Gene loci information

Transcript annotation

  • This transcript has been annotated as Ubiquitin-like modifier-activating enzyme 1.

Parent gene

Gene structure

  • The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.

Chromosome Gene Transcript Category ID Start End
chr_3 g3898 g3898.t3 TSS g3898.t3 28702074 28702074
chr_3 g3898 g3898.t3 isoform g3898.t3 28702095 28703339
chr_3 g3898 g3898.t3 exon g3898.t3.exon1 28702095 28702946
chr_3 g3898 g3898.t3 cds g3898.t3.CDS1 28702095 28702946
chr_3 g3898 g3898.t3 exon g3898.t3.exon2 28703274 28703339
chr_3 g3898 g3898.t3 cds g3898.t3.CDS2 28703274 28703339
chr_3 g3898 g3898.t3 TTS g3898.t3 NA NA

Sequences

>g3898.t3 Gene=g3898 Length=918
ATGTCCAAAGAAACTACAAATTTTTCTTCACCTGTCGCAAAGAAGAGAAAATTAGAGAGT
GAAATCGAGGATAATTCAGTTGCTAACAACTTTGGTACTACGCAACACTCCAAGAATTCG
ACGGGTGAATTGGAAAATAGTAAAAATCATTCAATAAATCAGCAACAGCAGCAACAACAA
CAAAATTTCTCAAATAAAAAAACAATGGCGAATGGAAATAATGAAGAAAAAGGGCACAAA
GAGATCGATGAGGCACTTTATAGCCGTCAATTATATGTGCTTGGACACGAGGCAATGAGA
AGAATGGCGGCCTCTGATGTCTTAATCTCTGGAATCAATGGATTGGGAGTTGAAATTGCT
AAAAATGTTATATTGGCTGGTGTAAAAAGTGTAACACTACATGACCAGCAAATTTGCTCA
TTGGCGGATCTTTCATCACAATTCTATTTGAGTGAATCATCAATTGGAACAAATCGTGCC
GAAGCTAGTTGTTCTCATTTAGCCGAGTTGAATCAATATGTTCCAACAACTGCCTATATT
GGCGATTTAGATGAGGAATTCTTGAAAAAATTCAGTGTTATAGTTTACACCGAGAACAAT
GAGGAAGAGCAGAAACGTCTTTCAAATATTGCTCGTAAACTTAACATCAAATTAATATTA
GCAATGACAAGAGGTTTATTTGGACAAATTTTCTGTGACTTTGGACCCGAATTTGTAGTT
TACGATGTAAATGGAGCCAGTCCTCTGTCAGCTATGATCGCAGGCATTTCGAAAGATCAA
GAGGGTGTAGTTACTTGCTTAGATGAAACACGTCATGGATTCGAAGACGGAGATTATGTG
ACATTTACGGAGGTTCAAGGAATGACACAGCTAAATGGATGTAATCCAATGAAAATCAAG
GTTCTTGGACCTTATACT

>g3898.t3 Gene=g3898 Length=306
MSKETTNFSSPVAKKRKLESEIEDNSVANNFGTTQHSKNSTGELENSKNHSINQQQQQQQ
QNFSNKKTMANGNNEEKGHKEIDEALYSRQLYVLGHEAMRRMAASDVLISGINGLGVEIA
KNVILAGVKSVTLHDQQICSLADLSSQFYLSESSIGTNRAEASCSHLAELNQYVPTTAYI
GDLDEEFLKKFSVIVYTENNEEEQKRLSNIARKLNIKLILAMTRGLFGQIFCDFGPEFVV
YDVNGASPLSAMIAGISKDQEGVVTCLDETRHGFEDGDYVTFTEVQGMTQLNGCNPMKIK
VLGPYT

Protein features from InterProScan

Transcript Database ID Name Start End E.value
11 g3898.t3 Gene3D G3DSA:3.50.50.80 - 79 195 1.0E-43
10 g3898.t3 Gene3D G3DSA:2.40.30.180 - 247 306 4.4E-27
9 g3898.t3 MobiDBLite mobidb-lite consensus disorder prediction 1 64 -
8 g3898.t3 MobiDBLite mobidb-lite consensus disorder prediction 24 64 -
3 g3898.t3 PANTHER PTHR10953:SF195 UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME 1 67 306 2.5E-98
4 g3898.t3 PANTHER PTHR10953 UBIQUITIN-ACTIVATING ENZYME E1 67 306 2.5E-98
5 g3898.t3 PRINTS PR01849 Ubiquitin-activating enzyme E1 signature 108 132 3.5E-26
6 g3898.t3 PRINTS PR01849 Ubiquitin-activating enzyme E1 signature 221 248 3.5E-26
2 g3898.t3 Pfam PF00899 ThiF family 87 245 1.6E-26
1 g3898.t3 Pfam PF16190 Ubiquitin-activating enzyme E1 FCCH domain 259 306 4.5E-22
7 g3898.t3 SUPERFAMILY SSF69572 Activating enzymes of the ubiquitin-like proteins 81 302 1.09E-67

Transmembrane regions from TMHMM

Disordered region

IUPRED3 score over 0.5 is predictive of a disordered region.

GO terms from InterProScan

GOID TERM ONTOLOGY
GO:0008641 ubiquitin-like modifier activating enzyme activity MF
GO:0006464 cellular protein modification process BP

KEGG

Orthology

This gene did not have any KEGG ortholog annotations (KAAS, GHOSTZ).

Expression

Transcript expression in Pv11 cells

TPM values are indicated as average +/- STDEV.

Differential expression

Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.

Raw TPM values