Gene loci information

Transcript annotation

  • This transcript has been annotated as Dihydrolipoyl dehydrogenase, mitochondrial.

Parent gene

Gene structure

  • The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.

Chromosome Gene Transcript Category ID Start End
chr_3 g2842 g2842.t8 TSS g2842.t8 20511705 20511705
chr_3 g2842 g2842.t8 isoform g2842.t8 20512728 20513635
chr_3 g2842 g2842.t8 exon g2842.t8.exon1 20512728 20513361
chr_3 g2842 g2842.t8 cds g2842.t8.CDS1 20512798 20513361
chr_3 g2842 g2842.t8 exon g2842.t8.exon2 20513433 20513512
chr_3 g2842 g2842.t8 cds g2842.t8.CDS2 20513433 20513438
chr_3 g2842 g2842.t8 exon g2842.t8.exon3 20513570 20513635
chr_3 g2842 g2842.t8 TTS g2842.t8 20513825 20513825

Sequences

>g2842.t8 Gene=g2842 Length=780
TAGCATTGGAGGAGTTGGAATTGATGGTGAAGTATCAAAAACCTTCCAAAAAGTTCTCAC
AAAACAAGGAATGCAATTTAGACTCGGTACAAAAGTGACTGGTGCACAACGTACTGGCAA
TGGAGCTGTAGTCTCAGTCGAATCAGTAAAAGACGGTTCAAAGGAAGATATTGAATGTGA
TGTTCTTCTTGTTTGTATTGGTCGTCGTCCATTTACAGAAGGATTAGGTCTCGAAAATGT
TGGAATTGCAACTGACGATCGTGGTAGAATCCCTGTTAATGCAATGCTTCAAACTATTGT
ACCTAATATTCATGCAATCGGCGATGTAATTCATGGACCTATGTTGGCGCACAAAGCTGA
AGATGAGGGAATAATCTGTGTTGAAGGAATTATGGGTGGTCACGTACATCTTGATTATAA
TTGTGTGCCCTCAGTTGTATATACACATCCAGAAGTTGCATGGGTTGGAAAATCTGAAGA
GGATCTGAAAAAAGAAGGAGTCGAATACAAAGTTGGCAAATTTCCATACATGGCAAACTC
TCGTGCTAAGACAAATAATGAAACAGACGGATTTGTAAAAGTTCTTGCCGACAAAGCAAC
AGACCGCATTTTGGGAACACATATGATCGGACCGAATTAATAAATGAAGCTGTTTTGGCT
ATGGAATATGGTGCATCGGCAGAAGATGTTGCACGAGTGTGTCACGCTCATCCTACCTGT
GCTGAAGCTCTGAGAGAAGCAAATCTGGCTGCATATATCGGTAAACCAATTAACTTCTAA

>g2842.t8 Gene=g2842 Length=189
MQFRLGTKVTGAQRTGNGAVVSVESVKDGSKEDIECDVLLVCIGRRPFTEGLGLENVGIA
TDDRGRIPVNAMLQTIVPNIHAIGDVIHGPMLAHKAEDEGIICVEGIMGGHVHLDYNCVP
SVVYTHPEVAWVGKSEEDLKKEGVEYKVGKFPYMANSRAKTNNETDGFVKVLADKATDRI
LGTHMIGPN

Protein features from InterProScan

Transcript Database ID Name Start End E.value
14 g2842.t8 Gene3D G3DSA:3.50.50.60 - 1 43 0
13 g2842.t8 Gene3D G3DSA:3.50.50.60 - 44 105 0
15 g2842.t8 Gene3D G3DSA:3.30.390.30 - 116 189 0
3 g2842.t8 PANTHER PTHR22912:SF151 DIHYDROLIPOYL DEHYDROGENASE, MITOCHONDRIAL 1 189 0
4 g2842.t8 PANTHER PTHR22912 DISULFIDE OXIDOREDUCTASE 1 189 0
6 g2842.t8 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 36 52 0
7 g2842.t8 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 37 51 0
5 g2842.t8 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 65 87 0
8 g2842.t8 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 80 87 0
10 g2842.t8 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 115 136 0
9 g2842.t8 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 180 189 0
1 g2842.t8 Pfam PF07992 Pyridine nucleotide-disulphide oxidoreductase 2 100 0
2 g2842.t8 Pfam PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 119 189 0
12 g2842.t8 SUPERFAMILY SSF51905 FAD/NAD(P)-binding domain 2 138 0
11 g2842.t8 SUPERFAMILY SSF55424 FAD/NAD-linked reductases, dimerisation (C-terminal) domain 115 189 0

Transmembrane regions from TMHMM

Disordered region

IUPRED3 score over 0.5 is predictive of a disordered region.

GO terms from InterProScan

GOID TERM ONTOLOGY
GO:0050660 flavin adenine dinucleotide binding MF
GO:0055114 NA NA
GO:0045454 cell redox homeostasis BP
GO:0016491 oxidoreductase activity MF

KEGG

Orthology

This gene did not have any KEGG ortholog annotations (KAAS, GHOSTZ).

Expression

Transcript expression in Pv11 cells

TPM values are indicated as average +/- STDEV.

Differential expression

Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.

Raw TPM values