General information for g423.t3
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Acetyl-CoA acetyltransferase, mitochondrial.
Parent gene
- The parent gene g423 is located on chr_3: 3310625..3312206 (+ strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_3 | g423 | g423.t3 | TSS | g423.t3 | 3308254 | 3308254 |
| chr_3 | g423 | g423.t3 | isoform | g423.t3 | 3308286 | 3310340 |
| chr_3 | g423 | g423.t3 | exon | g423.t3.exon1 | 3308286 | 3308538 |
| chr_3 | g423 | g423.t3 | cds | g423.t3.CDS1 | 3308286 | 3308538 |
| chr_3 | g423 | g423.t3 | exon | g423.t3.exon2 | 3308603 | 3309280 |
| chr_3 | g423 | g423.t3 | cds | g423.t3.CDS2 | 3308603 | 3309280 |
| chr_3 | g423 | g423.t3 | exon | g423.t3.exon3 | 3309870 | 3310340 |
| chr_3 | g423 | g423.t3 | cds | g423.t3.CDS3 | 3309870 | 3310183 |
| chr_3 | g423 | g423.t3 | TTS | g423.t3 | 3310299 | 3310299 |
Sequences
>g423.t3 Gene=g423 Length=1402
ATGGCATTTTCTATGAGATTAGCAAGAACAACAAGTCAAAATTTCCGATCATATTCGAGT
GGAAGAAAATTTAATGATGTAGTTATAGTTTCAGCAACACGAACTCCAATTGGTTCATTT
CAATCTTCATTACAATCACTTTCTGCAAGTCAATTAGGTGGCATTGCAATTCAATCAGCA
ATCAAACAAGCAGGAATTAGAAATGAGGATGTAGATGAAGTATTAATGGGAAATGTTGTC
TCTGTTGGAATGGGACAAGCACCAGCACGACAGGCAGCAATTTTCGCTGGTCTTCCAACT
TCTGTTTGCTGTACAACAATCAATAAAGTTTGCAGCAGTGGCCTAAAAACAGTTTCACTT
GCAGCACAAACACTTATGTTAGGTCAGGGTCAAGAAGTCATCGTCGCAGGTGGAATGGAA
TCAATGAGTAATGTGCCTTATTATTTAAAAAGAGGTTCAACACCCTATGGTGGAGTGAAT
TTAATTGATGGCATTGTTCATGATGGTTTATGGGATCCATATAACAAATTTCACATGGGT
AATTGTGCTGAAAATACAGCAAAAAAACTTGGAATTACAAGACAGCAACAAGATGAATAT
GGAATTTCAAGCTACAAACGATCAGCTGAAGCATGGAAAAATAAAATTTTTGATGCAGAA
ATCACACAAGTTTCAATTCCACAAAAGAAAGGCAAACCTGATATTGTAATTACAGAAGAT
GAGGAATATAAAAGAGTTAATTTTGATAAATTTGGCAGCTTGGGAACAGTCTTTCAAAAA
GAAAATGGAACAGTTACTGCTGGTAATGCAAGTACATTAAATGATGGTGGAGCAGCTTTA
GTCCTAATGACAGCTGAAGCTGCAGAAAAACATAAATGTAAACCACTCGCTCAAGTTGTT
GGCTTTGCTGATGCTGAAACTGATCCTATTGATTTCCCAATTGCACCAGCAAAAGCAGTA
CCAAAATTATTGGAACAAACAGGTGTGAGAAAACAAGATGTTTCATTGTGGGAAGTGAAT
GAAGCATTTTCACTTGTTGTGTTAGCAAACATGAAATTAATGGATTTGGATATAAAAAAT
GTAAATATTCATGGCGGAGCTGTTAGTCTTGGCCACCCTATTGGGATGTCGGGAGCTCGC
ATAGTAGTACATCTTCTTCACAATTTGAAACAGGGACAGTATGGTTGTGCATCAATTTGC
AATGGTGGCGGAGGTGCATCATCAATTATGATTCAGAAATTGTAAGTACAAAAAAAAATT
GTTGGAAGCAAACAAAAAAACTCTCCAATGAAATCAGATTGCATTTATTAAAATTTGTAA
TAATTTTATGAAAGTTTCGAATAAAAAAGTTTTTATTTTTCACTGCTGTTATCTCCTTAT
TCCTCATCTTCTGCCTTTCAGA
>g423.t3 Gene=g423 Length=414
MAFSMRLARTTSQNFRSYSSGRKFNDVVIVSATRTPIGSFQSSLQSLSASQLGGIAIQSA
IKQAGIRNEDVDEVLMGNVVSVGMGQAPARQAAIFAGLPTSVCCTTINKVCSSGLKTVSL
AAQTLMLGQGQEVIVAGGMESMSNVPYYLKRGSTPYGGVNLIDGIVHDGLWDPYNKFHMG
NCAENTAKKLGITRQQQDEYGISSYKRSAEAWKNKIFDAEITQVSIPQKKGKPDIVITED
EEYKRVNFDKFGSLGTVFQKENGTVTAGNASTLNDGGAALVLMTAEAAEKHKCKPLAQVV
GFADAETDPIDFPIAPAKAVPKLLEQTGVRKQDVSLWEVNEAFSLVVLANMKLMDLDIKN
VNIHGGAVSLGHPIGMSGARIVVHLLHNLKQGQYGCASICNGGGGASSIMIQKL
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 10 | g423.t3 | CDD | cd00751 | thiolase | 28 | 413 | 1.16719E-177 |
| 8 | g423.t3 | Gene3D | G3DSA:3.40.47.10 | - | 28 | 299 | 4.6E-141 |
| 7 | g423.t3 | Gene3D | G3DSA:3.40.47.10 | - | 150 | 411 | 4.6E-141 |
| 3 | g423.t3 | PANTHER | PTHR18919:SF156 | ACETYL-COA ACETYLTRANSFERASE, MITOCHONDRIAL | 16 | 414 | 1.8E-205 |
| 4 | g423.t3 | PANTHER | PTHR18919 | ACETYL-COA C-ACYLTRANSFERASE | 16 | 414 | 1.8E-205 |
| 9 | g423.t3 | PIRSF | PIRSF000429 | Ac-CoA_Ac_transf | 21 | 414 | 3.5E-119 |
| 2 | g423.t3 | Pfam | PF00108 | Thiolase, N-terminal domain | 27 | 285 | 1.0E-85 |
| 1 | g423.t3 | Pfam | PF02803 | Thiolase, C-terminal domain | 294 | 413 | 2.5E-42 |
| 11 | g423.t3 | ProSitePatterns | PS00098 | Thiolases acyl-enzyme intermediate signature. | 107 | 125 | - |
| 12 | g423.t3 | ProSitePatterns | PS00737 | Thiolases signature 2. | 362 | 378 | - |
| 6 | g423.t3 | SUPERFAMILY | SSF53901 | Thiolase-like | 26 | 292 | 5.51E-71 |
| 5 | g423.t3 | SUPERFAMILY | SSF53901 | Thiolase-like | 292 | 411 | 7.09E-35 |
| 13 | g423.t3 | TIGRFAM | TIGR01930 | AcCoA-C-Actrans: acetyl-CoA C-acyltransferase | 29 | 411 | 3.1E-126 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0016746 | acyltransferase activity | MF |
| GO:0016747 | acyltransferase activity, transferring groups other than amino-acyl groups | MF |
KEGG
Orthology
- This transcript has been annotated with K00626 (acetyl-CoA C-acetyltransferase)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
