Gene loci information

Transcript annotation

  • This transcript has been annotated as Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha.

Parent gene

Gene structure

  • The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.

Chromosome Gene Transcript Category ID Start End
chr_3 g3960 g3960.t1 TSS g3960.t1 29279442 29279442
chr_3 g3960 g3960.t1 isoform g3960.t1 29279504 29285212
chr_3 g3960 g3960.t1 exon g3960.t1.exon1 29279504 29279630
chr_3 g3960 g3960.t1 cds g3960.t1.CDS1 29279504 29279630
chr_3 g3960 g3960.t1 exon g3960.t1.exon2 29279693 29281554
chr_3 g3960 g3960.t1 cds g3960.t1.CDS2 29279693 29281554
chr_3 g3960 g3960.t1 exon g3960.t1.exon3 29281618 29281831
chr_3 g3960 g3960.t1 cds g3960.t1.CDS3 29281618 29281831
chr_3 g3960 g3960.t1 exon g3960.t1.exon4 29281888 29284204
chr_3 g3960 g3960.t1 cds g3960.t1.CDS4 29281888 29284204
chr_3 g3960 g3960.t1 exon g3960.t1.exon5 29284268 29284314
chr_3 g3960 g3960.t1 cds g3960.t1.CDS5 29284268 29284314
chr_3 g3960 g3960.t1 exon g3960.t1.exon6 29284391 29284544
chr_3 g3960 g3960.t1 cds g3960.t1.CDS6 29284391 29284544
chr_3 g3960 g3960.t1 exon g3960.t1.exon7 29284603 29285212
chr_3 g3960 g3960.t1 cds g3960.t1.CDS7 29284603 29285212
chr_3 g3960 g3960.t1 TTS g3960.t1 NA NA

Sequences

>g3960.t1 Gene=g3960 Length=5331
ATGTCTAAAATCGATGAAGAAGAAATTGTGAAAGCACTTAGTTTAGAGGAAGCAGCTCTT
AATGAGTTTAAAAGACGGAAAAATTCGTGTCCAGCTCCACAGAGTCACTCGAAAATTGCT
TTAAATGACAATAAACCAAATAATTCACTCTATTCATCATCTTCATCATCAAATATTTCA
AGACCAATTGATGAGTTAGATTTAATTTCATTCACTAGTGATATTCAAGAAAGTGCTCAT
AATGCAAGAAAAAAAACTGATGACGATCATTTTAATAAGCTTAAAGAGTCAATATTAAAG
TTAAACGATAATCGTAATCAGCTGCAAAAGCAACTAGTTCCATATAACAATCCTAATCAT
ATATATAGTGGAACAAATAATGTTAATCAGTTTTACAGTCAACAAATGTATTTCAATTCA
TCGCCTTATTCGCAAATTCCGAGAATCGGATTTGAAAACTTTATGCCTTATGGATTTCAT
TCACCGCAGCAGCAGCACCAGCTACAACAACAACAAACTTATGCATTTTCTCCACAACAA
TCTCAAATATGGAATCGCCCTTCAATTCAAGCAGCTTCTAATTCTTCTTCATCTTCTACT
AACACAATTTATTCGCCTCTATCTACATCTTCACAAAGTTTAGTAAGAAGCCAAACGAGA
TTATCAGAAACAAATTTGGCCATAAGAAAACCCGAGTCTGTTAAATCGTCACAGCAAAGC
AGCAATAATAATTCATCATTATCAACAATAAAAGATTTGATAAATTTAGATGATGCTGAT
GATTTAAATTTCATCGCAAATATTTTACAAGCTTTTGATCCGCTAATTGCCAAAAATGAA
GAAGCAAGTAATTCTTATTATTCGGATCAAGATCCTTTTGACTATATATATAGCGGTGGA
ACACAATACTCAGATCCACTCTATGAAGCAGTCATTCGAAGTGATCGTTCAGTCATTTCA
CCAAAAAATCATTCAGATCAAGATATATGTCAATATTACATAGCAGCATCTTCATCACCT
TCAACTTTACATAGGAAAATTGAAGAAACAAGTAATGAACAAGAACCACCACCATTACCA
CCTCGAAATTCATCGAGAACAGTTCAAGAAGAGACGTCGACTAGTCAACAAATTTATAAC
AATCAATACTCGAAAAAATTGTATGAAAACATTGTAGAATGTAGAAAATTTGATAAAGAT
TCTTTGGCATTCTACACAATGGTAAAAGAATTGCGATCGAAGTATCTTTATAATGATTAT
ACTTCAAACATAGGTCATATTGTTGCAGCTAAACTTGATAGCAAATATCTCAATGTATCA
AGTATTAAAATTTTAGTTTATCCCTCTATTGAATGCTACAAGGAAGGAAGCATTTATCAG
CAAGCTGCAAGAAGCAAGTTATTTGAAAATAATTATCAAAAACTTGATAACTATTTAGCA
CCAGTCGTTTTCACATGCGATATTGAGTCAAGCGTGATGCATGTTATTATGCAGACTTTG
GCAAGTCTTGAAAGTGAAATTACTGGAAGTGCTGAAATGTTTGCACTTAAAACTATCGGT
TCGCAAGAATGGTTGTCATATAATTCATGCCTTTCACAATTGGAATACATTCACAATAGT
ATTAAATTAGAAAAAGACGTTCTATTGGGACTATTTCCAAGAAAAGACGAATATATAAAA
GTAATTGCAAGAACGTATCAAGATGATATTCGTGATGCTGATTTAAAAATTGAAAATATT
GTACCAACTGATACAAATACATCCATCAGTTTCGAATCATTAATTATTTTATTAGAGACT
TTAGAAATGGAAATTGACAAATTAGAATCAGCAAGCGCCACACAGACTTATTCAACATTT
AATGCATCTGGTGTTGTTCAAGCTGTTAAAGCCATTTGTGCATTATTAGGTGCTATAGAT
ACTTTTGAATTACATAAGGCAATAAATAATTTGAAAGACACTTGTGATGAACAAATTCGA
CAGTTACAAAATTCAAATTCATTAGGAATGCATTCAAGATCAACTGTGAAAATTGAATAT
GAAAAAGGAAATTATGCACAAGTCTCATTAAGACCGAGAAGTGTGAGTGAAGAAATTAAA
TATCGATGTGATGAAGTACGAGATTCTGTTCAACATCTTCTTGAAGTCTACAGTCAAGCA
TTTCAAGTTAATTTTTCTGTCAATAGACCACAATGGCAAAGTGCAACAGTTAGTATTTCT
ACAGTGCAACAAAACGTCATGTTAAACGTTATGGCACTTCATCGCCCACCACCTCAATGG
AAATACGACGAATATACTTTAGGAATACAAATTTTTCATGGCACTAGATTTCTCAGTGAT
CCACTTGTTACTCAATGTTCAAACAGCACAATTGGGTTTTTCCCTCGTTTAACTTTTGAT
ATGTGGATGAATTTTGATGATGTCTCTGTGTGCTCTTTACCACGTGAATCAAGAATTGTT
TTTGTGCTTTATGGCTGCTTAAAGCAGCCTGTTGATGGTCAATCATCATCAAATGATAAT
AATCAAAGTAATAACAATAGCAACAATCAAGAAAATCAATCTATAAAAGAAGAATTAGGA
TGGACTTCAATTCAATTTTTTGATTTTGAAGGACAAATGATTCAAGGAACCTATTTTCTT
TCACTCTGGCCTCCATCAAATGACAAATATTACTGCCCTTCGCCACCAAAAGGAACTCAT
CCTCAAGGTGATTACTGTCCAATATTGAGCATCGAAATTCCAACATATGGAGGTCATCTT
GTCTTTCCTGACGTTATGATTAACATTAATTTACCAAAACTTGATTTTGAATGCTTAGAT
AGAAATTTACAAGAAGAATTAATTGATACAATTGATGGTCAAGGATTTTTATTTAATCAA
ATTGATAAAAGAGAAGTATTATGGGAAAAAAGAAATTATTTAAATAACTTTCCTAGAGCT
TTACCAAAAGTATTAAACACTGCTCATAGCTGGGACTATGCATCATTGTCTGATCTTCAT
GGCCTAGTCAGTAATTGGTCAGCATTAAAGCCTTTGGAAGCAATTGAATTACTTTTACCC
CGTTTTCCTGATCTTTTTGTGAGACATCAAGCAGTTAAATGGATATCAAAAATGAATGAA
CATGAACTCGCTGATTATTTACCGCAATTATTGCAAGCTTTAAGATTTGATTGTTATGAA
TCTTCACCTTTGGCTTGCTTTCTTCTTGGTAGATCGCTTGACTCACCAAGAGTTGCACAT
TATTTATATTGGCTGCTTATTCAAAATTTACCAGGAGATTGTCCACAAAATACTATGGAT
ACTACAAATCAAATTTATGAAGACAACTTTTTATTGTTACAATGTAGATTTCATAGAAGA
AATCAATTGATGCTTAGATCTTTGTTAGCCATTTGTGGTGAAAGCCTATGCAAAAGATTC
TTATCACAAAATCTTTTATGCAAAGCATTAGACGATTGTGCAAAAAGTGTTAAAGTTGCC
AAAGAATCATTAAAATTACCAATACTTCGTCAAAGTGTTGAAACTGTCCATCAAATTCTT
AGTGAAAATCCAACAAGTTTACCTATTTCTCCTGGTCTTGAGGTTAAGGGAGTTGTTGCA
AAAACTTGCTCTTACTTTAACTCAAATACTTTGCCATTAAAAATTAATTTCTTAGGACCA
GATGAATTAATCATTCCAGCAATTTTCAAATGCGGCGATGATCTTCAACAAGACATGCTT
ACACTACAAATTGTACGCATAATTGATAAAATGTGGCTGAAAGAAGGTTTAGATCTTAAA
ATGGTATCTTTTCAATGCATTCCAACTGGATTTAAAAAAGGAATGATTGAAATGATCACA
AATGCAGAAACATTAAGAAAAATTCAAGTTGAATGGGGATTGACTGGTTCATTCAAAGAT
AAACCGATTGCAGAATGGCTTCAGAAACAAAATCCTAATCAACTCGAATATCAGAGAGCA
GTGGATAATTTTACATCATCATGTGCAGGCTACAGTATTTTAACATATATTCTTGGTATT
TGTGATCGTCACAACGATAACATTTTGATTAAATCTAGCGGACACATTTTTCATATTGAT
TTCGGAAAATTTCTTGGTGATGCACAAATGTTTGGAAATTTTAAACGTGATCGTACACCA
TTCGTTTTAACCTCTGATATGGCTTATGTGATAAATGGTGGCGATAGACCATCTTCAAAG
TTTCACAATTTTGTTGATTTATGTTGTAAAGCTTTTAATATTGTTAGAAAACATGGAGAT
TTATTGTTACACATTTTTGCATTGATGGCATCTAGTGGTATTCCAGGAATCACAAGTGAT
GCAGTAAATTATGTTCGAAATGCTCTCATGCCAGGTGCATCAAATCCTGAGGCAGCAGCT
AATTTTGCGAAAATGATTCATGTCTCATTAAAAAGTTGGTTCACTCAGTTCAACTTTTTC
CTTCATAATCTCGCCCAAATGCGATTCAATAATCAAGGTGAAGGAGGAGAATTGCTGAGT
TTTGTACCTAAAACATATACAGTTGCACAAGAGGGAGCAATACAAAATATAACTGTTCAT
GGTTATCAAAAAAGATATGATTTAGAGAAATATTACACATATATTTTGATTATATATCGT
CAAAATCATCCCGATCCAGTATATTTGTTTCGTTCATATAAAGAATTCTGTGAATTGCAT
CAAAAACTCTGTTGCTTCTTTCCATTAGCTCGTCTTCATAGTCTGCAAAGTGGCATCAGT
GTTGGAAGATCTAATATTAAAACTGTTGCTGAGAGACGTTTACCAGAAGTTAGAAAGTTT
ATTAACTCTTTGCTAAATTCATCGACTGAAATTATTAATTCTGACTTGGTCATTACATTT
TTCCACCCAATATTAAGAGATCAACAAGAATCTGACATTCATGCACCTAAAATGCGAGAA
GATAAAAATAACGCAGAAAACAATATTGGAGGTGAAATCAAATTTTCAATCCACTATCAT
AGAGACACTTTTATCGTATTTATCCATCACGCACGAGGACTGCCTTTAACAACAAGTGGG
CAAGAGCCAAACACATACGTAAAAACTTACTTAACTCCTGATCGTTCTAAAATAACAAAA
AGAAAAACACGAGTTGTAAAGAAAAGCTGTTTTCCTAGTTTTATGGAAACATTAGAATAT
CGAATGCCAATTCAAGTTATCAAATTGAAGACGCTTCGAATTACAATTTGGAATCACGAT
ACACTACAAGAAAATGAATTTCTTGGTGGCGTTCAGATACCATTAGTTGATTTAAATTTG
AAAGAAGAAATTGTTGGATGGCATAAGCTTGTTTATCTGACAAGATCTTAA

>g3960.t1 Gene=g3960 Length=1776
MSKIDEEEIVKALSLEEAALNEFKRRKNSCPAPQSHSKIALNDNKPNNSLYSSSSSSNIS
RPIDELDLISFTSDIQESAHNARKKTDDDHFNKLKESILKLNDNRNQLQKQLVPYNNPNH
IYSGTNNVNQFYSQQMYFNSSPYSQIPRIGFENFMPYGFHSPQQQHQLQQQQTYAFSPQQ
SQIWNRPSIQAASNSSSSSTNTIYSPLSTSSQSLVRSQTRLSETNLAIRKPESVKSSQQS
SNNNSSLSTIKDLINLDDADDLNFIANILQAFDPLIAKNEEASNSYYSDQDPFDYIYSGG
TQYSDPLYEAVIRSDRSVISPKNHSDQDICQYYIAASSSPSTLHRKIEETSNEQEPPPLP
PRNSSRTVQEETSTSQQIYNNQYSKKLYENIVECRKFDKDSLAFYTMVKELRSKYLYNDY
TSNIGHIVAAKLDSKYLNVSSIKILVYPSIECYKEGSIYQQAARSKLFENNYQKLDNYLA
PVVFTCDIESSVMHVIMQTLASLESEITGSAEMFALKTIGSQEWLSYNSCLSQLEYIHNS
IKLEKDVLLGLFPRKDEYIKVIARTYQDDIRDADLKIENIVPTDTNTSISFESLIILLET
LEMEIDKLESASATQTYSTFNASGVVQAVKAICALLGAIDTFELHKAINNLKDTCDEQIR
QLQNSNSLGMHSRSTVKIEYEKGNYAQVSLRPRSVSEEIKYRCDEVRDSVQHLLEVYSQA
FQVNFSVNRPQWQSATVSISTVQQNVMLNVMALHRPPPQWKYDEYTLGIQIFHGTRFLSD
PLVTQCSNSTIGFFPRLTFDMWMNFDDVSVCSLPRESRIVFVLYGCLKQPVDGQSSSNDN
NQSNNNSNNQENQSIKEELGWTSIQFFDFEGQMIQGTYFLSLWPPSNDKYYCPSPPKGTH
PQGDYCPILSIEIPTYGGHLVFPDVMININLPKLDFECLDRNLQEELIDTIDGQGFLFNQ
IDKREVLWEKRNYLNNFPRALPKVLNTAHSWDYASLSDLHGLVSNWSALKPLEAIELLLP
RFPDLFVRHQAVKWISKMNEHELADYLPQLLQALRFDCYESSPLACFLLGRSLDSPRVAH
YLYWLLIQNLPGDCPQNTMDTTNQIYEDNFLLLQCRFHRRNQLMLRSLLAICGESLCKRF
LSQNLLCKALDDCAKSVKVAKESLKLPILRQSVETVHQILSENPTSLPISPGLEVKGVVA
KTCSYFNSNTLPLKINFLGPDELIIPAIFKCGDDLQQDMLTLQIVRIIDKMWLKEGLDLK
MVSFQCIPTGFKKGMIEMITNAETLRKIQVEWGLTGSFKDKPIAEWLQKQNPNQLEYQRA
VDNFTSSCAGYSILTYILGICDRHNDNILIKSSGHIFHIDFGKFLGDAQMFGNFKRDRTP
FVLTSDMAYVINGGDRPSSKFHNFVDLCCKAFNIVRKHGDLLLHIFALMASSGIPGITSD
AVNYVRNALMPGASNPEAAANFAKMIHVSLKSWFTQFNFFLHNLAQMRFNNQGEGGELLS
FVPKTYTVAQEGAIQNITVHGYQKRYDLEKYYTYILIIYRQNHPDPVYLFRSYKEFCELH
QKLCCFFPLARLHSLQSGISVGRSNIKTVAERRLPEVRKFINSLLNSSTEIINSDLVITF
FHPILRDQQESDIHAPKMREDKNNAENNIGGEIKFSIHYHRDTFIVFIHHARGLPLTTSG
QEPNTYVKTYLTPDRSKITKRKTRVVKKSCFPSFMETLEYRMPIQVIKLKTLRITIWNHD
TLQENEFLGGVQIPLVDLNLKEEIVGWHKLVYLTRS

Protein features from InterProScan

Transcript Database ID Name Start End E.value
25 g3960.t1 CDD cd04012 C2A_PI3K_class_II 737 923 3.5514E-52
26 g3960.t1 CDD cd05166 PI3Kc_II 1138 1486 0.0
24 g3960.t1 CDD cd08381 C2B_PI3K_class_II 1650 1770 1.39259E-47
23 g3960.t1 Coils Coil Coil 91 111 -
22 g3960.t1 Coils Coil Coil 591 611 -
21 g3960.t1 Coils Coil Coil 648 668 -
19 g3960.t1 Gene3D G3DSA:2.60.40.150 - 758 923 9.9E-26
17 g3960.t1 Gene3D G3DSA:1.25.40.70 - 933 1109 4.5E-43
15 g3960.t1 Gene3D G3DSA:3.30.1010.10 - 1135 1280 1.6E-37
18 g3960.t1 Gene3D G3DSA:1.10.1070.11 - 1281 1495 8.1E-76
16 g3960.t1 Gene3D G3DSA:3.30.1520.10 PX domain 1496 1634 2.4E-31
20 g3960.t1 Gene3D G3DSA:2.60.40.150 - 1635 1774 5.6E-30
34 g3960.t1 MobiDBLite mobidb-lite consensus disorder prediction 26 56 -
38 g3960.t1 MobiDBLite mobidb-lite consensus disorder prediction 28 56 -
37 g3960.t1 MobiDBLite mobidb-lite consensus disorder prediction 225 245 -
36 g3960.t1 MobiDBLite mobidb-lite consensus disorder prediction 343 376 -
35 g3960.t1 MobiDBLite mobidb-lite consensus disorder prediction 834 853 -
7 g3960.t1 PANTHER PTHR10048:SF64 LD28067P 350 1534 0.0
8 g3960.t1 PANTHER PTHR10048 PHOSPHATIDYLINOSITOL KINASE 350 1534 0.0
2 g3960.t1 Pfam PF00794 PI3-kinase family, ras-binding domain 477 552 4.1E-10
6 g3960.t1 Pfam PF00792 Phosphoinositide 3-kinase C2 763 892 5.5E-12
5 g3960.t1 Pfam PF00613 Phosphoinositide 3-kinase family, accessory domain (PIK domain) 962 1104 1.9E-31
1 g3960.t1 Pfam PF00454 Phosphatidylinositol 3- and 4-kinase 1226 1438 2.2E-55
4 g3960.t1 Pfam PF00787 PX domain 1549 1622 1.5E-4
3 g3960.t1 Pfam PF00168 C2 domain 1665 1770 1.5E-15
33 g3960.t1 ProSitePatterns PS00916 Phosphatidylinositol 3- and 4-kinases signature 2. 1327 1347 -
44 g3960.t1 ProSiteProfiles PS51546 Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain profile. 464 553 18.589
39 g3960.t1 ProSiteProfiles PS51547 Phosphatidylinositol 3-kinase C2 (PI3K C2) domain profile. 742 914 37.344
42 g3960.t1 ProSiteProfiles PS51545 PIK helical domain profile. 933 1109 21.725
40 g3960.t1 ProSiteProfiles PS50290 Phosphatidylinositol 3- and 4-kinases family profile. 1225 1488 62.517
43 g3960.t1 ProSiteProfiles PS50195 PX domain profile. 1512 1628 12.187
41 g3960.t1 ProSiteProfiles PS50004 C2 domain profile. 1663 1752 12.425
30 g3960.t1 SMART SM00144 pi3k_ras_2 429 556 0.0027
29 g3960.t1 SMART SM00142 pi3k_hr3_6 734 844 2.8E-12
28 g3960.t1 SMART SM00145 pi3k_hr2_4 933 1119 3.7E-39
31 g3960.t1 SMART SM00146 pi3k_hr1_6 1226 1487 1.9E-119
32 g3960.t1 SMART SM00312 PX_2 1512 1624 3.7E-13
27 g3960.t1 SMART SM00239 C2_3c 1663 1767 6.2E-15
10 g3960.t1 SUPERFAMILY SSF54236 Ubiquitin-like 482 556 1.24E-8
13 g3960.t1 SUPERFAMILY SSF49562 C2 domain (Calcium/lipid-binding domain, CaLB) 736 916 1.01E-23
9 g3960.t1 SUPERFAMILY SSF48371 ARM repeat 938 1095 1.5E-42
11 g3960.t1 SUPERFAMILY SSF56112 Protein kinase-like (PK-like) 1138 1481 3.37E-86
14 g3960.t1 SUPERFAMILY SSF64268 PX domain 1511 1631 1.83E-22
12 g3960.t1 SUPERFAMILY SSF49562 C2 domain (Calcium/lipid-binding domain, CaLB) 1647 1771 8.93E-26

Transmembrane regions from TMHMM

Disordered region

IUPRED3 score over 0.5 is predictive of a disordered region.

GO terms from InterProScan

GOID TERM ONTOLOGY
GO:0016301 kinase activity MF
GO:0048015 phosphatidylinositol-mediated signaling BP
GO:0046854 phosphatidylinositol phosphate biosynthetic process BP
GO:0035091 phosphatidylinositol binding MF

KEGG

Orthology

Pathway

  • This transcript belongs to the following pathways

Expression

Transcript expression in Pv11 cells

TPM values are indicated as average +/- STDEV.

Differential expression

Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.

Raw TPM values