Gene loci information

Transcript annotation

  • This transcript has been annotated as Alpha-mannosidase 2.

Parent gene

Gene structure

  • The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.

Chromosome Gene Transcript Category ID Start End
chr_3 g2966 g2966.t5 isoform g2966.t5 21618544 21619835
chr_3 g2966 g2966.t5 exon g2966.t5.exon1 21618544 21619500
chr_3 g2966 g2966.t5 cds g2966.t5.CDS1 21618545 21619495
chr_3 g2966 g2966.t5 exon g2966.t5.exon2 21619728 21619835
chr_3 g2966 g2966.t5 TSS g2966.t5 21620868 21620868
chr_3 g2966 g2966.t5 TTS g2966.t5 NA NA

Sequences

>g2966.t5 Gene=g2966 Length=1065
ATTAATAAAGAATAAGCAACTTGAGTTTGTCACGGGTGGTTGGGTAATGACAGATGAAGC
AGCATCACATTGGTATTCGATTCTCCAATCTTTAACTGAGGGCCAAGTACATGATGCCAT
TCTATTCATATGATGTTCCTCATACATGTGGTCCCGATCCGAAAATTTGTTGTCAGTTTG
ATTTCAAAAGACTTCCTGGTTATGGACTAAGCTGCCCATGGAAAGTTCCGCCGGTTCCTA
TCACTGACGATAATGTGGCAAAAAGAGCAGAAATGATAGTTGATCAATGGAGGAAAAAGT
CTGTTTTGTATAAAACTCGGTCAGTGTTGATACCGTTGGGTGATGATTTTCGTTACACTC
AATCAATGGAATGGGAAGCACAGCGTGTGAATTTTGAAAAAATATTTGAATATGTAAACA
ATGAACCCAGTTTTAACGTTGAAGCGAAATTTGCCACGCTGCAAGAATATTTCGATTCAG
TGCGTCATGAAAAAGGAACAAATCAATTTCCAAGTTTAACCGGAGACTTCTTTACATATG
CCGATCGTGACGACCATTATTGGTCAGGATATTTCACATCGAGACCATTTTACAAAAGAA
TTGATCGTATTTTAATGAATTATCTAAGAACTGCTGAAATGCTTCATTCATGGACATCAT
GGGAAAAATCGACGGGATTTGAGAAGCGTCTAGAGCAGGCAAGAAGAGCTCTTTCGATTT
TTCAACATCATGATGGTGTTACTGGTACAGCTAAAGATTATGTAATGGCAGACTATAATG
AAATGATGACTGATGGCATAAAGAATAGCAAATTTGTTATTCAACAAGCTGTCTATAAAT
TATTAACAGAATCAAATATTTATCATCCCGACTATTCATTTACTTATTTCAATATTGATG
ACTCTCGAACTGCTGCAAGCGATGATTCATCTCGTTCTGTTATTATAATTGGAGACGAAA
TTCCATATAAATATGTTGTTATACACAATTCACAGACATATTTGCGAAATGAAGTTGTGG
AATTCTTTGTAGCTAAACCTTTCGTGTGTGTAACTGACGCTGATG

>g2966.t5 Gene=g2966 Length=317
MPFYSYDVPHTCGPDPKICCQFDFKRLPGYGLSCPWKVPPVPITDDNVAKRAEMIVDQWR
KKSVLYKTRSVLIPLGDDFRYTQSMEWEAQRVNFEKIFEYVNNEPSFNVEAKFATLQEYF
DSVRHEKGTNQFPSLTGDFFTYADRDDHYWSGYFTSRPFYKRIDRILMNYLRTAEMLHSW
TSWEKSTGFEKRLEQARRALSIFQHHDGVTGTAKDYVMADYNEMMTDGIKNSKFVIQQAV
YKLLTESNIYHPDYSFTYFNIDDSRTAASDDSSRSVIIIGDEIPYKYVVIHNSQTYLRNE
VVEFFVAKPFVCVTDAD

Protein features from InterProScan

Transcript Database ID Name Start End E.value
8 g2966.t5 Gene3D G3DSA:3.20.110.10 Glycoside hydrolase 38 1 146 0
10 g2966.t5 Gene3D G3DSA:1.20.1270.50 Families 57/38 glycoside transferase middle domain 147 257 0
9 g2966.t5 Gene3D G3DSA:2.60.40.1180 - 258 317 0
3 g2966.t5 PANTHER PTHR11607:SF57 ALPHA-MANNOSIDASE 2X 1 317 0
4 g2966.t5 PANTHER PTHR11607 ALPHA-MANNOSIDASE 1 317 0
2 g2966.t5 Pfam PF01074 Glycosyl hydrolases family 38 N-terminal domain 1 143 0
1 g2966.t5 Pfam PF09261 Alpha mannosidase middle domain 148 243 0
7 g2966.t5 SMART SM00872 Alpha_mann_mid_2 148 225 0
5 g2966.t5 SUPERFAMILY SSF88713 Glycoside hydrolase/deacetylase 1 145 0
6 g2966.t5 SUPERFAMILY SSF88688 Families 57/38 glycoside transferase middle domain 148 254 0

Transmembrane regions from TMHMM

Disordered region

IUPRED3 score over 0.5 is predictive of a disordered region.

GO terms from InterProScan

GOID TERM ONTOLOGY
GO:0006013 mannose metabolic process BP
GO:0005975 carbohydrate metabolic process BP
GO:0003824 catalytic activity MF
GO:0004559 alpha-mannosidase activity MF

KEGG

Orthology

This gene did not have any KEGG ortholog annotations (KAAS, GHOSTZ).

Expression

Transcript expression in Pv11 cells

TPM values are indicated as average +/- STDEV.

Differential expression

Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.

Raw TPM values