Gene loci information

Transcript annotation

  • This transcript has been annotated as Dual oxidase.

Parent gene

Gene structure

  • The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.

Chromosome Gene Transcript Category ID Start End
chr_2 g6177 g6177.t1 TTS g6177.t1 14915901 14915901
chr_2 g6177 g6177.t1 isoform g6177.t1 14916225 14930121
chr_2 g6177 g6177.t1 exon g6177.t1.exon1 14916225 14916353
chr_2 g6177 g6177.t1 cds g6177.t1.CDS1 14916225 14916353
chr_2 g6177 g6177.t1 exon g6177.t1.exon2 14916430 14916558
chr_2 g6177 g6177.t1 cds g6177.t1.CDS2 14916430 14916558
chr_2 g6177 g6177.t1 exon g6177.t1.exon3 14916625 14916860
chr_2 g6177 g6177.t1 cds g6177.t1.CDS3 14916625 14916860
chr_2 g6177 g6177.t1 exon g6177.t1.exon4 14916917 14917888
chr_2 g6177 g6177.t1 cds g6177.t1.CDS4 14916917 14917888
chr_2 g6177 g6177.t1 exon g6177.t1.exon5 14917950 14919873
chr_2 g6177 g6177.t1 cds g6177.t1.CDS5 14917950 14919873
chr_2 g6177 g6177.t1 exon g6177.t1.exon6 14920071 14920474
chr_2 g6177 g6177.t1 cds g6177.t1.CDS6 14920071 14920474
chr_2 g6177 g6177.t1 exon g6177.t1.exon7 14920536 14920740
chr_2 g6177 g6177.t1 cds g6177.t1.CDS7 14920536 14920740
chr_2 g6177 g6177.t1 exon g6177.t1.exon8 14920883 14921232
chr_2 g6177 g6177.t1 cds g6177.t1.CDS8 14920883 14921232
chr_2 g6177 g6177.t1 exon g6177.t1.exon9 14927973 14928053
chr_2 g6177 g6177.t1 cds g6177.t1.CDS9 14927973 14928053
chr_2 g6177 g6177.t1 exon g6177.t1.exon10 14930067 14930121
chr_2 g6177 g6177.t1 cds g6177.t1.CDS10 14930067 14930121
chr_2 g6177 g6177.t1 TSS g6177.t1 NA NA

Sequences

>g6177.t1 Gene=g6177 Length=4485
ATGAAATGCATATTTGCAATTATTGTGATACAATTCGTGGACTTAACTGTTAATGAAAAA
TATTATAGTCATACTGAAAAGCAACGCTATGATGGCTGGTATAATAATTTGGCTCATCCG
GAATGGGGAGCGACAGATACACACTTAATACGCAAAGCACCGTCAGCTTATAGTGATGGA
GTTTATGGTATGGCTGGACCGAATCGTCCATCGCCACGGAAACTAAGTCGATTATTTATG
CGTGGTGAGGATGGTTTGAGTTCGATGGAAAATCGTACTGCTTTGTTGGCATTTTTCGGA
CAAGTCGTGACGAATGAAATTGTGATGGCGTCAGAATCGGGCTGTCCTATAGAAATGCAT
CGTATTGAAGTAGAGAAATGCGATGAGATGTATGACAAGGAGTGCCGTGGTGATCGTTAC
ATTCCATTTCATCGAGCTATGTACGATCGAAAGACGGGCCAAAGTCCAAATGCACCACGT
GAACAGATTAACCAAATGACAGCGTGGATCGACGGCAGTTTCATATATAGTACATCAGAA
GCATGGCTCAATGCAATGCGATCATTTCAAAATGGATCGCTTTTGACTGATAAAAGCGGC
AATATGCCCGTCAAAAATACAATGCGGGTGCCACTTTTCAACAATCCAGTGCCGCATGTC
ATGCGCGCTCTAAGCCCCGAGCGTTTATATCTGTTGGGCGATCCGCGCACTAATCAAAAT
CCCGCTTTGCTCTCGTTTGCCATACTACTCATGCGTTGGCACAATGTGCAAGCGCAAGAA
GTTAAACGACTTAATCCTGACTGGAGTGATGAAGAAATTTTTCAACGTGCGAGACGTCAA
GTGATTGCAAGTTTGCAGAGTATTTTTGTTTATGAATATTTACCTGCATTTCTGGGCGGA
ACGACACTTGAACCATATAGTGGTTATAAACAAGATGTCCACCCAGGCATTTCACATATG
TTCCAAGCTGCTGCTTTTCGATTTGGTCATTCTCTTATTCCACCTGGCATTATGAAAAGA
GATGGCAAATGTAACTTCAAATATACACGAGGTGCACCAGCAATCCGTCTTTGTTCAACA
TGGTGGGATTCCAGTGATATTTTCGAAGACACGAGCATTGAAGAGTTTCTTATGGGCATG
GCATCACAATTAGCCGAGAGAGAGGATCCCTTTCTTTGCTCTGACGTACGCGACAAACTT
TTTGGACCAATGGAATTTACAAGACGCGATCTTGGCGCTTTGAACATCATGCGTGGCCGT
GACAATGGTCTCGCCGATTATAACACAGCACGAGCCGCCTATAAACTACCAAAACATACA
AATTGGAAAGACATCAACCCAGAGTTATTTGAAAAGCATCCCGAATTGCTACAAATTTTA
ATTTCCGCCTACAAAGATAGACTAGACAATGTTGATGCCTATATAGGCGGCATGCTTGAA
TCGAATGGTAAACCTGGTGAACTTTTTACAAAAGTGATAATCGATCAATTTACAAGAATT
AGAGACGCTGATCGTTACTGGTTTGAAAATGAAGACAATGGCATCTTTACGAAGGAAGAG
ATCGAAAAGTTCCGTAATATTAAACTCTACGACATCATTGTCAATAGCACGAGCATTGAG
GCGGGGCAAATTCAACGTAATGTATTTCAATTTGTCGATGGCGACCCTTGCCCTCAGCCA
GAGCAACTGAATGCATCACTGTTGGAACCATGTAGTCACATTGAAGGCTTTGATTATTTC
TCTGGCTCTGAACTTGCTTACATTTATGCATGTGTTTTTCTTGGGTTTGTACCAATTTTA
TGTGCAACTGCTGGTTATTGTGTGGTAAAACTTCAAAATCGACGAAGAAGAAGATTGAAA
GTGAAACAAGAAACAATGCGAACAAAGGGTGGTAAACAGACTGTTGACAAGATGATTGCT
CGAGAATGGTTGCATGCAAACCATAAAAGACTTGTTACAGTAAAATTCGGACCAGAATCA
GCTATTTATACGGTTGACAGAAAAGGCGAAAAGTTGCGAACTTTCAATCTCAGAAATGTC
GATTCAATTCAAGTTGAATTGAGTGTTGAAAGTTATACAAATAAACGACCATTGGTACTA
TTGAGAATACATAATGATCACGATTTGGTACTAGAATTAGAGACAATTGGAGCGCGTCGC
AAGTTCGTCAAAAAGTTGGAAGATTTTCTCATTTTGCATAAGAAGGAAATGTCAATTAAT
GAGCAAAATCGTGAACTGATGCTTGCAAAAGCAGAAACACGAGAACGAAGACAGAAAAAA
CTAGAGCACTTCTTCCGAGAAGCTTATGCATTGACATTTGGCTTAAGACCTGGTGAGAGA
AGAAGACGTTCAGATGCATCAAGTGATGGTGAAGTTATGACTGTTATGCGAACAAGTTTA
TCAAAATCTGAATTCGCTGCAGCTCTTGGAATGAAACCAGATGCAATGTTTGTGAGAAAA
ATGTTTAATATTGTTGATAAAGACCAAGATGGAAGAATTTCATTCCAAGAATTCTTAGAA
ACAGTTGTACTTTTCTCACGTGGAAAAACTGAAGATAAATTAAGAATTATTTTTGACATG
TGTGATAATGATCGAAATGGTGTTATAGATAAATCAGAATTCGGTGAAATGATGAGATCT
TTAGTTGAAATTGCAAGAACAACAAGTTTAACTGACGATCAAGTAACTGAATTGATTGAC
TGCATGTTCTCGGACAGTGGACTTGAGCATAAAAATCATTTAACGTATAAAGATTTCAAA
GAAATGATGAAAGAATACAAAGGTGAATTTGTGGCTATTGGTTTGGATTGTAAAGGTGCA
AAACAAAATTTCTTAGACACTTCTACAAATATTGCTCGCATGACTTCATTTGCAATTGAA
CCGACAGAAAGTGAAAAACATTGGATACTTGAAAAATGGGATACATATACAACATTTTTG
GAAGAAAATCGTCAGAATATTTTCTATCTATTTCTCTTTTATGTCATTACAATTGCACTC
TTTGTCGAAAGATTTATTCATTATTCATTTATGGCTGAACATACAGATTTACGACACATT
ATGGGTGTGGGAATAGCAATTACTCGAGGCTCTGCTGCAGCGCTTTCCTTTTGTTACTCA
CTCCTTCTGCTCACAATGTCACGAAATTTTCTCACAAAACTCAAAGAGTTTCCCATTCAA
CAATACATTCCACTTGATTCACATATTCAATTCCATAAGATTGCCGCATGCACAGCTCTA
TTCTTTTCTCTTTTACATACAGTCGGTCACATTGTGAATTTCTATCACGTCTCAACACAA
TCGCATGAAAATTTGAGATGTCTAACAAGAGAAGTGCATTTTGCATCCGACTATAAACCT
GACATTACTTTTTGGCTTTTTAAAACTCTTACTGGCACAACTGGAGTTGCTCTCTTTGTA
ATTATGTGTATTATATTTGCCTTTGCTCATCCAACTATAAGAAAGCGTGCTTATAAATTC
TTCTGGAATACACATTCACTTTATATCCTTCTCTACATTCTCTCATTGCTTCATGGACTT
GCACGATTGACTGGTGCACCACGTTTTTGGATGTTCTTCATTGGTCCAGCAATAATTTTT
GTTATCGATAAAGTTGCTTCACTGCGCACAAAATACATGGCACTCGATGTCATTGATGTT
GAACTTCTTCCTTCAGATGTTATAAAAATTAAGTTTTATCGTCCGCCAAATTTAAAATAT
TTATCTGGACAATGGGTTCGATTTTCATGCACTGCCATTAAGCCTGAAGAAATGCATAGT
TTTACACTGACATCAGCGCCACATGAAAACTTTTTAAGCTGCCACATTAAAGCACAAGGT
CCATGGACATGGAAACTTAGAAATTATTTCGATCCTTGTAATTATAATCCTGATGATCAA
CCAAGGATCAGAATTGAAGGTCCATATGGTGGTGGCAATCAAGATTGGTATAAATTTGAA
GTTGCTGTCATGGTTGGTGGTGGAATTGGAGTGACACCATATGCAAGCATTTTAAATGAT
TTAGTCTTTGGAACAAGCACAAACAGATATTCTGGAGTAGCTTGTAAAAAAGTATATTTC
CTTTGGATTTGTCCATCACACAAACATTTTGAATGGTTCATTGATGTTTTACGTGATGTT
GAGAAGAAAGATGTGACAAATGTTTTGGAAATTCACATTTTCATTACTCAATTTTTCCAT
AAATTTGATTTAAGAACAACAATGTTGTACATTTGCGAAAATCATTTCCAACGACTGTCA
AAAACATCAATGTTTACGGGCCTTAAAGCAGTTAATCACTTTGGTCGTCCTGATATGTCT
AGCTTCTTAAAGTTTGTTCAGAAGAAACATTCATATGTGTCGAAGATTGGAGTGTTTTCA
TGTGGACCTAGACCGCTTACTAAGAGTGTTATGTCGGCGTGTGACGAAGTCAACAAAGGT
CGTAAACTTCCATACTTTATTCATCACTTTGAGAATTTCGGATAA

>g6177.t1 Gene=g6177 Length=1494
MKCIFAIIVIQFVDLTVNEKYYSHTEKQRYDGWYNNLAHPEWGATDTHLIRKAPSAYSDG
VYGMAGPNRPSPRKLSRLFMRGEDGLSSMENRTALLAFFGQVVTNEIVMASESGCPIEMH
RIEVEKCDEMYDKECRGDRYIPFHRAMYDRKTGQSPNAPREQINQMTAWIDGSFIYSTSE
AWLNAMRSFQNGSLLTDKSGNMPVKNTMRVPLFNNPVPHVMRALSPERLYLLGDPRTNQN
PALLSFAILLMRWHNVQAQEVKRLNPDWSDEEIFQRARRQVIASLQSIFVYEYLPAFLGG
TTLEPYSGYKQDVHPGISHMFQAAAFRFGHSLIPPGIMKRDGKCNFKYTRGAPAIRLCST
WWDSSDIFEDTSIEEFLMGMASQLAEREDPFLCSDVRDKLFGPMEFTRRDLGALNIMRGR
DNGLADYNTARAAYKLPKHTNWKDINPELFEKHPELLQILISAYKDRLDNVDAYIGGMLE
SNGKPGELFTKVIIDQFTRIRDADRYWFENEDNGIFTKEEIEKFRNIKLYDIIVNSTSIE
AGQIQRNVFQFVDGDPCPQPEQLNASLLEPCSHIEGFDYFSGSELAYIYACVFLGFVPIL
CATAGYCVVKLQNRRRRRLKVKQETMRTKGGKQTVDKMIAREWLHANHKRLVTVKFGPES
AIYTVDRKGEKLRTFNLRNVDSIQVELSVESYTNKRPLVLLRIHNDHDLVLELETIGARR
KFVKKLEDFLILHKKEMSINEQNRELMLAKAETRERRQKKLEHFFREAYALTFGLRPGER
RRRSDASSDGEVMTVMRTSLSKSEFAAALGMKPDAMFVRKMFNIVDKDQDGRISFQEFLE
TVVLFSRGKTEDKLRIIFDMCDNDRNGVIDKSEFGEMMRSLVEIARTTSLTDDQVTELID
CMFSDSGLEHKNHLTYKDFKEMMKEYKGEFVAIGLDCKGAKQNFLDTSTNIARMTSFAIE
PTESEKHWILEKWDTYTTFLEENRQNIFYLFLFYVITIALFVERFIHYSFMAEHTDLRHI
MGVGIAITRGSAAALSFCYSLLLLTMSRNFLTKLKEFPIQQYIPLDSHIQFHKIAACTAL
FFSLLHTVGHIVNFYHVSTQSHENLRCLTREVHFASDYKPDITFWLFKTLTGTTGVALFV
IMCIIFAFAHPTIRKRAYKFFWNTHSLYILLYILSLLHGLARLTGAPRFWMFFIGPAIIF
VIDKVASLRTKYMALDVIDVELLPSDVIKIKFYRPPNLKYLSGQWVRFSCTAIKPEEMHS
FTLTSAPHENFLSCHIKAQGPWTWKLRNYFDPCNYNPDDQPRIRIEGPYGGGNQDWYKFE
VAVMVGGGIGVTPYASILNDLVFGTSTNRYSGVACKKVYFLWICPSHKHFEWFIDVLRDV
EKKDVTNVLEIHIFITQFFHKFDLRTTMLYICENHFQRLSKTSMFTGLKAVNHFGRPDMS
SFLKFVQKKHSYVSKIGVFSCGPRPLTKSVMSACDEVNKGRKLPYFIHHFENFG

Protein features from InterProScan

Transcript Database ID Name Start End E.value
47 g6177.t1 CDD cd09820 dual_peroxidase_like 30 583 0.0
45 g6177.t1 CDD cd00051 EFh 785 840 5.97006E-7
46 g6177.t1 CDD cd00051 EFh 818 879 1.82628E-14
44 g6177.t1 CDD cd00051 EFh 853 924 5.79697E-7
48 g6177.t1 CDD cd06186 NOX_Duox_like_FAD_NADP 1217 1399 1.91204E-46
24 g6177.t1 Coils Coil Coil 732 752 -
21 g6177.t1 Gene3D G3DSA:1.10.640.10 Myeloperoxidase 13 578 1.2E-149
23 g6177.t1 Gene3D G3DSA:1.10.238.10 - 780 933 3.0E-29
22 g6177.t1 Gene3D G3DSA:2.40.30.10 Translation factors 1202 1291 9.5E-11
20 g6177.t1 Gene3D G3DSA:3.40.50.80 - 1303 1493 3.2E-48
7 g6177.t1 PANTHER PTHR11972 NADPH OXIDASE 113 1493 0.0
8 g6177.t1 PANTHER PTHR11972:SF175 DUAL OXIDASE 113 1493 0.0
14 g6177.t1 PRINTS PR00457 Animal haem peroxidase signature 51 62 1.5E-16
9 g6177.t1 PRINTS PR00457 Animal haem peroxidase signature 95 110 1.5E-16
12 g6177.t1 PRINTS PR00457 Animal haem peroxidase signature 230 248 1.5E-16
13 g6177.t1 PRINTS PR00457 Animal haem peroxidase signature 248 268 1.5E-16
11 g6177.t1 PRINTS PR00457 Animal haem peroxidase signature 273 299 1.5E-16
10 g6177.t1 PRINTS PR00457 Animal haem peroxidase signature 323 333 1.5E-16
4 g6177.t1 Pfam PF03098 Animal haem peroxidase 28 549 3.5E-153
2 g6177.t1 Pfam PF00036 EF hand 818 840 7.6E-7
1 g6177.t1 Pfam PF13499 EF-hand domain pair 852 924 1.7E-8
5 g6177.t1 Pfam PF01794 Ferric reductase like transmembrane component 1031 1175 1.7E-18
6 g6177.t1 Pfam PF08022 FAD-binding domain 1216 1310 7.7E-18
3 g6177.t1 Pfam PF08030 Ferric reductase NAD binding domain 1319 1474 3.3E-25
33 g6177.t1 Phobius SIGNAL_PEPTIDE Signal peptide region 1 15 -
34 g6177.t1 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide. 1 2 -
35 g6177.t1 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide. 3 10 -
43 g6177.t1 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide. 11 15 -
31 g6177.t1 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. 16 585 -
36 g6177.t1 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane. 586 609 -
28 g6177.t1 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. 610 986 -
39 g6177.t1 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane. 987 1007 -
32 g6177.t1 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. 1008 1018 -
42 g6177.t1 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane. 1019 1044 -
26 g6177.t1 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. 1045 1073 -
38 g6177.t1 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane. 1074 1095 -
29 g6177.t1 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. 1096 1124 -
41 g6177.t1 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane. 1125 1148 -
25 g6177.t1 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. 1149 1159 -
37 g6177.t1 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane. 1160 1181 -
30 g6177.t1 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. 1182 1186 -
40 g6177.t1 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane. 1187 1206 -
27 g6177.t1 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. 1207 1494 -
60 g6177.t1 ProSitePatterns PS00018 EF-hand calcium-binding domain. 826 838 -
59 g6177.t1 ProSitePatterns PS00018 EF-hand calcium-binding domain. 862 874 -
62 g6177.t1 ProSiteProfiles PS50292 Animal heme peroxidase superfamily profile. 18 572 107.324
63 g6177.t1 ProSiteProfiles PS50222 EF-hand calcium-binding domain profile. 813 848 13.23
65 g6177.t1 ProSiteProfiles PS50222 EF-hand calcium-binding domain profile. 849 884 13.872
64 g6177.t1 ProSiteProfiles PS50222 EF-hand calcium-binding domain profile. 894 929 7.093
61 g6177.t1 ProSiteProfiles PS51384 Ferredoxin reductase-type FAD binding domain profile. 1210 1315 13.77
67 g6177.t1 SFLD SFLDG01169 NADPH oxidase subgroup (NOX) 23 1493 0.0
68 g6177.t1 SFLD SFLDG01168 Ferric reductase subgroup (FRE) 986 1481 0.0
66 g6177.t1 SFLD SFLDS00052 Ferric Reductase Domain 987 1481 0.0
58 g6177.t1 SMART SM00054 efh_1 817 845 2.5E-5
57 g6177.t1 SMART SM00054 efh_1 853 881 1.2E-4
56 g6177.t1 SMART SM00054 efh_1 898 926 150.0
16 g6177.t1 SUPERFAMILY SSF48113 Heme-dependent peroxidases 24 583 2.0E-152
17 g6177.t1 SUPERFAMILY SSF47473 EF-hand 799 926 1.06E-28
15 g6177.t1 SUPERFAMILY SSF63380 Riboflavin synthase domain-like 1213 1311 3.19E-13
18 g6177.t1 SUPERFAMILY SSF52343 Ferredoxin reductase-like, C-terminal NADP-linked domain 1322 1479 4.32E-11
19 g6177.t1 SignalP_EUK SignalP-noTM SignalP-noTM 1 18 -
53 g6177.t1 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane. 586 608 -
54 g6177.t1 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane. 986 1008 -
52 g6177.t1 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane. 1023 1045 -
49 g6177.t1 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane. 1074 1096 -
51 g6177.t1 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane. 1126 1148 -
55 g6177.t1 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane. 1160 1179 -
50 g6177.t1 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane. 1189 1208 -

Transmembrane regions from TMHMM

Disordered region

IUPRED3 score over 0.5 is predictive of a disordered region.

GO terms from InterProScan

GOID TERM ONTOLOGY
GO:0016174 NAD(P)H oxidase H2O2-forming activity MF
GO:0020037 heme binding MF
GO:0055114 NA NA
GO:0006979 response to oxidative stress BP
GO:0004601 peroxidase activity MF
GO:0005509 calcium ion binding MF
GO:0050665 hydrogen peroxide biosynthetic process BP
GO:0016491 oxidoreductase activity MF

KEGG

Orthology

Pathway

  • This transcript belongs to the following pathways

Expression

Transcript expression in Pv11 cells

TPM values are indicated as average +/- STDEV.

Differential expression

Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.

Raw TPM values