1 | exon | g17037.t1.exon7 | 12277142 | 12277447 |
| chr_4 | g17037 | g17037.t1 | cds | g17037.t1.CDS7 | 12277142 | 12277447 |
| chr_4 | g17037 | g17037.t1 | exon | g17037.t1.exon8 | 12277541 | 12277959 |
| chr_4 | g17037 | g17037.t1 | cds | g17037.t1.CDS8 | 12277541 | 12277959 |
| chr_4 | g17037 | g17037.t1 | exon | g17037.t1.exon9 | 12278043 | 12278370 |
| chr_4 | g17037 | g17037.t1 | cds | g17037.t1.CDS9 | 12278043 | 12278370 |
| chr_4 | g17037 | g17037.t1 | TSS | g17037.t1 | NA | NA |
| chr_4 | g17037 | g17037.t1 | TTS | g17037.t1 | NA | NA |
Sequences
>g17037.t1 Gene=g17037 Length=4311
ATGAACAACATCATCCACATATCGGAATTAAATAAGTTACCAAAAGATGATTTCATCATA
TATGAACCAATTAAAGAACTTTTTACAACTAACACAAAAATTCAACCAAAAAAATTTCGA
AAATTTAAAATAAATGGAGCAACAGTGCTTAAGATCAGCATTTTTTTAATTTTCACATTT
TTACAAATCATTTCGGCACCAAGTTTAAGAAAGAAAATTAAGACTGAAAATGCAAAACCA
ACTGTTGAATCTTTACGGTTTAAAAGGGCAATTGACAATTTTACATTAGAAACTCCAATA
GTTCCACAGTCATTACCAAATGGAGGAATCTGCAAAACAGTCGATGCTCGCTTTGATATG
AACAAGATCAATGGACTATCAGGATGTCGAGTAGTTGAAGGTTCAATAACAATTCTTCTA
ATGGACGATATGGAAGCCAGAGATGTTGTAAATTTTACATTTCCAGAATTAGTTGAAGTC
ACAGGATTTATCATGCTTTATCGAATTGGTGGCTTTACAAGTCTTGATCAACTTTTTCCA
AATCTTGCAGTCATTCGTGGAAGAGATTTATTTAAGGACTATTCACTAATTATTTATGAA
ATGCTTCATTTAACTGACATTGGATTGAAAAATTTAATGACAATTGAAAGAGGAAATGTT
CGAATTGAAAAGAATGAAAATTTATGTTTCACAAATTCTATTAATTGGAATCAAATTATG
GTACAAAATGATGATCCTTATGTTGATAAAAATCGACTACCAGCACTTTGTCCAAGTTGT
CCAAATGACAAATGCACAAAATCAGCTGATGGAAAACAAAATTATTGCTGGAATGTTGAT
TACTGCCAAAGAACTTGTTTCCACTGCCAAAATCCAAATTTTAAAGGCGAAATGACTTAT
TGTTCACCAAATCAACAGATTTGTTGTGATCATAGTTGCATAGGAGGCTGCAAAGATGAC
AATCCAAAAGCTTGCTTTGCTTGTCGTAAATTTGCATTTGGAAATTATCCAAATATTCAA
TGTGTTGATGAATGTCCTAATGATACTTTTGCTTACCTCGATCGTCGATGCATCACCAAA
GCTCAATGCTATGATCTCAACACTGAAGGAATTTTAAAAGACCCAGAATCACCTTTCATC
CCTTTCAATGGTGAATGTCGAAAAGATTGTCCACCAAATTATAAAAAAGTCAACACAGGA
AGAAAATTGACATGTGAAAAATGTGTCGGTCCATGCTTAAAAGAATGTCCCTTTGGGAGT
GTCGATTCAATAGAAGCTGCACAAGCACTTAAAGGTTGCAATATCATCGATGGGCCACTT
GAAATTCAAATTAGAAGAATTTCAAAACATCCTGAATCTGGCAGAAATGTTGTGAAAGAA
CTTGAAAATTCACTGTCTGGCATTGTTGAAATTAAAGGATTTTTAAAAATTGCTCGAACT
TCTTCACTACTTTCATTGTCATTTTTAAAGAATCTTCGAAAAATTCATGGTAATAGTCTT
GATGCTGGTCGATATGCTATGATTGTTTGGGAAAATCCTAATTTACAAGAACTTTGGAAT
GCTTCACATAAAATCGAAATTGTTCGTGGAAAGTTTTTCTTTCATTTCAATCCAAAACTT
TGTTTTTATAAAATTGAACAATTTACAAAAAATAGCGCAATTAAAGGATTTAATACAACT
GACATGCTTGAAAATTTTGAAATGACGAAACTTTCAAATGGTGACAAAACACCTTGCGAT
TTGACACTATTAAGTGTAACAGTTGAGCAAATTTATCCACATGCTGCATTGCTTGTTTGG
GATCCATTGAAACTTGAAGATGAAAGAACTTTACTCAGTTATGTCGTTTATTATATTGCT
GCACCATATGCAAATGTCACATTATGGGATGGAAGAGATGCATGTGGCAATGATGGCTGG
AGTGTTAAAGATAAAAATGATTTTCGTGATAATAAGAAAATTTCACAACCATTGACTAAA
TTGGAACCTTATACTCAATATGCTTATTATGTTAAGGCTTATACATTGGCTACTGAAAAA
TATGGAGCACAAAGTGAAATTAGCTATTTCACTACAAAACCTGATGTGCCAGAAGTTGTT
AAGAAATTTAAAGTCACTGCTATTGGACCTGATAAAATTGAAGTTTCATGGGAAAAATTG
AAGAAAGTAAATGGACGATTAGATCATTATATTTTGCGAGCAAATGCAATTTCTCAAGAT
GATAAATTATTGGAACAAAGAGACTATTGTAAAGAACCAATTGAACAATCACCACCACCA
ACGAAACCATCAAAAGACATTTCATTTCTAAACATGAAACATAAAAATCCACTTTCATTT
TCAAATGGAACTTGTGATTGTCAAAGATGTTTAATTATGTGCGATGCAAACCAAGAAACA
TTAGAAGAAGGCGATGATAAACGAGAGTTGGCAAATAATTTTGAAGACAATATTCAAGAT
TTTGTCTACATTCGAACTGATGACAATACAATTGAATTAACAAGAGAAATACCAAAAGAA
GTAAAGAAAGTTAAACGACAAATTAAAACAATTGAATTTCCATCAGATTTACAATTTGAT
CCTTTAAATCAATCAACAATTGATCGTGAATATTTAAAAAATCAAAGTGATTTTTATAAT
GATGAAATTGGACCAGAACAGACAAGTTTCATCATAACTGGACTAAAACATTATACAACT
TATAATATTCAAATCAGAGCATGCAGAAAACGTGAAGAAGGTGAAACTTTGTTAGCTGAA
ATTTGCGGACCTGAAATTAAAGATTTTGCAACGACATTCAAAGAGCCAGCAAATGATAAT
ATTCCATTTTTTGATGTTCAAGCAATTGTCAATAAATCAATGACAAATATTTTAGTGCGA
TGGGAAGAACCAAAAAATCCTAATGGCCTTTTGTTGGCTTTTACTATTCGACACAAAAGA
GTTGACATTGATCACACTCAGCCAGTTTTGCATTGCATTTCACAGACAATGCTCAATGGA
TCAAGTCAGTATTTACTTCAGAAACTCAACTCAGGAAATTACAGCATTGACATGATGGCA
ACATCAATGGCTGGCAATGGAAATTACACAAATCCCAAATATATTTTTATCAATGAACAC
AATCAAATTGGCAATTTATATGCAATCATTGTTGTTCTTTTGACTTTATTTGTCGTTGGA
ATTATTGCAGTCATTTTGGCATTTAAGAAAATTTATCAAGCAAACATATCAAGTATGAAA
CTTGTTGCAAATGTCAATCCTGATTATGTCAATGTTATTTATAAACAAGATGAATGGGAA
ATTTCTAGAGAGAAAATTATTCAATTGCAGGAATTGGGTTTTGGAAGTTTTGGAATGGTC
TACGAAGGTCTCATAAAAGACTTCCATCAACCAGGTAATGATGTTCGTTGTGCAATAAAA
ACAGTGAATGAAAGTGCAACAGACAAAGAACGAATAAATTTTCTCAATGAAGCATCTGTA
ATGAAACAATTTGACACTTCTCATGTCGTTCGTCTTCTTGGTGTTGTGTCAGAAGGACAA
CCAACTTTAGTAGTTATGGAATTAATGGCAAATGGCGATTTGAAAACTTATTTACGATCA
CATCGACCTGAATATGACACAATAAGTTCAGATTCACCACCACAGCCACCAACATTGAGA
AGAATTCTTCAAATGGCTATTGAAATTGCTGATGGCATGGCTTATTTGTCAGCTAAGAAA
TTTGTACATAGAGATCTTGCTGCTAGAAATTGCATGGTTGCTGAAGATTTGACAGTTAAA
ATTGGTGACTTTGGAATGACTCGTGATATTTATGAAACTGATTATTACAGGAAAGGCACA
AAAGGACTTTTGCCGGTTCGTTGGATGAGTCCTGAATCTTTAAAAGATGGAGTTTTCTCA
TCAAGTAGTGATGTTTTCAGTTATGGAGTTGTTTTATGGGAAATGTCAACACTTGCTCAA
CAACCTTATGCTGGTCTTTCAAATGATCAAGTTTTACGTTATGTTGTAGAAGGAGGTGTA
ATGGAAAGACCAGAAAATTGTCCTGATAAACTTTATGAATTAATGCGACGATGTTGGCAG
CACCGACCTTCAGCACGTCCATCATTTATGGAAATTATTACAATGCTTTTAGATAGTGTC
AGTTCTGATTTTGAGAAAATAAGTTTTTTTCATTCACCTCTTGGTGTTGAAACTTGGCAA
CAAATGACACAAGAAATTGCTGTGATTAGTGACGATGTAACGACACCATTGAGACAAGAC
GATGAAGAAACAATGAGCAGTAATAGAAATCATATTGATGAAGATTTGTAA
>g17037.t1 Gene=g17037 Length=1436
MNNIIHISELNKLPKDDFIIYEPIKELFTTNTKIQPKKFRKFKINGATVLKISIFLIFTF
LQIISAPSLRKKIKTENAKPTVESLRFKRAIDNFTLETPIVPQSLPNGGICKTVDARFDM
NKINGLSGCRVVEGSITILLMDDMEARDVVNFTFPELVEVTGFIMLYRIGGFTSLDQLFP
NLAVIRGRDLFKDYSLIIYEMLHLTDIGLKNLMTIERGNVRIEKNENLCFTNSINWNQIM
VQNDDPYVDKNRLPALCPSCPNDKCTKSADGKQNYCWNVDYCQRTCFHCQNPNFKGEMTY
CSPNQQICCDHSCIGGCKDDNPKACFACRKFAFGNYPNIQCVDECPNDTFAYLDRRCITK
AQCYDLNTEGILKDPESPFIPFNGECRKDCPPNYKKVNTGRKLTCEKCVGPCLKECPFGS
VDSIEAAQALKGCNIIDGPLEIQIRRISKHPESGRNVVKELENSLSGIVEIKGFLKIART
SSLLSLSFLKNLRKIHGNSLDAGRYAMIVWENPNLQELWNASHKIEIVRGKFFFHFNPKL
CFYKIEQFTKNSAIKGFNTTDMLENFEMTKLSNGDKTPCDLTLLSVTVEQIYPHAALLVW
DPLKLEDERTLLSYVVYYIAAPYANVTLWDGRDACGNDGWSVKDKNDFRDNKKISQPLTK
LEPYTQYAYYVKAYTLATEKYGAQSEISYFTTKPDVPEVVKKFKVTAIGPDKIEVSWEKL
KKVNGRLDHYILRANAISQDDKLLEQRDYCKEPIEQSPPPTKPSKDISFLNMKHKNPLSF
SNGTCDCQRCLIMCDANQETLEEGDDKRELANNFEDNIQDFVYIRTDDNTIELTREIPKE
VKKVKRQIKTIEFPSDLQFDPLNQSTIDREYLKNQSDFYNDEIGPEQTSFIITGLKHYTT
YNIQIRACRKREEGETLLAEICGPEIKDFATTFKEPANDNIPFFDVQAIVNKSMTNILVR
WEEPKNPNGLLLAFTIRHKRVDIDHTQPVLHCISQTMLNGSSQYLLQKLNSGNYSIDMMA
TSMAGNGNYTNPKYIFINEHNQIGNLYAIIVVLLTLFVVGIIAVILAFKKIYQANISSMK
LVANVNPDYVNVIYKQDEWEISREKIIQLQELGFGSFGMVYEGLIKDFHQPGNDVRCAIK
TVNESATDKERINFLNEASVMKQFDTSHVVRLLGVVSEGQPTLVVMELMANGDLKTYLRS
HRPEYDTISSDSPPQPPTLRRILQMAIEIADGMAYLSAKKFVHRDLAARNCMVAEDLTVK
IGDFGMTRDIYETDYYRKGTKGLLPVRWMSPESLKDGVFSSSSDVFSYGVVLWEMSTLAQ
QPYAGLSNDQVLRYVVEGGVMERPENCPDKLYELMRRCWQHRPSARPSFMEIITMLLDSV
SSDFEKISFFHSPLGVETWQQMTQEIAVISDDVTTPLRQDDEETMSSNRNHIDEDL
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 31 | g17037.t1 | CDD | cd00064 | FU | 308 | 357 | 1.60907E-6 |
| 35 | g17037.t1 | CDD | cd00063 | FN3 | 586 | 692 | 2.00963E-5 |
| 34 | g17037.t1 | CDD | cd00063 | FN3 | 697 | 733 | 0.0028923 |
| 33 | g17037.t1 | CDD | cd00063 | FN3 | 885 | 915 | 0.0015334 |
| 36 | g17037.t1 | CDD | cd00063 | FN3 | 949 | 1035 | 1.67174E-4 |
| 32 | g17037.t1 | CDD | cd05032 | PTKc_InsR_like | 1099 | 1378 | 2.28346E-171 |
| 24 | g17037.t1 | Gene3D | G3DSA:3.80.20.20 | - | 105 | 285 | 2.5E-55 |
| 25 | g17037.t1 | Gene3D | G3DSA:2.10.220.10 | Hormone Receptor | 295 | 412 | 6.8E-22 |
| 23 | g17037.t1 | Gene3D | G3DSA:3.80.20.20 | - | 413 | 588 | 3.7E-51 |
| 19 | g17037.t1 | Gene3D | G3DSA:2.60.40.10 | Immunoglobulins | 589 | 692 | 4.5E-33 |
| 20 | g17037.t1 | Gene3D | G3DSA:2.60.40.10 | Immunoglobulins | 939 | 1045 | 1.1E-14 |
| 21 | g17037.t1 | Gene3D | G3DSA:3.30.200.20 | Phosphorylase Kinase; domain 1 | 1082 | 1187 | 8.7E-32 |
| 22 | g17037.t1 | Gene3D | G3DSA:1.10.510.10 | Transferase(Phosphotransferase) domain 1 | 1188 | 1396 | 2.2E-64 |
| 5 | g17037.t1 | PANTHER | PTHR24416:SF106 | INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR | 259 | 1392 | 3.8E-272 |
| 6 | g17037.t1 | PANTHER | PTHR24416 | TYROSINE-PROTEIN KINASE RECEPTOR | 259 | 1392 | 3.8E-272 |
| 9 | g17037.t1 | PRINTS | PR00109 | Tyrosine kinase catalytic domain signature | 1186 | 1199 | 5.1E-32 |
| 11 | g17037.t1 | PRINTS | PR00109 | Tyrosine kinase catalytic domain signature | 1235 | 1253 | 5.1E-32 |
| 8 | g17037.t1 | PRINTS | PR00109 | Tyrosine kinase catalytic domain signature | 1284 | 1294 | 5.1E-32 |
| 10 | g17037.t1 | PRINTS | PR00109 | Tyrosine kinase catalytic domain signature | 1303 | 1325 | 5.1E-32 |
| 7 | g17037.t1 | PRINTS | PR00109 | Tyrosine kinase catalytic domain signature | 1347 | 1369 | 5.1E-32 |
| 3 | g17037.t1 | Pfam | PF01030 | Receptor L domain | 128 | 239 | 5.9E-23 |
| 1 | g17037.t1 | Pfam | PF00757 | Furin-like cysteine rich region | 260 | 416 | 3.1E-23 |
| 2 | g17037.t1 | Pfam | PF01030 | Receptor L domain | 432 | 546 | 5.6E-24 |
| 4 | g17037.t1 | Pfam | PF07714 | Protein tyrosine and serine/threonine kinase | 1109 | 1376 | 1.4E-93 |
| 27 | g17037.t1 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. | 1 | 43 | - |
| 30 | g17037.t1 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 44 | 64 | - |
| 28 | g17037.t1 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. | 65 | 1045 | - |
| 29 | g17037.t1 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 1046 | 1068 | - |
| 26 | g17037.t1 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. | 1069 | 1436 | - |
| 46 | g17037.t1 | ProSitePatterns | PS00107 | Protein kinases ATP-binding region signature. | 1112 | 1140 | - |
| 44 | g17037.t1 | ProSitePatterns | PS00109 | Tyrosine protein kinases specific active-site signature. | 1241 | 1253 | - |
| 45 | g17037.t1 | ProSitePatterns | PS00239 | Receptor tyrosine kinase class II signature. | 1269 | 1277 | - |
| 47 | g17037.t1 | ProSiteProfiles | PS51379 | 4Fe-4S ferredoxin-type iron-sulfur binding domain profile. | 393 | 426 | 7.156 |
| 48 | g17037.t1 | ProSiteProfiles | PS50853 | Fibronectin type-III domain profile. | 577 | 695 | 12.474 |
| 49 | g17037.t1 | ProSiteProfiles | PS50853 | Fibronectin type-III domain profile. | 817 | 936 | 6.541 |
| 50 | g17037.t1 | ProSiteProfiles | PS50853 | Fibronectin type-III domain profile. | 942 | 1040 | 9.989 |
| 51 | g17037.t1 | ProSiteProfiles | PS50011 | Protein kinase domain profile. | 1106 | 1390 | 35.538 |
| 43 | g17037.t1 | SMART | SM00261 | furin_3 | 305 | 351 | 5.7E-7 |
| 39 | g17037.t1 | SMART | SM00060 | FN3_2 | 580 | 680 | 0.37 |
| 41 | g17037.t1 | SMART | SM00060 | FN3_2 | 697 | 914 | 1.1E-4 |
| 40 | g17037.t1 | SMART | SM00060 | FN3_2 | 939 | 1027 | 27.0 |
| 42 | g17037.t1 | SMART | SM00219 | tyrkin_6 | 1106 | 1376 | 3.8E-133 |
| 17 | g17037.t1 | SUPERFAMILY | SSF52058 | L domain-like | 111 | 278 | 1.02E-35 |
| 15 | g17037.t1 | SUPERFAMILY | SSF57184 | Growth factor receptor domain | 256 | 413 | 8.37E-8 |
| 16 | g17037.t1 | SUPERFAMILY | SSF52058 | L domain-like | 410 | 580 | 1.64E-36 |
| 12 | g17037.t1 | SUPERFAMILY | SSF49265 | Fibronectin type III | 579 | 694 | 9.35E-26 |
| 14 | g17037.t1 | SUPERFAMILY | SSF49265 | Fibronectin type III | 696 | 915 | 2.61E-12 |
| 13 | g17037.t1 | SUPERFAMILY | SSF49265 | Fibronectin type III | 879 | 1037 | 4.15E-15 |
| 18 | g17037.t1 | SUPERFAMILY | SSF56112 | Protein kinase-like (PK-like) | 1076 | 1376 | 2.32E-78 |
| 38 | g17037.t1 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. | 42 | 64 | - |
| 37 | g17037.t1 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. | 1046 | 1068 | - |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0016020 | membrane | CC |
| GO:0005524 | ATP binding | MF |
| GO:0006468 | protein phosphorylation | BP |
| GO:0004713 | protein tyrosine kinase activity | MF |
| GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | BP |
| GO:0005515 | protein binding | MF |
| GO:0004672 | protein kinase activity | MF |
| GO:0004714 | transmembrane receptor protein tyrosine kinase activity | MF |
KEGG
Orthology
- This transcript has been annotated with K05087 (insulin-like growth factor 1 receptor)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
