Gene loci information

Transcript annotation

  • This transcript has been annotated as Hexokinase type 2.

Parent gene

Gene structure

  • The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.

Chromosome Gene Transcript Category ID Start End
chr_3 g2925 g2925.t26 TSS g2925.t26 21267310 21267310
chr_3 g2925 g2925.t26 isoform g2925.t26 21267719 21273029
chr_3 g2925 g2925.t26 exon g2925.t26.exon1 21267719 21267778
chr_3 g2925 g2925.t26 cds g2925.t26.CDS1 21267719 21267778
chr_3 g2925 g2925.t26 exon g2925.t26.exon2 21271023 21271185
chr_3 g2925 g2925.t26 cds g2925.t26.CDS2 21271023 21271185
chr_3 g2925 g2925.t26 exon g2925.t26.exon3 21271251 21271435
chr_3 g2925 g2925.t26 cds g2925.t26.CDS3 21271251 21271435
chr_3 g2925 g2925.t26 exon g2925.t26.exon4 21271497 21271670
chr_3 g2925 g2925.t26 cds g2925.t26.CDS4 21271497 21271670
chr_3 g2925 g2925.t26 exon g2925.t26.exon5 21272698 21272797
chr_3 g2925 g2925.t26 cds g2925.t26.CDS5 21272698 21272797
chr_3 g2925 g2925.t26 exon g2925.t26.exon6 21272950 21273029
chr_3 g2925 g2925.t26 cds g2925.t26.CDS6 21272950 21273029
chr_3 g2925 g2925.t26 TTS g2925.t26 21274027 21274027

Sequences

>g2925.t26 Gene=g2925 Length=762
ATGGATTTGATAAAAAATATAAAGGACATAATTATTGGAGAACGAAGTAATTCGGATCTC
ATCAAGGAAGCCTGTCAGGAGTTGATATTGGATGACAAAACAATGAGAGAAATCATGAAG
AGATTTCTTCATGAAATTCAACTTGGGTTAAAGAAAGAGACACATCCAGCAGCTGACATT
AAGTGCTTCATAACTTACGTTCAAGATTTGCCAAATGGAAAAGAAAAAGGCAGATTCCTT
GCATTGGATTTAGGTGGTACGAATTTCCGTGTCCTTCTTATTCATCTCAAAGGTGACAGT
GAGTTCGAAATGCAATCAAAGATTTACGCCATCCCACAAAGTATTATGATTGGTTCGGGA
ACACAATTGTTTGACCATATTGCTGAATGTCTTGCAAATTTCATCAAGGAACATAAACTT
CAAAATGAACGGCTGCCATTAGGTTTTACTTTCTCCTTCCCTCTTAAACAGTTAGGTTTA
ACAAAGGGTATTTTAATCAGATGGACTAAAGGTTTCAATTGTGAGGGAGTTGTTGATCGT
GATGTCGTTGAACTGTTAGAAGAGGCATTAAAAAGACGTGGAGATGTTTCTATTGAAATT
TGTGCTATTCTTAATGATACAACTGGAACTCTTATGTCATGTGCCTGGAAAAATCACAAC
TGTAAAATCGGAGCTATTGTTGGTACTGGAAGTAATGCATGTTACGTAGAGCGTGTTGAG
AATGCAGAACTTTACGATGGTCCAGCAAATGGAAAAGAATAT

>g2925.t26 Gene=g2925 Length=254
MDLIKNIKDIIIGERSNSDLIKEACQELILDDKTMREIMKRFLHEIQLGLKKETHPAADI
KCFITYVQDLPNGKEKGRFLALDLGGTNFRVLLIHLKGDSEFEMQSKIYAIPQSIMIGSG
TQLFDHIAECLANFIKEHKLQNERLPLGFTFSFPLKQLGLTKGILIRWTKGFNCEGVVDR
DVVELLEEALKRRGDVSIEICAILNDTTGTLMSCAWKNHNCKIGAIVGTGSNACYVERVE
NAELYDGPANGKEY

Protein features from InterProScan

Transcript Database ID Name Start End E.value
12 g2925.t26 CDD cd00012 NBD_sugar-kinase_HSP70_actin 80 237 5.29388E-9
11 g2925.t26 Gene3D G3DSA:3.30.420.40 - 53 237 1.9E-75
3 g2925.t26 PANTHER PTHR19443:SF4 HEXOKINASE-2 21 247 2.1E-97
4 g2925.t26 PANTHER PTHR19443 HEXOKINASE 21 247 2.1E-97
6 g2925.t26 PRINTS PR00475 Hexokinase family signature 80 96 1.6E-37
7 g2925.t26 PRINTS PR00475 Hexokinase family signature 147 172 1.6E-37
8 g2925.t26 PRINTS PR00475 Hexokinase family signature 200 216 1.6E-37
5 g2925.t26 PRINTS PR00475 Hexokinase family signature 223 237 1.6E-37
2 g2925.t26 Pfam PF00349 Hexokinase 21 216 1.8E-72
1 g2925.t26 Pfam PF03727 Hexokinase 222 247 1.1E-5
13 g2925.t26 ProSitePatterns PS00378 Hexokinase domain signature. 147 172 -
14 g2925.t26 ProSiteProfiles PS51748 Hexokinase domain profile. 15 254 30.019
10 g2925.t26 SUPERFAMILY SSF53067 Actin-like ATPase domain 18 218 3.68E-78
9 g2925.t26 SUPERFAMILY SSF53067 Actin-like ATPase domain 220 247 4.26E-6

Transmembrane regions from TMHMM

Disordered region

IUPRED3 score over 0.5 is predictive of a disordered region.

GO terms from InterProScan

GOID TERM ONTOLOGY
GO:0001678 cellular glucose homeostasis BP
GO:0005524 ATP binding MF
GO:0016773 phosphotransferase activity, alcohol group as acceptor MF
GO:0006096 glycolytic process BP
GO:0005975 carbohydrate metabolic process BP
GO:0005536 glucose binding MF
GO:0004396 hexokinase activity MF

KEGG

Orthology

This gene did not have any KEGG ortholog annotations (KAAS, GHOSTZ).

Expression

Transcript expression in Pv11 cells

TPM values are indicated as average +/- STDEV.

Differential expression

Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below. There were no conditions that were differentially expressed