Gene loci information

Transcript annotation

  • This transcript has been annotated as Inosine-5’-monophosphate dehydrogenase.

Parent gene

Gene structure

  • The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.

Chromosome Gene Transcript Category ID Start End
chr_3 g3270 g3270.t4 TSS g3270.t4 24103754 24103754
chr_3 g3270 g3270.t4 isoform g3270.t4 24104172 24107455
chr_3 g3270 g3270.t4 exon g3270.t4.exon1 24104172 24104525
chr_3 g3270 g3270.t4 cds g3270.t4.CDS1 24104484 24104525
chr_3 g3270 g3270.t4 exon g3270.t4.exon2 24105528 24107455
chr_3 g3270 g3270.t4 cds g3270.t4.CDS2 24105528 24106832
chr_3 g3270 g3270.t4 TTS g3270.t4 24107451 24107451

Sequences

>g3270.t4 Gene=g3270 Length=2282
ATGAATAATCACAGCAGTAAAACTATGAATGGAGTTGTAAGTGAGAAACTTCTTGATGGT
TTATCCATTGATGAACTTTTTGAACGAGGCGAAGGTCTTGCATACAAGTAAGTTATCGGC
ATTAACTAATTAGACATGTGTTTTAGTTTGTTTCTCATGGCCACGTTTTTTTGATAACAC
ACAAAAAAAATTACTATTTACAGTGACTTTTTATTGTTGCCGGGTTATATTGATTTTACT
GCTGATGAAGTTGATTTAGAATCGAAATTGACAAAGAAAATCTCGTTAAAAGCACCACTT
GTATCATCACCCATGGACACCGTTACTGAAGCTGACATGGCAATTGCTATGGCCCTTTGC
GGTGGCATTGGAATAATTCATCACAATTGCACACCCGAATATCAAGCAAACGAGGTTCAT
AAAGTAAAAAAATATAAACATGGTTTCATCAATGATCCAGTTGTTATGTCACCAATTGCA
ACTGTTGCAGATGTACTAGAGGCAAAACGTAAAAATGGCTTCACTGGCTATCCCATCACT
GAAAATGGCAAACTTGGTGGAAAACTTGTCGGCATAGTAACATCGCGTGACATTGATTTT
CGTGAAAAAGATATTGATTTGAAACTTGAGGATGTGATGACAAAACTCGATGACATGGTC
ACAGCAAAACAAGGCATCAAATTGCAACAAGCTAATGAAATTCTCGAAAAAAGCAAAAAG
GGAAAATTGCCAATTATAAATCAAAATGGTGAACTTGTTGCTCTTATAGCACGAACTGAT
TTAAAGAAAGCTCGAAGCTATCCAAATGCGTCAAAAGATAGCAACAAGCAATTGTTAGTT
GGTGCAGCAATGGGAACACGTGAAGAAGATAAAGATCGATTAAAACTTTTAGTTCAAGCC
GGTGTTGATGTTGTCATTTTGGACTCATCGCAAGGAAATTCACGCTATCAAATTGAAATG
ATTCATTATATAAAATCGACATATCCAGATTTGCAAGTTGTTGCTGGAAATGTTGTAACA
CGAGCTCAAGCTAAAAACTTGATCGATGCTGGATGCGATGGTTTAAGAGTTGGCATGGGT
TGCGGATCGATTTGTATTACACAAGAAGTTATGGCCTGTGGCTGTCCACAAGCGACTGCT
GTTTATCAAGTTGCAAGTTATGCTCGCAAATTTAATGTACCAATCATTGCTGATGGTGGA
ATTCAAAATATTGGTCATATTATGAAAGCATTGAGTCTTGGTGCATCTACTGTTATGATG
GGTTCACTTTTGGCTGGAACATCGGAAGCACCAGGCGACTATTTCTTCTCTGATGGTGTT
CGTTTGAAGAAATATCGTGGAATGGGCAGCTTAGAAGCAATGGAAAGAAAAGATGCGAAA
GGTGCAGCAATGTCACGTTATTATCACAATGAAATGGACAAACTTCGAGTTGCACAAGGT
GTTTCAGGAAACATTGTCGATAAAGGCTCAGTGTTACGTTTCTTGCCATATTTAGAGTGC
GGACTACAACATAGCTGTCAAGATCTTGGTGCTCGGTCGCTTACTCACTTGAGTGAAATG
ATTTATTCAAATGAACTACGATTCATGAAAAGAACACATTCAGCACAGGCTGAAGGCAAT
GTTCACAGCTTGTTCTCATATGAAAAGAGACTTTTCTAACAACCAACTCAAGAAATGATG
AAGTCTACATGTGAGTGAGCAAAGGGACTAAATTTTTTTTCCTTAATTTTTTCCCTTATT
TTATTATTATCATAAGTGATGAAAAATAGTTTCATATGTATTTCTAAATTTCATCTGACT
GCAATAAACTTAATTTACAAAAATATTCCAACATACAAAATTTACTTAACTTTTCTGTGA
CAAAAATCAATTAGACTATTTTTACACACAAACAATTTGCTTAACGTCGCGGAATGTGAC
TTTAAAATTTACACAATGAAATTGTATCTAGTGATTCCCTTGATGAAAAAATTTAAATTA
CCTTTTAGTTTTTAATGAAATGAAAAATTGTGAAAATTTTTGTCTAATCATTATTGATAG
AAAATCATGATAAAAAAAAATATGAATGTGTTAAGAAGAAAGAAAAGAAAATATTTAATG
TTGAATTATTGAACTAGTAAGTATATATACTTATTAGAAAATAAATTGTAAAACTTACTT
ACTTACTTTTGATGTTTTCCACTAACTATGTAACTTTTAATTTGTATTAGATAAAAGAAA
ATTATTAAAAGAATTGTAGTGAAAATGAAGAGATAAATAAAGTAAAATTATATCAATAGA
AA

>g3270.t4 Gene=g3270 Length=448
MDTVTEADMAIAMALCGGIGIIHHNCTPEYQANEVHKVKKYKHGFINDPVVMSPIATVAD
VLEAKRKNGFTGYPITENGKLGGKLVGIVTSRDIDFREKDIDLKLEDVMTKLDDMVTAKQ
GIKLQQANEILEKSKKGKLPIINQNGELVALIARTDLKKARSYPNASKDSNKQLLVGAAM
GTREEDKDRLKLLVQAGVDVVILDSSQGNSRYQIEMIHYIKSTYPDLQVVAGNVVTRAQA
KNLIDAGCDGLRVGMGCGSICITQEVMACGCPQATAVYQVASYARKFNVPIIADGGIQNI
GHIMKALSLGASTVMMGSLLAGTSEAPGDYFFSDGVRLKKYRGMGSLEAMERKDAKGAAM
SRYYHNEMDKLRVAQGVSGNIVDKGSVLRFLPYLECGLQHSCQDLGARSLTHLSEMIYSN
ELRFMKRTHSAQAEGNVHSLFSYEKRLF

Protein features from InterProScan

Transcript Database ID Name Start End E.value
11 g3270.t4 CDD cd00381 IMPDH 1 416 3.70119E-137
10 g3270.t4 CDD cd04601 CBS_pair_IMPDH 46 159 4.53955E-53
6 g3270.t4 Hamap MF_01964 Inosine-5’-monophosphate dehydrogenase [guaB]. 1 446 72.68576
4 g3270.t4 PANTHER PTHR11911:SF129 INOSINE-5’-MONOPHOSPHATE DEHYDROGENASE 1B 1 448 6.6E-233
5 g3270.t4 PANTHER PTHR11911 INOSINE-5-MONOPHOSPHATE DEHYDROGENASE RELATED 1 448 6.6E-233
9 g3270.t4 PIRSF PIRSF000130 IMPDH 1 448 6.7E-172
3 g3270.t4 Pfam PF00478 IMP dehydrogenase / GMP reductase domain 1 438 1.1E-120
1 g3270.t4 Pfam PF00571 CBS domain 48 94 1.2E-4
2 g3270.t4 Pfam PF00571 CBS domain 106 161 8.9E-5
12 g3270.t4 ProSitePatterns PS00487 IMP dehydrogenase / GMP reductase signature. 251 263 -
18 g3270.t4 ProSiteProfiles PS51371 CBS domain profile. 45 105 10.087
17 g3270.t4 ProSiteProfiles PS51371 CBS domain profile. 109 167 11.351
15 g3270.t4 SMART SM01240 IMPDH_2 1 438 3.7E-212
13 g3270.t4 SMART SM00116 cbs_1 48 99 2.0E-7
14 g3270.t4 SMART SM00116 cbs_1 114 162 4.6E-6
8 g3270.t4 SUPERFAMILY SSF51412 Inosine monophosphate dehydrogenase (IMPDH) 1 60 2.75E-11
7 g3270.t4 SUPERFAMILY SSF51412 Inosine monophosphate dehydrogenase (IMPDH) 94 446 1.03E-105
16 g3270.t4 TIGRFAM TIGR01302 IMP_dehydrog: inosine-5’-monophosphate dehydrogenase 1 414 2.8E-174

Transmembrane regions from TMHMM

Disordered region

IUPRED3 score over 0.5 is predictive of a disordered region.

GO terms from InterProScan

GOID TERM ONTOLOGY
GO:0006164 purine nucleotide biosynthetic process BP
GO:0003938 IMP dehydrogenase activity MF
GO:0003824 catalytic activity MF
GO:0055114 NA NA
GO:0016491 oxidoreductase activity MF

KEGG

Orthology

This gene did not have any KEGG ortholog annotations (KAAS, GHOSTZ).

Expression

Transcript expression in Pv11 cells

TPM values are indicated as average +/- STDEV.

Differential expression

Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.

Raw TPM values