General information for g4527.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Putative Fibroblast growth factor receptor substrate 2.
Parent gene
- The parent gene g4527 is located on chr_2: 3062929..3064676 (+ strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_2 | g4527 | g4527.t1 | TSS | g4527.t1 | 3062465 | 3062465 |
| chr_2 | g4527 | g4527.t1 | isoform | g4527.t1 | 3062710 | 3064676 |
| chr_2 | g4527 | g4527.t1 | exon | g4527.t1.exon1 | 3062710 | 3062818 |
| chr_2 | g4527 | g4527.t1 | cds | g4527.t1.CDS1 | 3062710 | 3062818 |
| chr_2 | g4527 | g4527.t1 | exon | g4527.t1.exon2 | 3062929 | 3064676 |
| chr_2 | g4527 | g4527.t1 | cds | g4527.t1.CDS2 | 3062929 | 3064676 |
| chr_2 | g4527 | g4527.t1 | TTS | g4527.t1 | 3065352 | 3065352 |
Sequences
>g4527.t1 Gene=g4527 Length=1857
ATGGGATGTGTAGAGAGTAAAGTTGAAAATTTAAATCCAAATCTTTTCGAAGTCATTTTT
GCTGATACAGATGATTTGGTGTATTACAATTCACAACTTGAGATAAATGGAAATGATATT
ATATTGTATCGAAAAAATCGACCTCCTATATCGTGGCCATTAAAATCACTAAGAAGATAC
GGTTATGATGCGAATTTTTTTACGTTTGAAGCTGGAAGAAGATGTGCCACAGGTCCAGGA
ATTTTCAGTTTCAAGTGCCAAGGAAGAGCTGATGTGTTGTTCAATACACTTCAGCAATAT
ATAAATAATCAAGCATACAATCCAGAGGACATAAATCTCCATGATTTTGCAGTGCCAAAT
GCATCAAATAGAAATATTGCTCAGTTGAATAGTCTCAATTTAGGCGGGACACTTCATCAT
ACTGGCATTCAAGGAAGTTCATACATTGTAAACACAAGACCAAACAGTTCACTCAGTCCT
AATGGAACAAATTCAATTCAGAGTCGAAGCACAGATACATTGACTGCTGATTATTTAGAA
CCAAATCCTAGCAGATCAGTGACATCACATGTTGCACGGTTTTCATCAAATAATCGTATG
AGCTCATTTGGATCTGGTCCTCTTTCGCCCTCATCGCCTGGCTCACCAAATAGCTATACA
AATATTCTCGAAATTACAAATCTTAATCAACCTCAAACTCATGCACCTGGAAATATATAT
CAAGAATATCCATCTGGTAGTGTAAGTAAACCAATGAAATTATCATCAACCGACACTCAA
ACACAGCAGCAAACAGCCTTGCCTGTGGAACAAGGTTCAGTTACTAGTCAATTAAGAATC
GCAGCAGCAGTAGCTTCAAATAATTCTACAGCAACAACAAGCAGTGCAAATATTTCCACA
ACCACACCTCAAAAGAACGATCCCAATACAAATATATATATAAATGCTGAAATTGGTGAC
CCACGAAAAAAAGCAGTGACTACGGAAAATGTAATAAAACCCGTGCTGCGAGCAACACTT
GCACAAATGGAAAGCCTCGAGGTCGATCCTGAGGATGAACATTCTGTATCATCACCTGAC
TCTGTGAAAGTCAATCAAACTGCTCTTTATATGAATGTTGCAATTGGTGATGAAAACAAT
GGTGGACAAATGACATCACCACCACCAGCTCAACTACCTGCCAACTCCAATATTAAAGAA
AATCAACCTCCTATTGCTACAACTCCGCCTGTCTTGGCGAATAATCTCAATTCAAAACTG
AATGATATTCAGAAAGATTACACCAAGAATGTTGTGAATGGTAATAGTGGTAACATTTTT
GGTTTCACACGATCTCCATTCTCACTACAAGATACTGCTACTACTCGTTGCTATGAAAAT
CTGGAAATTGTCACTGGAATGACGGAAATGAAGCCGTTGATGATGAGAAATCGCTACTCG
CGGCCCGAAATTTTCTCAAAGGTAGATTTGCCACTAATTGATCGCACAGACAAATCAGAA
CCATGCACGCCAACACAACGTAAAGGAATTAACTATATTGTTCTTGATCTCGATTCTCAT
CCGATTAATGGCAGCAGCCTCGCTAGTAATAATTCAAATAATAATGGCAGTATCGATAGT
TGTAGTGATAATCAAAGTCAAATGACGAGTTCGACATCAAATGGACTGTTGCAGCCAGAA
AGTCCAAAGAAACTTGGCTATGCCACAATCGATTTTGATCGTTCGAATGCATTAAGCAAC
ATTCTTTTGAATAATCCCATTAATGACTTTGATCAAAGCTGCAGAAAAACTCGTCATGAC
TCAAATGTCACACCTATTTTGATGGCGATGAAACATAGCAACTCAATGAGTGACTAA
>g4527.t1 Gene=g4527 Length=618
MGCVESKVENLNPNLFEVIFADTDDLVYYNSQLEINGNDIILYRKNRPPISWPLKSLRRY
GYDANFFTFEAGRRCATGPGIFSFKCQGRADVLFNTLQQYINNQAYNPEDINLHDFAVPN
ASNRNIAQLNSLNLGGTLHHTGIQGSSYIVNTRPNSSLSPNGTNSIQSRSTDTLTADYLE
PNPSRSVTSHVARFSSNNRMSSFGSGPLSPSSPGSPNSYTNILEITNLNQPQTHAPGNIY
QEYPSGSVSKPMKLSSTDTQTQQQTALPVEQGSVTSQLRIAAAVASNNSTATTSSANIST
TTPQKNDPNTNIYINAEIGDPRKKAVTTENVIKPVLRATLAQMESLEVDPEDEHSVSSPD
SVKVNQTALYMNVAIGDENNGGQMTSPPPAQLPANSNIKENQPPIATTPPVLANNLNSKL
NDIQKDYTKNVVNGNSGNIFGFTRSPFSLQDTATTRCYENLEIVTGMTEMKPLMMRNRYS
RPEIFSKVDLPLIDRTDKSEPCTPTQRKGINYIVLDLDSHPINGSSLASNNSNNNGSIDS
CSDNQSQMTSSTSNGLLQPESPKKLGYATIDFDRSNALSNILLNNPINDFDQSCRKTRHD
SNVTPILMAMKHSNSMSD
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 6 | g4527.t1 | CDD | cd01202 | PTB_FRS2 | 11 | 102 | 5.46658E-40 |
| 5 | g4527.t1 | Gene3D | G3DSA:2.30.29.250 | - | 1 | 138 | 4.0E-35 |
| 9 | g4527.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 538 | 560 | - |
| 10 | g4527.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 538 | 559 | - |
| 2 | g4527.t1 | PANTHER | PTHR21258 | DOCKING PROTEIN RELATED | 1 | 605 | 6.3E-47 |
| 3 | g4527.t1 | PANTHER | PTHR21258:SF55 | FI23523P1 | 1 | 605 | 6.3E-47 |
| 1 | g4527.t1 | Pfam | PF02174 | PTB domain (IRS-1 type) | 28 | 104 | 5.6E-21 |
| 11 | g4527.t1 | ProSiteProfiles | PS51064 | IRS-type PTB domain profile. | 8 | 110 | 25.097 |
| 8 | g4527.t1 | SMART | SM00310 | PTBI_2 | 7 | 106 | 1.1E-17 |
| 7 | g4527.t1 | SMART | SM01244 | IRS_2 | 12 | 106 | 4.0E-26 |
| 4 | g4527.t1 | SUPERFAMILY | SSF50729 | PH domain-like | 12 | 114 | 4.43E-28 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
There are no GO annotations for this transcript.
KEGG
Orthology
- This transcript has been annotated with K12461 (fibroblast growth factor receptor substrate 2)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
