Gene loci information

Transcript annotation

  • This transcript has been annotated as Kelch-like ECH-associated protein 1.

Parent gene

Gene structure

  • The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.

Chromosome Gene Transcript Category ID Start End
chr_3 g2670 g2670.t1 TSS g2670.t1 19482638 19482638
chr_3 g2670 g2670.t1 isoform g2670.t1 19482901 19488669
chr_3 g2670 g2670.t1 exon g2670.t1.exon1 19482901 19482951
chr_3 g2670 g2670.t1 cds g2670.t1.CDS1 19482901 19482951
chr_3 g2670 g2670.t1 exon g2670.t1.exon2 19485815 19485976
chr_3 g2670 g2670.t1 cds g2670.t1.CDS2 19485815 19485976
chr_3 g2670 g2670.t1 exon g2670.t1.exon3 19486038 19486130
chr_3 g2670 g2670.t1 cds g2670.t1.CDS3 19486038 19486130
chr_3 g2670 g2670.t1 exon g2670.t1.exon4 19486188 19486705
chr_3 g2670 g2670.t1 cds g2670.t1.CDS4 19486188 19486705
chr_3 g2670 g2670.t1 exon g2670.t1.exon5 19486781 19487119
chr_3 g2670 g2670.t1 cds g2670.t1.CDS5 19486781 19487119
chr_3 g2670 g2670.t1 exon g2670.t1.exon6 19487233 19487373
chr_3 g2670 g2670.t1 cds g2670.t1.CDS6 19487233 19487373
chr_3 g2670 g2670.t1 exon g2670.t1.exon7 19487438 19487525
chr_3 g2670 g2670.t1 cds g2670.t1.CDS7 19487438 19487525
chr_3 g2670 g2670.t1 exon g2670.t1.exon8 19487601 19487738
chr_3 g2670 g2670.t1 cds g2670.t1.CDS8 19487601 19487738
chr_3 g2670 g2670.t1 exon g2670.t1.exon9 19487792 19487947
chr_3 g2670 g2670.t1 cds g2670.t1.CDS9 19487792 19487947
chr_3 g2670 g2670.t1 exon g2670.t1.exon10 19488019 19488669
chr_3 g2670 g2670.t1 cds g2670.t1.CDS10 19488019 19488669
chr_3 g2670 g2670.t1 TTS g2670.t1 19488983 19488983

Sequences

>g2670.t1 Gene=g2670 Length=2337
ATGAGAAATGATAATTTAATGACATCACACAAAAAAATTAGATTATCACAGTATTCAGCG
GACACAATGGATACGACAGATGATGATGACATATTAATGACTGCATCGTCGTCACCACCG
CAATCAAAATCGTCAGATGATCTCGGCGACATGACATTTTGCATGTCAAATTATGCGAAA
GAAGTCCTGAGAATGATGTACATGATGCGACAGCATCACATGCTCACCGATTGTGTTCTT
GAAGTAGACAATGAGCTGTTTCATGTTCATAAAGTTGTATTATCATCAGCTAGTCCTTAT
TTCAAAGCAATGTTCACAGGTGGATTGAAAGAATGTGAGATGTCACGCGTTAGACTTCAA
GGTGTTTGTCCAACATCAATGGCAAAAATTATCACATTTATGTACACAGGAAAGATTCAT
GTGTCAGAAGTGACTGTTTGTCAGTTATTACCTGCTGCTACAATGTTTCAAGTTCCCAAT
GTGATAGAAGCATGTTGTGCTTTTCTAGAACGTCAATTAGATCCAACTAACGCAATAGGA
ATTGCAAATTTTGCCGAACAACATGGTTGCGCAATTCTACGGCAAAAAGCTAACCAATTT
ATTGAGAGACATTTTACTCAGATTTGTCAAGAGGAAGAATTTTTACAACTTTCAGCAATG
CAGCTTGTTAATCTAATAAGAAAAGATGAGCTGAATGTACAGGATGAAAGAGAAGTTTAT
AATGCTGTTTTAAAATGGGTGAAATATGATGAAGATAATAGATATCCAAAGATGGAACAT
ATACTCTATGCAGTACGATGTCAATTCCTTACACCAAAATTCTTAAAAGAGCAAATGAAG
AACTGTGATGTTTTGAAAAAAGTGCCAGCGTGCCGTGAGTATTTGGCAAAAATCTTCAAG
GACCTTACATTACACAAGCGTCCAATTGTAAAAGAACGAAAACCAAATACAACTAGAATG
ATTTTTGTCGCTGGTGGCTATTTTCAACACTCATTAGACATACTCGAAGGCTATAATGTA
GATGATAGAACGTGGACAACACTTCCAAAGTTAACAGTGCCGCGTTCAGGTTTAGGTGCT
GCATTTTTGAAAGGAACTTTTTATGCAGTAGGTGGCAGAAATAATGCTCCTGGAGCGTCA
TATGATTCGGACTGGGTAGATAGATATGACCCAATAACAGAGCAATGGAGACCGTGTGCG
CCCATGAGTGTACCTAGAAATCGAGTAGGTGTTGCAACAATGGATGATTTTCTTTATGCT
GTTGGTGGCTCATCTGGCTCGGAATATCATAATTCTGTTGAATATTTTGATCCTGAACAA
GATAGATGGTTTGTTATTGCACCAATGCGCTCAAAAAGATTGGCTGTTGGTGTTGCTGTC
GTAAATAGATTGCTCTATGCTATAGGTGGCTTTGATGGTGAAAATAGATTAGCTTCCATG
GAATGTTATCATCCAGAAAATAATGAATGGACAGATATGCCACCAATGAAATATCCACGT
TCTGGGGCTGGCGTTGCTGTTCTCAATCAATACATTTATGTAGTTGGTGGTTTTGACGGC
ACAAGACAGTTAGCATCAGTTGAGAGATTTGATACAGATAATAAAACATGGGAGATTGTT
ACACCAATGAAAACATCACGAAGTGCATTATCAGTTAATGTGATTGATGGAAAATTATAC
GCTATGGGTGGATATGACGGCACACATTTTCTATCAAATGTTGAAGTCTATAATCCAGTA
GATGATGTTTGGGAAGATGGAATACCATTGACATCAGGTCGTTCAGGATTGGCTTCAGCT
GTGATTTATCAACCATCTTGTCCTCAAACATATTCCCAGGATTCATCAATAATTCAACAC
TCTGCCAATCGAGAATATGATGATAATGGAAAATCATCAGACATTCAAGGAGGTAGTGGA
AATTCTTCTATAAATTTTGGTTACTCAAGTAATGTTAATCAGAGAGGCTCATGTGGTCAA
GGTAGTGGTGGTCTAAGAGATCAATCTGATCTAATAAACTGTGATGATGAAGAATGTGAA
AAAAGTCCAGTAAAAAAGGATAAAAATAATACATGTATATTTTTACGTATGCATTCGAGA
TTTAAATGTAATCGCAGCAACAATAACGAGACTAGAAAAGATAAATTCATTAATTCAACT
ACAATTAATTATCATGAGCATCAAAGCAAATGTAATGGTTTAATTAAAAAGCATTCAAAA
TGCAAAGTCAATCCGTGTCCTATTCAACGGTTAACGCAAAAAATTCAACATTTTGTATCA
AATCGACGAAAATATTGTGATTATCAAAGCAGACTTAAAGAAAGTGAAGAAAATTAA

>g2670.t1 Gene=g2670 Length=778
MRNDNLMTSHKKIRLSQYSADTMDTTDDDDILMTASSSPPQSKSSDDLGDMTFCMSNYAK
EVLRMMYMMRQHHMLTDCVLEVDNELFHVHKVVLSSASPYFKAMFTGGLKECEMSRVRLQ
GVCPTSMAKIITFMYTGKIHVSEVTVCQLLPAATMFQVPNVIEACCAFLERQLDPTNAIG
IANFAEQHGCAILRQKANQFIERHFTQICQEEEFLQLSAMQLVNLIRKDELNVQDEREVY
NAVLKWVKYDEDNRYPKMEHILYAVRCQFLTPKFLKEQMKNCDVLKKVPACREYLAKIFK
DLTLHKRPIVKERKPNTTRMIFVAGGYFQHSLDILEGYNVDDRTWTTLPKLTVPRSGLGA
AFLKGTFYAVGGRNNAPGASYDSDWVDRYDPITEQWRPCAPMSVPRNRVGVATMDDFLYA
VGGSSGSEYHNSVEYFDPEQDRWFVIAPMRSKRLAVGVAVVNRLLYAIGGFDGENRLASM
ECYHPENNEWTDMPPMKYPRSGAGVAVLNQYIYVVGGFDGTRQLASVERFDTDNKTWEIV
TPMKTSRSALSVNVIDGKLYAMGGYDGTHFLSNVEVYNPVDDVWEDGIPLTSGRSGLASA
VIYQPSCPQTYSQDSSIIQHSANREYDDNGKSSDIQGGSGNSSINFGYSSNVNQRGSCGQ
GSGGLRDQSDLINCDDEECEKSPVKKDKNNTCIFLRMHSRFKCNRSNNNETRKDKFINST
TINYHEHQSKCNGLIKKHSKCKVNPCPIQRLTQKIQHFVSNRRKYCDYQSRLKESEEN

Protein features from InterProScan

Transcript Database ID Name Start End E.value
18 g2670.t1 CDD cd18458 BACK_KLHL19_KEAP1 172 262 0.0000000
17 g2670.t1 Gene3D G3DSA:3.30.710.10 Potassium Channel Kv1.1; Chain A 44 174 0.0000000
15 g2670.t1 Gene3D G3DSA:1.25.40.420 - 175 296 0.0000000
16 g2670.t1 Gene3D G3DSA:2.120.10.80 - 304 617 0.0000000
8 g2670.t1 PANTHER PTHR24412 KELCH PROTEIN 44 597 0.0000000
9 g2670.t1 PANTHER PTHR24412:SF401 FI11917P 44 597 0.0000000
12 g2670.t1 PRINTS PR00501 Kelch repeat signature 462 475 0.0000075
11 g2670.t1 PRINTS PR00501 Kelch repeat signature 479 493 0.0000075
10 g2670.t1 PRINTS PR00501 Kelch repeat signature 494 506 0.0000075
7 g2670.t1 Pfam PF00651 BTB/POZ domain 68 172 0.0000000
1 g2670.t1 Pfam PF07707 BTB And C-terminal Kelch 179 279 0.0000000
6 g2670.t1 Pfam PF01344 Kelch motif 354 403 0.0000000
5 g2670.t1 Pfam PF01344 Kelch motif 405 450 0.0000000
3 g2670.t1 Pfam PF01344 Kelch motif 454 496 0.0000000
2 g2670.t1 Pfam PF01344 Kelch motif 499 543 0.0000000
4 g2670.t1 Pfam PF01344 Kelch motif 547 585 0.0000000
27 g2670.t1 ProSiteProfiles PS50097 BTB domain profile. 76 143 20.1060000
19 g2670.t1 SMART SM00225 BTB_4 76 173 0.0000000
20 g2670.t1 SMART SM00875 BACK_2 178 280 0.0000000
25 g2670.t1 SMART SM00612 kelc_smart 320 365 0.0000087
21 g2670.t1 SMART SM00612 kelc_smart 366 416 0.0000000
26 g2670.t1 SMART SM00612 kelc_smart 417 463 0.0000000
24 g2670.t1 SMART SM00612 kelc_smart 464 510 0.0000000
23 g2670.t1 SMART SM00612 kelc_smart 511 557 0.0000000
22 g2670.t1 SMART SM00612 kelc_smart 558 604 0.0000000
14 g2670.t1 SUPERFAMILY SSF54695 POZ domain 52 171 0.0000000
13 g2670.t1 SUPERFAMILY SSF117281 Kelch motif 320 601 0.0000000

Transmembrane regions from TMHMM

Disordered region

IUPRED3 score over 0.5 is predictive of a disordered region.

GO terms from InterProScan

GOID TERM ONTOLOGY
GO:0005515 protein binding MF

KEGG

Orthology

Pathway

  • This transcript belongs to the following pathways

Expression

Transcript expression in Pv11 cells

TPM values are indicated as average +/- STDEV.

Differential expression

Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.

Raw TPM values