Gene loci information

Transcript annotation

  • This transcript has been annotated as Dihydrolipoyl dehydrogenase, mitochondrial.

Parent gene

Gene structure

  • The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.

Chromosome Gene Transcript Category ID Start End
chr_3 g2842 g2842.t4 TSS g2842.t4 20511705 20511705
chr_3 g2842 g2842.t4 isoform g2842.t4 20511806 20513635
chr_3 g2842 g2842.t4 exon g2842.t4.exon1 20511806 20511850
chr_3 g2842 g2842.t4 cds g2842.t4.CDS1 20511806 20511850
chr_3 g2842 g2842.t4 exon g2842.t4.exon2 20511981 20512071
chr_3 g2842 g2842.t4 cds g2842.t4.CDS2 20511981 20512071
chr_3 g2842 g2842.t4 exon g2842.t4.exon3 20512136 20513361
chr_3 g2842 g2842.t4 cds g2842.t4.CDS3 20512136 20513361
chr_3 g2842 g2842.t4 exon g2842.t4.exon4 20513423 20513512
chr_3 g2842 g2842.t4 cds g2842.t4.CDS4 20513423 20513512
chr_3 g2842 g2842.t4 exon g2842.t4.exon5 20513570 20513635
chr_3 g2842 g2842.t4 cds g2842.t4.CDS5 20513570 20513635
chr_3 g2842 g2842.t4 TTS g2842.t4 20513825 20513825

Sequences

>g2842.t4 Gene=g2842 Length=1518
ATGCAAGCAAACATTAGACAAGTTGCTTCATTATTTTCAAAGGTACTAAATATCAATACA
ATCCATCGTTCAGCCGCTGTACTTCAATGTCGTGCTTATTCGACAACGCATGATGCCGAT
TTAGTTGTTATTGGAGGTGGTCCAGGAGGATATGTCGCAGCAATTAAGGGCGCTCAAGTT
GGACTTAACACAGTTTGTATTGAAAAGAATGATACACTCGGTGGCACTTGTCTCAATGTT
GGATGCATTCCTTCAAAAGCTCTTCTCAACAACTCGCATTATTATCATATGGCACACTCT
GGTGACCTCAATAATCGCGGTATCACTGTTGGAAATGTGTCATTAGACTTGGAGAAAATG
ATGGGTCAAAAGTCAAACGCCGTAAAGTCACTGACCGGAGGAATTGCACAGTTATTTAAA
AAGAACAAAGTTACACATCTCAACGGTTGGGGACAAATCACAGGTCCAAATCAAGTTCAA
GCAAAAATGAAGGATGGTTCAGTCGAGACAGTAAATACAAAATACATGATCATTGCTAGC
GGTTCTGAAGTCACACCTTTCCCAGGAGTAACAATTGATGAGGAAGTTATTGTGTCAAGT
ACTGGTGCTTTGAGTTTAAAACAAGTTCCTAAGAAAATGGTCGTAATTGGAGCTGGTGTT
ATTGGTCTCGAATTAGGATCAGTTTGGTCACGTCTTGGCGCAGAAGTTATTGCCGTTGAA
TTCTTAAATAGCATTGGAGGAGTTGGAATTGATGGTGAAGTATCAAAAACCTTCCAAAAA
GTTCTCACAAAACAAGGAATGCAATTTAGACTCGGTACAAAAGTGACTGGTGCACAACGT
ACTGGCAATGGAGCTGTAGTCTCAGTCGAATCAGTAAAAGACGGTTCAAAGGAAGATATT
GAATGTGATGTTCTTCTTGTTTGTATTGGTCGTCGTCCATTTACAGAAGGATTAGGTCTC
GAAAATGTTGGAATTGCAACTGACGATCGTGGTAGAATCCCTGTTAATGCAATGCTTCAA
ACTATTGTACCTAATATTCATGCAATCGGCGATGTAATTCATGGACCTATGTTGGCGCAC
AAAGCTGAAGATGAGGGAATAATCTGTGTTGAAGGAATTATGGGTGGTCACGTACATCTT
GATTATAATTGTGTGCCCTCAGTTGTATATACACATCCAGAAGTTGCATGGGTTGGAAAA
TCTGAAGAGGATCTGAAAAAAGAAGGAGTCGAATACAAAGTTGGCAAATTTCCATACATG
GCAAACTCTCGTGCTAAGACAAATAATGAAACAGACGGATTTGTAAAAGTTCTTGCCGAC
AAAGCAACAGACCGCATTTTGGGAACACATATGATCGGACCGGGTGTGGGAGAATTAATA
AATGAAGCTGTTTTGGCTATGGAATATGGTGCATCGGCAGAAGATGTTGCACGAGTGTGT
CACGCTCATCCTACCTGTGCTGAAGCTCTGAGAGAAGCAAATCTGGCTGCATATATCGGT
AAACCAATTAACTTCTAA

>g2842.t4 Gene=g2842 Length=505
MQANIRQVASLFSKVLNINTIHRSAAVLQCRAYSTTHDADLVVIGGGPGGYVAAIKGAQV
GLNTVCIEKNDTLGGTCLNVGCIPSKALLNNSHYYHMAHSGDLNNRGITVGNVSLDLEKM
MGQKSNAVKSLTGGIAQLFKKNKVTHLNGWGQITGPNQVQAKMKDGSVETVNTKYMIIAS
GSEVTPFPGVTIDEEVIVSSTGALSLKQVPKKMVVIGAGVIGLELGSVWSRLGAEVIAVE
FLNSIGGVGIDGEVSKTFQKVLTKQGMQFRLGTKVTGAQRTGNGAVVSVESVKDGSKEDI
ECDVLLVCIGRRPFTEGLGLENVGIATDDRGRIPVNAMLQTIVPNIHAIGDVIHGPMLAH
KAEDEGIICVEGIMGGHVHLDYNCVPSVVYTHPEVAWVGKSEEDLKKEGVEYKVGKFPYM
ANSRAKTNNETDGFVKVLADKATDRILGTHMIGPGVGELINEAVLAMEYGASAEDVARVC
HAHPTCAEALREANLAAYIGKPINF

Protein features from InterProScan

Transcript Database ID Name Start End E.value
21 g2842.t4 Gene3D G3DSA:3.50.50.60 - 40 367 4.2E-121
22 g2842.t4 Gene3D G3DSA:3.50.50.60 - 185 309 4.2E-121
23 g2842.t4 Gene3D G3DSA:3.30.390.30 - 382 505 2.8E-48
3 g2842.t4 PANTHER PTHR22912:SF151 DIHYDROLIPOYL DEHYDROGENASE, MITOCHONDRIAL 36 505 9.1E-225
4 g2842.t4 PANTHER PTHR22912 DISULFIDE OXIDOREDUCTASE 36 505 9.1E-225
24 g2842.t4 PIRSF PIRSF000350 Hg-II_reductase_MerA 11 498 1.7E-87
10 g2842.t4 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 40 62 1.2E-78
6 g2842.t4 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 41 60 9.5E-34
17 g2842.t4 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 73 88 1.2E-78
7 g2842.t4 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 173 191 9.5E-34
15 g2842.t4 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 176 185 1.2E-78
8 g2842.t4 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 212 230 9.5E-34
18 g2842.t4 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 212 237 1.2E-78
5 g2842.t4 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 302 318 9.5E-34
11 g2842.t4 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 303 317 1.2E-78
9 g2842.t4 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 331 353 9.5E-34
13 g2842.t4 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 346 353 1.2E-78
16 g2842.t4 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 381 402 1.2E-78
12 g2842.t4 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 446 461 1.2E-78
14 g2842.t4 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 468 488 1.2E-78
1 g2842.t4 Pfam PF07992 Pyridine nucleotide-disulphide oxidoreductase 40 366 5.8E-65
2 g2842.t4 Pfam PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 385 493 3.6E-41
25 g2842.t4 ProSitePatterns PS00076 Pyridine nucleotide-disulphide oxidoreductases class-I active site. 74 84 -
20 g2842.t4 SUPERFAMILY SSF51905 FAD/NAD(P)-binding domain 35 403 1.13E-61
19 g2842.t4 SUPERFAMILY SSF55424 FAD/NAD-linked reductases, dimerisation (C-terminal) domain 381 497 2.75E-44
26 g2842.t4 TIGRFAM TIGR01350 lipoamide_DH: dihydrolipoyl dehydrogenase 39 503 1.0E-160

Transmembrane regions from TMHMM

Disordered region

IUPRED3 score over 0.5 is predictive of a disordered region.

GO terms from InterProScan

GOID TERM ONTOLOGY
GO:0004148 dihydrolipoyl dehydrogenase activity MF
GO:0050660 flavin adenine dinucleotide binding MF
GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor MF
GO:0055114 NA NA
GO:0045454 cell redox homeostasis BP
GO:0016491 oxidoreductase activity MF

KEGG

Orthology

Pathway

  • This transcript belongs to the following pathways

Expression

Transcript expression in Pv11 cells

TPM values are indicated as average +/- STDEV.

Differential expression

Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below. There were no conditions that were differentially expressed