Gene loci information

Transcript annotation

  • This transcript has been annotated as Inosine-5’-monophosphate dehydrogenase.

Parent gene

Gene structure

  • The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.

Chromosome Gene Transcript Category ID Start End
chr_3 g3270 g3270.t1 TSS g3270.t1 24103754 24103754
chr_3 g3270 g3270.t1 isoform g3270.t1 24104172 24106832
chr_3 g3270 g3270.t1 exon g3270.t1.exon1 24104172 24104278
chr_3 g3270 g3270.t1 cds g3270.t1.CDS1 24104172 24104278
chr_3 g3270 g3270.t1 exon g3270.t1.exon2 24104375 24104525
chr_3 g3270 g3270.t1 cds g3270.t1.CDS2 24104375 24104525
chr_3 g3270 g3270.t1 exon g3270.t1.exon3 24105528 24106832
chr_3 g3270 g3270.t1 cds g3270.t1.CDS3 24105528 24106832
chr_3 g3270 g3270.t1 TTS g3270.t1 24107451 24107451

Sequences

>g3270.t1 Gene=g3270 Length=1563
ATGAATAATCACAGCAGTAAAACTATGAATGGAGTTGTAAGTGAGAAACTTCTTGATGGT
TTATCCATTGATGAACTTTTTGAACGAGGCGAAGGTCTTGCATACAATGACTTTTTATTG
TTGCCGGGTTATATTGATTTTACTGCTGATGAAGTTGATTTAGAATCGAAATTGACAAAG
AAAATCTCGTTAAAAGCACCACTTGTATCATCACCCATGGACACCGTTACTGAAGCTGAC
ATGGCAATTGCTATGGCCCTTTGCGGTGGCATTGGAATAATTCATCACAATTGCACACCC
GAATATCAAGCAAACGAGGTTCATAAAGTAAAAAAATATAAACATGGTTTCATCAATGAT
CCAGTTGTTATGTCACCAATTGCAACTGTTGCAGATGTACTAGAGGCAAAACGTAAAAAT
GGCTTCACTGGCTATCCCATCACTGAAAATGGCAAACTTGGTGGAAAACTTGTCGGCATA
GTAACATCGCGTGACATTGATTTTCGTGAAAAAGATATTGATTTGAAACTTGAGGATGTG
ATGACAAAACTCGATGACATGGTCACAGCAAAACAAGGCATCAAATTGCAACAAGCTAAT
GAAATTCTCGAAAAAAGCAAAAAGGGAAAATTGCCAATTATAAATCAAAATGGTGAACTT
GTTGCTCTTATAGCACGAACTGATTTAAAGAAAGCTCGAAGCTATCCAAATGCGTCAAAA
GATAGCAACAAGCAATTGTTAGTTGGTGCAGCAATGGGAACACGTGAAGAAGATAAAGAT
CGATTAAAACTTTTAGTTCAAGCCGGTGTTGATGTTGTCATTTTGGACTCATCGCAAGGA
AATTCACGCTATCAAATTGAAATGATTCATTATATAAAATCGACATATCCAGATTTGCAA
GTTGTTGCTGGAAATGTTGTAACACGAGCTCAAGCTAAAAACTTGATCGATGCTGGATGC
GATGGTTTAAGAGTTGGCATGGGTTGCGGATCGATTTGTATTACACAAGAAGTTATGGCC
TGTGGCTGTCCACAAGCGACTGCTGTTTATCAAGTTGCAAGTTATGCTCGCAAATTTAAT
GTACCAATCATTGCTGATGGTGGAATTCAAAATATTGGTCATATTATGAAAGCATTGAGT
CTTGGTGCATCTACTGTTATGATGGGTTCACTTTTGGCTGGAACATCGGAAGCACCAGGC
GACTATTTCTTCTCTGATGGTGTTCGTTTGAAGAAATATCGTGGAATGGGCAGCTTAGAA
GCAATGGAAAGAAAAGATGCGAAAGGTGCAGCAATGTCACGTTATTATCACAATGAAATG
GACAAACTTCGAGTTGCACAAGGTGTTTCAGGAAACATTGTCGATAAAGGCTCAGTGTTA
CGTTTCTTGCCATATTTAGAGTGCGGACTACAACATAGCTGTCAAGATCTTGGTGCTCGG
TCGCTTACTCACTTGAGTGAAATGATTTATTCAAATGAACTACGATTCATGAAAAGAACA
CATTCAGCACAGGCTGAAGGCAATGTTCACAGCTTGTTCTCATATGAAAAGAGACTTTTC
TAA

>g3270.t1 Gene=g3270 Length=520
MNNHSSKTMNGVVSEKLLDGLSIDELFERGEGLAYNDFLLLPGYIDFTADEVDLESKLTK
KISLKAPLVSSPMDTVTEADMAIAMALCGGIGIIHHNCTPEYQANEVHKVKKYKHGFIND
PVVMSPIATVADVLEAKRKNGFTGYPITENGKLGGKLVGIVTSRDIDFREKDIDLKLEDV
MTKLDDMVTAKQGIKLQQANEILEKSKKGKLPIINQNGELVALIARTDLKKARSYPNASK
DSNKQLLVGAAMGTREEDKDRLKLLVQAGVDVVILDSSQGNSRYQIEMIHYIKSTYPDLQ
VVAGNVVTRAQAKNLIDAGCDGLRVGMGCGSICITQEVMACGCPQATAVYQVASYARKFN
VPIIADGGIQNIGHIMKALSLGASTVMMGSLLAGTSEAPGDYFFSDGVRLKKYRGMGSLE
AMERKDAKGAAMSRYYHNEMDKLRVAQGVSGNIVDKGSVLRFLPYLECGLQHSCQDLGAR
SLTHLSEMIYSNELRFMKRTHSAQAEGNVHSLFSYEKRLF

Protein features from InterProScan

Transcript Database ID Name Start End E.value
11 g3270.t1 CDD cd00381 IMPDH 32 488 4.31062E-162
10 g3270.t1 CDD cd04601 CBS_pair_IMPDH 118 231 4.65411E-52
6 g3270.t1 Hamap MF_01964 Inosine-5’-monophosphate dehydrogenase [guaB]. 32 518 80.585419
4 g3270.t1 PANTHER PTHR11911:SF129 INOSINE-5’-MONOPHOSPHATE DEHYDROGENASE 1B 20 520 6.5E-261
5 g3270.t1 PANTHER PTHR11911 INOSINE-5-MONOPHOSPHATE DEHYDROGENASE RELATED 20 520 6.5E-261
9 g3270.t1 PIRSF PIRSF000130 IMPDH 21 520 1.8E-192
3 g3270.t1 Pfam PF00478 IMP dehydrogenase / GMP reductase domain 32 510 5.0E-139
1 g3270.t1 Pfam PF00571 CBS domain 120 166 1.5E-4
2 g3270.t1 Pfam PF00571 CBS domain 178 233 1.1E-4
12 g3270.t1 ProSitePatterns PS00487 IMP dehydrogenase / GMP reductase signature. 323 335 -
17 g3270.t1 ProSiteProfiles PS51371 CBS domain profile. 117 177 10.087
18 g3270.t1 ProSiteProfiles PS51371 CBS domain profile. 181 239 11.351
15 g3270.t1 SMART SM01240 IMPDH_2 31 510 6.9E-257
13 g3270.t1 SMART SM00116 cbs_1 120 171 2.0E-7
14 g3270.t1 SMART SM00116 cbs_1 186 234 4.6E-6
8 g3270.t1 SUPERFAMILY SSF51412 Inosine monophosphate dehydrogenase (IMPDH) 30 490 1.16E-107
7 g3270.t1 SUPERFAMILY SSF54631 CBS-domain pair 119 231 8.17E-23
16 g3270.t1 TIGRFAM TIGR01302 IMP_dehydrog: inosine-5’-monophosphate dehydrogenase 32 486 3.4E-193

Transmembrane regions from TMHMM

Disordered region

IUPRED3 score over 0.5 is predictive of a disordered region.

GO terms from InterProScan

GOID TERM ONTOLOGY
GO:0006164 purine nucleotide biosynthetic process BP
GO:0003938 IMP dehydrogenase activity MF
GO:0003824 catalytic activity MF
GO:0055114 NA NA
GO:0016491 oxidoreductase activity MF

KEGG

Orthology

Pathway

  • This transcript belongs to the following pathways

Expression

Transcript expression in Pv11 cells

TPM values are indicated as average +/- STDEV.

Differential expression

Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.

Raw TPM values